-
1
-
-
79952748673
-
Lu-AA21004, a multimodal serotonergic agent, for the potential treatment of depression and anxiety
-
Adell, A., 2010. Lu-AA21004, a multimodal serotonergic agent, for the potential treatment of depression and anxiety. IDrugs 13, 900-910.
-
(2010)
IDrugs
, vol.13
, pp. 900-910
-
-
Adell, A.1
-
2
-
-
84855958018
-
Modulatory effects of two novel agonists for serotonin receptor 7 on emotion, motivation and circadian rhythm profiles in mice
-
Adriani, W., Travaglini, D., Lacivita, E., Saso, L., Leopoldo, M., Laviola, G., 2012. Modulatory effects of two novel agonists for serotonin receptor 7 on emotion, motivation and circadian rhythm profiles in mice. Neuropharmacology 62, 833-842.
-
(2012)
Neuropharmacology
, vol.62
, pp. 833-842
-
-
Adriani, W.1
Travaglini, D.2
Lacivita, E.3
Saso, L.4
Leopoldo, M.5
Laviola, G.6
-
3
-
-
84861065050
-
A double-blind, randomized, placebo-controlled, active reference study of Lu AA21004 in patients with major depressive disorder
-
Alvarez, E., Perez, V., Dragheim, M., Loft, H., Artigas, F., 2012. A double-blind, randomized, placebo-controlled, active reference study of Lu AA21004 in patients with major depressive disorder. Int. J. Neuropsychopharmacol. 15, 589-600.
-
(2012)
Int. J. Neuropsychopharmacol.
, vol.15
, pp. 589-600
-
-
Alvarez, E.1
Perez, V.2
Dragheim, M.3
Loft, H.4
Artigas, F.5
-
4
-
-
84858618643
-
Occupancy of the serotonin transporter after administration of Lu AA21004 and its relation to plasma concentration in healthy subjects
-
Areberg, J., Luntang-Jensen, M., Sogaard, B., Nilausen, D.O., 2012. Occupancy of the serotonin transporter after administration of Lu AA21004 and its relation to plasma concentration in healthy subjects. Basic Clin. Pharmacol. Toxicol. 110, 401-404.
-
(2012)
Basic Clin. Pharmacol. Toxicol.
, vol.110
, pp. 401-404
-
-
Areberg, J.1
Luntang-Jensen, M.2
Sogaard, B.3
Nilausen, D.O.4
-
5
-
-
84872347531
-
Serotonin receptors involved in antidepressant effects
-
Artigas, F., 2013. Serotonin receptors involved in antidepressant effects. Pharmacol. Ther. 137, 119-131.
-
(2013)
Pharmacol. Ther.
, vol.137
, pp. 119-131
-
-
Artigas, F.1
-
6
-
-
79955856369
-
Discovery of 1-[2-(2,4-dimethylphenylsulfanyl)phenyl]piperazine (Lu AA21004): A novel multimodal compound for the treatment of major depressive disorder
-
Bang-Andersen, B., Ruhland, T., Jorgensen, M., Smith, G., Frederiksen, K., Jensen, K.G., Zhong, H., Nielsen, S.M., Hogg, S., Mork, A., Stensbol, T.B., 2011. Discovery of 1-[2-(2,4-dimethylphenylsulfanyl)phenyl]piperazine (Lu AA21004): a novel multimodal compound for the treatment of major depressive disorder. J. Med. Chem. 54, 3206-3221.
-
(2011)
J. Med. Chem.
, vol.54
, pp. 3206-3221
-
-
Bang-Andersen, B.1
Ruhland, T.2
Jorgensen, M.3
Smith, G.4
Frederiksen, K.5
Jensen, K.G.6
Zhong, H.7
Nielsen, S.M.8
Hogg, S.9
Mork, A.10
Stensbol, T.B.11
-
7
-
-
0030046826
-
Aniracetam restores object recognition impaired by age, scopolamine, and nucleus basalis lesions
-
Bartolini, L., Casamenti, F., Pepeu, G., 1996. Aniracetam restores object recognition impaired by age, scopolamine, and nucleus basalis lesions. Pharmacol. Biochem. Behav. 53, 277-283.
-
(1996)
Pharmacol. Biochem. Behav.
