A Meta-Analysis to Determine the Effect of Primary Tumor Resection for Stage IV Colorectal Cancer with Unresectable Metastases on Patient Survival

Annals of Surgical Oncology

Volumn 21, Issue 12, 2014, Pages 3900-3908

  Clancy, Cillian ^a   Burke, John P ^a   Barry, Mitchel ^c   Kalady, Matthew F ^d   Calvin Coffey, J ^a,b  

^a UNIVERSITY HOSPITAL LIMERICK   (Ireland)

^b UNIVERSITY OF LIMERICK   (Ireland)

^c MATER MISERICORDIAE UNIVERSITY HOSPITAL   (Ireland)

^d LERNER RESEARCH INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTINEOPLASTIC AGENT;

ADVANCED CANCER; ARTICLE; CANCER CHEMOTHERAPY; CANCER MORTALITY; CANCER SURGERY; CANCER SURVIVAL; HIGH RISK PATIENT; HUMAN; LIVER METASTASIS; LOW RISK PATIENT; META ANALYSIS; METASTASIS; METASTATIC COLORECTAL CANCER; PRIMARY TUMOR; RECTUM CANCER; RISK REDUCTION; SURVIVAL TIME; SYSTEMATIC REVIEW; CANCER STAGING; COLORECTAL NEOPLASMS; MORTALITY; PATHOLOGY; PROGNOSIS; SURVIVAL RATE;

COLORECTAL NEOPLASMS; HUMANS; NEOPLASM METASTASIS; NEOPLASM STAGING; PROGNOSIS; SURVIVAL RATE;

EID: 84918781561     PISSN: 10689265     EISSN: 15344681     Source Type: Journal    
DOI: 10.1245/s10434-014-3805-4     Document Type: Article

References (37)

