MicroRNA-29c functions as a tumor suppressor by direct targeting oncogenic SIRT1 in hepatocellular carcinoma

Oncogene

Volumn 33, Issue 20, 2014, Pages 2557-2567

  Bae, H J ^a   Noh, J H ^a   Kim, J K ^a   Eun, J W ^a   Jung, K H ^a   Kim, M G ^a   Chang, Y G ^a   Shen, Q ^a   Kim, S J ^a   Park, W S ^a   Lee, J Y ^a   Nam, S W ^a  

^a The Catholic University of Korea   (South Korea)

Author keywords

cell cycle; hepatocellular carcinoma; miR 29c; SIRT1; tumor suppressor

Indexed keywords

CYCLIN A; CYCLIN D1; CYCLIN D3; CYCLIN DEPENDENT KINASE 2; CYCLIN DEPENDENT KINASE 6; MICRORNA 29; MICRORNA 29C; MYC PROTEIN; SIRTUIN 1; TRANSCRIPTION FACTOR DP1; TRANSCRIPTION FACTOR E2F; TRANSCRIPTION FACTOR E2F1; UNCLASSIFIED DRUG;

3' UNTRANSLATED REGION; ARTICLE; CANCER GROWTH; CANCER PROGNOSIS; CANCER TISSUE; CARCINOMA CELL; CELL CYCLE ARREST; CELL GROWTH; CELL PROLIFERATION; CONTROLLED STUDY; DOWN REGULATION; G1 PHASE CELL CYCLE CHECKPOINT; G2 PHASE CELL CYCLE CHECKPOINT; GENE EXPRESSION PROFILING; GENE FUNCTION; GENE SILENCING; GENETIC ANALYSIS; GENETIC TRANSCRIPTION; HUMAN; HUMAN CELL; HUMAN TISSUE; LIVER CARCINOGENESIS; LIVER CELL CARCINOMA; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN TARGETING; TUMOR SUPPRESSOR GENE; UPREGULATION;

MAMMALIA;

CARCINOMA, HEPATOCELLULAR; CELL DIVISION; CELL LINE, TUMOR; GENES, TUMOR SUPPRESSOR; HUMANS; LIVER NEOPLASMS; MICRORNAS; ONCOGENES; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SIRTUIN 1;

EID: 84901193349     PISSN: 09509232     EISSN: 14765594     Source Type: Journal    
DOI: 10.1038/onc.2013.216     Document Type: Article

References (25)