, vol.53
, pp. 277-283
-
-
Bartolini, L.1
Casamenti, F.2
Pepeu, G.3
-
8
-
-
79952993584
-
Memory facilitating effects of agomelatine in the novel object recognition memory paradigm in the rat
-
Bertaina-Anglade, V., Drieu-La-Rochelle, C., Mocaer, E., Seguin, L., 2011. Memory facilitating effects of agomelatine in the novel object recognition memory paradigm in the rat. Pharmacol. Biochem. Behav. 98, 511-517.
-
(2011)
Pharmacol. Biochem. Behav.
, vol.98
, pp. 511-517
-
-
Bertaina-Anglade, V.1
Drieu-La-Rochelle, C.2
Mocaer, E.3
Seguin, L.4
-
9
-
-
34247270861
-
Selective blockade of 5-hydroxytryptamine (5-HT)7 receptors enhances 5-HT transmission, antidepressant-like behavior, and rapid eye movement sleep suppression induced by citalopram in rodents
-
Bonaventure, P., Kelly, L., Aluisio, L., Shelton, J., Lord, B., Galici, R., Miller, K., Atack, J., Lovenberg, T.W., Dugovic, C., 2007. Selective blockade of 5-hydroxytryptamine (5-HT)7 receptors enhances 5-HT transmission, antidepressant-like behavior, and rapid eye movement sleep suppression induced by citalopram in rodents. J. Pharmacol. Exp. Ther. 321, 690-698.
-
(2007)
J. Pharmacol. Exp. Ther.
, vol.321
, pp. 690-698
-
-
Bonaventure, P.1
Kelly, L.2
Aluisio, L.3
Shelton, J.4
Lord, B.5
Galici, R.6
Miller, K.7
Atack, J.8
Lovenberg, T.W.9
Dugovic, C.10
-
10
-
-
59449083416
-
Antagonism of 5-HT(1A) receptors uncovers an excitatory effect of SSRIs on 5-HT neuronal activity, an action probably mediated by 5-HT(7) receptors
-
Bosker, F.J., Folgering, J.H., Gladkevich, A.V., Schmidt, A., van der Hart, M.C., Sprouse, J., den Boer, J.A., Westerink, B.H., Cremers, T.I., 2009. Antagonism of 5-HT(1A) receptors uncovers an excitatory effect of SSRIs on 5-HT neuronal activity, an action probably mediated by 5-HT(7) receptors. J. Neurochem. 108, 1126-1135.
-
(2009)
J. Neurochem.
, vol.108
, pp. 1126-1135
-
-
Bosker, F.J.1
Folgering, J.H.2
Gladkevich, A.V.3
Schmidt, A.4
Van Der Hart, M.C.5
Sprouse, J.6
Den Boer, J.A.7
Westerink, B.H.8
Cremers, T.I.9
-
11
-
-
84879355954
-
The role of serotonin in cognitive function: Evidence from recent studies and implications for understanding depression
-
Cowen, P., Sherwood, A.C., 2013. The role of serotonin in cognitive function: evidence from recent studies and implications for understanding depression. J. Psychopharmacol. 27, 575-583.
-
(2013)
J. Psychopharmacol.
, vol.27
, pp. 575-583
-
-
Cowen, P.1
Sherwood, A.C.2
-
13
-
-
84907169186
-
Selective agonists for serotonin 7 (5-HT7) receptor and their applications in preclinical models: An overview
-
Di Pilato, P., Niso, M., Adriani, W., Romano, E., Travaglini, D., Berardi, F., Colabufo, N.A., Perrone, R., Laviola, G., Lacivita, E., Leopoldo, M., 2014. Selective agonists for serotonin 7 (5-HT7) receptor and their applications in preclinical models: an overview. Rev. Neurosci. 25, 401-415.
-
(2014)
Rev. Neurosci.
, vol.25
, pp. 401-415
-
-
Di Pilato, P.1
Niso, M.2
Adriani, W.3
Romano, E.4
Travaglini, D.5
Berardi, F.6
Colabufo, N.A.7
Perrone, R.8
Laviola, G.9
Lacivita, E.10
Leopoldo, M.11
-
14
-
-
0029908469
-
Circadian rhythms and the pharmacology of affective illness
-
Duncan Jr., W.C., 1996. Circadian rhythms and the pharmacology of affective illness. Pharmacol. Ther. 71, 253-312.
