메뉴 건너뛰기




Volumn 24, Issue 11, 2014, Pages 1729-1737

High prevalence of psychotropic drug use among persons with and without Alzheimer[U+05F3]s disease in Finnish nationwide cohort

Author keywords

Alzheimer U+05F3 s disease; Older persons; Psychotropic drugs

Indexed keywords

ANTIDEPRESSANT AGENT; ARIPIPRAZOLE; ATYPICAL ANTIPSYCHOTIC AGENT; BENZODIAZEPINE; BENZODIAZEPINE DERIVATIVE; CHLORPROTHIXENE; CITALOPRAM; CLOZAPINE; DIXYRAZINE; ESCITALOPRAM; HALOPERIDOL; LORAZEPAM; MELPERONE; MIRTAZAPINE; NEUROLEPTIC AGENT; OLANZAPINE; OXAZEPAM; PALIPERIDONE; PERPHENAZINE; PRESCRIPTION DRUG; PSYCHOTROPIC AGENT; QUETIAPINE; RISPERIDONE; SEROTONIN UPTAKE INHIBITOR; TEMAZEPAM; THIORIDAZINE; TRICYCLIC ANTIDEPRESSANT AGENT; UNINDEXED DRUG; ZIPRASIDONE; ZUCLOPENTHIXOL;

EID: 84918840159     PISSN: 0924977X     EISSN: 18737862     Source Type: Journal    
DOI: 10.1016/j.euroneuro.2014.10.004     Document Type: Article
Times cited : (70)

