Making ends meet: A role of RNA ligase RTCB in unfolded protein response

EMBO Journal

Volumn 33, Issue 24, 2014, Pages 2887-2889

  Filipowicz, Witold ^a  

^a FRIEDRICH MIESCHER INSTITUTE FOR BIOMEDICAL RESEARCH   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

MESSENGER RNA; PROTEIN IRE1; PROTEIN RTCB; RETINOIC ACID INDUCIBLE PROTEIN I; RIBONUCLEASE L; RNA LIGASE; TRANSFER RNA; UNCLASSIFIED DRUG; X BOX BINDING PROTEIN 1; AMINO ACID TRANSFER RNA LIGASE; ANTIBODY; ARCHEASE PROTEIN, HUMAN; DNA BINDING PROTEIN; FAAP PROTEIN, MOUSE; PROTEIN; REGULATORY FACTOR X TRANSCRIPTION FACTORS; TRANSCRIPTION FACTOR;

ANTIBODY TITER; ARTICLE; B LYMPHOCYTE DIFFERENTIATION; CAENORHABDITIS ELEGANS; CYTOPLASM; EMBRYONIC STEM CELL; ENDOPLASMIC RETICULUM; ENDOPLASMIC RETICULUM MEMBRANE; ENDOPLASMIC RETICULUM STRESS; EXON; IMMUNOGLOBULIN PRODUCING CELL; INNATE IMMUNITY; INTRON; NONHUMAN; PHENOTYPE; PROTEIN CLEAVAGE; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; RNA INTERFERENCE; RNA SPLICING; UNFOLDED PROTEIN RESPONSE; ANIMAL; GENETICS; HUMAN; METABOLISM; PHYSIOLOGY; PLASMA CELL;

ANIMALIA; CAENORHABDITIS ELEGANS; MAMMALIA;

AMINO ACYL-TRNA SYNTHETASES; ANIMALS; ANTIBODIES; DNA-BINDING PROTEINS; HUMANS; PLASMA CELLS; PROTEINS; RNA SPLICING; RNA, MESSENGER; TRANSCRIPTION FACTORS; UNFOLDED PROTEIN RESPONSE;

EID: 84918815371     PISSN: 02614189     EISSN: 14602075     Source Type: Journal    
DOI: 10.15252/embj.201490425     Document Type: Article

References (16)

1. Anderson P, Ivanov P, (2014) tRNA fragments in human health and disease. FEBS Lett 588: 4297-4304
2. Cho JA, Lee AH, Platzer B, Cross BC, Gardner BM, De Luca H, Luong P, Harding HP, Glimcher LH, Walter P, Fiebiger E, Ron D, Kagan JC, Lencer WI, (2013) The unfolded protein response element IRE1α senses bacterial proteins invading the ER to activate RIG-I and innate immune signaling. Cell Host Microbe 13: 558-569
3. Filipowicz W, Konarska M, Gross HJ, Shatkin AJ, (1983) RNA 3′-terminal phosphate cyclase activity and RNA ligation in HeLa cell extract. Nucleic Acids Res 11: 1405-1418
4. Filipowicz W, Shatkin AJ, (1983) Origin of splice junction phosphate in tRNAs processed by HeLa cell extract. Cell 32: 547-557
5. Grosjean H, Szweykowska-Kulinska Z, Motorin Y, Fasiolo F, Simos G, (1997) Intron-dependent enzymatic formation of modified nucleosides in eukaryotic tRNAs: a review. Biochimie 79: 293-302
6. Gu C, Begley TJ, Dedon PC, (2014) tRNA modifications regulate translation during cellular stress. FEBS Lett 588: 4287-4296
7. Iwawaki T, Tokuda M, (2011) Function of yeast and amphioxus tRNA ligase in IRE1alpha-dependent XBP1 mRNA splicing. Biochem Biophys Res Commun 413: 527-531
8. Jurkin J, Henkel T, Nielsen AF, Minnich M, Popow J, Kaufmann T, Heindl K, Hoffmann T, Busslinger M, Martinez J, (2014) The mammalian tRNA ligase complex mediates splicing of XBP1 mRNA and controls antibody secretion in plasma cells. EMBO J 33: 2922-2936
9. Kosmaczewski SG, Edwards TJ, Han SM, Eckwahl MJ, Meyer BI, Peach S, Hesselberth JR, Wolin SL, Hammarlund M, (2014) The RtcB RNA ligase is an essential component of the metazoan unfolded protein response. EMBO Rep 15: 1278-1285
10. Laski FA, Fire AZ, RajBhandary UL, Sharp PA, (1983) Characterization of tRNA precursor splicing in mammalian extracts. J Biol Chem 258: 11974-11980
11. Lu Y, Liang FX, Wang X, (2014) A synthetic biology approach identifies the mammalian UPR RNA ligase RtcB. Mol Cell 55: 758-770
12. Malathi K, Dong B, Gale M Jr, Silverman RH, (2007) Small self-RNA generated by RNase L amplifies antiviral innate immunity. Nature 448: 816-819
13. Moore KA, Hollien J, (2012) The unfolded protein response in secretory cell function. Annu Rev Genet 46: 165-183
14. Popow J, Englert M, Weitzer S, Schleiffer A, Mierzwa B, Mechtler K, Trowitzsch S, Will CL, Luhrmann R, Soll D, Martinez J, (2011) HSPC117 is the essential subunit of a human tRNA splicing ligase complex. Science 331: 760-764
15. Popow J, Jurkin J, Schleiffer A, Martinez J, (2014) Analysis of orthologous groups reveals archease and DDX1 as tRNA splicing factors. Nature 511: 104-107
16. Walter P, Ron D, (2011) The unfolded protein response: form stress pathway to homeostatic regulation. Science 334: 1081-1086