-
(1996)
Pharmacol. Ther.
, vol.71
, pp. 253-312
-
-
Duncan, W.C.1
-
16
-
-
84865255393
-
7 receptor crosstalk in the regulation of emotional memory: Implications for effects of selective serotonin reuptake inhibitors
-
7 receptor crosstalk in the regulation of emotional memory: implications for effects of selective serotonin reuptake inhibitors. Neuropharmacology 63, 1150-1160.
-
(2012)
Neuropharmacology
, vol.63
, pp. 1150-1160
-
-
Eriksson, T.M.1
Holst, S.2
Stan, T.L.3
Hager, T.4
Sjogren, B.5
Ogren, S.O.6
Svenningsson, P.7
Stiedl, O.8
-
17
-
-
84892792149
-
7 receptor: Effect on object recognition performances in mice
-
7 receptor: effect on object recognition performances in mice. Psychopharmacol. Berl. 231, 393-400.
-
(2014)
Psychopharmacol. Berl.
, vol.231
, pp. 393-400
-
-
Freret, T.1
Paizanis, E.2
Beaudet, G.3
Gusmao-Montaigne, A.4
Nee, G.5
Dauphin, F.6
Bouet, V.7
Boulouard, M.8
-
19
-
-
33846300603
-
5-HT3 receptor-mediated photiclike responses of the circadian clock in the rat
-
Graff, C., Challet, E., Pevet, P., Wollnik, F., 2007. 5-HT3 receptor-mediated photiclike responses of the circadian clock in the rat. Neuropharmacology 52, 662-671.
-
(2007)
Neuropharmacology
, vol.52
, pp. 662-671
-
-
Graff, C.1
Challet, E.2
Pevet, P.3
Wollnik, F.4
-
20
-
-
0034070287
-
Characterization of SB-269970-A, a selective 5-HT(7) receptor antagonist
-
Hagan, J.J., Price, G.W., Jeffrey, P., Deeks, N.J., Stean, T., Piper, D., Smith, M.I., Upton, N., Medhurst, A.D., Middlemiss, D.N., Riley, G.J., Lovell, P.J., Bromidge, S.M., Thomas, D.R., 2000. Characterization of SB-269970-A, a selective 5-HT(7) receptor antagonist. Br. J. Pharmacol. 130, 539-548.
-
(2000)
Br. J. Pharmacol.
, vol.130
, pp. 539-548
-
-
Hagan, J.J.1
Price, G.W.2
Jeffrey, P.3
Deeks, N.J.4
Stean, T.5
Piper, D.6
Smith, M.I.7
Upton, N.8
Medhurst, A.D.9
Middlemiss, D.N.10
Riley, G.J.11
Lovell, P.J.12
Bromidge, S.M.13
Thomas, D.R.14
-
21
-
-
84893038100
-
A randomised, double-blind, study of vortioxetine versus agomelatine in adults with major depressive disorder (MDD) with inadequate response to SSRI/SNRI treatment
-
Häggström, L., Nielsen, R.Z., Danchenko, N., Poulsen, L., 2013. A randomised, double-blind, study of vortioxetine versus agomelatine in adults with major depressive disorder (MDD) with inadequate response to SSRI/SNRI treatment. Eur. Neuropsychopharmacol. 23, S412.
-
(2013)
Eur. Neuropsychopharmacol.
, vol.23
, pp. S412
-
-
Häggström, L.1
Nielsen, R.Z.2
Danchenko, N.3
Poulsen, L.4
-
22
-
-
0028930156
-
The circadian system and the therapeutics of the affective disorders
-
Healy, D., Waterhouse, J.M., 1995. The circadian system and the therapeutics of the affective disorders. Pharmacol. Ther. 65, 241-263.
-
(1995)
Pharmacol. Ther.
, vol.65
, pp. 241-263
-
-
Healy, D.1
Waterhouse, J.M.2
-
23
-
-
70349564337
-
7 receptor and disorders of the nervous system: An overview
-
7 receptor and disorders of the nervous system: an overview. Psychopharmacol. Berl. 206, 345-354.
-
(2009)
Psychopharmacol. Berl.