References (36)
  • 1
    • 0004235298 scopus 로고
    • American Psychiatric Association, Washington, DC
    • American Psychiatric Association Diagnostic and Statistical Manual of Mental Disorders 1994, American Psychiatric Association, Washington, DC. 4th ed.
    • (1994) Diagnostic and Statistical Manual of Mental Disorders
  • 3
  • 4
    • 80052913150 scopus 로고    scopus 로고
    • Antidepressant use and risk of adverse outcomes in older people: population based cohort study
    • Coupland C., Dhiman P., Morriss R., Arthur A., Barton G., Hippisley-Cox J. Antidepressant use and risk of adverse outcomes in older people: population based cohort study. Br. Med. J. 2011, 343:d4551.
    • (2011) Br. Med. J. , vol.343 , pp. d4551
    • Coupland, C.1    Dhiman, P.2    Morriss, R.3    Arthur, A.4    Barton, G.5    Hippisley-Cox, J.6
  • 5
    • 0041832177 scopus 로고    scopus 로고
    • Benzodiazepines and risk of hip fractures in older people: a review of the evidence
    • Cumming R.G., Le Couteur D.G. Benzodiazepines and risk of hip fractures in older people: a review of the evidence. CNS Drugs 2003, 17:825-837.
    • (2003) CNS Drugs , vol.17 , pp. 825-837
    • Cumming, R.G.1    Le Couteur, D.G.2
  • 6
    • 85067781508 scopus 로고    scopus 로고
    • EMA-European Medicines Agency, 2008. CHMP assessment report on conventional antipsychotics. Procedure under Article 5(3) of Regulation (EC) No. 726/2004. Available at
    • EMA-European Medicines Agency, 2008. CHMP assessment report on conventional antipsychotics. Procedure under Article 5(3) of Regulation (EC) No. 726/2004. Available at . http://www.ema.europa.eu/docs/en_GB/document_library/Report/2010/01/WC500054057.pdf.
  • 7
    • 85067782122 scopus 로고    scopus 로고
    • FDA - U.S. Food and Drug Administration, 2005. Public health advisory. Deaths with antipsychotics in elderly patients with behavioral disturbances. Available at (accessed 08.04.14.).
    • FDA - U.S. Food and Drug Administration, 2005. Public health advisory. Deaths with antipsychotics in elderly patients with behavioral disturbances. Available at (accessed 08.04.14.). http://www.fda.gov/Drugs/DrugSafety/PostmarketDrugSafetyInformationforPatientsandProviders/DrugSafetyInformationforHeathcareProfessionals/PublicHealthAdvisories/ucm053171.htm.
  • 8
    • 85067781025 scopus 로고    scopus 로고
    • FDA - U.S. Food and Drug Administration, 2008. Postmarketing drug safety for patients and providers. Information on conventional antipsychotics. Available at (accessed 08.04.14.).
    • FDA - U.S. Food and Drug Administration, 2008. Postmarketing drug safety for patients and providers. Information on conventional antipsychotics. Available at (accessed 08.04.14.). http://www.fda.gov/Drugs/DrugSafety/PostmarketDrugSafetyInformationforPatientsandProviders/ucm107211.htm.
  • 9
    • 85067758897 scopus 로고    scopus 로고
    • Finnish Medical Society Duodecim, Helsinki, 2010. Current care: memory disorders. [in Finnish with English summary]. Available at (accessed 10.04.14.).
    • Finnish Medical Society Duodecim, Helsinki, 2010. Current care: memory disorders. [in Finnish with English summary]. Available at (accessed 10.04.14.). http://www.kaypahoito.fi.
  • 11
    • 84870199798 scopus 로고    scopus 로고
    • Antipsychotic use and mortality risk in community-dwelling Alzheimer[U+05F3]s disease patients: evidence for a role of dementia severity
    • Gardette V., Lapeyre-Mestre M., Coley N., Cantet C., Montastruc J.L., Vellas B., Andrieu S. Antipsychotic use and mortality risk in community-dwelling Alzheimer[U+05F3]s disease patients: evidence for a role of dementia severity. Curr. Alzheimer Res. 2012, 9:1106-1116.
    • (2012) Curr. Alzheimer Res. , vol.9 , pp. 1106-1116
    • Gardette, V.1    Lapeyre-Mestre, M.2    Coley, N.3    Cantet, C.4    Montastruc, J.L.5    Vellas, B.6    Andrieu, S.7
  • 14
    • 79960458504 scopus 로고    scopus 로고
    • Mortality associated with benzodiazepines and benzodiazepine-related drugs among community-dwelling older people in Finland: a population-based retrospective cohort study
    • Gisev N., Hartikainen S., Chen T.F., Korhonen M., Bell J.S. Mortality associated with benzodiazepines and benzodiazepine-related drugs among community-dwelling older people in Finland: a population-based retrospective cohort study. Can. J. Psychiatry 2011, 56:377-381.
