Evaluation of carbapenem-resistant Enterobacteriaceae in an Italian setting: Report from the trench

Infection, Genetics and Evolution

Volumn 30, Issue , 2015, Pages 8-14

  Barbarini, D ^a   Russello, G ^b   Brovarone, F ^b   Capatti, C ^b   Colla, R ^c   Perilli, M ^d   Moro, M L ^e   Carretto, E ^b  

^a FONDAZIONE IRCCS POLICLINICO SAN MATTEO   (Italy)

^b S MARIA NUOVA HOSPITAL   (Italy)

^c PATHOLOGY UNIT   (Italy)

^d UNIVERSITY OF L'AQUILA   (Italy)

^e Area di Programma Rischio Infettivo Agenzia Sanitaria e Sociale Regione Emilia Romagna   (Italy)

Author keywords

Carbapenemases; Carbapenems resistant enterobacteriaceae; Epidemiology; MICs; Molecular typing; RAPD

Indexed keywords

CLOXACILLIN; ERTAPENEM; GENOMIC DNA; MEROPENEM; ANTIINFECTIVE AGENT; BACTERIAL DNA; BACTERIAL PROTEIN; BETA LACTAMASE; CARBAPENEM DERIVATIVE; CARBAPENEMASE;

ANTIBIOTIC RESISTANCE; ANTIBIOTIC SENSITIVITY; ARTICLE; BACTERIAL STRAIN; BACTERIUM IDENTIFICATION; BROTH DILUTION; CARBAPENEM RESISTANT ENTEROBACTERIACEAE; CONTROLLED STUDY; ENTEROBACTER CLOACAE; EPIDEMIOLOGICAL DATA; ESCHERICHIA COLI; GENE AMPLIFICATION; GENOTYPE; HUMAN; ITALY; KLEBSIELLA OXYTOCA; MINIMUM INHIBITORY CONCENTRATION; MOLECULAR TYPING; NONHUMAN; PHENOTYPE; POLYMERASE CHAIN REACTION; PROVIDENCIA STUARTII; RANDOM AMPLIFIED POLYMORPHIC DNA; CLASSIFICATION; CROSS INFECTION; DRUG EFFECTS; ENTEROBACTERIACEAE; ENTEROBACTERIACEAE INFECTIONS; ENZYMOLOGY; GENETICS; MICROBIAL SENSITIVITY TEST; MICROBIOLOGY; MOLECULAR EPIDEMIOLOGY; PROSPECTIVE STUDY;

ENTEROBACTER CLOACAE; ENTEROBACTERIACEAE; ESCHERICHIA COLI; KLEBSIELLA OXYTOCA; KLEBSIELLA PNEUMONIAE; PROVIDENCIA STUARTII;

ANTI-BACTERIAL AGENTS; BACTERIAL PROTEINS; BETA-LACTAM RESISTANCE; BETA-LACTAMASES; CARBAPENEMS; CROSS INFECTION; DNA, BACTERIAL; ENTEROBACTERIACEAE; ENTEROBACTERIACEAE INFECTIONS; HUMANS; ITALY; MICROBIAL SENSITIVITY TESTS; MOLECULAR EPIDEMIOLOGY; MOLECULAR TYPING; PROSPECTIVE STUDIES; RANDOM AMPLIFIED POLYMORPHIC DNA TECHNIQUE;

EID: 84917705847     PISSN: 15671348     EISSN: 15677257     Source Type: Journal    
DOI: 10.1016/j.meegid.2014.11.025     Document Type: Article

References (33)

