SAR Studies on tetrahydroisoquinoline derivatives: The role of flexibility and bioisosterism to raise potency and selectivity toward P-glycoprotein

Journal of Medicinal Chemistry

Volumn 57, Issue 23, 2014, Pages 9983-9994

  Capparelli, Elena ^a   Zinzi, Laura ^a   Cantore, Mariangela ^c   Contino, Marialessandra ^a   Perrone, Maria Grazia ^a   Luurtsema, Gert ^b   Berardi, Francesco ^a,c   Perrone, Roberto ^a,c   Colabufo, Nicola A ^a,c  

^a UNIVERSITY OF BARI   (Italy)

^b UNIVERSITY MEDICAL CENTER GRONINGEN   (Netherlands)

^c Biofordrug Srl Spin off DellUniversità Degli Studi di Bari A Moro   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

BIPHENYL DERIVATIVE; GLYCOPROTEIN; HYDROXYL GROUP; MULTIDRUG RESISTANCE PROTEIN; OXAZOLE DERIVATIVE; TETRAHYDROISOQUINOLINE; TETRAHYDROISOQUINOLINE DERIVATIVE; 6,7-DIMETHOXY-2-(4-METHOXYBIPHENYL-4-YL-METHYL)-1,2,3,4-TETRAHYDROISOQUINOLINE; BIPHENYL; CALCEIN AM; FLUORESCEIN DERIVATIVE; LIGAND; MULTIDRUG RESISTANCE-ASSOCIATED PROTEIN 1;

ARTICLE; DRUG POTENCY; DRUG STRUCTURE; DRUG SYNTHESIS; IN VITRO STUDY; MEDICINAL CHEMISTRY; NETHERLANDS; PROCESS OPTIMIZATION; SUZUKI REACTION; ANIMAL; CHEMISTRY; DOG; MDCK CELL LINE; METABOLISM; MOUSE; STRUCTURE ACTIVITY RELATION; SYNTHESIS;

ANIMALS; BIPHENYL COMPOUNDS; DOGS; FLUORESCEINS; LIGANDS; MADIN DARBY CANINE KIDNEY CELLS; MICE; MULTIDRUG RESISTANCE-ASSOCIATED PROTEINS; P-GLYCOPROTEIN; STRUCTURE-ACTIVITY RELATIONSHIP; TETRAHYDROISOQUINOLINES;

EID: 84918585092     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm501640e     Document Type: Article

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