Protective effect of metformin against walker 256 tumor growth is not dependent on metabolism improvement

Cellular Physiology and Biochemistry

Volumn 34, Issue 6, 2014, Pages 1920-1932

  Franco, Claudinéia Conationi Da Silva ^a   Miranda, Rosiane Aparecida ^a   De Oliveira, Júlio Cezar ^a   Barella, Luiz Felipe ^a   Agostinho, Aryane Rodrigues ^a   Prates, Kelly Valério ^a   Malta, Ananda ^a   Trombini, Amanda Bianchi ^a   Torrezan, Rosana ^a   Gravena, Clarice ^a   Tófolo, Laize P ^a   De Sant'anna, Juliane Rocha ^a   De Castro Prado, Marialba Avezum Alves ^a   De Souza, Camila Oliveira ^b   De Souza, Helenir Medri ^b   Beraldi, Evandro José ^a   De Freitas Mathias, Paulo Cezar ^a  

^a STATE UNIVERSITY OF MARINGÁ   (Brazil)

^b STATE UNIVERSITY OF LONDRINA   (Brazil)

Author keywords

Apoptosis; Metabolism; Metformin; Walker 256 tumor

Indexed keywords

GLUCOSE; GLUTAMATE SODIUM; INSULIN; METFORMIN; ANTIDIABETIC AGENT; GLUCOSE BLOOD LEVEL;

ADIPOSE TISSUE; ANIMAL CELL; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; AREA UNDER THE CURVE; ARTICLE; BODY HEIGHT; CACHEXIA; CANCER GRAFT; CANCER GROWTH; CANCER TRANSPLANTATION; CARCINOMA CELL; CONTROLLED STUDY; DRUG EFFECT; DRUG METABOLISM; GLUCOSE BLOOD LEVEL; GLUCOSE INTOLERANCE; HISTOLOGY; HYPERINSULINEMIA; INSULIN BLOOD LEVEL; INSULIN LIKE ACTIVITY; INSULIN RELEASE; INSULIN RESISTANCE; INSULINEMIA; LONG TERM CARE; MALE; METABOLIC SYNDROME X; NEWBORN; NICK END LABELING; NONHUMAN; PANCREAS ISLET; PRIORITY JOURNAL; RAT; TUMOR CELL INOCULATION; WALKER CARCINOMA; WEANING; ANIMAL; CARCINOMA 256, WALKER; CELL PROLIFERATION; CHEMICALLY INDUCED; DIABETES MELLITUS, EXPERIMENTAL; DRUG EFFECTS; GENETICS; METABOLISM; NEOPLASMS; PATHOLOGY;

RATTUS;

ANIMALS; BLOOD GLUCOSE; CARCINOMA 256, WALKER; CELL PROLIFERATION; DIABETES MELLITUS, EXPERIMENTAL; GLUCOSE INTOLERANCE; HYPOGLYCEMIC AGENTS; INSULIN; INSULIN RESISTANCE; ISLETS OF LANGERHANS; METFORMIN; NEOPLASMS; RATS; SODIUM GLUTAMATE;

EID: 84917691240     PISSN: 10158987     EISSN: 14219778     Source Type: Journal    
DOI: 10.1159/000366390     Document Type: Article

References (40)