1. Canton R., Akova M., Carmeli Y., Giske C.G., Glupczynski Y., Gniadkowski M., Livermore D.M., Miriagou V., Naas T., Rossolini G.M., Samuelsen O., Seifert H., Woodford N., Nordmann P. Rapid evolution and spread of carbapenemases among Enterobacteriaceae in Europe. Clin. Microbiol. Infect. 2012, 18:413-431. European Network on Carbapenemases.
2. Cartelle M., del Mar Tomas M., Pertega S., Beceiro A., Dominguez M.A., Velasco D., Molina F., Villanueva R., Bou G. Risk factors for colonization and infection in a hospital outbreak caused by a strain of Klebsiella pneumoniae with reduced susceptibility to expanded-spectrum cephalosporins. J. Clin. Microbiol. 2004, 42:4242-4249.
3. Performance Standards for Antimicrobial Susceptibility Testing: Twenty-First Informational Supplement 2011, vol. 31. CLSI, Clinical and Laboratory Standards Institute, pp. M100-S121.
4. Cornaglia G., Giamarellou H., Rossolini G.M. Metallo-beta-lactamases: a last frontier for beta-lactams?. Lancet Infect. Dis. 2011, 11:381-393.
5. Damiani G., Telecco S., Comincini S., Sironi M., Carretto E., Marone P. Comparison of an improved RAPD fingerprinting with different typing methods for discriminating clinical isolates of Staphylococcus spp. Eur. J. Epidemiol. 1996, 12:163-169.
6. Deleo F.R., Chen L., Porcella S.F., Martens C.A., Kobayashi S.D., Porter A.R., Chavda K.D., Jacobs M.R., Mathema B., Olsen R.J., Bonomo R.A., Musser J.M., Kreiswirth B.N. Molecular dissection of the evolution of carbapenem-resistant multilocus sequence type 258 Klebsiella pneumoniae. Proc. Natl. Acad. Sci. USA 2014, 111:4988-4993.
7. Doyle D., Peirano G., Lascols C., Lloyd T., Church D.L., Pitout J.D. Laboratory detection of Enterobacteriaceae that produce carbapenemases. J. Clin. Microbiol. 2012, 50:3877-3880.
8. European Centre for Disease Prevention and Control, 2010. Antimicrobial resistance surveillance in Europe 2009. Annual Report of the European Antimicrobial Resistance Surveillance Network (EARS-Net). ECDC, Stockholm.
9. European Centre for Disease Prevention and Control, 2014. Antimicrobial resistance surveillance in Europe 2013. Annual Report of the European Antimicrobial Resistance Surveillance Network (EARS-Net). ECDC, Stockholm.
10. Gagliotti C., Cappelli V., Carretto E., Pan A., Sarti M., Suzzi R., Tura G.A., Moro M.L. Indicazioni pratiche e protocolli operativi per la diagnosi, la sorveglianza e il controllo degli enterobatteri produttori di carbapenemasi nelle strutture sanitarie e socio-sanitarie 2011, Agenzia Sanitaria e Sociale Regionale Emilia Romagna, pp. 1-28.
11. Gagliotti C., Cappelli V., Carretto E., Marchi M., Pan A., Ragni P., Sarti M., Suzzi R., Tura G., Moro M. Control of carbapenemase-producing Klebsiella pneumoniae: a region-wide intervention. Euro. Surveill. 2014, 19. On Behalf Of The Emilia-Romagna Group For Cpe Control.
12. Gaiarsa S., Comandatore F., Gaibani P., Corbella M., Dalla Valle C., Epis S., Scaltriti E., Carretto E., Farina C., Labonia M., Landini M.P., Pongolini S., Sambri V., Bandi C., Marone P., Sassera D. Genomic epidemiology of Klebsiella pneumoniae: the Italian scenario, and novel insights into the origin and global evolution of resistance to carbapenem antibiotics. Antimicrob. Agents Chemother. 2014.
13. Gaibani P., Ambretti S., Berlingeri A., Cordovana M., Farruggia P., Panico M., Landini M.P., Sambri V. Outbreak of NDM-1-producing Enterobacteriaceae in northern Italy, July to August 2011. Euro. Surveill. 2011, 16:20027.
14. Gaibani P., Ambretti S., Farruggia P., Bua G., Berlingeri A., Tamburini M.V., Cordovana M., Guerra L., Mazzetti M., Roncarati G., Tenace C., Moro M.L., Gagliotti C., Landini M.P., Sambri V. Outbreak of Citrobacter freundii carrying VIM-1 in an Italian Hospital, identified during the carbapenemases screening actions, June 2012. Int. J. Infect. Dis. 2013, 17:e714-717.
15. Giani T., D'Andrea M.M., Pecile P., Borgianni L., Nicoletti P., Tonelli F., Bartoloni A., Rossolini G.M. Emergence in Italy of Klebsiella pneumoniae sequence type 258 producing KPC-3 Carbapenemase. J. Clin. Microbiol. 2009, 47:3793-3794.
16. Giani T., Pini B., Arena F., Conte V., Bracco S., Migliavacca R., Participants A.-C.S., Pantosti A., Pagani L., Luzzaro F., Rossolini G.M. Epidemic diffusion of KPC carbapenemase-producing Klebsiella pneumoniae in Italy: results of the first countrywide survey. Euro. Surveill. 2013, 18. 15 May to 30 June 2011.
