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Volumn 80, Issue 1, 2015, Pages 52-57

Selective estrogen receptor modulators (SERMs): A review of clinical data

Author keywords

Breast cancer; Endometrial cancer; Menopause; Osteoporosis; SERM

Indexed keywords

ARZOXIFENE; BAZEDOXIFENE; LASOFOXIFENE; OSPEMIFENE; RALOXIFENE; SELECTIVE ESTROGEN RECEPTOR MODULATOR; TAMOXIFEN; TOREMIFENE;

EID: 84918559184     PISSN: 03785122     EISSN: 18734111     Source Type: Journal    
DOI: 10.1016/j.maturitas.2014.10.010     Document Type: Review
Times cited : (73)

References (57)
  • 1
    • 33751542905 scopus 로고    scopus 로고
    • International Union of Pharmacology. LXIV. Estrogen receptors
    • K. Dahlman-Wright, V. Cavailles, and S.A. Fuqua International Union of Pharmacology. LXIV. Estrogen receptors Pharmacol Rev 58 2006 773 781
    • (2006) Pharmacol Rev , vol.58 , pp. 773-781
    • Dahlman-Wright, K.1    Cavailles, V.2    Fuqua, S.A.3
  • 2
    • 0034735859 scopus 로고    scopus 로고
    • Molecular mechanisms of estrogen action: Selective ligands and receptor pharmacology
    • B.S. Katzenellenbogen, I. Choi, and R. Delage-Mourroux Molecular mechanisms of estrogen action: selective ligands and receptor pharmacology J Steroid Biochem Mol Biol 74 2000 279 285
    • (2000) J Steroid Biochem Mol Biol , vol.74 , pp. 279-285
    • Katzenellenbogen, B.S.1    Choi, I.2    Delage-Mourroux, R.3
  • 3
    • 84898996394 scopus 로고    scopus 로고
    • An overview of current and emerging SERMs
    • [Review, Epub ahead of print]
    • B.S. Komm, and S. Mirkin An overview of current and emerging SERMs J Steroid Biochem Mol Biol 2014 [Review, Epub ahead of print]
    • (2014) J Steroid Biochem Mol Biol
    • Komm, B.S.1    Mirkin, S.2
  • 4
    • 77956652851 scopus 로고    scopus 로고
    • SERMs: Progress and future perspectives
    • J.H. Pickar, T. MacNeil, and K. Ohleth SERMs: progress and future perspectives Maturitas 67 2010 129 138
    • (2010) Maturitas , vol.67 , pp. 129-138
    • Pickar, J.H.1    Macneil, T.2    Ohleth, K.3
  • 5
    • 0034979311 scopus 로고    scopus 로고
    • Tamoxifen to raloxifene and beyond
    • R.M. O'Regan, and V.C. Jordan Tamoxifen to raloxifene and beyond Semin Oncol 28 2001 260 273
    • (2001) Semin Oncol , vol.28 , pp. 260-273
    • O'Regan, R.M.1    Jordan, V.C.2
  • 6
    • 0029994748 scopus 로고    scopus 로고
    • Raloxifene, tamoxifen, nafoxidine, or estrogen effects on reproductive and nonreproductive tissues in ovariectomized rats
    • M. Sato, M.K. Rippy, and H.U. Bryant Raloxifene, tamoxifen, nafoxidine, or estrogen effects on reproductive and nonreproductive tissues in ovariectomized rats FASEB J 10 1996 905 912
    • (1996) FASEB J , vol.10 , pp. 905-912
    • Sato, M.1    Rippy, M.K.2    Bryant, H.U.3
  • 7
    • 0023263237 scopus 로고
    • Species-specific pharmacology of antiestrogens: Role of metabolism
    • V.C. Jordan, and S.P. Robinson Species-specific pharmacology of antiestrogens: role of metabolism Fed Proc 46 1987 1870 1874
    • (1987) Fed Proc , vol.46 , pp. 1870-1874
    • Jordan, V.C.1    Robinson, S.P.2
  • 8
    • 0017098034 scopus 로고
