Sphere formation permits oct4 reprogramming of ciliary body epithelial cells into induced pluripotent stem cells

Stem Cells and Development

Volumn 23, Issue 24, 2014, Pages 3065-3071

  Ni, Aiguo ^a   Wu, Ming Jing ^a   Chavala, Sai H ^a  

^a UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALKALINE PHOSPHATASE; GENOMIC DNA; OCTAMER TRANSCRIPTION FACTOR 4; TRANSCRIPTION FACTOR NANOG; KRUPPEL LIKE FACTOR; KRUPPEL LIKE FACTOR 4;

ARTICLE; CILIARY BODY; DEMETHYLATION; EMBRYONIC STEM CELL; EPITHELIUM CELL; GERM LAYER; HUMAN; IMMUNOFLUORESCENCE; IN VITRO STUDY; KARYOTYPE; KARYOTYPING; NUCLEAR REPROGRAMMING; PLURIPOTENT STEM CELL; PROMOTER REGION; REAL TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RNA ISOLATION; SOMATIC CELL; UPREGULATION; ANIMAL; CYTOLOGY; GENETICS; INDUCED PLURIPOTENT STEM CELL; METABOLISM; MOUSE; MULTICELLULAR SPHEROID;

IPS;

ANIMALS; CELLULAR REPROGRAMMING; CILIARY BODY; EPITHELIAL CELLS; INDUCED PLURIPOTENT STEM CELLS; KRUPPEL-LIKE TRANSCRIPTION FACTORS; MICE; OCTAMER TRANSCRIPTION FACTOR-3; SPHEROIDS, CELLULAR;

EID: 84916883538     PISSN: 15473287     EISSN: 15578534     Source Type: Journal    
DOI: 10.1089/scd.2014.0064     Document Type: Article

References (30)