    • (2011) Can. J. Psychiatry , vol.56 , pp. 377-381
    • Gisev, N.1    Hartikainen, S.2    Chen, T.F.3    Korhonen, M.4    Bell, J.S.5
  • 15
    • 77955934462 scopus 로고    scopus 로고
    • The burden of psychotropic drug prescribing in people with dementia: a population database study
    • Guthrie B., Clark S.A., McCowan C. The burden of psychotropic drug prescribing in people with dementia: a population database study. Age Ageing 2010, 39:637-642.
    • (2010) Age Ageing , vol.39 , pp. 637-642
    • Guthrie, B.1    Clark, S.A.2    McCowan, C.3
  • 17
    • 35348949020 scopus 로고    scopus 로고
    • Medication as a risk factor for falls: critical systematic review
    • Hartikainen S., Lönnroos E., Louhivuori K. Medication as a risk factor for falls: critical systematic review. J. Gerontol. Med. Sci. 2007, 62A:1172-1181.
    • (2007) J. Gerontol. Med. Sci. , vol.62 A , pp. 1172-1181
    • Hartikainen, S.1    Lönnroos, E.2    Louhivuori, K.3
  • 21
    • 84873466648 scopus 로고    scopus 로고
    • Trends in the prevalence of antipsychotic drug use among patients with Alzheimer[U+05F3]s disease and other dementias including those treated with antidementia drugs in the community in the UK: a cohort study
    • Martinez C., Jones R.W., Rietbrock S. Trends in the prevalence of antipsychotic drug use among patients with Alzheimer[U+05F3]s disease and other dementias including those treated with antidementia drugs in the community in the UK: a cohort study. BMJ Open 2013, 7:3.
    • (2013) BMJ Open , vol.7 , pp. 3
    • Martinez, C.1    Jones, R.W.2    Rietbrock, S.3
  • 22
    • 0021271971 scopus 로고
    • Clinical diagnosis of Alzheimer[U+05F3]s disease: Report of the NINCDS-ADRDA work group under the auspices of department of health and human services task force on Alzheimer[U+05F3]s disease
    • McKhann G., Drachman D., Folstein M., Katzman R., Price D., Stadlan E.M. Clinical diagnosis of Alzheimer[U+05F3]s disease: Report of the NINCDS-ADRDA work group under the auspices of department of health and human services task force on Alzheimer[U+05F3]s disease. Neurology 1984, 34:939-944.
    • (1984) Neurology , vol.34 , pp. 939-944
    • McKhann, G.1    Drachman, D.2    Folstein, M.3    Katzman, R.4    Price, D.5    Stadlan, E.M.6
  • 23
    • 79551647270 scopus 로고    scopus 로고
    • Risk of cerebrovascular adverse events and death in elderly patients with dementia when treated with antipsychotic medications: a literature review of evidence
    • Mittal V., Kurup L., Williamson D., Muralee S., Tampi R.R. Risk of cerebrovascular adverse events and death in elderly patients with dementia when treated with antipsychotic medications: a literature review of evidence. Am. J. Alzheimers Dis. Other Dement. 2011, 26:10-28.
    • (2011) Am. J. Alzheimers Dis. Other Dement. , vol.26 , pp. 10-28
    • Mittal, V.1    Kurup, L.2    Williamson, D.3    Muralee, S.4    Tampi, R.R.5
  • 24
    • 84864781580 scopus 로고    scopus 로고
    • Psychotropic-related hip fractures: meta-analysis of first-generation and second-generation antidepressant and antipsychotic drugs
    • Oderda L.H., Young J.R., Asche C.V., Pepper G.A. Psychotropic-related hip fractures: meta-analysis of first-generation and second-generation antidepressant and antipsychotic drugs. Ann. Pharmacother. 2012, 46:917-928.
    • (2012) Ann. Pharmacother. , vol.46 , pp. 917-928
    • Oderda, L.H.1    Young, J.R.2    Asche, C.V.3    Pepper, G.A.4
  • 25
    • 0036107859 scopus 로고    scopus 로고
    • Long-term benzodiazepine use and cognitive decline in the elderly: the Epidemiology of Vascular Aging Study
    • Paterniti S., Dufouil C., Alperovitch A. Long-term benzodiazepine use and cognitive decline in the elderly: the Epidemiology of Vascular Aging Study. J. Clin. Psychopharmacol. 2002, 22:285-293.
    • (2002) J. Clin. Psychopharmacol. , vol.22 , pp. 285-293
    • Paterniti, S.1    Dufouil, C.2    Alperovitch, A.3
  • 27
    • 81755163924 scopus 로고    scopus 로고
    • Psychotropic medication burden and factors associated with antipsychotic use: an analysis of a population-based sample of community-dwelling older persons with dementia