    • Tamoxifen as an anti-tumour agent: Oestrogen binding as a predictive test for tumour response
    • V.C. Jordan, and T. Jaspan Tamoxifen as an anti-tumour agent: oestrogen binding as a predictive test for tumour response J Endocrinol 68 1976 453 460
    • (1976) J Endocrinol , vol.68 , pp. 453-460
    • Jordan, V.C.1    Jaspan, T.2
  • 9
    • 84876883246 scopus 로고    scopus 로고
    • The discovery and development of selective estrogen receptor modulators (SERMs) for clinical practice
    • P.Y. Maximov, T.M. Lee, and V.C. Jordan The discovery and development of selective estrogen receptor modulators (SERMs) for clinical practice Curr Clin Pharmacol 8 2013 35 155
    • (2013) Curr Clin Pharmacol , vol.8 , pp. 35-155
    • Maximov, P.Y.1    Lee, T.M.2    Jordan, V.C.3
  • 10
    • 33745902462 scopus 로고    scopus 로고
    • AstraZeneca Pharmaceuticals LP Wilmington, DE
    • Nolvadex [package insert] 2005 AstraZeneca Pharmaceuticals LP Wilmington, DE
    • (2005) Nolvadex [Package Insert]
  • 11
    • 0032537990 scopus 로고    scopus 로고
    • Tamoxifen for prevention of breast cancer: Report of the National Surgical Adjuvant Breast and Bowel Project P-1 Study
    • B. Fisher, J.P. Costantino, and D.L. Wickerham Tamoxifen for prevention of breast cancer: report of the National Surgical Adjuvant Breast and Bowel Project P-1 Study J Natl Cancer Inst 90 1998 1371 1388
    • (1998) J Natl Cancer Inst , vol.90 , pp. 1371-1388
    • Fisher, B.1    Costantino, J.P.2    Wickerham, D.L.3
  • 12
    • 27944492407 scopus 로고    scopus 로고
    • Tamoxifen for the prevention of breast cancer: Current status of the National Surgical Adjuvant Breast and Bowel Project P-1 Study
    • B. Fisher, J.P. Costantino, and D.L. Wickerham Tamoxifen for the prevention of breast cancer: current status of the National Surgical Adjuvant Breast and Bowel Project P-1 Study J Natl Cancer Inst 97 2005 1652 1662
    • (2005) J Natl Cancer Inst , vol.97 , pp. 1652-1662
    • Fisher, B.1    Costantino, J.P.2    Wickerham, D.L.3
  • 13
    • 33847793068 scopus 로고    scopus 로고
    • Long-term results of tamoxifen prophylaxis for breast cancer - 96-month follow-up of the randomized IBIS-I trial
    • J. Cuzick, J.F. Forbes, and I. Sestak Long-term results of tamoxifen prophylaxis for breast cancer - 96-month follow-up of the randomized IBIS-I trial J Natl Cancer Inst 99 2007 272 282
    • (2007) J Natl Cancer Inst , vol.99 , pp. 272-282
    • Cuzick, J.1    Forbes, J.F.2    Sestak, I.3
  • 14
    • 33847773775 scopus 로고    scopus 로고
    • Twenty-year follow-up of the Royal Marsden Randomized, Double-Blinded Tamoxifen Breast Cancer Prevention Trial
    • T.J. Powles Twenty-year follow-up of the Royal Marsden Randomized, Double-Blinded Tamoxifen Breast Cancer Prevention Trial J Natl Cancer Inst 99 2007 283 290
    • (2007) J Natl Cancer Inst , vol.99 , pp. 283-290
    • Powles, T.J.1
  • 15
    • 34249732092 scopus 로고    scopus 로고
    • Tamoxifen for the prevention of breast cancer: Late results of the Italian randomized tamoxifen prevention trial among women with hysterectomy
    • U. Veronesi, P. Maisonneuve, and N. Rotmensz Tamoxifen for the prevention of breast cancer: late results of the Italian randomized tamoxifen prevention trial among women with hysterectomy J Natl Cancer Inst 99 2007 727 737
