MiR-29c mediates epithelial-to-mesenchymal transition in human colorectal carcinoma metastasis via PTP4A and GNA13 regulation of β-catenin signaling

Annals of Oncology

Volumn 25, Issue 11, 2014, Pages 2196-2204

  Zhang, J X ^a,b   Mai, S J ^a   Huang, X X ^a   Wang, F W ^a   Liao, Y J ^a   Lin, M C ^c   Kung, H F ^a,c   Zeng, Y X ^a   Xie, Dan ^a,b  

^a State Key Laboratory of Oncology   (China)

^b SUN YAT SEN UNIVERSITY CANCER CENTER   (China)

^c CHINESE UNIVERSITY OF HONG KONG   (Hong Kong)

Author keywords

Colorectal carcinoma; Epithelial to mesenchymal transition; GNA13; Metastasis; MiR 29c; PTP4A

Indexed keywords

BETA CATENIN; GLYCOGEN SYNTHASE KINASE 3BETA; GUANINE NUCLEOTIDE BINDING PROTEIN ALPHA 13; GUANINE NUCLEOTIDE BINDING PROTEIN ALPHA SUBUNIT; MESSENGER RNA; MICRORNA 29; MICRORNA 29C; MITOGEN ACTIVATED PROTEIN KINASE; NON RECEPTOR PROTEIN TYROSINE PHOSPHATASE 4; PROTEIN TYROSINE PHOSPHATASE TYPE 4A; UNCLASSIFIED DRUG; CELL CYCLE PROTEIN; GLYCOGEN SYNTHASE KINASE 3; GLYCOGEN SYNTHASE KINASE 3 BETA; MEMBRANE PROTEIN; MICRORNA; MIRN29 MICRORNA, HUMAN; PROTEIN TYROSINE PHOSPHATASE; PTP4A1 PROTEIN, HUMAN;

3' UNTRANSLATED REGION; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CANCER PROGNOSIS; CELL INVASION; CELL MIGRATION; COLORECTAL CANCER CELL LINE; COLORECTAL CARCINOMA; CONTROLLED STUDY; DISTANT METASTASIS; DOWN REGULATION; EPITHELIAL MESENCHYMAL TRANSITION; EXPERIMENTAL METASTASIS; GENE EXPRESSION; HUMAN; HUMAN TISSUE; IN VITRO STUDY; IN VIVO STUDY; LIVER METASTASIS; MOUSE; NONHUMAN; PRIORITY JOURNAL; WNT SIGNALING PATHWAY; BIOSYNTHESIS; CELL MOTION; COLORECTAL TUMOR; FEMALE; GENE EXPRESSION REGULATION; GENETICS; METASTASIS; PATHOLOGY; TUMOR CELL LINE;

BETA CATENIN; CELL CYCLE PROTEINS; CELL LINE, TUMOR; CELL MOVEMENT; COLORECTAL NEOPLASMS; EPITHELIAL-MESENCHYMAL TRANSITION; FEMALE; GENE EXPRESSION REGULATION, NEOPLASTIC; GLYCOGEN SYNTHASE KINASE 3; HUMANS; MEMBRANE PROTEINS; MICRORNAS; NEOPLASM METASTASIS; PROTEIN TYROSINE PHOSPHATASES; WNT SIGNALING PATHWAY;

EID: 84917687070     PISSN: 09237534     EISSN: 15698041     Source Type: Journal    
DOI: 10.1093/annonc/mdu439     Document Type: Article

References (27)

