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Volumn 25, Issue 12, 2014, Pages 1023-1034

Selective in vivo targeting of human liver tumors by optimized AAV3 vectors in a murine xenograft model

Author keywords

[No Author keywords available]

Indexed keywords

ADENOVIRUS VECTOR; SERINE; SHIKONIN; THREONINE;

EID: 84918806026     PISSN: 10430342     EISSN: 15577422     Source Type: Journal    
DOI: 10.1089/hum.2014.099     Document Type: Article
Times cited : (44)

References (53)
  • 1
    • 84861189907 scopus 로고    scopus 로고
    • Highefficiency transduction of human monocyte-derived dendritic cells by capsid-modified recombinant aav2 vectors
    • Aslanidi, G.V., Rivers, A.E., Ortiz, L., et al. (2012). Highefficiency transduction of human monocyte-derived dendritic cells by capsid-modified recombinant AAV2 vectors. Vaccine 30, 3908-3917
    • (2012) Vaccine , vol.30 , pp. 3908-3917
    • Aslanidi, G.V.1    Rivers, A.E.2    Ortiz, L.3
  • 2
    • 84875092627 scopus 로고    scopus 로고
    • Optimization of the capsid of recombinant adeno-Associated virus 2 (aav2) vectors: The final threshold
    • Aslanidi, G.V., Rivers, A.E., Ortiz, L., et al. (2013). Optimization of the capsid of recombinant adeno-Associated virus 2 (AAV2) vectors: The final threshold? PLoS One 8, e59142
    • (2013) PLoS One , vol.8 , pp. e59142
    • Aslanidi, G.V.1    Rivers, A.E.2    Ortiz, L.3
  • 3
    • 84875870399 scopus 로고    scopus 로고
    • Liver cancer incidence and mortality in china 2009
    • Chen, W.Q., Zheng, R.S., and Zhang, S.W. (2013). Liver cancer incidence and mortality in China, 2009. Chin. J. Cancer 32, 162-169
    • (2013) Chin. J. Cancer , vol.32 , pp. 162-169
    • Chen, W.Q.1    Zheng, R.S.2    Zhang, S.W.3
  • 4
    • 84859610928 scopus 로고    scopus 로고
    • Development of optimized aav3 serotype vectors: Mechanism of high-efficiency transduction of human liver cancer cells
    • Cheng, B., Ling, C., Dai, Y., et al. (2012).Development of optimized AAV3 serotype vectors: Mechanism of high-efficiency transduction of human liver cancer cells. Gene Ther. 19, 375-384
    • (2012) Gene Ther , vol.19 , pp. 375-384
    • Cheng, B.1    Ling, C.2    Dai, Y.3
  • 5
    • 77953419972 scopus 로고    scopus 로고
    • Bms-777607, a smallmolecule met kinase inhibitor, suppresses hepatocyte growth factor-stimulated prostate cancer metastatic phenotype in vitro
    • Dai, Y., and Siemann, D.W. (2010). Bms-777607, a smallmolecule met kinase inhibitor, suppresses hepatocyte growth factor-stimulated prostate cancer metastatic phenotype in vitro. Mol. Cancer Ther. 9, 1554-1561
    • (2010) Mol. Cancer Ther , vol.9 , pp. 1554-1561
    • Dai, Y.1    Siemann, D.W.2
  • 6
    • 80052817050 scopus 로고    scopus 로고
    • Impact of hypoxia on the metastatic potential of human prostate cancer cells
    • Dai, Y., Bae, K., and Siemann, D.W. (2011). Impact of hypoxia on the metastatic potential of human prostate cancer cells. Int. J. Radiat. Oncol. Biol. Phys. 81, 521-528
    • (2011) Int. J. Radiat. Oncol. Biol. Phys , vol.81 , pp. 521-528
    • Dai, Y.1    Bae, K.2    Siemann, D.W.3
  • 7
    • 0037818636 scopus 로고    scopus 로고
    • Sex significantly influences transduction of murine liver by recombinant adeno-Associated viral vectors through an androgen-dependent pathway
    • Davidoff, A.M., Ng, C.Y., Zhou, J., et al. (2003). Sex significantly influences transduction of murine liver by recombinant adeno-Associated viral vectors through an androgen-dependent pathway. Blood 102, 480-488