    • (2007) J Natl Cancer Inst , vol.99 , pp. 727-737
    • Veronesi, U.1    Maisonneuve, P.2    Rotmensz, N.3
  • 16
    • 84871874920 scopus 로고    scopus 로고
    • Postoperative tamoxifen for ductal carcinoma in situ
    • OCTOBER
    • H. Staley, I. McCallum, and J. Bruce Postoperative tamoxifen for ductal carcinoma in situ Cochrane Database Syst Rev 10 October 2012 CD007847 10.1002/14651858.CD007847.pub2
    • (2012) Cochrane Database Syst Rev , vol.10 , pp. 007847
    • Staley, H.1    McCallum, I.2    Bruce, J.3
  • 17
    • 19344364880 scopus 로고    scopus 로고
    • Effects of chemotherapy and hormonal therapy for early breast cancer on recurrence and 15-year survival: An overview of the randomised trials
    • Early Breast Cancer Trialists' Collaborative Group (EBCTCG)
    • Early Breast Cancer Trialists' Collaborative Group (EBCTCG) Effects of chemotherapy and hormonal therapy for early breast cancer on recurrence and 15-year survival: an overview of the randomised trials Lancet 365 2005 1687 1717
    • (2005) Lancet , vol.365 , pp. 1687-1717
  • 18
    • 85203363507 scopus 로고    scopus 로고
    • Relevance of breast cancer hormone receptors and other factors to the efficacy of adjuvant tamoxifen: Patient-level meta-analysis of randomised trials
    • Early Breast Cancer Trialists Collaborative Group (EBCTCG)
    • Early Breast Cancer Trialists Collaborative Group (EBCTCG) Relevance of breast cancer hormone receptors and other factors to the efficacy of adjuvant tamoxifen: patient-level meta-analysis of randomised trials Lancet 378 2011 771 784
    • (2011) Lancet , vol.378 , pp. 771-784
  • 19
    • 84874745627 scopus 로고    scopus 로고
    • Long-term effects of continuing adjuvant tamoxifen to 10 years versus stopping at 5 years after diagnosis of oestrogen receptor-positive breast cancer: ATLAS, a randomised trial
    • C. Davies, P. Hongchao, and G. Jon Long-term effects of continuing adjuvant tamoxifen to 10 years versus stopping at 5 years after diagnosis of oestrogen receptor-positive breast cancer: ATLAS, a randomised trial Lancet 381 2013 805 816
    • (2013) Lancet , vol.381 , pp. 805-816
    • Davies, C.1    Hongchao, P.2    Jon, G.3
  • 20
    • 0030880472 scopus 로고    scopus 로고
    • The optimal duration of tamoxifen treatment for breast cancer remains uncertain: Randomize into aTTom
    • H. Earl, R. Gray, D. Kerr, and M. Lee The optimal duration of tamoxifen treatment for breast cancer remains uncertain: randomize into aTTom Clin Oncol (R Coll Radiol) 9 1997 141 143
    • (1997) Clin Oncol (R Coll Radiol) , vol.9 , pp. 141-143
    • Earl, H.1    Gray, R.2    Kerr, D.3    Lee, M.4
  • 21
    • 84857440651 scopus 로고    scopus 로고
    • Individualizing osteoporosis therapy
    • S. Silverman, and C. Christiansen Individualizing osteoporosis therapy Osteoporos Int 23 2012 797 809
    • (2012) Osteoporos Int , vol.23 , pp. 797-809
    • Silverman, S.1    Christiansen, C.2
  • 22
    • 0033575083 scopus 로고    scopus 로고
