Lactosylated PLGA nanoparticles containing μ-polylysine for the sustained release and liver-targeted delivery of the negatively charged proteins

International Journal of Pharmaceutics

Volumn 478, Issue 2, 2015, Pages 633-643

  Zhou, Ping ^a   An, Tong ^a   Zhao, Chuan ^a   Li, Yuan ^a   Li, Rongshan ^a   Yang, Rui ^a   Wang, Yinsong ^a   Gao, Xiujun ^a  

^a TIANJIN MEDICAL UNIVERSITY   (China)

Author keywords

Lactosylated; Nanoparticle; PLGA Polylysine; Protein; Sustained release

Indexed keywords

LACTOSE; POLYGLACTIN; POLYLYSINE; BOVINE SERUM ALBUMIN; DELAYED RELEASE FORMULATION; LACTIC ACID; NANOPARTICLE; POLYGLYCOLIC ACID; POLYLACTIC ACID-POLYGLYCOLIC ACID COPOLYMER;

ARTICLE; CONTROLLED STUDY; CYTOTOXICITY ASSAY; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; MICROCLIMATE; MTT ASSAY; PH; PROTEIN CONTENT; PROTEIN SECRETION; PROTEIN TARGETING; SUSTAINED DRUG RELEASE; SYNTHESIS; ADMINISTRATION AND DOSAGE; ANIMAL; CELL LINE; CELL SURVIVAL; CHEMISTRY; DELAYED RELEASE FORMULATION; DRUG DELIVERY SYSTEM; DRUG EFFECTS; DRUG RELEASE; FEMALE; HEPG2 CELL LINE; LD50; LIVER; MALE; METABOLISM; MOUSE; TOXICITY TESTING;

ANIMALS; CELL LINE; CELL SURVIVAL; DELAYED-ACTION PREPARATIONS; DRUG DELIVERY SYSTEMS; DRUG LIBERATION; FEMALE; HEP G2 CELLS; HUMANS; LACTIC ACID; LACTOSE; LETHAL DOSE 50; LIVER; MALE; MICE; NANOPARTICLES; POLYGLYCOLIC ACID; POLYLYSINE; SERUM ALBUMIN, BOVINE; TOXICITY TESTS, ACUTE;

EID: 84918820864     PISSN: 03785173     EISSN: 18733476     Source Type: Journal    
DOI: 10.1016/j.ijpharm.2014.12.017     Document Type: Article

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