Expression of Glucose Transporters 1 and 3 in metastatic and non-metastatic lower lip Squamous cell carcinoma

Brazilian Dental Journal

Volumn 25, Issue 5, 2014, Pages 372-378

  Demeda, Clarissa Favero ^a   De Carvalho, Cyntia Helena Pereira ^b   De Aquino, Ana Rafaela Luz ^a   Nonaka, Cassiano Francisco Weege ^c   De Souza, Lelia Batista ^a   Pinto, Leao Pereira ^a  

^a FEDERAL UNIVERSITY OF RIO GRANDE DO NORTE   (Brazil)

^b FEDERAL UNIVERSITY OF CAMPINA GRANDE   (Brazil)

^c STATE UNIVERSITY OF PARAÍBA   (Brazil)

Author keywords

Glucose transporter; Immunohistochemistry; Lower lip; Squamous cell carcinoma

Indexed keywords

GLUCOSE TRANSPORTER 1; GLUCOSE TRANSPORTER 3; KERATIN;

CANCER GRADING; CANCER STAGING; CELL MEMBRANE; CHEMISTRY; COMPARATIVE STUDY; CYTOPLASM; HUMAN; IMMUNOHISTOCHEMISTRY; LIP TUMOR; LYMPH NODE METASTASIS; PATHOLOGY; SECONDARY; SQUAMOUS CELL CARCINOMA; TUMOR INVASION;

CARCINOMA, SQUAMOUS CELL; CELL MEMBRANE; CYTOPLASM; GLUCOSE TRANSPORTER TYPE 1; GLUCOSE TRANSPORTER TYPE 3; HUMANS; IMMUNOHISTOCHEMISTRY; KERATINS; LIP NEOPLASMS; LYMPHATIC METASTASIS; NEOPLASM GRADING; NEOPLASM INVASIVENESS; NEOPLASM STAGING;

EID: 84919326229     PISSN: 01036440     EISSN: 18064760     Source Type: Journal    
DOI: 10.1590/0103-6440201300054     Document Type: Article

References (25)