    • (2003) Blood , vol.102 , pp. 480-488
    • Davidoff, A.M.1    Ng, C.Y.2    Zhou, J.3
  • 8
    • 84901437727 scopus 로고    scopus 로고
    • Advances in mesenchymal stem cells combined with traditional chinese medicine therapy for liver fibrosis
    • Dong, S., and Su, S.B. (2014). Advances in mesenchymal stem cells combined with traditional chinese medicine therapy for liver fibrosis. J. Integr. Med. 12, 147-155
    • (2014) J. Integr. Med , vol.12 , pp. 147-155
    • Dong, S.1    Su, S.B.2
  • 9
    • 80053088189 scopus 로고    scopus 로고
    • Hepatocellular carcinoma
    • El-Serag, H.B. (2011). Hepatocellular carcinoma. N. Engl. J. Med. 365, 1118-1127
    • (2011) N. Engl. J. Med , vol.365 , pp. 1118-1127
    • El-Serag, H.B.1
  • 10
    • 0037015049 scopus 로고    scopus 로고
    • Novel adenoassociated viruses from rhesus monkeys as vectors for human gene therapy
    • Gao, G.P., Alvira, M.R., Wang, L., et al. (2002). Novel adenoassociated viruses from rhesus monkeys as vectors for human gene therapy. Proc. Natl. Acad. Sci. USA 99, 11854-11859
    • (2002) Proc. Natl. Acad. Sci. USA , vol.99 , pp. 11854-11859
    • Gao, G.P.1    Alvira, M.R.2    Wang, L.3
  • 11
    • 84874346554 scopus 로고    scopus 로고
    • Gene therapy clinical trials worldwide to 2012-An update
    • Ginn, S.L., Alexander, I.E., Edelstein, M.L., et al. (2013). Gene therapy clinical trials worldwide to 2012-An update. J. Gene Med. 15, 65-77
    • (2013) J. Gene Med , vol.15 , pp. 65-77
    • Ginn, S.L.1    Alexander, I.E.2    Edelstein, M.L.3
  • 12
    • 70349748434 scopus 로고    scopus 로고
    • Aav3-mediated transfer and expression of the pyruvate dehydrogenase e1 alpha subunit gene causes metabolic remodeling and apoptosis of human liver cancer cells
    • Glushakova, L.G., Lisankie, M.J., Eruslanov, E.B., et al. (2009). AAV3-mediated transfer and expression of the pyruvate dehydrogenase E1 alpha subunit gene causes metabolic remodeling and apoptosis of human liver cancer cells. Mol. Genet. Metab. 98, 289-299
    • (2009) Mol. Genet. Metab , vol.98 , pp. 289-299
    • Glushakova, L.G.1    Lisankie, M.J.2    Eruslanov, E.B.3
  • 13
    • 81855218666 scopus 로고    scopus 로고
    • Shikonin, a chinese plant-derived naphthoquinone, induces apoptosis in hepatocellular carcinoma cells through reactive oxygen species: A potential new treatment for hepatocellular carcinoma
    • Gong, K., and Li, W. (2011). Shikonin, a Chinese plant-derived naphthoquinone, induces apoptosis in hepatocellular carcinoma cells through reactive oxygen species: A potential new treatment for hepatocellular carcinoma. Free Radic. Biol. Med. 51, 2259-2271
    • (2011) Free Radic. Biol. Med , vol.51 , pp. 2259-2271
    • Gong, K.1    Li, W.2
  • 14
    • 84856215097 scopus 로고    scopus 로고
    • Altered lkb1/crebregulated transcription co-Activator (crtc) signaling axis promotes esophageal cancer cell migration and invasion
    • Gu, Y., Lin, S., Li, J.L., et al. (2012). Altered LKB1/CREBregulated transcription co-Activator (CRTC) signaling axis promotes esophageal cancer cell migration and invasion. Oncogene. 31, 469-479
    • (2012) Oncogene , vol.31 , pp. 469-479
    • Gu, Y.1    Lin, S.2    Li, J.L.3
  • 15
    • 84864761391 scopus 로고    scopus 로고
    • Essential metabolic, anti-inflammatory, and anti-Tumorigenic functions of mir-122 in liver
    • Hsu, S.H., Wang, B., Kota, J., et al. (2012). Essential metabolic, anti-inflammatory, and anti-Tumorigenic functions of mir-122 in liver. J. Clin. Invest. 122, 2871-2883