, vol.206
, pp. 345-354
-
-
Hedlund, P.B.1
-
25
-
-
84862132965
-
A randomized, double-blind, placebo-controlled, duloxetine-referenced, fixed-dose study comparing the efficacy and safety of Lu AA21004 in elderly patients with major depressive disorder
-
Katona, C., Hansen, T., Olsen, C.K., 2012. A randomized, double-blind, placebo-controlled, duloxetine-referenced, fixed-dose study comparing the efficacy and safety of Lu AA21004 in elderly patients with major depressive disorder. Int. Clin. Psychopharmacol. 27, 215-223.
-
(2012)
Int. Clin. Psychopharmacol.
, vol.27
, pp. 215-223
-
-
Katona, C.1
Hansen, T.2
Olsen, C.K.3
-
26
-
-
84875221056
-
Biological rhythms and melatonin in mood disorders and their treatments
-
Lanfumey, L., Mongeau, R., Hamon, M., 2013. Biological rhythms and melatonin in mood disorders and their treatments. Pharmacol. Ther. 138, 176-184.
-
(2013)
Pharmacol. Ther.
, vol.138
, pp. 176-184
-
-
Lanfumey, L.1
Mongeau, R.2
Hamon, M.3
-
27
-
-
84906840118
-
The multimodal antidepressant vortioxetine increases frontal cortical oscillations unlike escitalopram and duloxetine - A quantitative electroencephalographic study in the rat
-
Leiser, S.C., Pehrson, A.L., Robichaud, P.J., Sanchez, C., 2014. The multimodal antidepressant vortioxetine increases frontal cortical oscillations unlike escitalopram and duloxetine - a quantitative electroencephalographic study in the rat. Br. J. Pharmacol. 171, 4255-4272.
-
(2014)
Br. J. Pharmacol.
, vol.171
, pp. 4255-4272
-
-
Leiser, S.C.1
Pehrson, A.L.2
Robichaud, P.J.3
Sanchez, C.4
-
28
-
-
0027368668
-
7) implicated in the regulation of mammalian circadian rhythms
-
7) implicated in the regulation of mammalian circadian rhythms. Neuron 11, 449-458.
-
(1993)
Neuron
, vol.11
, pp. 449-458
-
-
Lovenberg, T.W.1
Baron, B.M.2
De Lecea, L.3
Miller, J.D.4
Prosser, R.A.5
Rea, M.A.6
Foye, P.E.7
Racke, M.8
Slone, A.L.9
Siegel, B.W.10
-
29
-
-
84898427083
-
Randomized, double-blind, placebo-controlled study of the efficacy of vortioxetine on cognitive dysfunction in adult patients with major depressive disorder (MDD)
-
McIntyre, R.S., Lophaven, S., Olsen, C.K., 2013. Randomized, double-blind, placebo-controlled study of the efficacy of vortioxetine on cognitive dysfunction in adult patients with major depressive disorder (MDD). Neuropsychopharmacology 38, S380-S381.
-
(2013)
Neuropsychopharmacology
, vol.38
, pp. S380-S381
-
-
McIntyre, R.S.1
Lophaven, S.2
Olsen, C.K.3
-
30
-
-
84902577585
-
7 receptors, novel alternative
-
7 receptors, novel alternative. Rev. Neurosci. 25, 325-356.
-
(2014)
Rev. Neurosci.
, vol.25
, pp. 325-356
-
-
Meneses, A.1
-
31
-
-
84874182123
-
Vortioxetine (Lu AA21004), a novel multimodal antidepressant, enhances memory in rats
-
Mork, A., Montezinho, L.P., Miller, S., Trippodi-Murphy, C., Plath, N., Li, Y., Gulinello, M., Sanchez, C., 2013. Vortioxetine (Lu AA21004), a novel multimodal antidepressant, enhances memory in rats. Pharmacol. Biochem. Behav. 105, 41-50.
-
(2013)
Pharmacol. Biochem. Behav.
