Roux-en Y Gastric Bypass Is Superior to Duodeno-Jejunal Bypass in Improving Glycaemic Control in Zucker Diabetic Fatty Rats

Obesity Surgery

Volumn 24, Issue 11, 2014, Pages 1888-1895

  Seyfried, Florian ^a,b   Bueter, Marco ^c   Spliethoff, Kerstin ^c   Miras, Alexander D ^a   Abegg, Kathrin ^c   Lutz, Thomas A ^c   le Roux, Carel W ^a,d  

^a IMPERIAL COLLEGE LONDON   (United Kingdom)

^b UNIVERSITY HOSPITAL WÜRZBURG   (Germany)

^c UNIVERSITY OF ZURICH   (Switzerland)

^d UNIVERSITY COLLEGE DUBLIN   (Ireland)

Author keywords

Duodenal jejunal exclusion; Gastric bypass; Glucose control; Incretins; Rodent model; Roux en Y gastric bypass; Zucker fatty diabetic rat

Indexed keywords

GASTROINTESTINAL HORMONE; GLUCOSE; INSULIN; GLUCOSE BLOOD LEVEL;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BODY WEIGHT; CONTROLLED STUDY; DUODENO JEJUNAL BYPASS; FOOD INTAKE; GLUCOSE BLOOD LEVEL; GLYCEMIC CONTROL; HORMONE BLOOD LEVEL; INSULIN BLOOD LEVEL; INTERMETHOD COMPARISON; MALE; NONHUMAN; ORAL GLUCOSE TOLERANCE TEST; RAT; ROUX EN Y GASTRIC BYPASS; SHAM PROCEDURE; STOMACH BYPASS; WEIGHT CHANGE; WEIGHT REDUCTION; ZUCKER DIABETIC FATTY RAT; ANIMAL; BLOOD; COMPLICATION; DIABETES MELLITUS, TYPE 2; DISEASE MODEL; DUODENUM; GLUCOSE TOLERANCE TEST; JEJUNUM; METABOLISM; OBESITY, MORBID; PROCEDURES; ZUCKER RAT;

ANIMALS; BLOOD GLUCOSE; BODY WEIGHT; DIABETES MELLITUS, TYPE 2; DISEASE MODELS, ANIMAL; DUODENUM; GASTRIC BYPASS; GLUCOSE TOLERANCE TEST; INSULIN; JEJUNUM; MALE; OBESITY, MORBID; RATS; RATS, ZUCKER;

EID: 84917741230     PISSN: 09608923     EISSN: 17080428     Source Type: Journal    
DOI: 10.1007/s11695-014-1301-3     Document Type: Article

References (45)

