메뉴 건너뛰기




Volumn 64, Issue 6, 2014, Pages 507-513

Cardioprotection by ranolazine in perfused rat heart

Author keywords

Calcium; Cardioprotection; Ischemia; Ranolazine; Reperfusion

Indexed keywords

CALCIUM; OXYGEN; RANOLAZINE; RYANODINE; TRIPHENYLTETRAZOLIUM; ACETANILIDE DERIVATIVE; CARDIOTONIC AGENT; PIPERAZINE DERIVATIVE;

EID: 84918582499     PISSN: 01602446     EISSN: 15334023     Source Type: Journal    
DOI: 10.1097/FJC.0000000000000144     Document Type: Article
Times cited : (3)

References (41)
  • 1
    • 0348129532 scopus 로고    scopus 로고
    • Effects of ranolazine with atenolol, amlodipine, or diltiazem on exercise tolerance and angina in patients with severe chronic angina: A randomized controlled trial
    • Chaitman BR, Pepine CJ, Parker JO, et al. Effects of ranolazine with atenolol, amlodipine, or diltiazem on exercise tolerance and angina in patients with severe chronic angina: A randomized controlled trial. JAMA. 2004;291:309-316.
    • (2004) JAMA , vol.291 , pp. 309-316
    • Chaitman, B.R.1    Pepine, C.J.2    Parker, J.O.3
  • 2
    • 11144356285 scopus 로고    scopus 로고
    • Anti-ischemic effects and long-term survival during ranolazine monotherapy in patients with chronic severe angina
    • Chaitman BR, Skettino SL, Parker JO, et al. Anti-ischemic effects and long-term survival during ranolazine monotherapy in patients with chronic severe angina. J Am Coll Cardiol. 2004;43:1375-1382.
    • (2004) J Am Coll Cardiol. , vol.43 , pp. 1375-1382
    • Chaitman, B.R.1    Skettino, S.L.2    Parker, J.O.3
  • 3
    • 33746192571 scopus 로고    scopus 로고
    • Antianginal efficacy of ranolazine when added to treatment with amlodipine: The ERICA (Efficacy of Ranolazine in Chronic Angina) trial
    • Stone PH, Gratsiansky NA, Blokhin A, et al. Antianginal efficacy of ranolazine when added to treatment with amlodipine: The ERICA (Efficacy of Ranolazine in Chronic Angina) trial. J Am Coll Cardiol. 2006;48: 566-575.
    • (2006) J Am Coll Cardiol. , vol.48 , pp. 566-575
    • Stone, P.H.1    Gratsiansky, N.A.2    Blokhin, A.3
  • 4
    • 33847385380 scopus 로고    scopus 로고
    • Long-term safety of a novel antianginal agent in patients with severe chronic stable angina: The Ranolazine Open Label Experience (ROLE)
    • Koren MJ, Crager MR, Sweeney M. Long-term safety of a novel antianginal agent in patients with severe chronic stable angina: The Ranolazine Open Label Experience (ROLE). J Am Coll Cardiol. 2007;49: 1027-1034.
    • (2007) J Am Coll Cardiol. , vol.49 , pp. 1027-1034
    • Koren, M.J.1    Crager, M.R.2    Sweeney, M.3
  • 5
    • 34247526904 scopus 로고    scopus 로고
    • Effects of ranolazine on recurrent cardiovascular events in patients with non-ST-elevation acute coronary syndromes: The MERLIN-TIMI 36 randomized trial
    • Morrow DA, Scirica BM, Karwatowska-Prokopczuk E, et al. Effects of ranolazine on recurrent cardiovascular events in patients with non-ST-elevation acute coronary syndromes: The MERLIN-TIMI 36 randomized trial. JAMA. 2007;297:1775-1783.