, vol.105
, pp. 41-50
-
-
Mork, A.1
Montezinho, L.P.2
Miller, S.3
Trippodi-Murphy, C.4
Plath, N.5
Li, Y.6
Gulinello, M.7
Sanchez, C.8
-
32
-
-
84863403855
-
Pharmacological effects of Lu AA21004: A novel multimodal compound for the treatment of major depressive disorder
-
Mork, A., Pehrson, A., Brennum, L.T., Nielsen, S.M., Zhong, H., Lassen, A.B., Miller, S., Westrich, L., Boyle, N.J., Sanchez, C., Fischer, C.W., Liebenberg, N., Wegener, G., Bundgaard, C., Hogg, S., Bang-Andersen, B., Stensbol, T.B., 2012. Pharmacological effects of Lu AA21004: a novel multimodal compound for the treatment of major depressive disorder. J. Pharmacol. Exp. Ther. 340, 666-675.
-
(2012)
J. Pharmacol. Exp. Ther.
, vol.340
, pp. 666-675
-
-
Mork, A.1
Pehrson, A.2
Brennum, L.T.3
Nielsen, S.M.4
Zhong, H.5
Lassen, A.B.6
Miller, S.7
Westrich, L.8
Boyle, N.J.9
Sanchez, C.10
Fischer, C.W.11
Liebenberg, N.12
Wegener, G.13
Bundgaard, C.14
Hogg, S.15
Bang-Andersen, B.16
Stensbol, T.B.17
-
34
-
-
0031671214
-
Brain serotonin neurotransmission: An overview and update with an emphasis on serotonin subsystem heterogeneity, multiple receptors, interactions with other neurotransmitter systems, and consequent implications for understanding the actions of serotonergic drugs
-
Murphy, D.L., Andrews, A.M., Wichems, C.H., Li, Q., Tohda, M., Greenberg, B., 1998. Brain serotonin neurotransmission: an overview and update with an emphasis on serotonin subsystem heterogeneity, multiple receptors, interactions with other neurotransmitter systems, and consequent implications for understanding the actions of serotonergic drugs. J. Clin. Psychiatry 59 (Suppl. 15), 4-12.
-
(1998)
J. Clin. Psychiatry
, vol.59
, pp. 4-12
-
-
Murphy, D.L.1
Andrews, A.M.2
Wichems, C.H.3
Li, Q.4
Tohda, M.5
Greenberg, B.6
-
35
-
-
0033561801
-
5-HT1B receptor-mediated presynaptic inhibition of retinal input to the suprachiasmatic nucleus
-
Pickard, G.E., Smith, B.N., Belenky, M., Rea, M.A., Dudek, F.E., Sollars, P.J., 1999. 5-HT1B receptor-mediated presynaptic inhibition of retinal input to the suprachiasmatic nucleus. J. Neurosci. 19, 4034-4045.
-
(1999)
J. Neurosci.
, vol.19
, pp. 4034-4045
-
-
Pickard, G.E.1
Smith, B.N.2
Belenky, M.3
Rea, M.A.4
Dudek, F.E.5
Sollars, P.J.6
-
36
-
-
0027403068
-
Serotonin receptor gene expression in the rat suprachiasmatic nuclei
-
Roca, A.L., Weaver, D.R., Reppert, S.M., 1993. Serotonin receptor gene expression in the rat suprachiasmatic nuclei. Brain Res. 608, 159-165.
-
(1993)
Brain Res.
, vol.608
, pp. 159-165
-
-
Roca, A.L.1
Weaver, D.R.2
Reppert, S.M.3
-
37
-
-
51049122112
-
Modelling biological rhythms
-
Roenneberg, T., Chua, E.J., Bernardo, R., Mendoza, E., 2008. Modelling biological rhythms. Curr. Biol. 18, R826-R835.
-
(2008)
Curr. Biol.
, vol.18
, pp. R826-R835
-
-
Roenneberg, T.1
Chua, E.J.2
Bernardo, R.3
Mendoza, E.4
-
39
-
-
84884281105
-
5-HTT and 5-HT1A receptor occupancy of the novel substance vortioxetine (Lu AA21004). A PET study in control subjects
-
Stenkrona, P., Halldin, C., Lundberg, J., 2013. 5-HTT and 5-HT1A receptor occupancy of the novel substance vortioxetine (Lu AA21004). A PET study in control subjects. Eur. Neuropsychopharmacol. 23, 1190-1198.
-
(2013)
Eur. Neuropsychopharmacol.