    • The effect of raloxifene on risk of breast cancer in postmenopausal women: Results from the MORE randomized trial. Multiple Outcomes of Raloxifene Evaluation
    • S.R. Cummings, S. Eckert, and K.A. Krueger The effect of raloxifene on risk of breast cancer in postmenopausal women: results from the MORE randomized trial. Multiple Outcomes of Raloxifene Evaluation JAMA 281 1999 2189 2197
    • (1999) JAMA , vol.281 , pp. 2189-2197
    • Cummings, S.R.1    Eckert, S.2    Krueger, K.A.3
  • 23
    • 0035120523 scopus 로고    scopus 로고
    • Continued breast cancer risk reduction in postmenopausal women treated with raloxifene: 4-year results from the MORE trial. Multiple Outcomes of Raloxifene Evaluation
    • J.A. Cauley, L. Norton, and M.E. Lippman Continued breast cancer risk reduction in postmenopausal women treated with raloxifene: 4-year results from the MORE trial. Multiple Outcomes of Raloxifene Evaluation Breast Cancer Res Treat 65 2001 125 134
    • (2001) Breast Cancer Res Treat , vol.65 , pp. 125-134
    • Cauley, J.A.1    Norton, L.2    Lippman, M.E.3
  • 24
    • 33745249570 scopus 로고    scopus 로고
    • Effects of tamoxifen vs raloxifene on the risk of developing invasive breast cancer and other disease outcomes: The NSABP Study of Tamoxifen and Raloxifene (STAR) P-2 trial
    • V.G. Vogel, J.P. Costantino, and D.L. Wickerham Effects of tamoxifen vs raloxifene on the risk of developing invasive breast cancer and other disease outcomes: the NSABP Study of Tamoxifen and Raloxifene (STAR) P-2 trial JAMA 295 2006 2727 2741
    • (2006) JAMA , vol.295 , pp. 2727-2741
    • Vogel, V.G.1    Costantino, J.P.2    Wickerham, D.L.3
  • 25
    • 77953529620 scopus 로고    scopus 로고
    • Update of the National Surgical Adjuvant Breast and Bowel Project Study of Tamoxifen and Raloxifene (STAR) P-2 Trial: Preventing breast cancer
    • V.G. Vogel, J.P. Costantino, and D.L. Wickerham Update of the National Surgical Adjuvant Breast and Bowel Project Study of Tamoxifen and Raloxifene (STAR) P-2 Trial: preventing breast cancer Cancer Prev Res (Phila, PA) 3 2010 696 706
    • (2010) Cancer Prev Res (Phila, PA) , vol.3 , pp. 696-706
    • Vogel, V.G.1    Costantino, J.P.2    Wickerham, D.L.3
  • 26
    • 33745876266 scopus 로고    scopus 로고
    • Effects of raloxifene on cardiovascular events and breast cancer in postmenopausal women
    • E. Barrett-Connor, L. Mosca, and P. Collins Effects of raloxifene on cardiovascular events and breast cancer in postmenopausal women N Engl J Med 355 2006 125 137
    • (2006) N Engl J Med , vol.355 , pp. 125-137
    • Barrett-Connor, E.1    Mosca, L.2    Collins, P.3
  • 27
    • 23844531615 scopus 로고    scopus 로고
    • Bazedoxifene acetate: A selective estrogen receptor modulator with improved selectivity
    • B.S. Komm, Y.P. Kharode, P.V. Bodine, H.A. Harris, C.P. Miller, and C.R. Lyttle Bazedoxifene acetate: a selective estrogen receptor modulator with improved selectivity Endocrinology 46 2005 3999 4008
    • (2005) Endocrinology , vol.46 , pp. 3999-4008
    • Komm, B.S.1    Kharode, Y.P.2    Bodine, P.V.3    Harris, H.A.4    Miller, C.P.5    Lyttle, C.R.6
  • 28
    • 70350438889 scopus 로고    scopus 로고
    • Bazedoxifene effects on the reproductive tract in postmenopausal women at risk for osteoporosis