    • (2012) J. Clin. Invest , vol.122 , pp. 2871-2883
    • Hsu, S.H.1    Wang, B.2    Kota, J.3
  • 17
    • 0347360271 scopus 로고    scopus 로고
    • 1-Azakenpaullone is a selective inhibitor of glycogen synthase kinase-3 beta
    • Kunick, C., Lauenroth, K., Leost, M., et al. (2004). 1-Azakenpaullone is a selective inhibitor of glycogen synthase kinase-3 beta. Bioorg. Med. Chem. Lett. 14, 413-416
    • (2004) Bioorg. Med. Chem. Lett , vol.14 , pp. 413-416
    • Kunick, C.1    Lauenroth, K.2    Leost, M.3
  • 18
    • 84874788226 scopus 로고    scopus 로고
    • Proteomic and functional analyses reveal the role of chromatin reader sfmbt1 in regulating epigenetic silencing and the myogenic gene program
    • Lin, S., Shen, H., Li, J.L., et al. (2013). Proteomic and functional analyses reveal the role of chromatin reader SFMBT1 in regulating epigenetic silencing and the myogenic gene program. J. Biol. Chem. 288, 6238-6247
    • (2013) J. Biol. Chem , vol.288 , pp. 6238-6247
    • Lin, S.1    Shen, H.2    Li, J.L.3
  • 19
    • 84885172948 scopus 로고    scopus 로고
    • Ddx5 is a positive regulator of oncogenic notch1 signaling in t cell acute lymphoblastic leukemia
    • Lin, S., Tian, L., Shen, H., et al. (2013). Ddx5 is a positive regulator of oncogenic notch1 signaling in T cell acute lymphoblastic leukemia. Oncogene 32, 4845-4853
    • (2013) Oncogene , vol.32 , pp. 4845-4853
    • Lin, S.1    Tian, L.2    Shen, H.3
  • 20
    • 78650105132 scopus 로고    scopus 로고
    • Human hepatocyte growth factor receptor is a cellular coreceptor for adenoassociated virus serotype 3
    • Ling, C., Lu, Y., Kalsi, J.K., et al. (2010). Human hepatocyte growth factor receptor is a cellular coreceptor for adenoassociated virus serotype 3. Hum. Gene Ther. 21, 1741-1747
    • (2010) Hum. Gene Ther , vol.21 , pp. 1741-1747
    • Ling, C.1    Lu, Y.2    Kalsi, J.K.3
  • 21
    • 80355128088 scopus 로고    scopus 로고
    • High-efficiency transduction of liver cancer cells by recombinant adenoassociated virus serotype 3 vectors
    • Ling, C., Lu, Y., Cheng, B., et al. (2011). High-efficiency transduction of liver cancer cells by recombinant adenoassociated virus serotype 3 vectors. J. Vis. Exp
    • (2011) J. Vis. Exp
    • Ling, C.1    Lu, Y.2    Cheng, B.3
  • 22
    • 84906828502 scopus 로고    scopus 로고
    • The roles of traditional chinese medicine in gene therapy
    • Ling, C.Q., Wang, L.N., Wang, Y., et al. (2014). The roles of traditional Chinese medicine in gene therapy. J. Integr. Med. 12, 67-75
    • (2014) J. Integr. Med , vol.12 , pp. 67-75
    • Ling, C.Q.1    Wang, L.N.2    Wang, Y.3
  • 23
    • 84907383258 scopus 로고    scopus 로고
    • Three advantages of using traditional chinese medicine to prevent and treat tumor[aaa]
    • Ling, C.Q., Yue, X.Q., and Ling, C. (2014). Three advantages of using traditional Chinese medicine to prevent and treat tumor. J. Integr. Med. 12, 331-335
    • (2014) J. Integr. Med , vol.12 , pp. 331-335
    • Ling, C.Q.1    Yue, X.Q.2    Ling, C.3
  • 24
    • 84894242894 scopus 로고    scopus 로고
    • Selection and evaluation of clinically relevant aav variants in a xenograft liver model
    • Lisowski, L., Dane, A.P., Chu, K., et al. (2014). Selection and evaluation of clinically relevant AAV variants in a xenograft liver model. Nature 506, 382-386
    • (2014) Nature , vol.506 , pp. 382-386
    • Lisowski, L.1    Dane, A.P.2    Chu, K.3
  • 25
