L-citrulline improves splanchnic perfusion and reduces gut injury during exercise

Medicine and Science in Sports and Exercise

Volumn 46, Issue 11, 2014, Pages 2039-2046

  Van Wijck, Kim ^a,b   Wijnands, Karolina A P ^b   Meesters, Dennis M ^b   Boonen, Bas ^b   Van Loon, Luc J C ^a,b   Buurman, Wim A ^b   Dejong, Cornelis H C ^a,b   Lenaerts, Kaatje ^a,b   Poeze, Martijn ^b  

^a TOP INSTITUTE FOOD AND NUTRITION   (Netherlands)

^b MAASTRICHT UNIVERSITY MEDICAL CENTER   (Netherlands)

Author keywords

Cycling; Gastrointestinal damage; Human; L citrulline; Microcirculation

Indexed keywords

ARGININE; CITRULLINE; FATTY ACID BINDING PROTEIN;

ADULT; BLOOD; CONTROLLED STUDY; CROSSOVER PROCEDURE; CYCLING; DIET SUPPLEMENTATION; DOUBLE BLIND PROCEDURE; EXERCISE; HUMAN; INTESTINE CELL; MALE; MICROCIRCULATION; ORAL DRUG ADMINISTRATION; PATHOLOGY; PHYSIOLOGY; RANDOMIZED CONTROLLED TRIAL; SMALL INTESTINE; SPLANCHNIC BLOOD FLOW; VASCULARIZATION; YOUNG ADULT;

ADMINISTRATION, ORAL; ADULT; ARGININE; BICYCLING; CITRULLINE; CROSS-OVER STUDIES; DIETARY SUPPLEMENTS; DOUBLE-BLIND METHOD; ENTEROCYTES; EXERCISE; FATTY ACID-BINDING PROTEINS; HUMANS; INTESTINE, SMALL; MALE; MICROCIRCULATION; SPLANCHNIC CIRCULATION; YOUNG ADULT;

EID: 84916942671     PISSN: 01959131     EISSN: 15300315     Source Type: Journal    
DOI: 10.1249/MSS.0000000000000332     Document Type: Article

References (39)