    • (2007) JAMA , vol.297 , pp. 1775-1783
    • Morrow, D.A.1    Scirica, B.M.2    Karwatowska-Prokopczuk, E.3
  • 6
    • 0025134189 scopus 로고
    • Prevention of myocardial enzyme release by ranolazine in a primate model of ischemia with reperfusion
    • Allely MC, Alps BJ. Prevention of myocardial enzyme release by ranolazine in a primate model of ischemia with reperfusion. Br J Pharmacol. 1990;99:5-6.
    • (1990) Br J Pharmacol. , vol.99 , pp. 5-6
    • Allely, M.C.1    Alps, B.J.2
  • 7
    • 0027241659 scopus 로고
    • Protective effects of ranolazine in guinea-pig hearts during low-flow ischemia and their association with increases in active pyruvate dehydrogenase
    • Clarke B, Spedding M, Patmore L, et al. Protective effects of ranolazine in guinea-pig hearts during low-flow ischemia and their association with increases in active pyruvate dehydrogenase. Br J Pharmacol. 1993;109: 748-750.
    • (1993) Br J Pharmacol. , vol.109 , pp. 748-750
    • Clarke, B.1    Spedding, M.2    Patmore, L.3
  • 8
    • 0028030471 scopus 로고
    • Cardioprotective effects of ranolazine (RS-43285) in the isolated perfused rabbit heart
    • Gralinski MR, Black SC, Kilgore KS, et al. Cardioprotective effects of ranolazine (RS-43285) in the isolated perfused rabbit heart. Cardiovasc Res. 1994;28:1231-1237.
    • (1994) Cardiovasc Res. , vol.28 , pp. 1231-1237
    • Gralinski, M.R.1    Black, S.C.2    Kilgore, K.S.3
  • 9
    • 0035917675 scopus 로고    scopus 로고
    • Ranolazine, a partial fatty acid oxidation inhibitor, reduces myocardial infarct size and cardiac troponin t release in the rat
    • Zacharowski K, Blackburn B, Thiemermann C. Ranolazine, a partial fatty acid oxidation inhibitor, reduces myocardial infarct size and cardiac troponin t release in the rat. Eur J Pharmacol. 2001;418: 105-110.
    • (2001) Eur J Pharmacol. , vol.418 , pp. 105-110
    • Zacharowski, K.1    Blackburn, B.2    Thiemermann, C.3
  • 10
    • 33745266444 scopus 로고    scopus 로고
    • Improved left ventricular function and reduced necrosis after myocardial ischemia/reperfusion in rabbits treated with ranolazine, an inhibitor of the late sodium channel
    • Hale SL, Leeka JA, Kloner RA. Improved left ventricular function and reduced necrosis after myocardial ischemia/reperfusion in rabbits treated with ranolazine, an inhibitor of the late sodium channel. J Pharmacol Exp Ther. 2006;318:418-423.
    • (2006) J Pharmacol Exp Ther. , vol.318 , pp. 418-423
    • Hale, S.L.1    Leeka, J.A.2    Kloner, R.A.3
  • 11
    • 80052963908 scopus 로고    scopus 로고
    • Ranolazine reduces Ca2+ overload and oxidative stress and improves mitochondrial integrity to protect against ischemia reperfusion injury in isolated hearts
    • Aldakkak M, Camara AK, Heisner JS, et al. Ranolazine reduces Ca2+ overload and oxidative stress and improves mitochondrial integrity to protect against ischemia reperfusion injury in isolated hearts. Pharmacol Res. 2011;64:381-392.
    • (2011) Pharmacol Res. , vol.64 , pp. 381-392
    • Aldakkak, M.1    Camara, A.K.2    Heisner, J.S.3
  • 12
    • 0028657558 scopus 로고
    • Effect of ranolazine on infarct size in a canine model of regional myocardial ischemia/reperfusion
    • Black SC, Gralinski MR, McCormack JG, et al. Effect of ranolazine on infarct size in a canine model of regional myocardial ischemia/reperfusion. J Cardiovasc Pharmacol. 1994;24:921-928.