    • 84874759776 scopus 로고    scopus 로고
    • Endocytic processing of adeno-Associated virus type 8 vectors for transduction of target cells
    • Liu, Y., Joo, K.I., and Wang, P. (2012). Endocytic processing of adeno-Associated virus type 8 vectors for transduction of target cells. Gene Ther. 20, 308-317
    • (2012) Gene Ther , vol.20 , pp. 308-317
    • Liu, Y.1    Joo, K.I.2    Wang, P.3
  • 26
    • 84899790254 scopus 로고    scopus 로고
    • Codelivery of doxorubicin and paclitaxel by cross-linked multilamellar liposome enables synergistic antitumor activity
    • Liu, Y., Fang, J., Kim, Y.J., et al. (2014). Codelivery of doxorubicin and paclitaxel by cross-linked multilamellar liposome enables synergistic antitumor activity. Mol. Pharm. 11, 1651-1661
    • (2014) Mol. Pharm , vol.11 , pp. 1651-1661
    • Liu, Y.1    Fang, J.2    Kim, Y.J.3
  • 27
    • 47949116252 scopus 로고    scopus 로고
    • Sorafenib in advanced hepatocellular carcinoma
    • Llovet, J.M., Ricci, S., Mazzaferro, V., et al. (2008). Sorafenib in advanced hepatocellular carcinoma. N. Engl. J. Med. 359, 378-390
    • (2008) N. Engl. J. Med , vol.359 , pp. 378-390
    • Llovet, J.M.1    Ricci, S.2    Mazzaferro, V.3
  • 28
    • 77649271981 scopus 로고    scopus 로고
    • Comparative transduction efficiency of aav vector serotypes 1-6 in the substantia nigra and striatum of the primate brain
    • Markakis, E.A., Vives, K.P., Bober, J., et al. (2010). Comparative transduction efficiency of AAV vector serotypes 1-6 in the substantia nigra and striatum of the primate brain. Mol. Ther. 18, 588-593
    • (2010) Mol. Ther , vol.18 , pp. 588-593
    • Markakis, E.A.1    Vives, K.P.2    Bober, J.3
  • 29
    • 78650898983 scopus 로고    scopus 로고
    • High-efficiency transduction and correction of murine hemophilia b using aav2 vectors devoid of multiple surfaceexposed tyrosines
    • Markusic, D.M., Herzog, R.W., Aslanidi, G.V., et al. (2010). High-efficiency transduction and correction of murine hemophilia b using aav2 vectors devoid of multiple surfaceexposed tyrosines. Mol. Ther. 18, 2048-2056
    • (2010) Mol. Ther , vol.18 , pp. 2048-2056
    • Markusic, D.M.1    Herzog, R.W.2    Aslanidi, G.V.3
  • 30
    • 84883450737 scopus 로고    scopus 로고
    • Regulatory evaluation of glybera in europe-Two committees, one mission
    • Melchiorri, D., Pani, L., Gasparini, P., et al. (2013). Regulatory evaluation of Glybera in Europe-Two committees, one mission. Nat. Rev. Drug Discov. 12, 719
    • (2013) Nat. Rev. Drug Discov , vol.12 , pp. 719
    • Melchiorri, D.1    Pani, L.2    Gasparini, P.3
  • 31
    • 84880877500 scopus 로고    scopus 로고
    • Adenoassociated viral vectors based on serotype 3b use components of the fibroblast growth factor receptor signaling complex for efficient transduction
    • Messina, E.L., Nienaber, J., Daneshmand, M., et al. (2012). Adenoassociated viral vectors based on serotype 3b use components of the fibroblast growth factor receptor signaling complex for efficient transduction. Hum. Gene Ther. 23, 1031-1042
    • (2012) Hum. Gene Ther , vol.23 , pp. 1031-1042
    • Messina, E.L.1    Nienaber, J.2    Daneshmand, M.3
  • 32
    • 79954622209 scopus 로고    scopus 로고
    • Therapeutic in vivo gene transfer for genetic disease using aav: Progress and challenges
    • Mingozzi, F., and High, K.A. (2011). Therapeutic in vivo gene transfer for genetic disease using AAV: Progress and challenges. Nat. Rev. Genet. 12, 341-355
    • (2011) Nat. Rev. Genet , vol.12 , pp. 341-355