    • J.V. Pinkerton, D.F. Archer, and W.H. Utian Bazedoxifene effects on the reproductive tract in postmenopausal women at risk for osteoporosis Menopause 16 2009 1102 1108
    • (2009) Menopause , vol.16 , pp. 1102-1108
    • Pinkerton, J.V.1    Archer, D.F.2    Utian, W.H.3
  • 29
    • 70350443878 scopus 로고    scopus 로고
    • Bazedoxifene, a selective estrogen receptor modulator: Effects on the endometrium, ovaries, and breast from a randomized controlled trial in osteoporotic postmenopausal women
    • D.F. Archer, J.V. Pinkerton, and W.H. Utian Bazedoxifene, a selective estrogen receptor modulator: effects on the endometrium, ovaries, and breast from a randomized controlled trial in osteoporotic postmenopausal women Menopause 16 2009 1109 1115
    • (2009) Menopause , vol.16 , pp. 1109-1115
    • Archer, D.F.1    Pinkerton, J.V.2    Utian, W.H.3
  • 30
    • 68949097428 scopus 로고    scopus 로고
    • Lasofoxifene, a new selective estrogen receptor modulator for the treatment of osteoporosis and vaginal atrophy
    • L. Gennari Lasofoxifene, a new selective estrogen receptor modulator for the treatment of osteoporosis and vaginal atrophy Expert Opin Pharmacother 10 2009 2209 2220
    • (2009) Expert Opin Pharmacother , vol.10 , pp. 2209-2220
    • Gennari, L.1
  • 31
    • 77349090257 scopus 로고    scopus 로고
    • Lasofoxifene in postmenopausal women with osteoporosis
    • S.R. Cummings, K. Ensrud, and P.D. Delmas Lasofoxifene in postmenopausal women with osteoporosis N Engl J Med 362 2010 686 696
    • (2010) N Engl J Med , vol.362 , pp. 686-696
    • Cummings, S.R.1    Ensrud, K.2    Delmas, P.D.3
  • 32
    • 78649352823 scopus 로고    scopus 로고
    • Breast cancer incidence in the randomized PEARL trial of lasofoxifene in postmenopausal osteoporotic women
    • PEARL Investigators
    • A.Z. LaCroix, T. Powles, C.K. Osborne PEARL Investigators Breast cancer incidence in the randomized PEARL trial of lasofoxifene in postmenopausal osteoporotic women J Natl Cancer Inst 102 2010 1706 1715
    • (2010) J Natl Cancer Inst , vol.102 , pp. 1706-1715
    • Lacroix, A.Z.1    Powles, T.2    Osborne, C.K.3
  • 33
    • 33644775813 scopus 로고    scopus 로고
    • Arzoxifene: The development and clinical outcome of an ideal SERM
    • P.N. Munster Arzoxifene: the development and clinical outcome of an ideal SERM Expert Opin Invest Drugs 15 2006 317 326
    • (2006) Expert Opin Invest Drugs , vol.15 , pp. 317-326
    • Munster, P.N.1
  • 34
    • 79251498941 scopus 로고    scopus 로고
    • Arzoxifene for prevention of fractures and invasive breast cancer in postmenopausal women
    • S.R. Cummings, M. McClung, and J.Y. Reginster Arzoxifene for prevention of fractures and invasive breast cancer in postmenopausal women J Bone Miner Res 26 2011 397 404
    • (2011) J Bone Miner Res , vol.26 , pp. 397-404
    • Cummings, S.R.1    McClung, M.2    Reginster, J.Y.3
  • 35
    • 84918574275 scopus 로고    scopus 로고
    • Bridgewater, NJ: Prostrakan Inc.
    • Fareston [package insert]. Bridgewater, NJ: Prostrakan Inc.; 2012. Available at: http://www.fareston.com/uploads/documents/fareston-pi.pdf.