    • (1994) J Cardiovasc Pharmacol. , vol.24 , pp. 921-928
    • Black, S.C.1    Gralinski, M.R.2    McCormack, J.G.3
  • 13
    • 84862577191 scopus 로고    scopus 로고
    • A pilot randomized study of ranolazine for reduction of myocardial damage during elective percutaneous coronary intervention
    • Pelliccia F, Pasceri V, Marazzi G, et al. A pilot randomized study of ranolazine for reduction of myocardial damage during elective percutaneous coronary intervention. Am Heart J. 2012;163:1019-1023.
    • (2012) Am Heart J. , vol.163 , pp. 1019-1023
    • Pelliccia, F.1    Pasceri, V.2    Marazzi, G.3
  • 14
    • 84868212488 scopus 로고    scopus 로고
    • Effect of ranolazine on left ventricular dyssynchrony in patients with coronary artery disease
    • Venkataraman R, Chen J, Garcia EV, et al. Effect of ranolazine on left ventricular dyssynchrony in patients with coronary artery disease. Am J Cardiol. 2012;110:1440-1445.
    • (2012) Am J Cardiol. , vol.110 , pp. 1440-1445
    • Venkataraman, R.1    Chen, J.2    Garcia, E.V.3
  • 15
    • 4344577023 scopus 로고    scopus 로고
    • Electrophysiological effects of ranolazine, a novel antianginal agent with antiarrhythmic properties
    • Antzelevitch C, Belardinelli L, Zygmunt AC, et al. Electrophysiological effects of ranolazine, a novel antianginal agent with antiarrhythmic properties. Circulation. 2004;110:904-910.
    • (2004) Circulation , vol.110 , pp. 904-910
    • Antzelevitch, C.1    Belardinelli, L.2    Zygmunt, A.C.3
  • 16
    • 40949122385 scopus 로고    scopus 로고
    • Inibition of the late sodium current to reduce electrical and mechanical dysfunction of ischaemic myocardium
    • Shryrock JC, Belandinelli L. Inibition of the late sodium current to reduce electrical and mechanical dysfunction of ischaemic myocardium. Br J Pharmacol. 2008;153:1133-1142.
    • (2008) Br J Pharmacol. , vol.153 , pp. 1133-1142
    • Shryrock, J.C.1    Belandinelli, L.2
  • 17
    • 50649110687 scopus 로고    scopus 로고
    • Pathophysiology and pharmacology of the cardiac late sodium current
    • Zaza A, Belardinelli L, Shryock JC. Pathophysiology and pharmacology of the cardiac late sodium current. Pharmacol Ther. 2008;119: 326-339.
    • (2008) Pharmacol Ther. , vol.119 , pp. 326-339
    • Zaza, A.1    Belardinelli, L.2    Shryock, J.C.3
  • 18
    • 34347329260 scopus 로고    scopus 로고
    • Biochemical basis of ischemic heart injury and of cardioprotective interventions
    • Zucchi R, Ghelardoni S, Evangelista E. Biochemical basis of ischemic heart injury and of cardioprotective interventions. Curr Med Chem. 2007; 14:1619-1637.
    • (2007) Curr Med Chem. , vol.14 , pp. 1619-1637
    • Zucchi, R.1    Ghelardoni, S.2    Evangelista, E.3
  • 19
    • 0017376487 scopus 로고
    • Reduction of ischemic myocardial damage in the dog by lidocaine infusion
    • Schaub RG, Stewart G, Strong M, et al. Reduction of ischemic myocardial damage in the dog by lidocaine infusion. Am J Pathol. 1977;87: 399-414.
    • (1977) Am J Pathol. , vol.87 , pp. 399-414
    • Schaub, R.G.1    Stewart, G.2    Strong, M.3
  • 20
    • 0034985278 scopus 로고    scopus 로고
    • Lidocaine reduces ischaemic but not reperfusion injury in isolated rat heart
    • Ebel D, Lipfert P, Fraessdorf J, et al. Lidocaine reduces ischaemic but not reperfusion injury in isolated rat heart. Br J Anaesth. 2001;86:846-852.