    • Mingozzi, F.1    High, K.A.2
  • 33
    • 84875766008 scopus 로고    scopus 로고
    • Arsenic trioxide stabilizes accumulations of adeno-Associated virus virions at the perinuclear region, increasing transduction in vitro and in vivo
    • Mitchell, A.M., Li, C., and Samulski, R.J. (2013). Arsenic trioxide stabilizes accumulations of adeno-Associated virus virions at the perinuclear region, increasing transduction in vitro and in vivo. J. Virol. 87, 4571-4583
    • (2013) J. Virol , vol.87 , pp. 4571-4583
    • Mitchell, A.M.1    Li, C.2    Samulski, R.J.3
  • 34
    • 33645528206 scopus 로고    scopus 로고
    • Selfcomplementary adeno-Associated virus vectors containing a novel liver-specific human factor ix expression cassette enable highly efficient transduction of murine and nonhuman primate liver
    • Nathwani, A.C., Gray, J.T., Ng, C.Y., et al. (2006). Selfcomplementary adeno-Associated virus vectors containing a novel liver-specific human factor IX expression cassette enable highly efficient transduction of murine and nonhuman primate liver. Blood 107, 2653-2661
    • (2006) Blood , vol.107 , pp. 2653-2661
    • Nathwani, A.C.1    Gray, J.T.2    Ng, C.Y.3
  • 35
    • 33846934410 scopus 로고    scopus 로고
    • Safe and efficient transduction of the liver after peripheral vein infusion of self-complementary aav vector results in stable therapeutic expression of human fix in nonhuman primates
    • Nathwani, A.C., Gray, J.T., McIntosh, J., et al. (2007). Safe and efficient transduction of the liver after peripheral vein infusion of self-complementary AAV vector results in stable therapeutic expression of human fix in nonhuman primates. Blood 109, 1414-1421
    • (2007) Blood , vol.109 , pp. 1414-1421
    • Nathwani, A.C.1    Gray, J.T.2    McIntosh, J.3
  • 36
    • 84893847671 scopus 로고    scopus 로고
    • Rationally designed capsid and transgene cassette of aav6 vectors for dendritic cell-based cancer immunotherapy
    • Pandya, J., Ortiz, L., Ling, C., et al. (2013). Rationally designed capsid and transgene cassette of AAV6 vectors for dendritic cell-based cancer immunotherapy. Immunol. Cell Biol. 92, 116-123
    • (2013) Immunol. Cell Biol , vol.92 , pp. 116-123
    • Pandya, J.1    Ortiz, L.2    Ling, C.3
  • 37
    • 0034085607 scopus 로고    scopus 로고
    • Transduction of hepatocellular carcinoma (hcc) using recombinant adenoassociated virus (raav) in vitro and in vivo effects of genotoxic agents
    • Peng, D., Qian, C., Sun, Y., et al. (2000). Transduction of hepatocellular carcinoma (HCC) using recombinant adenoassociated virus (rAAV): In vitro and in vivo effects of genotoxic agents. J. Hepatol. 32, 975-985
    • (2000) J. Hepatol , vol.32 , pp. 975-985
    • Peng, D.1    Qian, C.2    Sun, Y.3
  • 38
    • 4444352441 scopus 로고    scopus 로고
    • Cross-dressing the virion: The transcapsidation of adenoassociated virus serotypes functionally defines subgroups
    • Rabinowitz, J.E., Bowles, D.E., Faust, S.M., et al. (2004). Cross-dressing the virion: The transcapsidation of adenoassociated virus serotypes functionally defines subgroups. J. Virol. 78, 4421-4432
    • (2004) J. Virol , vol.78 , pp. 4421-4432
    • Rabinowitz, J.E.1    Bowles, D.E.2    Faust, S.M.3
  • 39
    • 84878650130 scopus 로고    scopus 로고
    • Anti-Tumor action of trichosanthin, a type 1 ribosome-inactivating protein, employed in traditional chinese medicine: A mini review