1. de Campos KE, Sinzato YK, Pimenta Wde P, Rudge MV, Damasceno DC: Effect of maternal obesity on Diabetes development in adult rat offspring. Life Sci 2007;81:1473-1478
2. Megna JL, Schwartz TL, Siddiqui UA, Herrera Rojas M: Obesity in adults with serious and persistent mental illness: A review of postulated mechanisms and current interventions. Ann Clin Psychiatry 2011;23:131-140
3. Giovannucci E, Harlan DM, Archer MC, Bergenstal RM, Gapstur SM, Habel LA, Pollak M, Regensteiner JG, Yee D: Diabetes and cancer: A consensus report. Diabetes Care 2010;33:1674-1685
4. Kasper JS, Giovannucci E: A meta-Analysis of diabetes mellitus and the risk of prostate cancer. Cancer Epidemiol Biomarkers Prev 2006;15:2056-2062
5. Vigneri P, Frasca F, Sciacca L, Pandini G, Vigneri R: Diabetes and cancer. Endocr Relat Cancer 2009;16:1103-1123
6. Hother-Nielsen O, Schmitz O, Andersen PH, Beck-Nielsen H, Pedersen O: Metformin improves peripheral but not hepatic insulin action in obese patients with type ii diabetes. Acta Endocrinol (Copenh) 1989;120:257-265
7. Wollen N, Bailey CJ: Inhibition of hepatic gluconeogenesis by metformin. Synergism with insulin. Biochem Pharmacol 1988;37:4353-4358
8. Strack T: Metformin: A review. Drugs Today (Barc) 2008;44:303-314
9. Bost F, Sahra IB, Le Marchand-Brustel Y, Tanti JF: Metformin and cancer therapy. Curr Opin Oncol 2012;24:103-108
10. Tzatsos A, Kandror KV: Nutrients suppress phosphatidylinositol 3-kinase/akt signaling via raptor-dependent mtor-mediated insulin receptor substrate 1 phosphorylation. Mol Cell Biol 2006;26:63-76
11. Evans JM, Donnelly LA, Emslie-Smith AM, Alessi DR, Morris AD: Metformin and reduced risk of cancer in Diabetic patients. BMJ 2005;330:1304-1305
12. Hawley SA, Boudeau J, Reid JL, Mustard KJ, Udd L, Makela TP, Alessi DR, Hardie DG: Complexes between the lkb1 tumor suppressor, strad alpha/beta and mo25 alpha/beta are upstream kinases in the amp-Activated protein kinase cascade. J Biol 2003;2:28
13. Li D, Yeung SC, Hassan MM, Konopleva M, Abbruzzese JL: Antidiabetic therapies affect risk of pancreatic cancer. Gastroenterology 2009;137:482-488
14. Alimova IN, Liu B, Fan Z, Edgerton SM, Dillon T, Lind SE, Thor AD: Metformin inhibits breast cancer cell growth, colony formation and induces cell cycle arrest in vitro. Cell Cycle 2009;8:909-915
15. Sikka A, Kaur M, Agarwal C, Deep G, Agarwal R: Metformin suppresses growth of human head and neck squamous cell carcinoma via global inhibition of protein translation. Cell Cycle 2012;11:1374-1382
16. Andreazzi AE, Grassiolli S, Marangon PB, Martins AG, de Oliveira JC, Torrezan R, Gravena C, Garcia RM, Mathias PC: Impaired sympathoadrenal axis function contributes to enhanced insulin secretion in prediabetic obese rats. Exp Diabetes Res 2011;2011:947917
17. Quaile MP, Melich DH, Jordan HL, Nold JB, Chism JP, Polli JW, Smith GA, Rhodes MC: Toxicity and toxicokinetics of metformin in rats. Toxicol Appl Pharmacol 2010;243:340-347
18. Yuan H, Li L, Zheng W, Wan J, Ge P, Li H, Zhang L: Antidiabetic drug metformin alleviates endotoxin-induced fulminant liver injury in mice. Int Immunopharmacol 2012;12:682-688
19. Bernardis LL, Patterson BD: Correlation between 'lee index' and carcass fat content in weanling and adult female rats with hypothalamic lesions. J Endocrinol 1968;40:527-528
20. DuBois RN: Cyclooxygenase-2 and colorectal cancer. Prog ExpTumor Res 2003;37:124-137
21. Scott AM, Atwater I, Rojas E: A method for the simultaneous measurement of insulin release and b cell membrane potential in single mouse islets of langerhans. Diabetologia 1981;21:470-475