    • (2001) Br J Anaesth. , vol.86 , pp. 846-852
    • Ebel, D.1    Lipfert, P.2    Fraessdorf, J.3
  • 21
    • 84868199983 scopus 로고    scopus 로고
    • Adenocaine and Mg2+ reduce fluid requirement to maintain hypotensive resuscitation and improve cardiac and renal function in a porcine model of severe hemorrhagic shock
    • Granfeldt A, Nielsen TK, Solling C, et al. Adenocaine and Mg2+ reduce fluid requirement to maintain hypotensive resuscitation and improve cardiac and renal function in a porcine model of severe hemorrhagic shock. Crit Care Med. 2012;40:3013-3025.
    • (2012) Crit Care Med. , vol.40 , pp. 3013-3025
    • Granfeldt, A.1    Nielsen, T.K.2    Solling, C.3
  • 22
    • 77956535593 scopus 로고    scopus 로고
    • The anti-ischemic mechanism of action of ranolazine in stable ischemic heart disease
    • Stone PH, Chaitman BR, Stocke K, et al. The anti-ischemic mechanism of action of ranolazine in stable ischemic heart disease. J Am Coll Cardiol. 2010;56:934-942.
    • (2010) J Am Coll Cardiol. , vol.56 , pp. 934-942
    • Stone, P.H.1    Chaitman, B.R.2    Stocke, K.3
  • 23
    • 0030032681 scopus 로고    scopus 로고
    • Ranolazine stimulates glucose oxidation in normoxic, ischemic and reperfused ischemic rat hearts
    • McCormack JG, Barr RL, Wolff AA, et al. Ranolazine stimulates glucose oxidation in normoxic, ischemic and reperfused ischemic rat hearts. Circulation. 1996;93:135-142.
    • (1996) Circulation , vol.93 , pp. 135-142
    • McCormack, J.G.1    Barr, R.L.2    Wolff, A.A.3
  • 24
    • 33947431938 scopus 로고    scopus 로고
    • A comparison between ranolazine and CVT-4325, a novel inhibitor of fatty acid oxidation, on cardiac metabolism and left ventricular function in rat isolated perfused heart during ischemia and reperfusion
    • Wang P, Fraser H, Lloyd SG, et al. A comparison between ranolazine and CVT-4325, a novel inhibitor of fatty acid oxidation, on cardiac metabolism and left ventricular function in rat isolated perfused heart during ischemia and reperfusion. J Pharmacol Exp Ther. 2007;321: 213-220.
    • (2007) J Pharmacol Exp Ther. , vol.321 , pp. 213-220
    • Wang, P.1    Fraser, H.2    Lloyd, S.G.3
  • 25
    • 0035055985 scopus 로고    scopus 로고
    • Modulation of sarcoplasmic reticulum function: A new strategy in cardioprotection?
    • Zucchi R, Ronca F, Ronca-Testoni S. Modulation of sarcoplasmic reticulum function: A new strategy in cardioprotection? Pharmacol Ther. 2001;89:47-65.
    • (2001) Pharmacol Ther. , vol.89 , pp. 47-65
    • Zucchi, R.1    Ronca, F.2    Ronca-Testoni, S.3
  • 26
    • 84861330609 scopus 로고    scopus 로고
    • Ranolazine stabilizes cardiac ryanodine receptors: A novel mechanism for the suppression of early afterdepolarization and torsades de pointes in long QT type 2
    • Parikh A, Mantravadi R, Kozhevnikov D, et al. Ranolazine stabilizes cardiac ryanodine receptors: A novel mechanism for the suppression of early afterdepolarization and torsades de pointes in long QT type 2. Heart Rhythm. 2012;9:953-960.