1. Jemal A, Bray F, Center MM et al. Global cancer statistics. CA Cancer J Clin 2011; 61: 69-90.
2. Thiery JP. Epithelial-mesenchymal transitions in tumour progression. Nat Rev Cancer 2002; 2: 442-454.
3. Spaderna S, Schmalhofer O, Hlubek F et al. A transient, EMT-linked loss of basement membranes indicates metastasis and poor survival in colorectal cancer. Gastroenterology 2006; 131: 830-840.
4. Brabletz T, Jung A, Reu S et al. Variable beta-catenin expression in colorectal cancers indicates tumor progression driven by the tumor environment. Proc Natl Acad Sci USA 2001; 98: 10356-10361.
5. Polyak K, Weinberg RA. Transitions between epithelial and mesenchymal states: acquisition of malignant and stem cell traits. Nat Rev Cancer 2009; 9: 265-273.
6. Brabletz T, Jung A, Spaderna S et al. Opinion: migrating cancer stem cells-an integrated concept of malignant tumour progression. Nat Rev Cancer 2005; 5: 744-749.
7. Iorio MV, Croce CM. MicroRNA dysregulation in cancer: diagnostics, monitoring and therapeutics. A comprehensive review. EMBO Mol Med 2012; 4: 143-159.
8. Zheng F, Liao YJ, Cai MY et al. The putative tumour suppressor microRNA-124 modulates hepatocellular carcinoma cell aggressiveness by repressing ROCK2 and EZH2. Gut 2012; 61: 278-289.
9. Yan Y, Luo YC, Wan HY et al. MicroRNA-10a is involved in the metastatic process by regulating Eph tyrosine kinase receptor A4-mediated epithelial-mesenchymal transition and adhesion in hepatoma cells. Hepatology 2013; 57: 667-677.
10. Cai J, Guan H, Fang L et al. MicroRNA-374a activates Wnt/beta-catenin signaling to promote breast cancer metastasis. J Clin Invest 2013; 123: 566-579.
11. Meng X, Wu J, Pan C et al. Genetic and epigenetic down-regulation of microRNA-212 promotes colorectal tumor metastasis via dysregulation of MnSOD. Gastroenterology 2013; 145: 426-436.e1-6.
12. Hur K, Toiyama Y, Takahashi M et al. MicroRNA-200c modulates epithelial-tomesenchymal transition (EMT) in human colorectal cancer metastasis. Gut 2013; 62: 1315-1326.
13. Bae HJ, Noh JH, Kim JK et al. MicroRNA-29c functions as a tumor suppressor by direct targeting oncogenic SIRT1 in hepatocellular carcinoma. Oncogene 2013; 33: 2557-2567.
14. Zhang JX, Qian D, Wang FW et al. MicroRNA-29c enhances the sensitivities of human nasopharyngeal carcinoma to cisplatin-based chemotherapy and radiotherapy. Cancer Lett 2013; 329: 91-98.
15. Yang IP, Tsai HL, Huang CW et al. The functional significance of microRNA-29c in patients with colorectal cancer: a potential circulating biomarker for predicting early relapse. PLoS One 2013; 8: e66842.
16. Jope RS, Johnson GV. The glamour and gloom of glycogen synthase kinase-3. Trends Biochem Sci 2004; 29: 95-102.
17. Cohen P, Frame S. The renaissance of GSK3. Nat Rev Mol Cell Biol 2001; 2: 769-776.
18. Achiwa H, Lazo JS. PRL-1 tyrosine phosphatase regulates c-Src levels, adherence, and invasion in human lung cancer cells. Cancer Res 2007; 67: 643-650.
19. Luo Y, Liang F, Zhang ZY. PRL1 promotes cell migration and invasion by increasing MMP2 and MMP9 expression through Src and ERK1/2 pathways. Biochemistry 2009; 48: 1838-1846.
20. Avizienyte E, Frame MC. Src and FAK signalling controls adhesion fate and the epithelial-to-mesenchymal transition. Curr Opin Cell Biol 2005; 17: 542-547.
21. Kelly P, Moeller BJ, Juneja J et al. The G12 family of heterotrimeric G proteins promotes breast cancer invasion and metastasis. Proc Natl Acad Sci USA 2006; 103: 8173-8178.
22. Kelly P, Stemmle LN, Madden JF et al. A role for the G12 family of heterotrimeric G proteins in prostate cancer invasion. J Biol Chem 2006; 281: 26483-26490.
23. Meigs TE, Fedor-Chaiken M, Kaplan DD et al. Galpha12 and Galpha13 negatively regulate the adhesive functions of cadherin. J Biol Chem 2002; 277: 24594-24600.
24. Orsulic S, Huber O, Aberle H et al. E-cadherin binding prevents beta-catenin nuclear localization and beta-catenin/LEF-1-mediated transactivation. J Cell Sci 1999; 112 (Pt 8): 1237-1245.
25. Kalluri R, Weinberg RA. The basics of epithelial-mesenchymal transition. J Clin Invest 2009; 119: 1420-1428.
26. Chen J, Chan AW, To KF et al. SIRT2 overexpression in hepatocellular carcinoma mediates epithelial to mesenchymal transition by protein kinase B/glycogen synthase kinase-3beta/beta-catenin signaling. Hepatology 2013; 57: 2287-2298.
27. Ha GH, Park JS, Breuer EK. TACC3 promotes epithelial-mesenchymal transition (EMT) through the activation of PI3K/Akt and ERK signaling pathways. Cancer Lett 2013; 332: 63-73.