Microglial P2X7 receptor in the hypothalamic paraventricular nuclei contributes to sympathoexcitatory responses in acute myocardial infarction rat

Neuroscience Letters

Volumn 587, Issue , 2015, Pages 22-28

  Du, Dongshu ^a   Jiang, Meiyan ^c   Liu, Min ^b   Wang, Jin ^b   Xia, Chunmei ^b   Guan, Ruijuan ^b   Shen, Linlin ^b   Ji, Yonghua ^a   Zhu, Danian ^b  

^a SHANGHAI UNIVERSITY   (China)

^b FUDAN UNIVERSITY   (China)

^c OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

Author keywords

Acute myocardial infarction; Hypothalamic paraventricular nucleus; Microglia; Oxytocinergic and vasopressinergic neuron; P2X7 receptor; Proinflammatory cytokines

Indexed keywords

ADENOSINE TRIPHOSPHATE; BIOLOGICAL MARKER; BRILLIANT BLUE; IBA 1 PROTEIN; INTERLEUKIN 1BETA; MESSENGER RNA; NEURON SPECIFIC NUCLEAR PROTEIN; OXYTOCIN; OXYTOCIN RECEPTOR; PURINERGIC P2X7 RECEPTOR; SMALL INTERFERING RNA; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; VASOPRESSIN; VASOPRESSIN RECEPTOR; ACTIN BINDING PROTEIN; AIF1 PROTEIN, RAT; CALCIUM BINDING PROTEIN; CELL NUCLEUS ANTIGEN; COOMASSIE BRILLIANT BLUE; FUCHSINE; NERVE PROTEIN; NEUN PROTEIN, RAT; PURINERGIC P2X RECEPTOR ANTAGONIST; VASOPRESSIN DERIVATIVE;

ACUTE HEART INFARCTION; ADULT; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CYTOKINE PRODUCTION; GENE SILENCING; HEART RATE VARIABILITY; HYPOTHALAMIC PARAVENTRICULAR NUCLEUS; IMMUNOFLUORESCENCE; IMMUNOHISTOCHEMISTRY; MALE; MEAN ARTERIAL PRESSURE; NONHUMAN; PROTEIN EXPRESSION; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SYMPATHETIC TONE; UPREGULATION; WESTERN BLOTTING; ANIMAL; BLOOD PRESSURE; GENETICS; HEART INFARCTION; HEART RATE; METABOLISM; PATHOPHYSIOLOGY; SPRAGUE DAWLEY RAT;

ADENOSINE TRIPHOSPHATE; ANIMALS; ANTIGENS, NUCLEAR; BLOOD PRESSURE; CALCIUM-BINDING PROTEINS; HEART RATE; INTERLEUKIN-1BETA; MALE; MICROFILAMENT PROTEINS; MYOCARDIAL INFARCTION; NERVE TISSUE PROTEINS; OXYTOCIN; PARAVENTRICULAR HYPOTHALAMIC NUCLEUS; PURINERGIC P2X RECEPTOR ANTAGONISTS; RATS, SPRAGUE-DAWLEY; RECEPTORS, PURINERGIC P2X7; RNA, SMALL INTERFERING; ROSANILINE DYES; TUMOR NECROSIS FACTOR-ALPHA; VASOPRESSINS;

EID: 84918793105     PISSN: 03043940     EISSN: 18727972     Source Type: Journal    
DOI: 10.1016/j.neulet.2014.12.026     Document Type: Article

References (25)