    • (2012) Heart Rhythm. , vol.9 , pp. 953-960
    • Parikh, A.1    Mantravadi, R.2    Kozhevnikov, D.3
  • 27
    • 45549105581 scopus 로고    scopus 로고
    • Ranolazine improves diastolic dysfunction in isolated myocardium from failing human hearts-role of late sodium current and intracellular ion accumulation
    • Sossalla S, Wagner S, Rasenack EC, et al. Ranolazine improves diastolic dysfunction in isolated myocardium from failing human hearts-role of late sodium current and intracellular ion accumulation. J Mol Cell Cardiol. 2008;45:32-43.
    • (2008) J Mol Cell Cardiol. , vol.45 , pp. 32-43
    • Sossalla, S.1    Wagner, S.2    Rasenack, E.C.3
  • 28
    • 0036884410 scopus 로고    scopus 로고
    • Ca2+ channel remodeling in perfused heart: Effects of mechanical work and interventions affecting Ca2+ cycling on sarcolemmal and sarcoplasmic reticulum Ca2+ channels
    • Zucchi R, Ghelardoni S, Carnicelli V, et al. Ca2+ channel remodeling in perfused heart: effects of mechanical work and interventions affecting Ca2+ cycling on sarcolemmal and sarcoplasmic reticulum Ca2+ channels. FASEB J. 2002;16:1976-1978.
    • (2002) FASEB J. , vol.16 , pp. 1976-1978
    • Zucchi, R.1    Ghelardoni, S.2    Carnicelli, V.3
  • 29
    • 0025041173 scopus 로고
    • Purine release from isolated rat heart: A new approach to the study of energy metabolism
    • Zucchi R, Limbruno U, Poddighe R, et al. Purine release from isolated rat heart: A new approach to the study of energy metabolism. J Mol Cell Cardiol. 1990;22:815-826.
    • (1990) J Mol Cell Cardiol. , vol.22 , pp. 815-826
    • Zucchi, R.1    Limbruno, U.2    Poddighe, R.3
  • 30
    • 0029068518 scopus 로고
    • Postischemic changes in cardiac sarcoplasmic reticulum Ca2+ channels: A possible mechanism of ischemic preconditioning
    • Zucchi R, Ronca-Testoni S, Yu G, et al. Postischemic changes in cardiac sarcoplasmic reticulum Ca2+ channels: A possible mechanism of ischemic preconditioning. Circ Res. 1995;76:1049-1056.
    • (1995) Circ Res. , vol.76 , pp. 1049-1056
    • Zucchi, R.1    Ronca-Testoni, S.2    Yu, G.3
  • 31
    • 0027983081 scopus 로고
    • Effect of ischemia and reperfusion on cardiac ryanodine receptors-sarcoplasmic reticulum Ca2+ channels
    • Zucchi R, Ronca-Testoni S, Yu G, et al. Effect of ischemia and reperfusion on cardiac ryanodine receptors-sarcoplasmic reticulum Ca2+ channels. Circ Res. 1994;74:271-280.
    • (1994) Circ Res. , vol.74 , pp. 271-280
    • Zucchi, R.1    Ronca-Testoni, S.2    Yu, G.3
  • 32
    • 74349118169 scopus 로고    scopus 로고
    • Modulation of cardiac ionic homeostasis by 3-iodothyronamine
    • Ghelardoni S, Suffredini S, Frascarelli S, et al. Modulation of cardiac ionic homeostasis by 3-iodothyronamine. J Cell Mol Med. 2009;13: 3082-3090.
    • (2009) J Cell Mol Med. , vol.13 , pp. 3082-3090
    • Ghelardoni, S.1    Suffredini, S.2    Frascarelli, S.3
  • 33
    • 56749180947 scopus 로고    scopus 로고
    • Ranolazine: A review of its use in chronic stable angina pectoris
    • Keating GM. Ranolazine: A review of its use in chronic stable angina pectoris. Drugs. 2008;68:2483-2503.
