Repression of zeb1 and hypoxia cause sequential mesenchymal-to-epithelial transition and induction of aid, Oct4, and dnmt1, leading to immortalization and multipotential reprogramming of fibroblasts in spheres

Stem Cells

Volumn 31, Issue 7, 2013, Pages 1350-1362

  Liu, Yongqing ^a,b,c   Mukhopadhyay, Partha ^c   Pisano, M Michele ^c   Lu, Xiaoqin ^b   Huang, Li ^b,d   Lu, Qingxian ^a,b   Dean, Douglas C ^a,b,c  

^a UNIVERSITY OF LOUISVILLE SCHOOL OF MEDICINE   (United States)

^b Department of Ophthalmology ^*  (China)

^c UNIVERSITY OF LOUISVILLE SCHOOL OF MEDICINE   (United States)

^d ZHEJIANG UNIVERSITY   (China)

Author keywords

Adult stem cells; Differentiation; Hypoxia; Reprogramming

Indexed keywords

ARF PROTEIN; CYCLIN DEPENDENT KINASE INHIBITOR; DNA METHYLTRANSFERASE 1; HYPOXIA INDUCIBLE FACTOR 1ALPHA; OCTAMER TRANSCRIPTION FACTOR 4; TRANSCRIPTION FACTOR NANOG; TRANSCRIPTION FACTOR ZEB1;

ANIMAL CELL; ARTICLE; CELL CONTACT; CELL DIFFERENTIATION; CELL IMMORTALIZATION; CELL SHAPE; CONTROLLED STUDY; DEMETHYLATION; DOWN REGULATION; EPITHELIAL MESENCHYMAL TRANSITION; FIBROBLAST; GENE EXPRESSION; GENE SILENCING; HYPOXIA; MESENCHYMAL STEM CELL; NONHUMAN; PROMOTER REGION; PROTEIN BINDING; SIDE POPULATION CELL; WILD TYPE;

ADULT STEM CELLS; DIFFERENTIATION; HYPOXIA; REPROGRAMMING;

ANIMALS; CELL DIFFERENTIATION; CELL HYPOXIA; CELLS, CULTURED; CYTIDINE DEAMINASE; DNA (CYTOSINE-5-)-METHYLTRANSFERASE; DNA METHYLATION; EPITHELIAL-MESENCHYMAL TRANSITION; FIBROBLASTS; GENE KNOCKDOWN TECHNIQUES; HOMEODOMAIN PROTEINS; HYPOXIA-INDUCIBLE FACTOR 1, ALPHA SUBUNIT; KRUPPEL-LIKE TRANSCRIPTION FACTORS; MICE; MULTIPOTENT STEM CELLS; OCTAMER TRANSCRIPTION FACTOR-3; PROMOTER REGIONS, GENETIC; STEM CELLS; TRANSCRIPTOME;

EID: 84879953422     PISSN: 10665099     EISSN: None     Source Type: Journal    
DOI: 10.1002/stem.1382     Document Type: Article

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