Cytokine profile in children with inflammatory bowel disease

Biochemistry (Moscow)

Volumn 79, Issue 12, 2014, Pages 1371-1375

  Toptygina, A P ^a,b   Semikina, E L ^c,d   Bobyleva, G V ^a   Miroshkina, L V ^c   Petrichuk, S V ^c  

^a GN Gabrichevsky Moscow Research Institute of Epidemiology and Microbiology   (Russian Federation)

^b MOSCOW STATE UNIVERSITY   (Russian Federation)

^c INSTITUTE OF BIOMEDICAL CHEMISTRY   (Russian Federation)

^d PIROGOV RUSSIAN NATIONAL RESEARCH MEDICAL UNIVERSITY   (Russian Federation)

Author keywords

children; Crohn's disease; cytokines; interleukin; ulcerative colitis

Indexed keywords

CYTOKINE; WATER;

ADOLESCENT; BLOOD; CHEMISTRY; CHILD; CROHN DISEASE; FEMALE; HUMAN; MALE; ULCERATIVE COLITIS;

ADOLESCENT; CHILD; COLITIS, ULCERATIVE; CROHN DISEASE; CYTOKINES; FEMALE; HUMANS; MALE; WATER;

EID: 84918586726     PISSN: 00062979     EISSN: 16083040     Source Type: Journal    
DOI: 10.1134/S0006297914120116     Document Type: Article

References (28)

