Impairment of insulin secretion in pancreatic islets isolated from Walker 256 tumor-bearing rats

American Journal of Physiology - Cell Physiology

Volumn 271, Issue 3 40-3, 1996, Pages

  El Razi Neto, Semaan ^b   Zorn, Telma M T ^b   Curi, Rui ^b   Carpinelli, Angelo R ^a  

^a UNIVERSITY OF SÃO PAULO   (Brazil)

^b NONE

Author keywords

calcium 45 flux; fractional outflow rate; ionic fluxes; isolated islets; phosphoinositide metabolism; rubidium 86 flux

Indexed keywords

CALCIUM CHANNEL; INSULIN;

ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CALCIUM TRANSPORT; CELL STRUCTURE; CONTROLLED STUDY; HORMONE DETERMINATION; INSULIN RELEASE; ISOTOPE LABELING; MALE; NONHUMAN; PANCREAS ISLET CELL; PHOSPHOINOSITIDE METABOLISM; PRIORITY JOURNAL; RAT; WALKER CARCINOMA;

EID: 9844231985     PISSN: 03636143     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpcell.1996.271.3.c804     Document Type: Article

References (24)

1. Agueleiro, B., M. T. Lozano, M. E. Adad, and H. García. Electron microscopic immunocytochemical study of the endocrine pancreas of sea bass (Dicentarchus labrax). Cell Tissue Res. 274: 303-314, 1993.
2. Arkhammar, P., T. Nilsson, M. Welsh, N. Welsh, and P. O. Berggren. Effects of protein kinase C activation on the regulation of the stimulus-secretion coupling in pancreatic B-cells. Biochem. J. 264: 207-215, 1989.
3. Ashcroft, F. M., S. J. H. Ashcroft, and E. Harrisson. The glucose-sensitive potassium channel in rat pancreatic B-cells is inhibited by ATP (Abstract). J. Physiol. Lond. 369: 101P, 1985.
4. Ashcroft, F. M., D. E. Harrisson, and S. J. H. Ashcroft. Glucose induces closure of single potassium channels in isolated rat pancreatic B-cells. Nature Lond. 312: 446-448, 1984.
5. +-channels: a link between B-cell metabolism and insulin secretion. Biochem. Trans. 18: 109-111, 1989.
6. Boschero, A. C., S. Kawazu, G. Duncan, and W. J. Malaisse. Effects of glucose on potassium ion handling by pancreatic islets. FEBS Lett. 83: 151-154, 1977.
7. + outflow from pancreatic islets: the dual effect of nutrient secretagogues. J. Physiol. Lond. 315: 143-156, 1981.
8. El Razi, S., R. Curi, and A. R. Carpinelli. Utilization of rat and human sera to carry out incubation and perfusion of pancreatic islets. J. Pharmacol. Methods 28: 181-184, 1992.
9. Fernandes, L. C., A. R. Carpinelli, N. S. Hell, and R. Curi. Improvement of cancer cachexia and decrease of Walker 256 tumor growth by insulin administration in rats. Cancer Ther. Control 1: 259-268, 1991.
10. Fernandes, L. C., U. F. Machado, C. R. Nogueira, A. R. Carpinelli, and R. Curi. Insulin secretion in Walker 256 tumor cachexia. Am. J. Physiol. 258 (Endocrinol. Metab. 21): E1033-E1036, 1990.
11. + channels in mouse B cells. J. Clin. Invest. 91: 871-880, 1993.
12. + channels in mouse B cells. J. Clin. Invest. 89: 1288-1275, 1989.
13. Goodlad, G. A. J., A. G. H. Mitchell, L. McPhail, and C. M. Clark. Serum insulin and somatomedin levels in the tumor-bearing rats. Eur. J. Cancer 11: 733-737, 1975.
14. Guaitani, A., M. Recchia, M. Carli, M. Rocchetti, I. Bartosek, and S. Garattini. Walker carcinoma 256: a model for studies on tumor-induced anorexia and cachexia. Oncology 39: 173-178, 1982.
15. Lacy, P. E., and M. Kostianovsky. Method for the isolation of the intact islets of Langerhans from the rat pancreas. Diabetes 16: 35-39, 1967.
16. Herchuelz, A., E. Couturier, and W. J. Malaisse. Regulation of calcium fluxes in pancreatic islets. Glucose-induced calcium-calcium exchange. Am. J. Physiol. 238 (Endocrinol. Metab. 1): E96-E103, 1980.
17. Lundholm, K., G. Holm, and T. Scherten. Insulin resistance in patients with cancer. Cancer Res. 38: 4665-4670, 1978.
18. Malaisse, W. J., A. Sener, A. Herchuelz, and J. C. Hutton. Insulin release: the fuel hypothesis. Metabolism 28: 373-385, 1979.
19. Moley, J. F., S. D. Morrison, and J. A. Norton. Insulin reversal of cancer cachexia in rats. Cancer Res. 45: 4925-4931, 1985.
20. 2+, cAMP, phospholipid-derived messengers in the coupling mechanism of insulin secretion. Physiol. Rev. 67: 1185-1248, 1987.
21. Santos, A., Jr., F. G. Villela, U. F. Machado, R. Curi, and A. R. Carpinelli. Insulin secretion in the isolated islets of single, regular-fasted and fed rats. Physiol. Behav. 45: 923-927, 1989.
22. 2+ homeostasis by islet endoplasmic reticulum and its role in insulin secretion. Am. J. Physiol. 254 (Endocrinol. Metab. 17): E121-E136, 1988.
23. 2+ cAMP and diacylglycerol. Mol. Cell. Endocrinol. 70: 119-137, 1990.
24. Zawalich, W. S., and K. C. Zawalich. Phosphoinositide hydrolysis and insulin release from isolated perifused rat islets. Studies with glucose. Diabetes 37: 1294-1300, 1988.