, vol.23
, pp. 1190-1198
-
-
Stenkrona, P.1
Halldin, C.2
Lundberg, J.3
-
40
-
-
84865865322
-
Synergistic mechanisms involved in the antidepressant effects of agomelatine
-
Tardito, D., Molteni, R., Popoli, M., Racagni, G., 2012. Synergistic mechanisms involved in the antidepressant effects of agomelatine. Eur. Neuropsychopharmacol. 22 (Suppl. 3), S482-S486.
-
(2012)
Eur. Neuropsychopharmacol.
, vol.22
, pp. S482-S486
-
-
Tardito, D.1
Molteni, R.2
Popoli, M.3
Racagni, G.4
-
41
-
-
59449099494
-
7 Receptor Agonists for the Treatment of Pain
-
International application published under the patent cooperation treaty (PCT) WO 2008
-
7 Receptor Agonists for the Treatment of Pain. International application published under the patent cooperation treaty (PCT) WO 2008/000495 A1 2008.
-
(2008)
-
-
Vela Hernandez, J.M.1
Torrens-Jover, A.2
Buschmann, H.3
Romero-Alonzo, L.4
-
42
-
-
84876108581
-
In vitro and in vivo effects of the multimodal antidepressant vortioxetine (Lu AA21004) at human and rat targets
-
Westrich, L., Pehrson, A., Zhong, H., Nielsen, S.M., Frederiksen, K., Stensbol, T.B., Boyle, N.J., Hentzer, M., Sanchez, C., 2012. In vitro and in vivo effects of the multimodal antidepressant vortioxetine (Lu AA21004) at human and rat targets. Int. J. Psychiatry Clin. Pract. 5 (Suppl. 1), 47.
-
(2012)
Int. J. Psychiatry Clin. Pract.
, vol.5
, pp. 47
-
-
Westrich, L.1
Pehrson, A.2
Zhong, H.3
Nielsen, S.M.4
Frederiksen, K.5
Stensbol, T.B.6
Boyle, N.J.7
Hentzer, M.8
Sanchez, C.9
-
44
-
-
0346360716
-
Chronobiology and mood disorders
-
Wirz-Justice, A., 2003. Chronobiology and mood disorders. Dialogues Clin. Neurosci. 5, 315-325.
-
(2003)
Dialogues Clin. Neurosci.
, vol.5
, pp. 315-325
-
-
Wirz-Justice, A.1
-
45
-
-
33646682125
-
Biological rhythm disturbances in mood disorders
-
Wirz-Justice, A., 2006. Biological rhythm disturbances in mood disorders. Int. Clin. Psychopharmacol. 21 (Suppl. 1), S11-S15.
-
(2006)
Int. Clin. Psychopharmacol.
, vol.21
, pp. S11-S15
-
-
Wirz-Justice, A.1
-
46
-
-
11144353910
-
PERIOD2:: LUCIFERASE real-time reporting of circadian dynamics reveals persistent circadian oscillations in mouse peripheral tissues
-
Yoo, S.H., Yamazaki, S., Lowrey, P.L., Shimomura, K., Ko, C.H., Buhr, E.D., Siepka, S.M., Hong, H.K., Oh, W.J., Yoo, O.J., Menaker, M., Takahashi, J.S., 2004. PERIOD2:: LUCIFERASE real-time reporting of circadian dynamics reveals persistent circadian oscillations in mouse peripheral tissues. Proc. Natl. Acad. Sci. U. S. A. 101, 5339-5346.
-
(2004)
Proc. Natl. Acad. Sci. U. S. A.
, vol.101
, pp. 5339-5346
-
-
Yoo, S.H.1
Yamazaki, S.2
Lowrey, P.L.3
Shimomura, K.4
Ko, C.H.5
Buhr, E.D.6
Siepka, S.M.7
Hong, H.K.8
Oh, W.J.9
Yoo, O.J.10
Menaker, M.11
Takahashi, J.S.12
-
47
-
-
80053102580
-
Disrupting the circadian clock: Gene-specific effects on aging, cancer, and other phenotypes
-
Yu, E.A., Weaver, D.R., 2011. Disrupting the circadian clock: gene-specific effects on aging, cancer, and other phenotypes. Aging (Albany N. Y.) 3, 479-493.
-
(2011)
Aging (Albany N. Y.)
, vol.3
, pp. 479-493
-
-
Yu, E.A.1
Weaver, D.R.2
|