1. Kim YW, Kim IY. The role of surgery for asymptomatic primary tumors in unresectable stage IV colorectal cancer. Ann Coloproctol. 2013;29:44–54.
2. Anwar S, Peter MB, Dent J, Scott NA. Palliative excisional surgery for primary colorectal cancer in patients with incurable metastatic disease. Is there a survival benefit? A systematic review. Colorectal Dis. 2012;14:920–30.
3. Cook AD, Single R, McCahill LE. Surgical resection of primary tumors in patients who present with stage IV colorectal cancer: an analysis of surveillance, epidemiology and end-results data 1988–2000. Ann Surg Oncol. 2005;12:637–45.
4. Aslam MI, Kelkar A, Sharpe D, Jameson JS. Ten years experience of managing the primary tumors in patients with stage IV colorectal cancer. Int J Surg. 2010;8:305–13.
5. Ruo L, Gougoutas C, Paty PB, Gillem JG, Cohen AM, Wong WD. Elective bowel resection for incurable stage IV colorectal cancer: prognostic variables for asymptomatic patients. J Am Coll Surg. 2003;196:722–8.
6. DerSimonian R, Laird N. Meta-analysis in clinical trials. Control Clin Trials. 1986;7:177–88.
7. Clancy C, Burke JP, Coffey JC. KRAS mutation does not predict the efficacy of neoadjuvant chemoradiotherapy in rectal cancer: a systematic review and meta-analysis. Surg Oncol. 2013;22:105–11.
8. Clancy C, Burke JP, Kalady MF, Coffey JC. BRAF mutation is associated with distinct clinicopathological characteristics in colorectal cancer: a systematic review and meta-analysis. Colorectal Dis. 2013;15(12):e711–8.
9. Lau J, Ioannidis J, Schmid C. Quantitative synthesis in systematic reviews. Ann Intern Med. 1997;127:820–6.
10. Cellini C, Hunt S, Fleshman J, Birnbaum EH, Bierhals AJ, Mutvh MG. Stage IV rectal cancer with liver metastases: is there a benefit to resection of the primary tumor? World J Surg. 2010;34:1102–8.
11. Verberne C, de Bock G, Pijl M, Baas PC, Sieling S, Wiggers T. Palliative resection of the primary tumor in stage IV rectal cancer. Colorectal Dis. 2012;14:314–9.
12. Boselli C, Renzi C, Gemini A, Castellani E, Trastulli S, Desiderio J, et al. Surgery in asymptomatic patients with colorectal cancer and unresectable liver metastases: the authors’ experience. Onco Targets Ther. 2013;6:267–72.
13. Benoist S, Pautrat K, Mitry E, Rougier P, Penna C, Nordlinger B. Treatment strategy for patients with colorectal cancer and synchronous irresectable liver metastases. Br J Surg. 2005;92:1155–60.
14. Galizia G, Lieto E, Orditura M, Castellano P, Imperatore V, Pinto M, et al. First-line chemotherapy vs. Bowel tumor resection plus chemotherapy for patients with unresectable synchronous colorectal hepatic metastases. Arch Surg. 2008;143:352–8.
15. Scoggins CR, Meszoely IM, Blanke CD, Beauchamp RD, Leach SD. Nonoperative management of primary colorectal cancer in patients with stage IV disease. Ann Surg Oncol. 1999;6:651–7.
16. Tebbutt NC, Norman AR, Cunningham D, Hill ME, Tait D, Oates J, et al. Intestinal complications after chemotherapy for patients with unresected primary colorectal cancer and synchronous metastases. Gut. 2003;52:568–73.
17. Michel P, Roque L, Di Fiore F, Langlois S, Scotte M, Tenière P, et al. Colorectal cancer with non-resectable synchronous metastases: should the primary tumor be resected? Gastroenterol Clin Biol. 2004;28:434–7.
18. Cummins ER, Vicky KD, Poole GV. Incurable colorectal carcinoma: the role of surgical palliation. Am Surg. 2004;70:433–7.
19. Kaufman MS, Radhakrishnan N, Roy R, Gecelter G, Tsang J, Thomas A, et al. Influence of palliative surgical resection on overall survival in patients with advanced colorectal cancer: a retrospective single institutional study. Colorectal Dis. 2008;10:498–502.
20. Chan TW, Brown C, Ho CC, Gill S. Primary tumor resection in patients presenting with metastatic colorectal cancer: analysis of a provincial population based cohort. Am J Clin Oncol. 2010;33:52–5.
21. Seo GJ, Park JW, Yoo SB, Kim SY, Choi HS, Chang HJ, et al. Intestinal complications after palliative treatment for asymptomatic patients with unresectable stage IV colorectal cancer. J Surg Oncol. 2010;102:94–9.
22. Karoui M, Roudot-Thoroval F, Mesli F, Mitry E, Aparicio T, Des Guetz G, et al. Primary colectomy in patients with stage IV colon cancer and unresectable distant metastases improves overall survival: results of a multicentric study. Dis Colon Rectum. 2011;54:930–8.
23. Venderbosch S, de Wilt JH, Teerenstra S, Loosveld OJ, van Bochove A, Sinnige HA, et al. Prognostic value of resection of primary tumor in patients with stage IV colorectal cancer: retrospective analysis of two randomized studies and a review of the literature. Ann Surg Oncol. 2011;18:3252–60.
24. Koopman M, Antonini NF, Douma J, Wals J, Honkoop AH, Erdkamp FL, et al. Sequential versus combination chemotherapy with capecitabine, irinotecan, and oxaliplatin in advanced colorectal cancer (CAIRO): a phase III randomised controlled trial. Lancet. 2007;370:135–42.
25. Tol J, Koopman M, Rodenburg CJ, Cats A, Creemers GJ, Schrama JG, et al. A randomised phase III study on capecitabine, oxaliplatin and bevacizumab with or without cetuximab in first-line advanced colorectal cancer: the CAIRO 2 study of the Dutch Colorectal Cancer Group (DCCG). An interim analysis of toxicity. Ann Oncol. 2008;19:734–8.
26. Kim SK, Lee CH, Lee MR, Kim JH. Multivariate analysis of the survival rate for treatment modalities in incurable stage IV colorectal cancer. J Korean Soc Coloproctol. 2012;28:35–41.
27. Ferrand F, Malka D, Bourredjem A, Allonier C, Bouché O, Louafi S, et al. Impact of primary tumor resection on survival of patients with colorectal cancer and synchronous metastases treated by chemotherapy: results from the multicentre, randomized trial Fédération Francophone de Cancérologie Digestive 9601. Eur J Cancer. 2013;49:90–7.
28. Tsang WY, Ziogas A, Lin BS, Seery TE, Karnes W, Stamos MJ, et al. Role of primary tumor resection among chemotherapy treated patients with synchronous stage IV colorectal cancer: a survival analysis. J Gastrointest Surg. 2014;18:592–8.
29. Ahmed S, Leis A, Fields A, Chandra-Kanthan S, Haider K, Alvi R, et al. Survival impact of surgical resection of primary tumor in patients with stage IV colorectal cancer: Results from a large population-based cohort study. Cancer. 2014;120:683–91.
30. Simmonds PC. Palliative chemotherapy for advanced colorectal cancer: systematic review and meta-analysis. Colorectal Cancer Collaborative Group. BMJ. 2000;321:531–5.
31. Verhoef C, de Wilt J, Burger JW, Verheul HM, Koopman M. Surgery of the primary in stage IV colorectal cancer with unresectable metastases. Eur J Cancer. 2011;47 Suppl 3:S61–6.
32. Cirocchi R, Trastulli S, Abraha I, Vettoretto N, Boselli C, Montedori A, et al. Non-resection versus resection for an asymptomatic primary tumor in patients with unresectable stage IV colorectal cancer. Cochrane Database Syst Rev. 2012;8:CD008997.
33. Harris E, Barry M, Kell MR. Meta-analysis to determine if surgical resection of the primary tumour in the setting of stage IV breast cancer impacts survival. Ann Surg Oncol. 2013;20:2828–34.
34. Cambien B, Richard-Fiardo P, Karimdjee BF, Martini V, Ferrua B, Pitard B, et al. CCL5 neutralization restricts cancer growth and potentiates the targeting of PDGFRβ in colorectal carcinoma. PLoS One. 2011;6:e28842.
35. Chen HJ, Edwards R, Tucci S, Bu P, Milsom J, Lee S, et al. Chemokine 25-induced signalling suppresses colon cancer invasion and metastasis. J Clin Invest. 2012;122:3184–96.
36. Coffey JC, Wang JH, Smith MJ, Bouchier-Hayes D, Cotter TG, Redmond HP. Excisional surgery for cancer cure: therapy at a cost. Lancet Oncol. 2003;4:760–8.
37. Coffey JC, Wang JH, Bouchier-Hayes D, Cotter TG, Redmond HP. The targeting of phosphoinositide-3 kinase attenuates pulmonary metastatic tumor growth following laparotomy. Ann Surg. 2006;243:250–6.