Cytokine expression provides clues to the pathophysiology of Gulf War illness and myalgic encephalomyelitis

Cytokine

Volumn 72, Issue 1, 2015, Pages 1-8

  Khaiboullina, Svetlana F ^a,b   DeMeirleir, Kenny L ^b   Rawat, Shanti ^b   Berk, Grady S ^b   Gaynor Berk, Rory S ^c   Mijatovic, Tatjana ^d   Blatt, Natalia ^b,e   Rizvanov, Albert A ^b,e   Young, Sheila G ^c   Lombardi, Vincent C ^a,b,c  

^a UNIVERSITY OF NEVADA SCHOOL OF MEDICINE   (United States)

^b WPI   (United States)

^c VA Sierra Nevada Health Care System   (United States)

^d R E D LABORATORIES   (Belgium)

^e KAZAN FEDERAL UNIVERSITY   (Russian Federation)

Author keywords

Cytokines; Gulf war illness; Myalgic encephalomyelitis; Random forest: interleukin 7

Indexed keywords

CYTOKINE; INTERLEUKIN 13; INTERLEUKIN 17F; INTERLEUKIN 4; INTERLEUKIN 7; TUMOR NECROSIS FACTOR ALPHA; BIOLOGICAL MARKER; INTERLEUKIN 17; TUMOR NECROSIS FACTOR;

ADULT; AGED; ARTICLE; CHRONIC FATIGUE SYNDROME; CONTROLLED STUDY; FEMALE; HUMAN; MAJOR CLINICAL STUDY; MALE; PATHOPHYSIOLOGY; PERSIAN GULF SYNDROME; RANDOM FOREST; SENSITIVITY AND SPECIFICITY; ALGORITHM; BLOOD; IMMUNOLOGY; MIDDLE AGED; VERY ELDERLY; YOUNG ADULT;

ADULT; AGED; AGED, 80 AND OVER; ALGORITHMS; BIOMARKERS; CYTOKINES; FATIGUE SYNDROME, CHRONIC; FEMALE; HUMANS; INTERLEUKIN-13; INTERLEUKIN-17; INTERLEUKIN-4; INTERLEUKIN-7; MALE; MIDDLE AGED; PERSIAN GULF SYNDROME; TUMOR NECROSIS FACTOR-ALPHA; YOUNG ADULT;

EID: 84916896595     PISSN: 10434666     EISSN: 10960023     Source Type: Journal    
DOI: 10.1016/j.cyto.2014.11.019     Document Type: Article

References (48)

