Simultaneous determination of bendamustine and its active metabolite, gamma-hydroxy-bendamustine in human plasma and urine using HPLC-fluorescence detector: Application to a pharmacokinetic study in Chinese cancer patients

Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences

Volumn 960, Issue , 2014, Pages 98-104

  Xie, Feifan ^a   Cheng, Zeneng ^a   Cheng, Hang ^b   Yu, Peng ^a  

^a CENTRAL SOUTH UNIVERSITY   (China)

^b Hunan Tiger Xiangya R and D Company Ltd   (China)

Author keywords

Bendamustine; Gamma hydroxy bendamustine; HPLC fluorescence detector; Human plasma; Pharmacokinetics

Indexed keywords

DISEASES; FLUORESCENCE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; METABOLITES; PHARMACOKINETICS; PLASMA (HUMAN);

BENDAMUSTINE; CHRONIC LYMPHOCYTIC LEUKEMIAS; GAMMA-HYDROXY-BENDAMUSTINE; HPLC-FLUORESCENCE DETECTORS; HUMAN PLASMAS; PHARMACOKINETIC STUDIES; REVERSED PHASE HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; SIMULTANEOUS DETERMINATIONS;

BODY FLUIDS;

BENDAMUSTINE; GAMMA HYDROXY BENDAMUSTINE; METHANOL; PERCHLORIC ACID; UNCLASSIFIED DRUG; ALKYLATING AGENT; CHLORMETHINE DERIVATIVE;

ACCURACY; ADULT; AREA UNDER THE CURVE; ARTICLE; B CELL LYMPHOMA; CALIBRATION; CANCER PATIENT; CHINESE; CHRONIC LYMPHATIC LEUKEMIA; CLINICAL ARTICLE; DRUG DETERMINATION; DRUG HALF LIFE; FEMALE; FLUORESCENCE; HUMAN; MALE; MAXIMUM PLASMA CONCENTRATION; PLASMA; PRECIPITATION; PRIORITY JOURNAL; REVERSED PHASE HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; SINGLE DRUG DOSE; TIME TO MAXIMUM PLASMA CONCENTRATION; URINE; VALIDATION PROCESS; AGED; BLOOD; CHINA; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; LEUKEMIA, LYMPHOCYTIC, CHRONIC, B-CELL; LYMPHOMA, B-CELL; MIDDLE AGED; PROCEDURES; REPRODUCIBILITY; SENSITIVITY AND SPECIFICITY; STATISTICAL MODEL;

AGED; ANTINEOPLASTIC AGENTS, ALKYLATING; CHINA; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; FEMALE; HUMANS; LEUKEMIA, LYMPHOCYTIC, CHRONIC, B-CELL; LINEAR MODELS; LYMPHOMA, B-CELL; MALE; MIDDLE AGED; NITROGEN MUSTARD COMPOUNDS; REPRODUCIBILITY OF RESULTS; SENSITIVITY AND SPECIFICITY;

EID: 84899871449     PISSN: 15700232     EISSN: 1873376X     Source Type: Journal    
DOI: 10.1016/j.jchromb.2014.04.027     Document Type: Article

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