    • Sha, O., Niu, J., Ng, T.B., et al. (2013). Anti-Tumor action of trichosanthin, a type 1 ribosome-inactivating protein, employed in traditional Chinese medicine: A mini review. Cancer Chemother. Pharmacol. 71, 1387-1393
    • (2013) Cancer Chemother. Pharmacol , vol.71 , pp. 1387-1393
    • Sha, O.1    Niu, J.2    Ng, T.B.3
  • 40
    • 84881005956 scopus 로고    scopus 로고
    • Bioactivity of five components of chinese herbal formula jiangzhi granules against hepatocellular steatosis
    • Song, H.Y., Zhang, L., Pan, J.L., et al. (2013). Bioactivity of five components of Chinese herbal formula jiangzhi granules against hepatocellular steatosis. J. Integr. Med. 11, 262-268
    • (2013) J. Integr. Med , vol.11 , pp. 262-268
    • Song, H.Y.1    Zhang, L.2    Pan, J.L.3
  • 41
    • 0034202983 scopus 로고    scopus 로고
    • Adeno-Associated viral-mediated gene transfer to hepatoma: Thymidine kinase/interleukin 2 is more effective in tumor killing in nonganciclovir (gcv)-Treated than in gcv-Treated animals
    • Su, H., Lu, R., Ding, R., and Kan, Y.W. (2000). Adeno-Associated viral-mediated gene transfer to hepatoma: Thymidine kinase/interleukin 2 is more effective in tumor killing in nonganciclovir (GCV)-Treated than in GCV-Treated animals. Mol. Ther. 1, 509-515
    • (2000) Mol. Ther , vol.1 , pp. 509-515
    • Su, H.1    Lu, R.2    Ding, R.3    Kan, Y.W.4
  • 42
    • 67449135811 scopus 로고    scopus 로고
    • The management of hepatocellular carcinoma current expert opinion and recommendations derived from the 10th world congress on gastrointestinal cancer, barcelona 2008
    • Verslype, C., Van Cutsem, E., Dicato, M., et al. (2009). The management of hepatocellular carcinoma. Current expert opinion and recommendations derived from the 10th World Congress on Gastrointestinal Cancer, Barcelona, 2008. Ann. Oncol. 20 Suppl 7, vii1-vii6
    • (2009) Ann. Oncol , vol.20 , pp. vii1-vii6
    • Verslype, C.1    Van Cutsem, E.2    Dicato, M.3
  • 43
    • 19644378907 scopus 로고    scopus 로고
    • Adeno-Associated virus serotype 8 efficiently delivers genes to muscle and heart
    • Wang, Z., Zhu, T., Qiao, C., et al. (2005). Adeno-Associated virus serotype 8 efficiently delivers genes to muscle and heart. Nat. Biotechnol. 23, 321-328
    • (2005) Nat. Biotechnol , vol.23 , pp. 321-328
    • Wang, Z.1    Zhu, T.2    Qiao, C.3
  • 44
    • 84897931068 scopus 로고    scopus 로고
    • Pristimerin enhances recombinant adeno-Associated virus vector-mediated transgene expression in human cell lines in vitro and murine hepatocytes in vivo
    • Wang, L.N., Wang, Y., Lu, Y., et al. (2014). Pristimerin enhances recombinant adeno-Associated virus vector-mediated transgene expression in human cell lines in vitro and murine hepatocytes in vivo. J. Integr. Med. 12, 20-34
    • (2014) J. Integr. Med , vol.12 , pp. 20-34
    • Wang, L.N.1    Wang, Y.2    Lu, Y.3
  • 45
    • 64249097600 scopus 로고    scopus 로고
    • Shikonin exerts antitumor activity via proteasome inhibition and cell death induction in vitro and in vivo
    • Yang, H., Zhou, P., Huang, H., et al. (2009). Shikonin exerts antitumor activity via proteasome inhibition and cell death induction in vitro and in vivo. Int. J. Cancer 124, 2450-2459
    • (2009) Int. J. Cancer , vol.124 , pp. 2450-2459
    • Yang, H.1    Zhou, P.2    Huang, H.3
  • 46
    • 80052033164 scopus 로고    scopus 로고
    • C-met represents a potential therapeutic target for personalized treatment in hepatocellular carcinoma
