Stabilities of neutral and basic esters of bendamustine in plasma compared to the parent compound: Kinetic investigations by HPLC

Journal of Pharmaceutical and Biomedical Analysis

Volumn 104, Issue , 2015, Pages 137-143

  Huber, S ^a   Antoni, F ^a   Schickaneder, C ^b   Schickaneder, H ^c   Bernhardt, G ^a   Buschauer, A ^a  

^a UNIVERSITY OF REGENSBURG   (Germany)

^b NONE   (Germany)

^c NONE   (Germany)

Author keywords

Bendamustine ester; Butyrylcholinesterase; Ester cleavage; Hydrolysis; Nitrogen mustard

Indexed keywords

ALBUMIN; BENDAMUSTINE; BUFFER; CHLORMETHINE; CHOLINESTERASE; ESTER; ESTERASE; PHYSOSTIGMINE; CHLORMETHINE DERIVATIVE;

ARTICLE; DRUG BLOOD LEVEL; DRUG DECOMPOSITION; DRUG DEGRADATION; DRUG HALF LIFE; DRUG STABILITY; ENZYME ACTIVITY; FLUORESCENCE ANALYSIS; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HYDROLYSIS; IN VITRO STUDY; NONHUMAN; PROTEIN CONTENT; SIGNAL NOISE RATIO; ANIMAL; BLOOD; COMPARATIVE STUDY; MOUSE; NUDE MOUSE; PHARMACOKINETICS; PROCEDURES;

ANIMALS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; ESTERS; HUMANS; MICE; MICE, NUDE; NITROGEN MUSTARD COMPOUNDS; PHARMACOKINETICS;

EID: 84916898867     PISSN: 07317085     EISSN: 1873264X     Source Type: Journal    
DOI: 10.1016/j.jpba.2014.11.038     Document Type: Article

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