Reanalysis of study of pancreatic effects of incretin therapy: Methodological deficiencies

Diabetes, Obesity and Metabolism

Volumn 16, Issue 7, 2014, Pages 661-666

  Bonner Weir, S ^a   In't Veld, P A ^b   Weir, G C ^a  

^a HARVARD MEDICAL SCHOOL   (United States)

^b VRIJE UNIVERSITEIT BRUSSEL   (Belgium)

Author keywords

Incretin therapy; Islets; Type 2 diabetes

Indexed keywords

INCRETIN;

AGE DISTRIBUTION; ANALYTICAL ERROR; BODY MASS; DIABETIC KETOACIDOSIS; DYSPLASIA; EXOCRINE SECRETION; GLUCAGON MICROADENOMA; HUMAN; INSULIN DEPENDENT DIABETES MELLITUS; LETTER; MICROADENOMA; NEUROENDOCRINE TUMOR; NON INSULIN DEPENDENT DIABETES MELLITUS; ORGAN DONOR; ORGAN WEIGHT; PANCREAS DISEASE; PANCREAS DYSPLASIA; PANCREAS ISLET BETA CELL; PANCREAS ISLET CELL HYPERPLASIA; PANCREATITIS; PATIENT SAFETY; SECONDARY ANALYSIS; TREATMENT INDICATION; DIABETES MELLITUS, TYPE 2; DRUG EFFECTS; FEMALE; MALE; PANCREAS;

DIABETES MELLITUS, TYPE 2; FEMALE; HUMANS; INCRETINS; INSULIN-SECRETING CELLS; MALE; PANCREAS;

EID: 84903183754     PISSN: 14628902     EISSN: 14631326     Source Type: Journal    
DOI: 10.1111/dom.12257     Document Type: Letter

References (20)

1. Butler AE, Campbell-Thompson M, Gurlo T, Dawson DW, Atkinson M, Butler PC. Marked expansion of exocrine and endocrine pancreas with incretin therapy in humans with increased exocrine pancreas dysplasia and the potential for glucagon-producing neuroendocrine tumors. Diabetes 2013; 62: 2595-2604.
2. Campbell-Thompson M, Wasserfall C, Kaddis J et al. Network for pancreatic organ donors with diabetes (nPOD): developing a tissue biobank for type 1 diabetes. Diabetes Metab Res Rev 2012; 28: 608-617.
3. Cohen D. Has pancreatic damage from glucagon suppressing diabetes drugs been underplayed? BMJ 2013; 346: f3680.
4. Drucker DJ. Incretin action in the pancreas: potential promise, possible perils, and pathological pitfalls. Diabetes 2013; 62: 3316-3323.
5. Kahn SE. Incretin therapy and islet pathology: a time for caution. Diabetes 2013; 62: 2178-2180.
6. Holst JJ. Pancreatic safety of GLP-1-based therapeutic agents: further insights from rodent studies? Diabetologia 2013; 56: 1869-1872.
7. Harja E, Lord J, Skyler JS. An analysis of characteristics of subjects examined for incretin effects on pancreatic pathology. Diabetes Technol Ther 2013; 15: 609-618.
8. Andea A, Sarkar F, Adsay VN. Clinicopathological correlates of pancreatic intraepithelial neoplasia: a comparative analysis of 82 cases with and 152 cases without pancreatic ductal adenocarcinoma. Mod Pathol 2003; 16: 996-1006.
9. Kimura W, Kuroda A, Morioka Y. Clinical pathology of endocrine tumors of the pancreas. Analysis of autopsy cases. Dig Dis Sci 1991; 36: 933-942.
10. Saisho Y, Butler AE, Meier JJ et al. Pancreas volumes in humans from birth to age one hundred taking into account sex, obesity, and presence of type-2 diabetes. Clin Anat 2007; 20: 933-942.
11. Rahier J, Guiot Y, Goebbels RM, Sempoux C, Henquin JC. Pancreatic beta-cell mass in European subjects with type 2 diabetes. Diabetes Obes Metab 2008; 10(Suppl. 4): 32-42.
12. Campbell-Thompson M, Wasserfall C, Montgomery EL, Atkinson MA, Kaddis JS. Pancreas organ weight in individuals with disease-associated autoantibodies at risk for type 1 diabetes. JAMA 2012; 308: 2337-2339.
13. Klöppel G, Lohr M, Habich K, Oberholzer M, Heitz PU. Islet pathology and the pathogenesis of type 1 and type 2 diabetes mellitus revisited. Surv Synth Pathol Res 1985; 4: 110-125.
14. Butler AE, Janson J, Bonner-Weir S, Ritzel R, Rizza RA, Butler PC. Beta-cell deficit and increased beta-cell apoptosis in humans with type 2 diabetes. Diabetes 2003; 52: 102-110.
15. Yoon KH, Ko SH, Cho JH et al. Selective b-cell loss and a-cell expansion in patients with type 2 diabetes mellitus in Korea. J Clin Endocrinol Metab 2003; 88: 2300-2308.
16. Saito K, Takahashi T, Yaginuma N, Iwama N. Islet morphometry in the diabetic pancreas of man. Tohoku J Exp Med 1978; 125: 185-197.
17. Saito K, Yaginuma N, Takahashi T. Differential volumetry of A, B, and D cells in the pancreatic islets of diabetic and non-diabetic subjects. Tohoku J Exp Med 1979; 129: 273-283.
18. Buchholz M, Braun M, Heidenblut A et al. Transcriptome analysis of microdissected pancreatic intraepithelial neoplastic lesions. Oncogene 2005; 24: 6626-6636.
19. In't Veld P, De Munck N, Van Belle K et al. Beta-cell replication is increased in donor organs from young patients after prolonged life support. Diabetes 2010; 59: 1702-1708.
20. Yoneda S, Uno S, Iwahashi H et al. Predominance of beta-cell neogenesis rather than replication in humans with an impaired glucose tolerance and newly diagnosed diabetes. J Clin Endocrinol Metab 2013; 98: 2053-2061.