New formulated "DOX-MTX-loaded nanoparticles" downregulate HER2 gene expression and improve the clinical outcome in OSCCs model in rat: The effect of IV and oral modalities

Asian Pacific Journal of Cancer Prevention

Volumn 15, Issue 21, 2014, Pages 9355-9360

  Abbasi, Mehran Mesgari ^a,b   Monfaredan, Amir ^c   Hamishehkar, Hamed ^a   Jahanban Esfahlan, Rana ^b  

^a TABRIZ UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^b TABRIZ UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^c ISLAMIC AZAD UNIVERSITY   (Iran)

Author keywords

DOX MTX NPs; HER2; Oral and IV route; Oral squamous cell carcinoma(OSCC)

Indexed keywords

ANTINEOPLASTIC AGENT; DOXORUBICIN; MESSENGER RNA; METHOTREXATE; NANOPARTICLE;

ANALYSIS OF VARIANCE; ANIMAL; CARCINOMA, SQUAMOUS CELL; CHI SQUARE DISTRIBUTION; COMPARATIVE STUDY; DISEASE MODEL; DOWN REGULATION; DRUG DELIVERY SYSTEM; DRUG EFFECTS; GENE EXPRESSION REGULATION; GENETICS; INTRAVENOUS DRUG ADMINISTRATION; MALE; METABOLISM; MOLECULARLY TARGETED THERAPY; MOUTH NEOPLASMS; NEOPLASMS, EXPERIMENTAL; ORAL DRUG ADMINISTRATION; PROCEDURES; PROTO ONCOGENE; RANDOMIZATION; RAT; REFERENCE VALUE; SPRAGUE DAWLEY RAT; TREATMENT OUTCOME;

ADMINISTRATION, ORAL; ANALYSIS OF VARIANCE; ANIMALS; ANTINEOPLASTIC COMBINED CHEMOTHERAPY PROTOCOLS; CARCINOMA, SQUAMOUS CELL; CHI-SQUARE DISTRIBUTION; DISEASE MODELS, ANIMAL; DOWN-REGULATION; DOXORUBICIN; DRUG DELIVERY SYSTEMS; GENE EXPRESSION REGULATION, NEOPLASTIC; GENES, ERBB-2; INFUSIONS, INTRAVENOUS; MALE; METHOTREXATE; MOLECULAR TARGETED THERAPY; MOUTH NEOPLASMS; NANOPARTICLES; NEOPLASMS, EXPERIMENTAL; RANDOM ALLOCATION; RATS; RATS, SPRAGUE-DAWLEY; REFERENCE VALUES; RNA, MESSENGER; TREATMENT OUTCOME;

EID: 84918535635     PISSN: 15137368     EISSN: None     Source Type: Journal    
DOI: 10.7314/APJCP.2014.15.21.9355     Document Type: Article

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