1. Ding J.Y., Shin Y.H., Konishi H., Lee S.J., Kiyama H. Possible ATP release through lysosomal exocytosis from primary sensory neurons. Biochem. Biophys. Res. Commun. 2013, 430:488-493.
2. Dringen R. Oxidative and antioxidative potential of brain microglial cells. Antioxid. Redox Signal. 2005, 7:1223-1233.
3. Eder C. Regulation of microglial behavior by ion channel activity. J. Neurosci. Res. 2005, 81:314-321.
4. Felder R.B. Mineralocorticoid receptors, inflammation and sympathetic drive in a rat model of systolic heart failure. Exp. Physiol. 2010, 95:19-25.
5. Felder R.B., Yu Y., Zhang Z.H., Wei S.G. Pharmacological treatment for heart failure: a view from the brain. Clin. Pharmacol. Ther. 2009, 86:216-220.
6. 7 receptor: a key player in IL-1 processing and release. J. Immunol. 2006, 176:3877-3883.
7. 7 receptor expression after ischemia in the cerebral cortex of rats. J. Neuropathol. Exp. Neurol. 2004, 63:686-699.
8. Gibson C.J., Hossain M.M., Richardson J.R., Aleksunes L.M. Inflammatory regulation of ATP binding cassette efflux transporter expression and function in microglia. J. Pharmacol. Exp. Ther. 2012, 343:650-660.
9. Granger J.P. An emerging role for inflammatory cytokines in hypertension. Am. J. Physiol. Heart Circ. Physiol. 2006, 290:H923-924.
10. Hasko G., Pacher P., Deitch E.A., Vizi E.S. Shaping of monocyte and macrophage function by adenosine receptors. Pharmacol. Ther. 2007, 113:264-275.
11. Hide I., Tanaka M., Inoue A., Nakajima K., Kohsaka S., Inoue K., Nakata Y. Extracellular ATP triggers tumor necrosis factor-alpha release from rat microglia. J. Neurochem. 2000, 75:965-972.
12. Inoue K. Microglial activation by purines and pyrimidines. Glia 2002, 40:156-163.
13. Jiang M.Y., Chen J., Wang J., Xiao F., Zhang H.H., Zhang C.R., Du D.S., Cao Y.X., Shen L.L., Zhu D.N. Nitric oxide modulates cardiovascular function in the rat by activating adenosine A2A receptors and inhibiting acetylcholine release in the rostral ventrolateral medulla. Clin. Exp. Pharmacol. Physiol. 2011, 38:380-386.
14. Kaushik D.K., Mukhopadhyay R., Kumawat K.L., Gupta M., Basu A. Therapeutic targeting of Kruppel-like factor 4 abrogates microglial activation. J. Neuroinflamm. 2012, 9:57.
15. Koizumi S., Shigemoto-Mogami Y., Nasu-Tada K., Shinozaki Y., Ohsawa K., Tsuda M., Joshi B.V., Jacobson K.A., Kohsaka S., Inoue K. UDP acting at P2Y6 receptors is a mediator of microglial phagocytosis. Nature 2007, 446:1091-1095.
16. Lin S., Yin Q., Zhong Q., Lv F.L., Zhou Y., Li J.Q., Wang J.Z., Su B.Y., Yang Q.W. Heme activates TLR4-mediated inflammatory injury via MyD88/TRIF signaling pathway in intracerebral hemorrhage. J. Neuroinflamm. 2012, 9:46.
17. Ma M., Ren Q., Zhang J.C., Hashimoto K. Effects of brilliant blue G on serum tumor necrosis factor-α levels and depression-like behavior in mice after lipopolysaccharide administration. Clin. Psychopharmacol. Neurosci. 2014, 12:31-36.
18. Siebenlist U., Franzoso G., Brown K. Structure, regulation and function of NF-kappa B. Annu. Rev. Cell Biol. 1994, 10:405-455.
19. Takenouchi T., Iwamaru Y., Sugama S., Sato M., Hashimoto M., Kitani H. Lysophospholipids and ATP mutually suppress maturation and release of IL-1 beta in mouse microglial cells using a Rho-dependent pathway. J. Immunol. 2008, 180:7827-7839.
20. Takenouchi T., Sugama S., Iwamaru Y., Hashimoto M., Kitani H. Modulation of the ATP-induced release and processing of IL-1β in microglial cells. Crit. Rev. Immunol. 2009, 29:335-345.
21. Wsol A., Cudnoch-Jedrzejewska A., Szczepanska-Sadowska E., Kowalewski S., Dobruch J. Central oxytocin modulation of acute stress-induced cardiovascular responses after myocardial infarction in the rat. Stress 2009, 12:517-525.
22. Xiao F., Jiang M., Du D., Xia C., Wang J., Cao Y., Shen L., Zhu D. Orexin A regulates cardiovascular responses in stress-induced hypertensive rats. Neuropharmacology 2013, 67:16-24.
23. Yang Z., Han D., Coote J.H. Cardiac sympatho-excitatory action of PVN-spinal oxytocin neurones. Auton. Neurosci.: Basic Clin. 2009, 147:80-85.
24. Yosten G.L., Pate A.T., Samson W.K. Neuronostatin acts in brain to biphasically increase mean arterial pressure through sympatho-activation followed by vasopressin secretion: the role of melanocortin receptors. Am. J. Physiol. Regul. Integr. Comp. Physiol. 2011, 300:R1194-1199.
25. Yu Y., Kang Y.M., Zhang Z.H., Wei S.G., Chu Y., Weiss R.M., Felder R.B. Increased cyclooxygenase-2 expression in hypothalamic paraventricular nucleus in rats with heart failure: role of nuclear factor kappaB. Hypertension 2007, 49:511-518.