1. Zini A, Czerninski R, Sgan-Cohen H. Oral cancer over four decades: epidemiology, trends, histology, and survival by anatomical sites. J Oral Pathol Med 2010;39:299-305.
2. Salgarelli AC, Sartorelli F, Cangiano A, Pagani R, Collini M. Surgical treatment of lip cancer: our experience with 106 cases. J Oral Maxillofac Surg 2009;67:840-845.
3. Gutierrez-Pascual M, Vicente-Martin FJ, Fernandez-Alvarez JG, Martin-Lopez R, Pinedo-Moraleda F, Lopez-Estebaranz JL. Squamous cell carcinoma of the lip: a retrospective study of 146 patients. J Eur Acad Dermatol Venereol 2012;26:1116-1121.
4. Kunkel M, Moergel M, Stockinger M, Jeong JH, Fritz G, Lehr HA, et al. Overexpression of GLUT-1 is associated with resistance to radiotherapy and adverse prognosis in squamous cell carcinoma of the oral cavity. Oral Oncol 2007;43:796-803.
5. Ortega AD, Sanchez-Arago M, Giner-Sanchez D, Sanchez-Cenizo L, Willers I, Cuezva JM. Glucose avidity of carcinomas. Cancer Lett 2009;276:125-135.
6. Perez-Sayans M, Suarez-Penaranda JM, Pilar GD, Barros-Anqueira F, Gandara-Rey JM, Garcia-Garcia A. Hypoxia-inducible factors in OSCC. Cancer Lett 2011;313:1-8.
7. Macheda ML, Rogers S, Best JD. Molecular and cellular regulation of glucose transporter (GLUT) proteins in cancer. J Cell Pyshiol 2005;202:654-262.
8. Ohba S, Fujii H, Ito S, Fujimaki M, Matsumoto F, Furukawa M, et al.. Overexpression of GLUT-1 in the invasion front is associated with depth of oral squamous cell carcinoma and prognosis. J Oral Pathol Med 2010;39:74-78.
9. Ogane N, Yasuda M, Shimizu M, Miyazawa M, Kamoshida S, Ueda A, et al.. Clinicopathological implications of expressions of hypoxia-related molecules in esophageal superficial squamous cell carcinoma. Ann Diagn Pathol 2010;14:23-29.
10. Oliver RJ, Woodwards RT, Sloan P, Thakker NS, Stratford IJ, Airley RE. Prognostic value of facilitative glucose transporter Glut-1 in oral squamous cell carcinomas treated by surgical resection: results of EORTC Translational Research Fund studies. Eur J Cancer 2004;40:503-507.
11. Roh JL, Cho KJ, Kwon GY, Ryu CH, Chang HW, Choi SH, et al.. The prognostic value of hypoxia markers in T2-staged oral tongue cancer. Oral Oncol 2009;45:63-68.
12. Kondo Y, Yoshikawa K, Omura Y, Shinohara A, Kazaoka Y, Sano J, et al.. Clinicopathological significance of carbonic anhydrase 9, glucose transporter-1, Ki-67 and p53 expression in oral squamous cell carcinoma. Oncol Rep 2011;25:1227-1233.
13. Eckert AW, Lautner MH, Schutze A, Taubert H, Schubert J, Bilkenroth U. Coexpression of hypoxia-inducible factor-1α and glucose transporter-1 is associated with poor prognosis in oral squamous cell carcinoma patients. Histopathology 2011;58:1136-1147.
14. Kunkel M, Reichert TE, Benz P, Lehr HA, Jeong JH, Wieand S, et al.. Overexpression of Glut-1 and increased glucose metabolism in tumors are associated with a poor prognosis in patients with oral squamous cell carcinoma. Cancer 2003;97:1015-1024.
15. Ayala FR, Rocha RM, Carvalho KC, Carvalho AL, da Cunha IW, Lourenco SV, et al.. GLUT1 and GLUT3 as potential prognostic markers for oral squamous cell carcinoma. Molecules 2010;15:2374-2387.
16. Cardesa A, Gale N, Nadal A, Zidar N. Squamous cell carcinoma. In: Barnes L, Eveson JW, Reichart P, Sidransky D, editors. World Health Organization classification of tumours. Pathology and genetics of head and neck tumours. Lyon: IARC Press; 2005. p.118-121.
17. Bryne M. Is the invasive front of an oral carcinoma the most important area for prognostication? Oral Dis 1998;4:70-77.
18. Silveira EJ, Godoy GP, Lins RD, Arruda M de L, Ramos CC, Freitas R de A, et al.. Correlation of clinical, histological, and cytokeratin profiles of the squamous cell carcinoma of the oral tongue with prognosis. Int J Surg Pathol 2007;15:376-383.
19. Kondoh H. Cellular life span and the Warburg effect. Exp Cell Res 2008;314:1923-1928.
20. Rademakers SE, Lok J, van der Kogel AJ, Bussink J, Kaanders JH. Metabolic markers in relation to hypoxia staining patterns and colocalization of pimonidazole, HIF-1α, CAIX, LDH-5, GLUT-1, MCT1 and MCT4. BMC Cancer 2011;11:167.
21. Eckert AW, Kappler M, Schubert J, Taubert H. Correlation of expression of hypoxia-related proteins with prognosis in oral squamous cell carcinoma patients. Oral Maxillofac Surg 2012;16:189-196.
22. Tian M, Zhang H, Nakasone Y, Mogi K, Endo K. Expression of Glut-1 and Glut-3 in untreated oral squamous cell carcinoma compared with FDG accumulation in a PET study. Eur J Nucl Med Mol Imaging 2004;31:5-12.
23. Yamada T, Uchida M, Kwang-Lee K, Kitamura N, Yoshimura T, Sasabe E, et al.. Correlation of metabolism/hypoxia markers and fluorodeoxyglucose uptake in oral squamous cell carcinoma. Oral Surg Oral Med Oral Pathol Oral Radiol 2012;113:464-471.
24. Zhou S, Wang S, Wu Q, Fan J, Wang Q. Expression of glucose transporter-1 and-3 in the head and neck carcinoma-the correlation of the expression with the biological behaviors. ORL J Otorhinolaryngol Relat Spec 2008;70:189-194.
25. Grimm M, Alexander D, Munz A, Hoffmann J, Reinert S. Increased LDH5 expression is associated with lymph node metastasis and outcome in oral squamous cell carcinoma. Clin Exp Metastasis 2013;30:529-540.