    • Rhee Y.J., Csernansky J.G., Emanuel L.L., Chang C.G., Shega J.W. Psychotropic medication burden and factors associated with antipsychotic use: an analysis of a population-based sample of community-dwelling older persons with dementia. J. Am. Geriatr. Soc. 2011, 59:2100-2107.
    • (2011) J. Am. Geriatr. Soc. , vol.59 , pp. 2100-2107
    • Rhee, Y.J.1    Csernansky, J.G.2    Emanuel, L.L.3    Chang, C.G.4    Shega, J.W.5
  • 28
    • 79960785452 scopus 로고    scopus 로고
    • Selective serotonin reuptake inhibitor treatment and depression are associated with poststroke mortality
    • Ried L.D., Jia H., Feng H., Cameon R., Wang X., Tueth M., Wu S.S. Selective serotonin reuptake inhibitor treatment and depression are associated with poststroke mortality. Ann. Pharmacother. 2011, 45:888-897.
    • (2011) Ann. Pharmacother. , vol.45 , pp. 888-897
    • Ried, L.D.1    Jia, H.2    Feng, H.3    Cameon, R.4    Wang, X.5    Tueth, M.6    Wu, S.S.7
  • 29
    • 33947264305 scopus 로고    scopus 로고
    • Risk of death associated with the use of conventional versus atypical antipsychotic drugs among elderly patients
    • Schneeweiss S., Setoguchi S., Brookhart A., Dormuth C., Wang P.S. Risk of death associated with the use of conventional versus atypical antipsychotic drugs among elderly patients. Can. Med. Assoc. J. 2007, 176:627-632.
    • (2007) Can. Med. Assoc. J. , vol.176 , pp. 627-632
    • Schneeweiss, S.1    Setoguchi, S.2    Brookhart, A.3    Dormuth, C.4    Wang, P.S.5
  • 30
    • 26844538114 scopus 로고    scopus 로고
    • Risk of death with atypical antipsychotic drug treatment for dementia: meta-analysis of randomized placebo-controlled trials
    • Schneider L.S., Dagerman K.S., Insel P. Risk of death with atypical antipsychotic drug treatment for dementia: meta-analysis of randomized placebo-controlled trials. J. Am. Med. Assoc. 2005, 294:1934-1943.
    • (2005) J. Am. Med. Assoc. , vol.294 , pp. 1934-1943
    • Schneider, L.S.1    Dagerman, K.S.2    Insel, P.3
  • 32
    • 84884207245 scopus 로고    scopus 로고
    • Impact of safety warnings on antipsychotic prescriptions in dementia: nothing has changed but the years and the substances
    • Schulze J., van den Bussche H., Glaeske G., Kaduszkiewicz H., Wiese B., Hoffmann F. Impact of safety warnings on antipsychotic prescriptions in dementia: nothing has changed but the years and the substances. Eur. Neuropsychopharmacol. 2013, 23:1034-1042.
    • (2013) Eur. Neuropsychopharmacol. , vol.23 , pp. 1034-1042
    • Schulze, J.1    van den Bussche, H.2    Glaeske, G.3    Kaduszkiewicz, H.4    Wiese, B.5    Hoffmann, F.6
  • 33
    • 84902141749 scopus 로고    scopus 로고
    • Use of existing data sources in clinical epidemiology: Finnish health care registers in Alzheimer[U+05F3]s disease research - the Medication use among persons with Alzheimer[U+05F3]s disease (MEDALZ-2005) study
    • Tolppanen A.M., Taipale H., Koponen M., Lavikainen P., Tanskanen A., Tiihonen J., Hartikainen S. Use of existing data sources in clinical epidemiology: Finnish health care registers in Alzheimer[U+05F3]s disease research - the Medication use among persons with Alzheimer[U+05F3]s disease (MEDALZ-2005) study. Clin. Epidemiol. 2013, 5:277-285.
    • (2013) Clin. Epidemiol. , vol.5 , pp. 277-285
    • Tolppanen, A.M.1    Taipale, H.2    Koponen, M.3    Lavikainen, P.4    Tanskanen, A.5    Tiihonen, J.6    Hartikainen, S.7
  • 35
    • 85067782220 scopus 로고    scopus 로고
    • WHO Collaborating Centre for Drug Statistics Methodology, 2014. The Anatomical Therapeutic Chemical Classification System. (accessed 10.04.14.).
    • WHO Collaborating Centre for Drug Statistics Methodology, 2014. The Anatomical Therapeutic Chemical Classification System. (accessed 10.04.14.). http://www.whocc.no/atc_ddd_index/.
  • 36
    • 84891858320 scopus 로고    scopus 로고
    • Association between use of benzodiazepines and risk of fractures: a meta-analysis
    • Xing D., Ma X.L., Wang J., Yang Y., Chen Y. Association between use of benzodiazepines and risk of fractures: a meta-analysis. Osteoporos. Int. 2014, 25:105-120.
    • (2014) Osteoporos. Int. , vol.25 , pp. 105-120
    • Xing, D.1    Ma, X.L.2    Wang, J.3    Yang, Y.4    Chen, Y.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.