Sweat but no gain: Inhibiting proliferation of multidrug resistant cancer cells with ersatzdroges

International Journal of Cancer

Volumn 136, Issue 4, 2015, Pages E188-E196

  Kam, Yoonseok ^a   Das, Tuhin ^a   Tian, Haibin ^a   Foroutan, Parastou ^a   Ruiz, Epifanio ^a   Martinez, Gary ^a   Minton, Susan ^a   Gillies, Robert J ^a   Gatenby, Robert A ^a  

^a H LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE   (United States)

Author keywords

ABCB1 transporters; Breast cancer; Multidrug resistance

Indexed keywords

ADENOSINE TRIPHOSPHATASE; ANTINEOPLASTIC AGENT; CHLOROQUINE; CLARITHROMYCIN; CYCLOSPORIN; DOXORUBICIN; ERSATZDROGE; ERYTHROMYCIN; GLUCOSE; MULTIDRUG RESISTANCE PROTEIN 1; UNCLASSIFIED DRUG; VERAPAMIL; ABCB1 PROTEIN, HUMAN; MULTIDRUG RESISTANCE PROTEIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIPROLIFERATIVE ACTIVITY; ARTICLE; CANCER CELL; CANCER SURVIVAL; CELL PROLIFERATION; CELL SURVIVAL; CONTROLLED STUDY; ENERGY CONSUMPTION; ENERGY EXPENDITURE; FEMALE; GLUCOSE TRANSPORT; IC50; IN VITRO STUDY; IN VIVO STUDY; MOUSE; MULTIDRUG RESISTANCE; NONHUMAN; PHENOTYPE; POSITRON EMISSION TOMOGRAPHY; PROGRESSION FREE SURVIVAL; PROTEIN EXPRESSION; TUMOR GROWTH; TUMOR VOLUME; ANIMAL; DRUG EFFECTS; DRUG RESISTANCE; DRUG SCREENING; GENE EXPRESSION; GENETICS; HUMAN; MAMMARY NEOPLASMS, EXPERIMENTAL; MCF 7 CELL LINE; METABOLISM; MOLECULARLY TARGETED THERAPY; NUDE MOUSE; PATHOLOGY;

ANIMALS; ANTINEOPLASTIC AGENTS; CELL PROLIFERATION; CELL SURVIVAL; CLARITHROMYCIN; CYCLOSPORINE; DRUG RESISTANCE, MULTIPLE; DRUG RESISTANCE, NEOPLASM; ERYTHROMYCIN; FEMALE; GENE EXPRESSION; HUMANS; MAMMARY NEOPLASMS, EXPERIMENTAL; MCF-7 CELLS; MICE, NUDE; MOLECULAR TARGETED THERAPY; P-GLYCOPROTEINS; TUMOR BURDEN; VERAPAMIL; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 84918561119     PISSN: 00207136     EISSN: 10970215     Source Type: Journal    
DOI: 10.1002/ijc.29158     Document Type: Article

References (17)

1. Fletcher JI, Haber M, Henderson MJ, et al. ABC transporters in cancer: More than just drug efflux pumps. Nat Rev Cancer 2010;10:147-56
2. Wind NS, Holen I. Multidrug resistance in breast cancer: From in vitro models to clinical studies. Int J Breast Cancer 2011;2011:967419
3. Marchetti S, Mazzanti R, Beijnen JH, et al. Concise review: Clinical relevance of drug drug and herb drug interactions mediated by the ABC transporter ABCB1 (MDR1, P-glycoprotein). Oncologist 2007;12:927-41
4. Wishart GC, Plumb JA, Going JJ, et al. P-glycoprotein expression in primary breast cancer detected by immunocytochemistry with two monoclonal antibodies. Br J Cancer 1990;62:758-61
5. Schneider J, Bak M, Efferth T, et al. P-glycoprotein expression in treated and untreated human breast cancer. Br J Cancer 1989;60:815-8
6. Sanfilippo O, Ronchi E, De Marco C, et al. Expression of P-glycoprotein in breast cancer tissue and in vitro resistance to doxorubicin and vincristine. Eur J Cancer 1991;27:155-8
7. Gerlinger M, Swanton C. How Darwinian models inform therapeutic failure initiated by clonal heterogeneity in cancer medicine. Br J Cancer 2010; 103:1139-43
8. Aktipis CA, Kwan VS, Johnson KA, et al. Overlooking evolution: A systematic analysis of cancer relapse and therapeutic resistance research. PloS one 2011;6:e26100
9. Gatenby RA, Silva AS, Gillies RJ, et al. Adaptive therapy. Cancer Res 2009;69:4894-903
10. Silva AS, Kam Y, Khin ZP, et al. Evolutionary approaches to prolong progression-free survival in breast cancer. Cancer Res 2012;72: 6362-70
11. Dalton WS, Durie BG, Alberts DS, et al. Characterization of a new drug-resistant human myeloma cell line that expresses P-glycoprotein. Cancer Res 1986;46:5125-30
12. Broxterman HJ, Pinedo HM, Kuiper CM, et al. Induction by verapamil of a rapid increase in ATP consumption in multidrug-resistant tumor cells. FASEB J 1988;2:2278-82
13. Broxterman HJ, Pinedo HM, Kuiper CM, et al. Glycolysis in P-glycoprotein-overexpressing human tumor cell lines. Effects of resistancemodifying agents. FEBS Lett 1989;247: 405-10
14. Kaplan O, Navon G, Lyon RC, et al. Effects of 2- deoxyglucose on drug-sensitive and drug-resistant human breast cancer cells: Toxicity and magnetic resonance spectroscopy studies of metabolism. Cancer Res 1990;50:544-51
15. Harper ME, Antoniou A, Villalobos-Menuey E, et al. Characterization of a novel metabolic strategy used by drug-resistant tumor cells. FASEB J 2002;16:1550-7
16. Ledoux S, Yang R, Friedlander G, et al. Glucose depletion enhances P-glycoprotein expression in hepatoma cells: Role of endoplasmic reticulum stress response. Cancer Res 2003;63:7284-90
17. Jansen RS, Kucukosmanoglu A, de Haas M, et al. ABCC6 prevents ectopic mineralization seen in pseudoxanthoma elasticum by inducing cellular nucleotide release. Proc Natl Acad Sci USA 2013; 110:20206-11.