1. Yablokova, E. A., Gorelov, A. V., Ratnikova, M. A., Sichinava, I. V., Grammatopulo, M. I., Polotnyanko, E. Yu., and Borisova, E. V. (2006) Inflammatory bowel disease in children, Pediatriya, 5, 99-102.
2. Abraham, C., and Medzhitov, R. (2011) Interactions between the host innate immune system and microbes in inflammatory bowel disease, Gastroenterology, 140, 1729-1737.
3. Hansen, R., Thomson, J. M., El-Omar, E. M., and Hold, G. L. (2010) The role of infection in the aetiology of inflammatory bowel disease, J. Gastroenterol., 45, 266-276.
4. Kaur, N., Chen, C. C., Luther, J., and Kao, J. Y. (2011) Intestinal dysbiosis in inflammatory bowel disease, Gut Microbes, 2, 211-216.
5. Frank, D. N., St. Amand, A. L., Feldman, R. A., Boedeker, E. C., Harpaz, N., and Pace, N. R. (2007) Molecular-phylogenetic characterization of microbial community imbalances in human inflammatory bowel diseases, Proc. Natl. Acad. Sci. USA, 104, 13780-13785.
6. Sokol, H., Seksik, P., Rigottier-Gois, L., Lay, C., Lepage, P., Podglajen, I., Marteau, P., and Dore, J. (2006) Specificities of the fecal microbiota in inflammatory bowel disease, Inflamm. Bowel Dis., 12, 106-111.
7. Neut, C., Bulois, P., Desreumaux, P., Membre, J. M., Lederman, E., Gambiez, L., Cortot, A., Quandalle, P., van Kruiningen, H., and Colombel, J. F. (2002) Changes in the bacterial flora of the neoterminal ileum after ileocolonic resection for Crohn's disease, Am. J. Gastroenterol., 97, 939-946.
8. Andoh, A., Kuzuoka, H., Tsujikawa, T., Nakamura, S., Hirai, F., Suzuki, Y., Matsui, T., Fujiyama, Y., and Matsumoto, T. (2012) Multicenter analysis of fecal microbiota profiles in Japanese patients with Crohn's disease, J. Gastroenterol., 47, 1298-1307.
9. Mukhopadhya, I., Hansen, R., El-Omar, E. M., and Hold, G. L. (2012) IBD-what role do Proteobacteria play? Nat. Rev. Gastroenterol. Hepatol., 9, 219-230.
10. Simms, L. A., Doecke, J. D., Walsh, M. D., Huang, N., Fowler, E. V., and Radford-Smith, G. L. (2008) Reduced alpha-defensin expression is associated with inflammation and not NOD2 mutation status in ileal Crohn's disease, Gut, 57, 903-910.
11. Abraham, C., and Cho, J. H. (2009) Inflammatory bowel disease, N. Engl. J. Med., 361, 2066-2078.
12. Sanchez-Munoz, F., Dominguez-Lopez, A., and Yamamoto-Furusho, J. K. (2008) Role of cytokines in inflammatory bowel disease, World J. Gastroenterol., 14, 4280-4288.
13. Fuss, I. J., Neurath, M., Boirivant, M., Klein, J. S., de la Motte, C., Strong, S. A., Fiocchi, C., and Strober, W. (1996) Disparate CD4+ lamina propria (LP) lymphokine secretion profiles in inflammatory bowel disease. Crohn's disease LP cells manifest increased secretion of IFN-gamma, whereas ulcerative colitis LP cells manifest increased secretion of IL-5, J. Immunol., 157, 1261-1270.
14. Bamias, G., Nyce, M. R., De La Rue, S. A., and Cominelli, F. (2005) New concepts in the pathophysiology of inflammatory bowel disease, Ann. Intern. Med., 143, 895-904.
15. Elgbratt, K., Kurlberg, G., Hahn-Zohric, M., and Hultgren Hornquist, E. (2010) Rapid migration of thymic emigrants to the colonic mucosa in ulcerative colitis patients, Clin. Exp. Immunol., 162, 325-336.
16. Fina, D., and Pallone, F. (2008) What is the role of cytokines and chemokines in IBD? Inflamm. Bowel Dis., 14, 117-118.
17. Muzes, G., Molnar, B., Tulassay, Z., and Sipos, F. (2012) Changes of the cytokine profile in inflammatory bowel diseases, World J. Gastroenterol., 18, 5848-5861.
18. Ostanin, A. A., and Chernykh, E. P. (2005) Comparative assessment of the level of 17 cytokines in serum and blood of healthy donors using flow fluorimetry, Tsitokiny Vospalenie, 4, 25-32.
19. Toptygina, A. P., and Aleshkin, V. A. (2011) Production of cytokines in intact children and children vaccinated with the Priorix vaccine in response to stimulation by measles and rubella virus antigens, Immunologiya, 32, 200-205.
20. Shen, W., and Durum, S. K. (2010) Synergy of IL-23 and Th17 cytokines: new light on inflammatory bowel disease, Neurochem. Res., 35, 940-946.
21. Ito, R., Kita M., Shin-Ya, M., Kishida, T., Urano, A., Takada, R., Sakagami, J., Imanishi, J., Iwakura, Y., Okanoue, T., Yoshikawa, T., Kataoka, K., and Mazda, O. (2008) Involvement of IL-17A in the pathogenesis of DSS-induced colitis in mice, Biochem. Biophys. Res. Commun., 377, 12-16.
22. Fahlen, L., Read, S., Gorelik, L., Hurst, S. D., Coffman, R. L., Flavell, R. A., and Powrie, F. (2005) T cells that cannot respond to TGF-beta escape control by CD4(+)CD25(+) regulatory T cells, J. Exp. Med., 201, 737-746.
23. Miroshkina, L. V., Petrichuk, S. V., Tsimbalova, E. G., Potapov, A. S., Venediktova, M. M., Toptygina, A. P., Kurbatova, O. V., Izmailova, T. D., Semikina, E. L., and Varichkina, M. A. (2013) Cytokine profile in children with inflammatory bowel diseases as a predictor of efficiency of therapy with infliximab, Vopr. Diagnost. Pediatr., 5, 33-38.
24. Toptygina, A. P., Bobyleva, G. V., and Aleshkin, V. A. (2008) Correlation between mucosal and systemic immune responses in infants, Ros. Immunol. Zh., 2, 449-453.
25. Nielsen, O. H., Kirman, I., Rudiger, N., Hendel, J., and Vainer, B. (2003) Upregulation of interleukin-12 and -17 in active inflammatory bowel disease, Scand. J. Gastroenterol., 38, 180-185.
26. Sakuraba, A., Sato, T., Kamada, N., Kitazume, M., Sugita, A., and Hibi, T. (2009) Th1/Th17 immune response is induced by mesenteric lymph node dendritic cells in Crohn's disease, Gastroenterology, 137, 1736-1745.
27. Shalapour, S., Deiser, K., Kuhl, A. A., Glauben, R., Krug, S. M., Fischer, A., Sercan, O., Chappaz, S., Bereswill, S., Heimesaat, M. M., Loddenkemper, C., Fromm, M., Finke, D., Hammerling, G. J., Arnold, B., Siegmund, B., and Schuler, T. (2012) Interleukin-7 links T lymphocyte and intestinal epithelial cell homeostasis, PLoS One, 7, e31939.
28. Xavier, R. J., and Podolsky, D. K. (2007) Unravelling the pathogenesis of inflammatory bowel disease, Nature, 448, 427-434.