A single module type I polyketide synthase directs de Novo macrolactone biogenesis during galbonolide biosynthesis in Streptomyces galbus

Journal of Biological Chemistry

Volumn 289, Issue 50, 2014, Pages 34557-34568

  Kim, Hyun Ju ^a   Karki, Suman ^a   Kwon, So Yeon ^a   Park, Si Hyung ^b   Nahm, Baek Hie ^a,c   Kim, Yeon Ki ^c   Kwon, Hyung Jin ^a  

^a Myong Ji University   (South Korea)

^b Mokpo National University   (South Korea)

^c Genomics Genetics Institute   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

BACTERIA; BIOCHEMISTRY; CHAINS; EXPERIMENTS; GENES; KETONES; PROTEINS;

ACYL CARRIER PROTEINS; CHAIN ASSEMBLIES; CHAIN EXTENSION; CYTOCHROME P450; FEEDING EXPERIMENTS; HYDROXYL GROUPS; POLYKETIDE SYNTHASES; POLYKETIDE SYNTHESIS;

BIOSYNTHESIS;

CARBON 13; CARRIER PROTEIN; CYTOCHROME P450; GALBONOLIDE; GALBONOLIDE A; GALBONOLIDE B; GALBONOLIDE C; GALBONOLIDE D; GALBONOLIDE E; HYDROXYL GROUP; LACTONE DERIVATIVE; MALONIC ACID DERIVATIVE; METHOXYMALONATE; METHYLMALONIC ACID; MICROLACTONE; POLYKETIDE; POLYKETIDE SYNTHASE; PROPIONIC ACID; TYPE I POLYKETIDE SYNTHASE; UNCLASSIFIED DRUG; VICENISTATIN; LACTONE; PROPIONIC ACID DERIVATIVE; RUSTMICIN;

ARTICLE; BACTERIAL GENOME; BIOGENESIS; BIOSYNTHESIS; CONTROLLED STUDY; GENE CLUSTER; GENE DELETION; GENE INACTIVATION; NONHUMAN; NUCLEOTIDE SEQUENCE; ORTHOLOGY; STREPTOMYCES; STREPTOMYCES GALBUS; STREPTOMYCES HALSTEDII; CHEMISTRY; DEFICIENCY; ENZYMOLOGY; GENE SILENCING; GENETICS; METABOLISM; MULTIGENE FAMILY; PROTEIN TERTIARY STRUCTURE;

STREPTOMYCES GALBUS; STREPTOMYCES HALSTEDII;

GENE SILENCING; LACTONES; MULTIGENE FAMILY; POLYKETIDE SYNTHASES; PROPIONATES; PROTEIN STRUCTURE, TERTIARY; STREPTOMYCES;

EID: 84918511550     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M114.602334     Document Type: Article

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