    • You, H., Ding, W., Dang, H., et al. (2011). C-met represents a potential therapeutic target for personalized treatment in hepatocellular carcinoma. Hepatology 54, 879-889
    • (2011) Hepatology , vol.54 , pp. 879-889
    • You, H.1    Ding, W.2    Dang, H.3
  • 47
    • 84875626667 scopus 로고    scopus 로고
    • Traditional herbal medicine in preventing recurrence after resection of small hepatocellular carcinoma: A multicenter randomized controlled trial
    • Zhai, X.F., Chen, Z., Li, B., et al. (2013). Traditional herbal medicine in preventing recurrence after resection of small hepatocellular carcinoma: A multicenter randomized controlled trial. J. Integr. Med. 11, 90-100
    • (2013) J. Integr. Med , vol.11 , pp. 90-100
    • Zhai, X.F.1    Chen, Z.2    Li, B.3
  • 48
    • 79951513909 scopus 로고    scopus 로고
    • Celastrol enhances aav1-mediated gene expression in mice adipose tissues
    • Zhang, F.L., Jia, S.Q., Zheng, S.P., and Ding, W. (2010). Celastrol enhances AAV1-mediated gene expression in mice adipose tissues. Gene Ther. 18, 128-134
    • (2010) Gene Ther , vol.18 , pp. 128-134
    • Zhang, F.L.1    Jia, S.Q.2    Zheng, S.P.3    Ding, W.4
  • 49
    • 84918780947 scopus 로고    scopus 로고
    • Cytotoxic genes from traditional chinese medicine inhibit tumor growth both in vitro and in vivo
    • In press
    • Zhang, Y., Wang, Y., Yusufali, A., et al. (2014) Cytotoxic genes from traditional Chinese medicine inhibit tumor growth both in vitro and in vivo. J. Integr. Med. (In press
    • (2014) J. Integr. Med
    • Zhang, Y.1    Wang, Y.2    Yusufali, A.3
  • 50
    • 84892572282 scopus 로고    scopus 로고
    • V8, a newly synthetic flavonoid, induces apoptosis through ros-mediated er stress pathway in hepatocellular carcinoma
    • Zhang, Y., Zhao, L., Li, X., et al. (2014). V8, a newly synthetic flavonoid, induces apoptosis through ROS-mediated ER stress pathway in hepatocellular carcinoma. Arch. Toxicol. 88, 97-107
    • (2014) Arch. Toxicol , vol.88 , pp. 97-107
    • Zhang, Y.1    Zhao, L.2    Li, X.3
  • 51
    • 45549090635 scopus 로고    scopus 로고
    • Next generation of adeno-Associated virus 2 vectors: Point mutations in tyrosines lead to high-efficiency transduction at lower doses
    • Zhong, L., Li, B., Mah, C.S., et al. (2008). Next generation of adeno-Associated virus 2 vectors: Point mutations in tyrosines lead to high-efficiency transduction at lower doses. Proc. Natl. Acad. Sci. USA 105, 7827-7832
    • (2008) Proc. Natl. Acad. Sci. USA , vol.105 , pp. 7827-7832
    • Zhong, L.1    Li, B.2    Mah, C.S.3
  • 52
    • 84862817427 scopus 로고    scopus 로고
    • Oroxylin a reverses cam-dr of hepg2 cells by suppressing integrinb1 and its related pathway
    • Zhu, B., Zhao, L., Zhu, L., et al. (2012). Oroxylin A reverses CAM-DR of HepG2 cells by suppressing Integrinb1 and its related pathway. Toxicol. Appl. Pharmacol. 259, 387-394
    • (2012) Toxicol. Appl. Pharmacol , vol.259 , pp. 387-394
    • Zhu, B.1    Zhao, L.2    Zhu, L.3
  • 53
    • 44349170706 scopus 로고    scopus 로고
    • Analysis of aav serotypes 1-9 mediated gene expression and tropism in mice after systemic injection
    • Zincarelli, C., Soltys, S., Rengo, G., and Rabinowitz, J.E. (2008). Analysis of AAV serotypes 1-9 mediated gene expression and tropism in mice after systemic injection. Mol. Ther. 16, 1073-1080
    • (2008) Mol. Ther , vol.16 , pp. 1073-1080
    • Zincarelli, C.1    Soltys, S.2    Rengo, G.3    Rabinowitz, J.E.4


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