1. Carruthers B.M., van de Sande M.I., De Meirleir K.L., Klimas N.G., Broderick G., Mitchell T., et al. Myalgic encephalomyelitis: international consensus criteria. J Intern Med 2011, 270:327-338.
2. Nicolson G.L., Nicolson N.L. Gulf War illnesses: complex medical, scientific and political paradox. Med, Conflict, Survival 1998, 14:156-165.
3. De Meirleir K, Khaiboullina S, Fremont M, Hulstaert J, Rizvanov A, Palotas A, et al. Plasmacytoid dendritic cells in the duodenum of individuals diagnosed with myalgic encephalomyelitis are uniquely immunoreactive to antibodies to human endogenous retroviral proteins in vivo; 2013. p. 27.
4. Buchwald D., Umali J., Pearlman T., Kith P., Ashley R., Wener M. Postinfectious chronic fatigue: a distinct syndrome?. Clin Infect Dis: Off Publ Infect Dis Soc Am 1996, 23:385-387.
5. Iversen A., Chalder T., Wessely S. Gulf War illness: lessons from medically unexplained symptoms. Clin Psy Rev 2007, 27:842-854.
6. Fukuda K., Nisenbaum R., Stewart G., Thompson W.W., Robin L., Washko R.M., et al. Chronic multisymptom illness affecting Air Force veterans of the Gulf War. JAMA, J Am Med Assoc 1998, 280:981-988.
7. Gupta S., Vayuvegula B. A comprehensive immunological analysis in chronic fatigue syndrome. Scand J Immunol 1991, 33:319-327.
8. Whiteside T.L., Friberg D. Natural killer cells and natural killer cell activity in chronic fatigue syndrome. Am J Med 1998, 105:27S-34S.
9. Broderick G., Fuite J., Kreitz A., Vernon S.D., Klimas N., Fletcher M.A. A formal analysis of cytokine networks in chronic fatigue syndrome. Brain Behav Immun 2010, 24:1209-1217.
10. Tomoda A., Joudoi T., Rabab el M., Matsumoto T., Park T.H., Miike T. Cytokine production and modulation: comparison of patients with chronic fatigue syndrome and normal controls. Psychiatry Res 2005, 134:101-104.
11. Patarca-Montero R., Antoni M., Fletcher M.A., Klimas N.G. Cytokine and other immunologic markers in chronic fatigue syndrome and their relation to neuropsychological factors. Appl Neuropsy 2001, 8:51-64.
12. Chao C.C., Janoff E.N., Hu S.X., Thomas K., Gallagher M., Tsang M., et al. Altered cytokine release in peripheral blood mononuclear cell cultures from patients with the chronic fatigue syndrome. Cytokine 1991, 3:292-298.
13. Natelson B.H., Weaver S.A., Tseng C.L., Ottenweller J.E. Spinal fluid abnormalities in patients with chronic fatigue syndrome. Clin Diagn Lab Immunol 2005, 12:52-55.
14. Zhang Q., Zhou X.D., Denny T., Ottenweller J.E., Lange G., LaManca J.J., et al. Changes in immune parameters seen in Gulf War veterans but not in civilians with chronic fatigue syndrome. Clin Diagn Lab Immunol 1999, 6:6-13.
15. Maes M., Twisk F.N., Johnson C. Myalgic Encephalomyelitis (ME), Chronic Fatigue Syndrome (CFS), and Chronic Fatigue (CF) are distinguished accurately: results of supervised learning techniques applied on clinical and inflammatory data. Psychiatry Res 2012, 200:754-760.
16. Maes M., Twisk F.N., Kubera M., Ringel K. Evidence for inflammation and activation of cell-mediated immunity in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS): increased interleukin-1, tumor necrosis factor-alpha, PMN-elastase, lysozyme and neopterin. J Affect Disord 2012, 136:933-939.
17. Fletcher M.A., Zeng X.R., Barnes Z., Levis S., Klimas N.G. Plasma cytokines in women with chronic fatigue syndrome. J Trans Med 2009, 7:96.
18. Smylie A.L., Broderick G., Fernandes H., Razdan S., Barnes Z., Collado F., et al. A comparison of sex-specific immune signatures in Gulf War illness and chronic fatigue syndrome. BMC Immunol 2013, 14:29.
19. Skowera A., Cleare A., Blair D., Bevis L., Wessely S.C., Peakman M. High levels of type 2 cytokine-producing cells in chronic fatigue syndrome. Clin Exp Immunol 2004, 135:294-302.
20. Skowera A., Hotopf M., Sawicka E., Varela-Calvino R., Unwin C., Nikolaou V., et al. Cellular immune activation in Gulf War veterans. J Clin Immunol 2004, 24:66-73.
21. Carruthers B., Jain A.K., De Meirleir K., Peterson D., Klimas N., Lerner A., et al. Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: clinical working case definition, diagnostic and treatment protocols. J Chron Fatigue Synd 2003, 11:1-12.
22. Fukuda K., Straus S.E., Hickie I., Sharpe M.C., Dobbins J.G., Komaroff A. The chronic fatigue syndrome: a comprehensive approach to its definition and study. International chronic fatigue syndrome study group. Ann Intern Med 1994, 121:953-959.
23. Centers for Disease C, Prevention. Unexplained illness among Persian Gulf War veterans in an Air National Guard Unit: preliminary report - August 1990-March 1995. MMWR Morbidity and mortality weekly report. 1995; 44: 443-7.
