Further evaluation of [11C]MP-10 as a radiotracer for phosphodiesterase 10A: PET imaging study in rhesus monkeys and brain tissue metabolite analysis

Synapse

Volumn 69, Issue 2, 2015, Pages 86-95

  Lin, Shu Fei ^a   Labaree, David ^a   Chen, Ming Kai ^a   Holden, Daniel ^a   Gallezot, Jean Dominique ^a   Kapinos, Michael ^a   Teng, Jo Ku ^a   Najafzadeh, Soheila ^a   Plisson, Christophe ^a   Rabiner, Eugenii A ^a   Gunn, Roger N ^a   Carson, Richard E ^a   Huang, Yiyun ^a  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Brain; PDE10A; PET; Radiometabolite; 11C MP 10

Indexed keywords

MP10 C 11; PHOSPHODIESTERASE; PHOSPHODIESTERASE 10A; TRACER; UNCLASSIFIED DRUG; 2-((4-(1-METHYL-4-PYRIDIN-4-YL-1H-PYRAZOL-3-YL)PHENOXY)METHYL)QUINOLINE; PYRAZOLE DERIVATIVE; QUINOLINE DERIVATIVE; RADIOPHARMACEUTICAL AGENT;

AMYGDALOID NUCLEUS; ANIMAL EXPERIMENT; ARTICLE; BABOON; BRAIN REGION; BRAIN SCINTISCANNING; BRAIN TISSUE; CEREBELLUM; CINGULATE GYRUS; CONTROLLED STUDY; DRUG BINDING; EX VIVO STUDY; FRONTAL CORTEX; MALE; METABOLITE; NONHUMAN; NUCLEUS ACCUMBENS; OCCIPITAL CORTEX; POSITRON EMISSION TOMOGRAPHY; PRIORITY JOURNAL; PUTAMEN; RADIOCHEMISTRY; RAT; RHESUS MONKEY; SPRAGUE DAWLEY RAT; SUBSTANTIA NIGRA; VOLUME OF DISTRIBUTION; ANIMAL; BRAIN; EVALUATION STUDY; METABOLISM; SCINTISCANNING; TISSUE DISTRIBUTION;

ANIMALS; BRAIN; MACACA MULATTA; MALE; PHOSPHORIC DIESTER HYDROLASES; POSITRON-EMISSION TOMOGRAPHY; PYRAZOLES; QUINOLINES; RADIOPHARMACEUTICALS; RATS; RATS, SPRAGUE-DAWLEY; TISSUE DISTRIBUTION;

EID: 84919339350     PISSN: 08874476     EISSN: 10982396     Source Type: Journal    
DOI: 10.1002/syn.21792     Document Type: Article

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