1. Jemal A, Bray F, Center MM, Ferlay J, Ward E, Forman D. Global cancer statistics. CA Cancer J Clin 2011; 61: 69-90
2. Whittaker S, Marais R, Zhu AX. The role of signaling pathways in the development and treatment of hepatocellular carcinoma. Oncogene 2010; 29: 4989-5005
3. Fabbri M, Garzon R, Cimmino A, Liu Z, Zanesi N, Callegari E et al. MicroRNA-29 family reverts aberrant methylation in lung cancer by targeting DNA methyltransferases 3A and 3B. Proc Natl Acad Sci USA 2007; 104: 15805-15810. (Pubitemid 350035380
4. Blander G, Guarente L. The Sir2 family of protein Deacetylases. Annu Rev Biochem 2004; 73: 417-435. (Pubitemid 39050375
5. Huffman DM, Grizzle WE, Bamman MM, Kim JS, Eltoum IA, Elgavish A et al. SIRT1 is significantly elevated in mouse and human prostate cancer. Cancer Res 2007; 67: 6612-6618. (Pubitemid 47105506
6. Jang KY, Kim KS, Hwang SH, Kwon KS, Kim KR, Park HS et al. Expression and prognostic significance of SIRT1 in ovarian epithelial tumours. Pathology 2009; 41: 366-371
7. Cha EJ, Noh SJ, Kwon KS, Kim CY, Park BH, Park HS et al. Expression of DBC1 and SIRT1 is associated with poor prognosis of gastric carcinoma. Clin Cancer Res 2009; 15: 4453-4459
8. Stunkel W, Peh BK, Tan YC, Nayagam VM, Wang X, Salto-Tellez M et al. Function of the SIRT1 protein Deacetylase in cancer. Biotechnol J 2007; 2: 1360-1368. (Pubitemid 350176266
9. Chen J, Zhang B, Wong N, Lo AW, To KF, Chan AW et al. Sirtuin 1 is upregulated in a subset of hepatocellular carcinomas where it is essential for telomere maintenance and tumor cell growth. Cancer Res 2011; 71: 4138-4149
10. Bartel DP. MicroRNAs: Genomics, biogenesis, mechanism, and function. Cell 2004; 116: 281-297
11. Meng F, Henson R, Wehbe-Janek H, Ghoshal K, Jacob ST, Patel T. MicroRNA-21 regulates expression of the PTEN tumor suppressor gene in human hepatocellular cancer. Gastroenterology 2007; 133: 647-658. (Pubitemid 47187346
12. Xiong Y, Fang JH, Yun JP, Yang J, Zhang Y, Jia WH et al. Effects of microRNA-29 on apoptosis, tumorigenicity, and prognosis of hepatocellular carcinoma. Hepatology 2010; 51: 836-845
13. Pineau P, Volinia S, McJunkin K, Marchio A, Battiston C, Terris B et al. miR-221 overexpression contributes to liver tumorigenesis. Proc Natl Acad Sci USA 2010; 107: 264-269
14. Ota H, Tokunaga E, Chang K, Hikasa M, Iijima K, Eto M et al. Sirt1 inhibitor, Sirtinol, induces senescence-like growth arrest with attenuated Ras-MAPK signaling in human cancer cells. Oncogene 2006; 25: 176-185. (Pubitemid 43083679
15. Firestein R, Blander G, Michan S, Oberdoerffer P, Ogino S, Campbell J et al. The SIRT1 deacetylase suppresses intestinal tumorigenesis and colon cancer growth. PLoS One 2008; 3: E2020
16. Wang RH, Sengupta K, Li C, Kim HS, Cao L, Xiao C et al. Impaired DNA damage response, genome instability, and tumorigenesis in SIRT1 mutant mice. Cancer Cell 2008; 14: 312-323
17. Kabra N, Li Z, Chen L, Li B, Zhang X, Wang C et al. SirT1 is an inhibitor of proliferation and tumor formation in colon cancer. J Biol Chem 2009; 284: 18210-18217
18. Noh JH, Jung KH, Kim JK, Eun JW, Bae HJ, Xie HJ et al. Aberrant regulation of HDAC2 mediates proliferation of hepatocellular carcinoma cells by deregulating expression of G1/S cell cycle proteins. PLoS One 6: E28103
19. Xie HJ, Noh JH, Kim JK, Jung KH, Eun JW, Bae HJ et al. HDAC1 inactivation induces mitotic defect and caspase-independent autophagic cell death in liver cancer. PLoS One 7: E34265
20. Saunders LR, Sharma AD, Tawney J, Nakagawa M, Okita K, Yamanaka S et al. miRNAs regulate SIRT1 expression During mouse embryonic stem cell differentiation and in adult mouse tissues. Aging (Albany NY) 2010; 2: 415-431
21. Cao Q, Mani RS, Ateeq B, Dhanasekaran SM, Asangani IA, Prensner JR et al. Coordinated regulation of polycomb group complexes through microRNAs in cancer. Cancer Cell 2011; 20: 187-199
22. Kriegel AJ, Liu Y, Fang Y, Ding X, Liang M. The miR-29 family: Genomics, cell biology, and relevance to renal and cardiovascular injury. Physiol Genomics 2012; 44: 237-244
23. Jung KH, Noh JH, Kim JK, Eun JW, Bae HJ, Chang YG et al. Histone deacetylase 6 functions as a tumor suppressor by activating c-Jun NH2-Terminal kinase-mediated beclin 1-dependent autophagic cell death in liver cancer. Hepatology 2012; 56: 644-657
24. Kim JK, Noh JH, Jung KH, Eun JW, Bae HJ, Kim MG et al. Sirtuin7 oncogenic potential in human hepatocellular carcinoma and its regulation by the tumor suppressors MiR-125a-5p and MiR-125b. Hepatology 2013; 57: 1055-1067
25. Niyazi M, Niyazi I, Belka C. Counting colonies of clonogenic assays by using densitometric software. Radiat Oncol 2007; 2: 4