    • (2012) Fareston [Package Insert]
  • 36
    • 9844266794 scopus 로고    scopus 로고
    • A phase III comparison of two toremifene doses to tamoxifen in postmenopausal women with advanced breast cancer. Eastern European Study Group
    • M. Gershanovich, A. Garin, and D. Baltina A phase III comparison of two toremifene doses to tamoxifen in postmenopausal women with advanced breast cancer. Eastern European Study Group Breast Cancer Res Treat 45 1997 251 262
    • (1997) Breast Cancer Res Treat , vol.45 , pp. 251-262
    • Gershanovich, M.1    Garin, A.2    Baltina, D.3
  • 37
    • 0029084658 scopus 로고
    • Randomized comparison of tamoxifen and two separate doses of toremifene in postmenopausal patients with metastatic breast cancer
    • D.F. Hayes, J.A. Van Zyl, and A. Hacking Randomized comparison of tamoxifen and two separate doses of toremifene in postmenopausal patients with metastatic breast cancer J Clin Oncol 13 1995 2556 2566
    • (1995) J Clin Oncol , vol.13 , pp. 2556-2566
    • Hayes, D.F.1    Van Zyl, J.A.2    Hacking, A.3
  • 38
    • 2642657654 scopus 로고    scopus 로고
    • Comparison of toremifene and tamoxifen in post-menopausal patients with advanced breast cancer: A randomized double-blind, the 'nordic' phase III study
    • S. Pyrhonen, R. Valavaara, and H. Modig Comparison of toremifene and tamoxifen in post-menopausal patients with advanced breast cancer: a randomized double-blind, the 'nordic' phase III study Br J Cancer 76 1997 270 277
    • (1997) Br J Cancer , vol.76 , pp. 270-277
    • Pyrhonen, S.1    Valavaara, R.2    Modig, H.3
  • 39
    • 0030741983 scopus 로고    scopus 로고
    • Dissection of the molecular mechanism of action of GW5638, a novel estrogen receptor ligand, provides insights into the role of estrogen receptor in bone
    • T.M. Willson, J.D. Norris, and B.L. Wagner Dissection of the molecular mechanism of action of GW5638, a novel estrogen receptor ligand, provides insights into the role of estrogen receptor in bone Endocrinology 138 1997 3901 3911
    • (1997) Endocrinology , vol.138 , pp. 3901-3911
    • Willson, T.M.1    Norris, J.D.2    Wagner, B.L.3
  • 41
    • 0642367765 scopus 로고    scopus 로고
    • Effects of ospemifene, a novel SERM, on hormones, genital tract, climacteric symptoms, and quality of life in postmenopausal women: A double-blind, randomized trial
    • E.M. Rutanen, J. Heikkinen, K. Halonen, J. Komi, R. Lammintausta, and O. Ylikorkala Effects of ospemifene, a novel SERM, on hormones, genital tract, climacteric symptoms, and quality of life in postmenopausal women: a double-blind, randomized trial Menopause 10 2003 433 439
    • (2003) Menopause , vol.10 , pp. 433-439
    • Rutanen, E.M.1    Heikkinen, J.2    Halonen, K.3    Komi, J.4    Lammintausta, R.5    Ylikorkala, O.6
  • 42
    • 0037464769 scopus 로고    scopus 로고
    • Overview of the main outcomes in breast-cancer prevention trials
    • J. Cuzick, T. Powles, and U. Veronesi Overview of the main outcomes in breast-cancer prevention trials Lancet 361 2003 296 300
    • (2003) Lancet , vol.361 , pp. 296-300
    • Cuzick, J.1    Powles, T.2    Veronesi, U.3
  • 43
    • 77952228433 scopus 로고    scopus 로고
    • Endometrial safety: A key hurdle for selective estrogen receptor modulators in development
    • J.V. Pinkerton, and S.R. Goldstein Endometrial safety: a key hurdle for selective estrogen receptor modulators in development Menopause 17 2010 642 653 10.1097/gme.0b013e3181c4f1d6
    • (2010) Menopause , vol.17 , pp. 642-653