24. Steele L. Prevalence and patterns of Gulf War illness in Kansas veterans: association of symptoms with characteristics of person, place, and time of military service. Am J Epidemiol 2000, 152:992-1002.
25. Breiman L. Random Forests. Mach Learn 2001, 45:5-32.
26. Ware C.F., Crowe P.D., Grayson M.H., Androlewicz M.J., Browning J.L. Expression of surface lymphotoxin and tumor necrosis factor on activated T, B, and natural killer cells. J Immunol 1992, 149:3881-3888.
27. Grivennikov S.I., Tumanov A.V., Liepinsh D.J., Kruglov A.A., Marakusha B.I., Shakhov A.N., et al. Distinct and nonredundant in vivo functions of TNF produced by t cells and macrophages/neutrophils: protective and deleterious effects. Immunity 2005, 22:93-104.
28. Scheller J., Chalaris A., Schmidt-Arras D., Rose-John S. The pro- and anti-inflammatory properties of the cytokine interleukin-6. Biochim Biophys Acta 2011, 1813:878-888.
29. Whistler T., Fletcher M.A., Lonergan W., Zeng X.R., Lin J.M., Laperriere A., et al. Impaired immune function in Gulf War illness. BMC Med Genomics 2009, 2:12.
30. Moss R.B., Mercandetti A., Vojdani A. TNF-alpha and chronic fatigue syndrome. J Clin Immunol 1999, 19:314-316.
31. Rook G.A., Zumla A. Gulf War syndrome: is it due to a systemic shift in cytokine balance towards a Th2 profile?. Lancet 1997, 349:1831-1833.
32. Abdi K. IL-12: the role of p40 versus p75. Scand J Immunol 2002, 56:1-11.
33. Robbe P., Spierenburg E.A., Draijer C., Brandsma C.A., Telenga E., van Oosterhout A.J., et al. Shifted T-cell polarisation after agricultural dust exposure in mice and men. Thorax 2014, 69:630-637.
34. Harris K.M., Ramachandran G., Basu S., Rollins S., Mann D., Cross A.S. The IL-23/Th17 axis is involved in the adaptive immune response to Bacillus anthracis in humans. Eur J Immunol 2014, 44:752-762.
35. Rosenkrands I., Vingsbo-Lundberg C., Bundgaard T.J., Lindenstrom T., Enouf V., van der Werf S., et al. Enhanced humoral and cell-mediated immune responses after immunization with trivalent influenza vaccine adjuvanted with cationic liposomes. Vaccine 2011, 29:6283-6291.
36. DeFuria J., Belkina A.C., Jagannathan-Bogdan M., Snyder-Cappione J., Carr J.D., Nersesova Y.R., et al. B cells promote inflammation in obesity and type 2 diabetes through regulation of T-cell function and an inflammatory cytokine profile. Proc Natl Acad Sci USA 2013, 110:5133-5138.
37. Swindell W.R., Johnston A., Voorhees J.J., Elder J.T., Gudjonsson J.E. Dissecting the psoriasis transcriptome: inflammatory- and cytokine-driven gene expression in lesions from 163 patients. BMC Genomics 2013, 14:527.
38. Valeyev N.V., Hundhausen C., Umezawa Y., Kotov N.V., Williams G., Clop A., et al. A systems model for immune cell interactions unravels the mechanism of inflammation in human skin. PLoS Comput Biol 2010, 6:e1001024.
39. Fry T.J., Mackall C.L. Interleukin-7: from bench to clinic. Blood 2002, 99:3892-3904.
40. Rosenberg S.A., Sportes C., Ahmadzadeh M., Fry T.J., Ngo L.T., Schwarz S.L., et al. IL-7 administration to humans leads to expansion of CD8+ and CD4+ cells but a relative decrease of CD4+ T-regulatory cells. J Immunother 2006, 29:313-319.
41. Pellegrini M., Calzascia T., Toe J.G., Preston S.P., Lin A.E., Elford A.R., et al. IL-7 engages multiple mechanisms to overcome chronic viral infection and limit organ pathology. Cell 2011, 144:601-613.
42. Konstantinov K., von Mikecz A., Buchwald D., Jones J., Gerace L., Tan E.M. Autoantibodies to nuclear envelope antigens in chronic fatigue syndrome. J Clin Investig 1996, 98:1888-1896.
43. von Mikecz A., Konstantinov K., Buchwald D.S., Gerace L., Tan E.M. High frequency of autoantibodies to insoluble cellular antigens in patients with chronic fatigue syndrome. Arthritis Rheum 1997, 40:295-305.
44. Fluge O., Bruland O., Risa K., Storstein A., Kristoffersen E.K., Sapkota D., et al. Benefit from B-lymphocyte depletion using the anti-CD20 antibody rituximab in chronic fatigue syndrome. A double-blind and placebo-controlled study. PLoS ONE 2011, 6:e26358.
45. Fluge O., Mella O. Clinical impact of B-cell depletion with the anti-CD20 antibody rituximab in chronic fatigue syndrome: a preliminary case series. BMC Neurol 2009, 9:28.
46. Dooms H. Interleukin-7: fuel for the autoimmune attack. J Autoimmun 2013, 45:40-48.
47. Oliphant C.J., Barlow J.L., McKenzie A.N. Insights into the initiation of type 2 immune responses. Immunology 2011, 134:378-385.
48. Iwakura Y., Nakae S., Saijo S., Ishigame H. The roles of IL-17A in inflammatory immune responses and host defense against pathogens. Immunol Rev 2008, 226:57-79.