17. Kocsis E., Savio C., Piccoli M., Cornaglia G., Mazzariol A. Klebsiella pneumoniae harbouring OXA-48 carbapenemase in a Libyan refugee in Italy. Clin. Microbiol. Infect. 2013, 19:E409-E411.
18. Kumarasamy K.K., Toleman M.A., Walsh T.R., Bagaria J., Butt F., Balakrishnan R., Chaudhary U., Doumith M., Giske C.G., Irfan S., Krishnan P., Kumar A.V., Maharjan S., Mushtaq S., Noorie T., Paterson D.L., Pearson A., Perry C., Pike R., Rao B., Ray U., Sarma J.B., Sharma M., Sheridan E., Thirunarayan M.A., Turton J., Upadhyay S., Warner M., Welfare W., Livermore D.M., Woodford N. Emergence of a new antibiotic resistance mechanism in India, Pakistan, and the UK: a molecular, biological, and epidemiological study. Lancet Infect. Dis. 2010, 10:597-602.
19. Lauretti L., Riccio M.L., Mazzariol A., Cornaglia G., Amicosante G., Fontana R., Rossolini G.M. Cloning and characterization of blaVIM, a new integron-borne metallo-beta-lactamase gene from a Pseudomonas aeruginosa clinical isolate. Antimicrob. Agents Chemother. 1999, 43:1584-1590.
20. Monaco M., Giani T., Raffone M., Arena F., Garcia-Fernandez A., Pollini S., Network Eu S.-I.C., Grundmann H., Pantosti A., Rossolini G. Colistin resistance superimposed to endemic carbapenem-resistant Klebsiella pneumoniae: a rapidly evolving problem in Italy. Euro. Surveill. 2014, 19. November 2013 to April 2014.
21. Nordmann P. Carbapenemase-producing Enterobacteriaceae: overview of a major public health challenge. Medecine et maladies infectieuses 2014, 44:51-56.
22. Petrosillo N., Giannella M., Lewis R., Viale P. Treatment of carbapenem-resistant Klebsiella pneumoniae: the state of the art. Expert Rev. Anti Infect. Ther. 2013, 11:159-177.
23. Poirel L., Hombrouck-Alet C., Freneaux C., Bernabeu S., Nordmann P. Global spread of New Delhi metallo-beta-lactamase 1. Lancet Infect. Dis. 2010, 10:832.
24. Poirel L., Walsh T.R., Cuvillier V., Nordmann P. Multiplex PCR for detection of acquired carbapenemase genes. Diagn. Microbiol. Infect. Dis. 2011, 70:119-123.
25. Poirel L., Bonnin R.A., Nordmann P. Genetic features of the widespread plasmid coding for the carbapenemase OXA-48. Antimicrob. Agents Chemother. 2012, 56:559-562.
26. Queenan A.M., Bush K. Carbapenemases: the versatile beta-lactamases. Clin. Microbiol. Rev. 2007, 20:440-458.
27. Tenover F.C., Kalsi R.K., Williams P.P., Carey R.B., Stocker S., Lonsway D., Rasheed J.K., Biddle J.W., McGowan J.E., Hanna B. Carbapenem resistance in Klebsiella pneumoniae not detected by automated susceptibility testing. Emerg. Infect. Dis. 2006, 12:1209-1213.
28. Tsakris A., Kristo I., Poulou A., Markou F., Ikonomidis A., Pournaras S. First occurrence of KPC-2-possessing Klebsiella pneumoniae in a Greek hospital and recommendation for detection with boronic acid disc tests. J. Antimicrob. Chemother. 2008, 62:1257-1260.
29. Tzouvelekis L.S., Markogiannakis A., Psichogiou M., Tassios P.T., Daikos G.L. Carbapenemases in Klebsiella pneumoniae and other Enterobacteriaceae: an evolving crisis of global dimensions. Clin. Microbiol. Rev. 2012, 25:682-707.
30. van Belkum A., Tassios P.T., Dijkshoorn L., Haeggman S., Cookson B., Fry N.K., Fussing V., Green J., Feil E., Gerner-Smidt P., Brisse S., Struelens M. Guidelines for the validation and application of typing methods for use in bacterial epidemiology. Clin. Microbiol. Infect. 2007, 13(Suppl. 3):1-46. European Society of Clinical Microbiology and Infectious Diseases.
31. Woodford N., Eastaway A.T., Ford M., Leanord A., Keane C., Quayle R.M., Steer J.A., Zhang J., Livermore D.M. Comparison of BD Phoenix, Vitek 2, and MicroScan automated systems for detection and inference of mechanisms responsible for carbapenem resistance in Enterobacteriaceae. J. Clin. Microbiol. 2010, 48:2999-3002.
32. Yigit H., Queenan A.M., Anderson G.J., Domenech-Sanchez A., Biddle J.W., Steward C.D., Alberti S., Bush K., Tenover F.C. Novel carbapenem-hydrolyzing beta-lactamase, KPC-1, from a carbapenem-resistant strain of Klebsiella pneumoniae. Antimicrob. Agents Chemother. 2001, 45:1151-1161.
33. Yong D., Toleman M.A., Giske C.G., Cho H.S., Sundman K., Lee K., Walsh T.R. Characterization of a new metallo-beta-lactamase gene, bla(NDM-1), and a novel erythromycin esterase gene carried on a unique genetic structure in Klebsiella pneumoniae sequence type 14 from India. Antimicrob. Agents Chemother. 2009, 53:5046-5054.