    • Pinkerton, J.V.1    Goldstein, S.R.2
  • 44
    • 84905023056 scopus 로고    scopus 로고
    • Differential effects of menopausal therapies on the endometrium
    • [Epub ahead of print]
    • S. Mirkin, D.F. Archer, H.S. Taylor, J.H. Pickar, and B.S. Komm Differential effects of menopausal therapies on the endometrium Menopause 2014 [Epub ahead of print]
    • (2014) Menopause
    • Mirkin, S.1    Archer, D.F.2    Taylor, H.S.3    Pickar, J.H.4    Komm, B.S.5
  • 45
    • 0028208456 scopus 로고
    • Endometrial cancer in tamoxifen-treated breast cancer patients: Findings from the National Surgical Adjuvant Breast and Bowel Project (NSABP) B-14
    • B. Fisher, J.P. Costantino, C.K. Redmond, E.R. Fisher, D.L. Wickerham, and W.M. Cronin Endometrial cancer in tamoxifen-treated breast cancer patients: findings from the National Surgical Adjuvant Breast and Bowel Project (NSABP) B-14 J Natl Cancer Inst 86 1994 527 537
    • (1994) J Natl Cancer Inst , vol.86 , pp. 527-537
    • Fisher, B.1    Costantino, J.P.2    Redmond, C.K.3    Fisher, E.R.4    Wickerham, D.L.5    Cronin, W.M.6
  • 46
    • 85046911962 scopus 로고    scopus 로고
    • Association of tamoxifen and uterine sarcoma
    • D.L. Wickerham, B. Fisher, and N. Wolmark Association of tamoxifen and uterine sarcoma J Clin Oncol 20 2002 2758 2760
    • (2002) J Clin Oncol , vol.20 , pp. 2758-2760
    • Wickerham, D.L.1    Fisher, B.2    Wolmark, N.3
  • 47
    • 51649084822 scopus 로고    scopus 로고
    • Impact of raloxifene or tamoxifen use on endometrial cancer risk: A population-based case-control study
    • A. DeMichele, A.B. Troxel, and J.A. Berlin Impact of raloxifene or tamoxifen use on endometrial cancer risk: a population-based case-control study J Clin Oncol 26 2008 4151 4159
    • (2008) J Clin Oncol , vol.26 , pp. 4151-4159
    • Demichele, A.1    Troxel, A.B.2    Berlin, J.A.3
  • 48
    • 84887467281 scopus 로고    scopus 로고
    • Tissue-selective estrogen complexes for postmenopausal women
    • S. Mirkin, and B. Komm Tissue-selective estrogen complexes for postmenopausal women Maturitas 76 2013 213 220
    • (2013) Maturitas , vol.76 , pp. 213-220
    • Mirkin, S.1    Komm, B.2
  • 49
    • 84924778836 scopus 로고    scopus 로고
    • Endometrial safety of ospemifene: Results of the phase 2/3 clinical development program
    • JUNE [Epub ahead of print]
    • G.D. Constantine, S.R. Goldstein, and D.F. Archer Endometrial safety of ospemifene: results of the phase 2/3 clinical development program Menopause June 2014 [Epub ahead of print]
    • (2014) Menopause
    • Constantine, G.D.1    Goldstein, S.R.2    Archer, D.F.3
  • 50
    • 1542406150 scopus 로고    scopus 로고
    • Antiresorptive treatment of postmenopausal osteoporosis: Review of randomized clinical studies and rationale for the Evista alendronate comparison (EVA) trial
    • E.G. Lufkin, S. Sarkar, and P.M. Kulkarni Antiresorptive treatment of postmenopausal osteoporosis: review of randomized clinical studies and rationale for the Evista alendronate comparison (EVA) trial Curr Med Res Opin 20 2004 351 357
    • (2004) Curr Med Res Opin , vol.20 , pp. 351-357
    • Lufkin, E.G.1    Sarkar, S.2    Kulkarni, P.M.3
  • 51
    • 84908506694 scopus 로고    scopus 로고
    • ®-based fracture risk assessments to identify patients who will benefit from osteoporosis therapy
    • JULY [Epub ahead of print]
    • ®-based fracture risk assessments to identify patients who will benefit from osteoporosis therapy Maturitas July 2014 [Epub ahead of print]