1. Batista MA, Nicoli JR, Martins Fdos S, et al. Pretreatment with citrulline improves gut barrier after intestinal obstruction in mice. JPEN J Parenter Enteral Nutr. 2012;36(1):69-76.
2. Bjarnason I, MacPherson A, Hollander D. Intestinal permeability: an overview. Gastroenterology. 1995;108(5):1566-81.
3. Bode-Boger SM, Boger RH, Galland A, Tsikas D, Frolich JC. L-arginine-induced vasodilation in healthy humans: pharmacokinetic- pharmacodynamic relationship. Br J Clin Pharmacol. 1998;46(5): 489-97.
4. Boerma EC, Mathura KR, van der Voort PH, Spronk PE, Ince C. Quantifying bedside-derived imaging of microcirculatory abnormalities in septic patients: a prospective validation study. Crit Care. 2005;9(6):R601-6.
5. Chou CC, Coatney RW. Nutrient-induced changes in intestinal blood flow in the dog. Br Vet J. 1994;150(5):423-37.
6. Curis E, Crenn P, Cynober L. Citrulline and the gut. Curr Opin Clin Nutr Metab Care. 2007;10(5):620-6.
7. Cynober L, Moinard C, De Bandt JP. The 2009 ESPEN Sir David Cuthbertson. Citrulline: a new major signaling molecule or just another player in the pharmaconutrition game? Clin Nutr. 2010;29(5): 545-51.
8. De Backer D, Hollenberg S, Boerma C, et al. How to evaluate the microcirculation: report of a round table conference. Crit Care. 2007;11(5):R101.
9. El-Hattab AW, Emrick LT, Craigen WJ, Scaglia F. Citrulline and arginine utility in treating nitric oxide deficiency in mitochondrial disorders. Mol Genet Metab. 2012;107(3):247-52.
10. Gazoni LM, Tribble CG, Zhao MQ, et al. Pulmonary macrophage inhibition and inhaled nitric oxide attenuate lung ischemiareperfusion injury. Ann Thorac Surg. 2007;84(1):247-53.
11. Gentilcore D, Nair NS, Vanis L, et al. Comparative effects of oral and intraduodenal glucose on blood pressure, heart rate, and splanchnic blood flow in healthy older subjects. Am J Physiol Regul Integr Comp Physiol. 2009;297(3):R716-22.
12. Germann P, Braschi A, Della Rocca G, et al. Inhaled nitric oxide therapy in adults: European expert recommendations. Intensive Care Med. 2005;31(8):1029-41.
13. Goodwin BL, Solomonson LP, Eichler DC. Argininosuccinate synthase expression is required to maintain nitric oxide production and cell viability in aortic endothelial cells. J Biol Chem. 2004;279(18): 18353-60.
14. Gou L, Zhang L, Yin C, et al. Protective effect of L-citrulline against acute gastric mucosal lesions induced by ischemiareperfusion in rats. Can J Physiol Pharmacol. 2011;89(5):317-27.
15. Grimble GK. Adverse gastrointestinal effects of arginine and related amino acids. J Nutr. 2007;137(6 Suppl 2):1693S-701.
16. Groner W, Winkelman JW, Harris AG, et al. Orthogonal polarization spectral imaging: a new method for study of the microcirculation. Nat Med. 1999;5(10):1209-12.
17. Knowles TP, Mullin RA, Hunter JA, Douce FH. Effects of syringe material, sample storage time, and temperature on blood gases and oxygen saturation in arterialized human blood samples. Respir Care. 2006;51(7):732-6.
18. Kolkman JJ, Groeneveld AB, Meuwissen SG. Effect of ranitidine on basal and bicarbonate enhanced intragastric PCO2: a tonometric study. Gut. 1994;35(6):737-41.
19. Kuipers H, Verstappen FT, Keizer HA, Geurten P, van Kranenburg G. Variability of aerobic performance in the laboratory and its physiologic correlates. Int J Sports Med. 1985;6(4):197-201.
20. Luiking YC, Engelen MP, Deutz NE. Regulation of nitric oxide production in health and disease. Curr Opin Clin Nutr Metab Care. 2010;13(1):97-104.
21. Martin MJ, Jimenez MD, Motilva V. New issues about nitric oxide and its effects on the gastrointestinal tract. Curr Pharm Des. 2001;7(10):881-908.
22. Moinard C, Nicolis I, Neveux N, Darquy S, Benazeth S, Cynober L. Dose-ranging effects of citrulline administration on plasma amino acids and hormonal patterns in healthy subjects: the Citrudose pharmacokinetic study. Br J Nutr. 2008;99(4):855-62.
23. Morris SM Jr. Enzymes of arginine metabolism. J Nutr. 2004; 134(10 Suppl):2743S-7; discussion 65S-7.
24. Peters HP, Bos M, Seebregts L, et al. Gastrointestinal symptoms in long-distance runners, cyclists, and triathletes: prevalence, medication, and etiology. Am J Gastroenterol. 1999;94(6):1570-81.
25. Poeze M, Bruins MJ, Kessels F, Luiking YC, Lamers WH, Deutz NE. Effects of L-arginine pretreatment on nitric oxide metabolism and hepatosplanchnic perfusion during porcine endotoxemia. Am J Clin Nutr. 2011;93(6):1237-47.
26. Puiman PJ, Stoll B, van Goudoever JB, Burrin DG. Enteral arginine does not increase superior mesenteric arterial blood flow but induces mucosal growth in neonatal pigs. J Nutr. 2011;141(1):63-70.
27. Qamar MI, Read AE. Effects of exercise on mesenteric blood flow in man. Gut. 1987;28(5):583-7.
28. Romero MJ, Platt DH, Caldwell RB, Caldwell RW. Therapeutic use of citrulline in cardiovascular disease. Cardiovasc Drug Rev. 2006;24(3-4):275-90.
29. Spronk PE, Ince C, Gardien MJ, Mathura KR, Oudemans-van Straaten HM, Zandstra DF. Nitroglycerin in septic shock after intravascular volume resuscitation. Lancet. 2002;360(9343):1395-6.
30. van de Poll MC, Siroen MP, van Leeuwen PA, et al. Interorgan amino acid exchange in humans: consequences for arginine and citrulline metabolism. Am J Clin Nutr. 2007;85(1):167-72.
31. van Eijk HM, Rooyakkers DR, Deutz NE. Rapid routine determination of amino acids in plasma by high-performance liquid chromatography with a 2-3 microns Spherisorb ODS II column. J Chromatogr. 1993;620(1):143-8.
32. van Wijck K, Lenaerts K, Grootjans J, et al. Physiology and pathophysiology of splanchnic hypoperfusion and intestinal injury during exercise: strategies for evaluation and prevention. Am J Physiol Gastrointest Liver Physiol. 2012;303(2):G155-68.
33. van Wijck K, Lenaerts K, van Loon LJ, Peters WH, Buurman WA, Dejong CH. Exercise-induced splanchnic hypoperfusion results in gut dysfunction in healthy men. PLoS One. 2011; 6(7):e22366.
34. van Wijck K, Pennings B, van Bijnen AA, et al. Dietary protein digestion and absorption are impaired during acute postexercise recovery in young men. Am J Physiol Regul Integr Comp Physiol. 2013;304(5):R356-61.
35. van Wijck K, van Eijk HM, Buurman WA, Dejong CH, Lenaerts K. Novel analytical approach to a multi-sugar whole gut permeability assay. J Chromatogr B Analyt Technol Biomed Life Sci. 2011;879(26):2794-801.
36. van Wijck K, Verlinden TJ, van Eijk HM, et al. Novel multisugar assay for site-specific gastrointestinal permeability analysis: a randomized controlled crossover trial. Clin Nutr. 2013; 32(2):245-51.
37. Verdant CL, De Backer D, Bruhn A, et al. Evaluation of sublingual and gut mucosal microcirculation in sepsis: a quantitative analysis. Crit Care Med. 2009;37(11):2875-81.
38. Wijnands KA, Vink H, Briede JJ, et al. Citrulline a more suitable substrate than arginine to restore NO production and the microcirculation during endotoxemia. PLoS One. 2012; 7(5):e37439.
39. Wu G, Meininger CJ. Regulation of L-arginine synthesis from L-citrulline by L-glutamine in endothelial cells. Am J Physiol. 1993;265(6 Pt 2): H1965-71.