    • (2008) Drugs , vol.68 , pp. 2483-2503
    • Keating, G.M.1
  • 34
    • 70350438424 scopus 로고    scopus 로고
    • Ranolazine antagonizes the effects of increased late sodium current on intracellular calcium cycling in rat isolated intact heart
    • Wasserstrom JA, Sharma R, O'Toole MJ, et al. Ranolazine antagonizes the effects of increased late sodium current on intracellular calcium cycling in rat isolated intact heart. J Pharmacol Exp Ther. 2009;331: 382-391.
    • (2009) J Pharmacol Exp Ther. , vol.331 , pp. 382-391
    • Wasserstrom, J.A.1    Sharma, R.2    O'Toole, M.J.3
  • 35
    • 33646386662 scopus 로고    scopus 로고
    • Molecular basis of ranolazine block of LQT-3 mutant sodium channels: Evidence for site of action
    • Fredj S, Sampson KJ, Liu K, et al. Molecular basis of ranolazine block of LQT-3 mutant sodium channels: evidence for site of action. Br J Pharmacol. 2006;148:16-24.
    • (2006) Br J Pharmacol. , vol.148 , pp. 16-24
    • Fredj, S.1    Sampson, K.J.2    Liu, K.3
  • 36
    • 0030610319 scopus 로고    scopus 로고
    • The sarcoplasmic reticulum Ca2+ channel/ryanodine receptor: Modulation by endogenous effectors, drugs and disease states
    • Zucchi R, Ronca-Testoni S. The sarcoplasmic reticulum Ca2+ channel/ryanodine receptor: modulation by endogenous effectors, drugs and disease states. Pharmacol Rev. 1997;49:1-51.
    • (1997) Pharmacol Rev. , vol.49 , pp. 1-51
    • Zucchi, R.1    Ronca-Testoni, S.2
  • 37
    • 0037049977 scopus 로고    scopus 로고
    • Cardiac excitation-contraction coupling
    • Bers DM. Cardiac excitation-contraction coupling. Nature. 2002;415: 198-205.
    • (2002) Nature , vol.415 , pp. 198-205
    • Bers, D.M.1
  • 38
    • 3242692393 scopus 로고    scopus 로고
    • Macromolecular complexes regulating cardiac ryanodine receptor function
    • Bers DM. Macromolecular complexes regulating cardiac ryanodine receptor function. J Mol Cell Cardiol. 2004;37:417-429.
    • (2004) J Mol Cell Cardiol. , vol.37 , pp. 417-429
    • Bers, D.M.1
  • 39
    • 67649085854 scopus 로고    scopus 로고
    • Diastolic transient inward current in long QT syndrome type 3 is caused by Ca2+ overload and inhibited by ranolazine
    • Lindegger N, Hagen BM, Marks AR, et al. Diastolic transient inward current in long QT syndrome type 3 is caused by Ca2+ overload and inhibited by ranolazine. J Mol Cell Cardiol. 2009;47:326-334.
    • (2009) J Mol Cell Cardiol. , vol.47 , pp. 326-334
    • Lindegger, N.1    Hagen, B.M.2    Marks, A.R.3
  • 40
    • 0034013661 scopus 로고    scopus 로고
    • Protection of ischemic rat heart by dantrolene, an antagonist of the sarcoplasmic reticulum calcium release channel
    • Yu G, Zucchi R, Ronca-Testoni S, et al. Protection of ischemic rat heart by dantrolene, an antagonist of the sarcoplasmic reticulum calcium release channel. Basic Res Cardiol. 2000;95:137-143.
    • (2000) Basic Res Cardiol. , vol.95 , pp. 137-143
    • Yu, G.1    Zucchi, R.2    Ronca-Testoni, S.3
  • 41
    • 84866458466 scopus 로고    scopus 로고
    • Toward an integrative computational model of the Guinea pig cardiac myocyte
    • Gauthier LD, Greenstein JL, Winslow RL. Toward an integrative computational model of the guinea pig cardiac myocyte. Front Physiol. 2012;3:244.
    • (2012) Front Physiol. , vol.3 , pp. 244
    • Gauthier, L.D.1    Greenstein, J.L.2    Winslow, R.L.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.