1. Ni A, MJ Wu, Y Nakanishi and SH Chavala. (2013). Facile and efficient reprogramming of ciliary body epithelial cells into induced pluripotent stem cells. StemCells Dev 22:2543-2550
2. Forrest AW, RB Keyser and WH Spencer. (1978). Iridocyclectomy formelanomas of the ciliary body: a follow-up study of pathology and surgical morbidity. Ophthalmology 85:1237-1249
3. Engin G, C Yilmazli, KN Engin, G Gulkilik and L Bilgic. (2004). Combined cyclectomy-trabeculectomy procedure for refractory glaucoma. Ophthalmic Surg Lasers Imaging 35:507-511
4. Damato BE. (2012). Local resection of uveal melanoma. Dev Ophthalmol 49:66-80
5. Reynolds BA and RL Rietze. (2005). Neural stem cells and neurospheres-re-evaluating the relationship. Nat Methods 2:333-336
6. Pastrana E, V Silva-Vargas and F Doetsch. (2011). Eyes wide open: a critical review of sphere-formation as an assay for stem cells. Cell Stem Cell 8:486-498
7. Tropepe V, BL Coles, BJ Chiasson, DJ Horsford, AJ Elia, RR McInnes and D van der Kooy. (2000). Retinal stem cells in the adult mammalian eye. Science 287:2032-2036
8. Cicero SA, D Johnson, S Reyntjens, S Frase, S Connell, LM Chow, SJ Baker, BP Sorrentino and MA Dyer. (2009). Cells previously identified as retinal stem cells are pigmented ciliary epithelial cells. Proc Natl Acad Sci U S A 106:6685-6690
9. Gualdoni S, M Baron, J Lakowski, S Decembrini, AJ Smith, RA Pearson, RR Ali and JC Sowden. (2010). Adult ciliary epithelial cells, previously identified as retinal stem cells with potential for retinal repair, fail to differentiate into new rod photoreceptors. Stem Cells 28:1048-1059
10. Colman A and O Dreesen. (2009). Pluripotent stem cells and disease modeling. Cell Stem Cell 5:244-247
11. Kim JB, V Sebastiano, G Wu, MJ Arauzo-Bravo, P Sasse, L Gentile, K Ko, D Ruau, MEhrich, et al. (2009). Oct4-induced pluripotency in adult neural stem cells. Cell 136:411-419
12. Kim JB, H Zaehres, G Wu, L Gentile, K Ko, V Sebastiano, MJ Arauzo-Bravo, D Ruau, DW Han, M Zenke and HR Scholer. (2008). Pluripotent stem cells induced from adult neural stem cells by reprogramming with two factors. Nature 454:646-650
13. Takahashi K, K Okita, M Nakagawa and S Yamanaka. (2007). Induction of pluripotent stem cells from fibroblast cultures. Nat Protoc 2:3081-3089
14. Ying QL, J Wray, J Nichols, L Batlle-Morera, B Doble, J Woodgett, P Cohen and A Smith. (2008). The ground state of embryonic stem cell self-renewal. Nature 453:519-523
15. Okada M, M Oka and Y Yoneda. (2010). Effective culture conditions for the induction of pluripotent stem cells. Biochim Biophys Acta 1800:956-963
16. Imamura M, K Miura, K Iwabuchi, T Ichisaka, M Nakagawa, J Lee, M Kanatsu-Shinohara, T Shinohara and S Yamanaka. (2006). Transcriptional repression and DNA hypermethylation of a small set of ES cell marker genes in male germline stem cells. BMC Dev Biol 6:34
17. Western PS, JA van den Bergen, DC Miles and AH Sinclair. (2010). Male fetal germ cell differentiation involves complex repression of the regulatory network controlling pluripotency. FASEB J 24:3026-3035
18. Hou P, Y Li, X Zhang, C Liu, J Guan, H Li, T Zhao, J Ye, W Yang, et al. (2013). Pluripotent stem cells induced from mouse somatic cells by small-molecule compounds. Science 341:651-654
19. Samavarchi-Tehrani P, A Golipour, L David, HK Sung, TA Beyer, A Datti, K Woltjen, A Nagy and JL Wrana. (2010). Functional genomics reveals a BMP-driven mesenchymalto-epithelial transition in the initiation of somatic cell reprogramming. Cell Stem Cell 7:64-77
20. Buganim Y, DA Faddah, AW Cheng, E Itskovich, S Markoulaki, K Ganz, SL Klemm, A van Oudenaarden and R Jaenisch. (2012). Single-cell expression analyses during cellular reprogramming reveal an early stochastic and a late hierarchic phase. Cell 150:1209-1222
21. Chia NY, YS Chan, B Feng, X Lu, YL Orlov, D Moreau, P Kumar, L Yang, J Jiang, et al. (2010). A genome-wide RNAi screen reveals determinants of human embryonic stem cell identity. Nature 468:316-320
22. Payer B, M Rosenberg, M Yamaji, Y Yabuta, M Koyanagi-Aoi, K Hayashi, S Yamanaka, M Saitou and JT Lee. (2013). Tsix RNA and the germline factor, PRDM14, link X reactivation and stem cell reprogramming. Mol Cell 52:805-818
23. Feng B, J Jiang, P Kraus, JH Ng, JC Heng, YS Chan, LP Yaw, W Zhang, YH Loh, et al. (2009). Reprogramming of fibroblasts into induced pluripotent stem cells with orphan nuclear receptor Esrrb. Nat Cell Biol 11: 197-203
24. Maekawa M, K Yamaguchi, T Nakamura, R Shibukawa, I Kodanaka, T Ichisaka, Y Kawamura, H Mochizuki, N Goshima and S Yamanaka. (2011). Direct reprogramming of somatic cells is promoted by maternal transcription factor Glis1. Nature 474:225-229
25. Bagci H and AG Fisher. (2013). DNA demethylation in pluripotency and reprogramming: the role of tet proteins and cell division. Cell Stem Cell 13:265-269
26. Li R, J Liang, S Ni, T Zhou, X Qing, H Li, W He, J Chen, F Li, et al. (2010). A mesenchymal-to-epithelial transition initiates and is required for the nuclear reprogramming of mouse fibroblasts. Cell Stem Cell 7:51-63
27. Liu X, H Sun, J Qi, L Wang, S He, J Liu, C Feng, C Chen, W Li, et al. (2013). Sequential introduction of reprogramming factors reveals a time-sensitive requirement for individual factors and a sequential EMT-MET mechanism for optimal reprogramming. Nat Cell Biol 15:829-838
28. Di Stefano B, JL Sardina, C van Oevelen, S Collombet, EM Kallin, GP Vicent, J Lu, D Thieffry, M Beato and T Graf. (2013). C/EBPalpha poises B cells for rapid reprogramming into induced pluripotent stem cells. Nature 506:235-239
29. Su G, Y Zhao, J Wei, Z Xiao, B Chen, J Han, L Chen, J Guan, R Wang, Q Dong and J Dai. (2013). Direct conversion of fibroblasts into neural progenitor-like cells by forced growth into 3D spheres on low attachment surfaces. Biomaterials 34:5897-5906
30. Liu Y, P Mukhopadhyay, MM Pisano, X Lu, L Huang, Q Lu and DC Dean. (2013). Repression of Zeb1 and hypoxia cause sequential mesenchymal-to-epithelial transition and induction of aid, Oct4, and Dnmt1, leading to immortalization and multipotential reprogramming of fibroblasts in spheres. Stem Cells 31:1350-1362.