    • (2014) Maturitas
    • Silverman, S.L.1    Komm, B.S.2    Mirkin, S.3
  • 52
    • 84901265590 scopus 로고    scopus 로고
    • Ospemifene, a non-oestrogen selective oestrogen receptor modulator for the treatment of vaginal dryness associated with postmenopausal vulvar and vaginal atrophy: A randomised, placebo-controlled, phase III trial
    • JUNE 2 [Epub 2014 Mar 12]
    • D. Portman, S. Palacios, R.E. Nappi, and A.O. Mueck Ospemifene, a non-oestrogen selective oestrogen receptor modulator for the treatment of vaginal dryness associated with postmenopausal vulvar and vaginal atrophy: a randomised, placebo-controlled, phase III trial Maturitas 78 June (2) 2014 91 98 10.1016/j.maturitas.2014.02.015 [Epub 2014 Mar 12]
    • (2014) Maturitas , vol.78 , pp. 91-98
    • Portman, D.1    Palacios, S.2    Nappi, R.E.3    Mueck, A.O.4
  • 53
    • 84879172530 scopus 로고    scopus 로고
    • Ospemifene, a novel selective estrogen receptor modulator for treating dyspareunia associated with postmenopausal vulvar and vaginal atrophy
    • JUNE 6 Ospemifene Study Group 10.1097/gme.0b013e318279ba64
    • D.J. Portman, G.A. Bachmann, J.A. Simon Ospemifene Study Group Ospemifene, a novel selective estrogen receptor modulator for treating dyspareunia associated with postmenopausal vulvar and vaginal atrophy Menopause 20 June (6) 2013 623 630 10.1097/gme.0b013e318279ba64
    • (2013) Menopause , vol.20 , pp. 623-630
    • Portman, D.J.1    Bachmann, G.A.2    Simon, J.A.3
  • 54
    • 84896712271 scopus 로고    scopus 로고
    • Clinical effects of selective estrogen receptor modulators on vulvar and vaginal atrophy
    • MARCH 3
    • J.V. Pinkerton, and F.Z. Stanczyk Clinical effects of selective estrogen receptor modulators on vulvar and vaginal atrophy Menopause 21 March (3) 2014 309 319 10.1097/GME.0b013e31829755ed
    • (2014) Menopause , vol.21 , pp. 309-319
    • Pinkerton, J.V.1    Stanczyk, F.Z.2
  • 55
    • 84891739837 scopus 로고    scopus 로고
    • Bazedoxifene/conjugated estrogens for managing the burden of estrogen deficiency symptoms
    • JANUARY 1 [Review]
    • S. Mirkin, K.A. Ryan, A.B. Chandran, and B.S. Komm Bazedoxifene/conjugated estrogens for managing the burden of estrogen deficiency symptoms Maturitas 77 January (1) 2014 24 31 10.1016/j.maturitas.2013.10.009 [Review]
    • (2014) Maturitas , vol.77 , pp. 24-31
    • Mirkin, S.1    Ryan, K.A.2    Chandran, A.B.3    Komm, B.S.4
  • 56
    • 84875517862 scopus 로고    scopus 로고
    • Evolution of the tissue selective estrogen complex (TSEC)
    • JULY 7
    • B.S. Komm, and S. Mirkin Evolution of the tissue selective estrogen complex (TSEC) J Cell Physiol 228 July (7) 2013 1423 1427 10.1002/jcp.24324 [Review]
    • (2013) J Cell Physiol , vol.228 , pp. 1423-1427
    • Komm, B.S.1    Mirkin, S.2
  • 57
    • 78149283316 scopus 로고    scopus 로고
    • Lasofoxifene and cardiovascular events in postmenopausal women with osteoporosis: Five-year results from the Postmenopausal Evaluation and Risk Reduction with Lasofoxifene (PEARL) trial
    • [Epub 2010 Oct 11]
    • K. Ensrud, A. LaCroix, and J.R. Thompson Lasofoxifene and cardiovascular events in postmenopausal women with osteoporosis: five-year results from the Postmenopausal Evaluation and Risk Reduction with Lasofoxifene (PEARL) trial Circulation 122 2010 1716 1724 [Epub 2010 Oct 11]
    • (2010) Circulation , vol.122 , pp. 1716-1724
    • Ensrud, K.1    Lacroix, A.2    Thompson, J.R.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.