22. Lundbaek K: Intravenous glucose tolerance as a tool in Definition and diagnosis of diabetes mellitus. Br Med J 1962;1:1507-1513
23. Gravena C, Mathias PC, Ashcroft SJ: Acute effects of fatty acids on insulin secretion from rat and human islets of langerhans. J Endocrinol 2002;173:73-80
24. Black JM, Nesheim MC, Kinsella JE: Dietary level of maize oil affects growth and lipid composition of walker 256 carcinosarcoma. The British journal of nutrition 1994;71:283-294
25. Cassolla P, Moreira CC, Liboni TF, Zaia CT, Borba-Murad GR, Bazotte RB, de Souza HM: Changes in blood metabolic parameters during the development of walker-256 tumour-induced cachexia in rats are not caused by decreased food intake. Cell Biochem Funct 2012;30:265-270
26. Aita K, Irie H, Tanuma Y, Toida S, Okuma Y, Mori S, Shiga J: Apoptosis in murine lymphoid organs following intraperitoneal administration of dimethyl sulfoxide (dmso). Exp Mol Pathol 2005;79:265-271
27. Lobato NS, Filgueira FP, Hagihara GN, Akamine EH, Pariz JR, Tostes RC, Carvalho MH, Fortes ZB: Improvement of metabolic parameters and vascular function by metformin in obese non-diabetic rats. Life Sci 2012;90:228-235
28. Viollet B, Guigas B, Sanz Garcia N, Leclerc J, Foretz M, Andreelli F: Cellular and molecular mechanisms of metformin: An overview. Clinical Sci 2012;122:253-270
29. Fonseca EAI, de Oliveira MA, Lobato ND, Akamine EH, Colquhoun A, de Carvalho MHC, Zyngier SB, Fortes ZB: Metformin reduces the stimulatory effect of obesity on in vivo walker-256 tumor development and increases the area of tumor necrosis. Life Sci 2011;88:846-852
30. Graham GG, Punt J, Arora M, Day RO, Doogue MP, Duong JK, Furlong TJ, Greenfield JR, Greenup LC, Kirkpatrick CM, Ray JE, Timmins P, Williams KM: Clinical pharmacokinetics of metformin. Clin Pharmacokinet 2011;50:81-98
31. Scheen AJ: Clinical pharmacokinetics of metformin. Clinical pharmacokinetics 1996;30:359-371
32. Fernandes LC, Machado UF, Nogueira CR, Carpinelli AR, Curi R: Insulin secretion in walker 256 tumor cachexia. Am J Physiol1990;258:E1033-1036
33. el Razi Neto S, Zorn TM, Curi R, Carpinelli AR: Impairment of insulin secretion in pancreatic islets isolated from walker 256 tumor-bearing rats. Am J Physiol 1996;271:C804-809
34. Moley JF, Morrison SD, Gorschboth CM, Norton JA: Body composition changes in rats with experimental cancer cachexia: Improvement with exogenous insulin. Cancer Res 1988;48:2784-2787
35. Balbo SL, Grassiolli S, Ribeiro RA, Bonfleur ML, Gravena C, Brito Mdo N, Andreazzi AE, Mathias PC, Torrezan R: Fat storage is partially dependent on vagal activity and insulin secretion of hypothalamic obese rat. Endocrine 2007;31:142-148
36. Dowling RJ, Niraula S, Stambolic V, Goodwin PJ: Metformin in cancer: Translational challenges. J Mol Endocrinol 2012;48:R31-43
37. Goodwin PJ: Insulin in the adjuvant breast cancer setting: A novel therapeutic target for lifestyle and pharmacologic interventions?. J Clin Oncol 2008;26:833-834
38. Pearce EL, Walsh MC, Cejas PJ, Harms GM, Shen H, Wang LS, Jones RG, Choi Y: Enhancing cd8 t-cell memory by modulating fatty acid metabolism. Nature 2009;460:103-107
39. Elia EM, Quintana R, Carrere C, Bazzano MV, Rey-Valzacchi G, Paz DA, Pustovrh MC: Metformin Decreases the incidence of ovarian hyperstimulation syndrome: An experimental study. J Ovar Res 2013;6:62
40. Rattan R, Graham RP, Maguire JL, Giri S, Shridhar V: Metformin suppresses ovarian cancer growth and metastasis with enhancement of cisplatin cytotoxicity in vivo. Neoplasia 2011;13:483-491