1. Shaw JE, Sicree RA, Zimmet PZ. Global estimates of the prevalence of diabetes for 2010 and 2030. Diabetes Res Clin Pract. 2010;87(1):4–14.
2. Carlsson LM et al. Bariatric surgery and prevention of type 2 diabetes in Swedish obese subjects. N Engl J Med. 2012;367(8):695–704.
3. Schauer PR et al. Bariatric surgery versus intensive medical therapy in obese patients with diabetes. N Engl J Med. 2012;366(17):1567–76.
4. Pournaras DJ et al. Effect of the definition of type II diabetes remission in the evaluation of bariatric surgery for metabolic disorders. Br J Surg. 2012;99(1):100–3.
5. Pournaras DJ et al. Remission of type 2 diabetes after gastric bypass and banding: mechanisms and 2 year outcomes. Ann Surg. 2010;252(6):966–71.
6. Cohen RV et al. Diabetes remission without weight loss after duodenal bypass surgery. Surg Obes Relat Dis. 2012;8(5):e66–8.
7. Ferzli GS et al. Clinical improvement after duodenojejunal bypass for nonobese type 2 diabetes despite minimal improvement in glycemic homeostasis. World J Surg. 2009;33(5):972–9.
8. Klein S et al. Moderate effect of duodenal-jejunal bypass surgery on glucose homeostasis in patients with type 2 diabetes. Obesity (Silver Spring). 2012;20(6):1266–72.
9. Kindel TL et al. Duodenal-jejunal exclusion improves glucose tolerance in the diabetic, Goto-Kakizaki rat by a GLP-1 receptor-mediated mechanism. J Gastrointest Surg. 2009;13(10):1762–72.
10. Rubino F, Marescaux J. Effect of duodenal-jejunal exclusion in a non-obese animal model of type 2 diabetes: a new perspective for an old disease. Ann Surg. 2004;239(1):1–11.
11. Speck M et al. Duodenal-jejunal bypass protects GK rats from β-cell loss and aggravation of hyperglycemia and increases enteroendocrine cells coexpressing GIP and GLP-1. Am J Physiol Endocrinol Metab. 2011;300(5):E923–32.
12. Jiao J et al. Restoration of euglycemia after duodenal bypass surgery is reliant on central and peripheral inputs in Zucker fa/fa rats. Diabetes. 2013;62(4):1074–83.
13. Rubino F et al. The role of the small bowel in the regulation of circulating ghrelin levels and food intake in the obese Zucker rat. Endocrinology. 2005;146(4):1745–51.
14. Breen DM et al. Jejunal nutrient sensing is required for duodenal-jejunal bypass surgery to rapidly lower glucose concentrations in uncontrolled diabetes. Nat Med. 2012;18(6):950–5.
15. Jurowich CF et al. Duodenal-jejunal bypass improves glycemia and decreases SGLT1-mediated glucose absorption in rats with streptozotocin-induced type 2 diabetes. Ann Surg. 2013;258(1):89–97.
16. Pories WJ et al. Who would have thought it? An operation proves to be the most effective therapy for adult-onset diabetes mellitus. Ann Surg. 1995;222(3):339–50. discussion 350-2.
17. Gavin TP et al. Duodenal-jejunal bypass surgery does not increase skeletal muscle insulin signal transduction or glucose disposal in Goto-Kakizaki type 2 diabetic rats. Obes Surg. 2011;21(2):231–7.
18. Kindel TL et al. Bypassing the duodenum does not improve insulin resistance associated with diet-induced obesity in rodents. Obesity (Silver Spring). 2011;19(2):380–7.
19. Patel RT et al. Surgical control of obesity and diabetes: the role of intestinal vs. gastric mechanisms in the regulation of body weight and glucose homeostasis. Obesity (Silver Spring). 2014;22(1):159–69.
20. Patel RT, et al. Surgical control of obesity and diabetes: the role of intestinal vs gastric mechanisms in the regulation of body weight and glucose homeostasis. Obesity (Silver Spring), 2013.
21. Bjorklund P et al. Is the Roux limb a determinant for meal size after gastric bypass surgery? Obes Surg. 2010;20(10):1408–14.
22. Li SQ et al. Upregulation of IRS-1 expression in Goto-Kakizaki rats following Roux-en-Y gastric bypass surgery: resolution of type 2 diabetes? Tohoku J Exp Med. 2011;225(3):179–86.
23. Meirelles K et al. Mechanisms of glucose homeostasis after Roux-en-Y gastric bypass surgery in the obese, insulin-resistant Zucker rat. Ann Surg. 2009;249(2):277–85.
24. Rubino F et al. The mechanism of diabetes control after gastrointestinal bypass surgery reveals a role of the proximal small intestine in the pathophysiology of type 2 diabetes. Ann Surg. 2006;244(5):741–9.
25. Wang TT et al. Ileal transposition controls diabetes as well as modified duodenal jejunal bypass with better lipid lowering in a nonobese rat model of type II diabetes by increasing GLP-1. Ann Surg. 2008;247(6):968–75.
26. Isbell JM et al. The importance of caloric restriction in the early improvements in insulin sensitivity after Roux-en-Y gastric bypass surgery. Diabetes Care. 2010;33(7):1438–42.
27. Lara-Castro C et al. Effects of short-term very low-calorie diet on intramyocellular lipid and insulin sensitivity in nondiabetic and type 2 diabetic subjects. Metabolism. 2008;57(1):1–8.
28. Kasiske BL, O'Donnell MP, Keane WF. The Zucker rat model of obesity, insulin resistance, hyperlipidemia, and renal injury. Hypertension. 1992;19(1 Suppl):I110–5.
29. Bueter M et al. Roux-en-Y gastric bypass operation in rats. J Vis Exp. 2012;64:e3940.
30. Saeidi N et al. Reprogramming of intestinal glucose metabolism and glycemic control in rats after gastric bypass. Science. 2013;341(6144):406–10.
31. Li JV et al. Metabolic surgery profoundly influences gut microbial-host metabolic cross-talk. Gut. 2011;60(9):1214–23.
32. Bradley D et al. Gastric bypass and banding equally improve insulin sensitivity and beta cell function. J Clin Invest. 2012;122(12):4667–74.
33. Jackness C et al. Very low-calorie diet mimics the early beneficial effect of Roux-en-Y gastric bypass on insulin sensitivity and β-cell function in type 2 diabetic patients. Diabetes. 2013;62(9):3027–32.
34. Geloneze B et al. Metabolic surgery for non-obese type 2 diabetes: incretins, adipocytokines, and insulin secretion/resistance changes in a 1-year interventional clinical controlled study. Ann Surg. 2012;256(1):72–8.
35. Bueter M et al. Gastric bypass increases energy expenditure in rats. Gastroenterology. 2010;138(5):1845–53.
36. Bueter M et al. Vagal sparing surgical technique but not stoma size affects body weight loss in rodent model of gastric bypass. Obes Surg. 2010;20(5):616–22.
37. Salinari S, et al. Duodenal-Jejunal bypass and jejunectomy improve insulin sensitivity in Goto-Kakizaki Diabetic rats without changes in incretins or insulin secretion. Diabetes, 2013.
38. Cummings DE et al. Plasma ghrelin levels after diet-induced weight loss or gastric bypass surgery. N Engl J Med. 2002;346(21):1623–30.
39. le Roux CW et al. Gut hormone profiles following bariatric surgery favor an anorectic state, facilitate weight loss, and improve metabolic parameters. Ann Surg. 2006;243(1):108–14.
40. le Roux CW et al. Gut hormones as mediators of appetite and weight loss after Roux-en-Y gastric bypass. Ann Surg. 2007;246(5):780–5.
41. Holdstock C et al. Ghrelin and adipose tissue regulatory peptides: effect of gastric bypass surgery in obese humans. J Clin Endocrinol Metab. 2003;88(7):3177–83.
42. Sundbom M et al. Early changes in ghrelin following Roux-en-Y gastric bypass: influence of vagal nerve functionality? Obes Surg. 2007;17(3):304–10.
43. Aprahamian CJ et al. A rat model of childhood diet-induced obesity: Roux-en-Y gastric bypass induced changes in metabolic parameters and gastric peptide ghrelin. Pediatr Surg Int. 2007;23(7):653–7.
44. Suzuki S et al. Changes in GI hormones and their effect on gastric emptying and transit times after Roux-en-Y gastric bypass in rat model. Surgery. 2005;138(2):283–90.
45. Wang Y, Liu J. Combination of bypassing stomach and vagus dissection in high-fat diet-induced obese rats-a long-term investigation. Obes Surg. 2010;20(3):375–9.