메뉴 건너뛰기




Volumn 94, Issue 2, 2014, Pages 353-366

Dominant negative mutant of PlasmodiumRad51 causes reduced parasite burden in host by abrogating DNA double-strand break repair

Author keywords

[No Author keywords available]

Indexed keywords

DOUBLE STRANDED DNA; RAD51 PROTEIN; MUTANT PROTEIN;

EID: 84916879839     PISSN: 0950382X     EISSN: 13652958     Source Type: Journal    
DOI: 10.1111/mmi.12762     Document Type: Article
Times cited : (18)

References (40)
  • 1
    • 84864478099 scopus 로고    scopus 로고
    • Characterization of Rad51 from apicomplexan parasite Toxoplasma gondii: an implication for inefficient gene targeting
    • Achanta, S.S., Varunan, S.M., Bhattacharyya, S., and Bhattacharyya, M.K. (2011) Characterization of Rad51 from apicomplexan parasite Toxoplasma gondii: an implication for inefficient gene targeting. PLoS ONE 7: e41925.
    • (2011) PLoS ONE , vol.7 , pp. e41925
    • Achanta, S.S.1    Varunan, S.M.2    Bhattacharyya, S.3    Bhattacharyya, M.K.4
  • 2
    • 0030575805 scopus 로고    scopus 로고
    • Bypass of DNA heterologies during RuvAB-mediated three- and four-strand branch migration
    • Adams, D.E., and West, S.C. (1996) Bypass of DNA heterologies during RuvAB-mediated three- and four-strand branch migration. J Mol Biol 263: 582-596.
    • (1996) J Mol Biol , vol.263 , pp. 582-596
    • Adams, D.E.1    West, S.C.2
  • 3
    • 69849097676 scopus 로고    scopus 로고
    • Analysis of repair mechanism choice during homologous recombination
    • Agmon, N., Pur, S., Liefshitz, B., and Kupiec, M. (2009) Analysis of repair mechanism choice during homologous recombination. Nucleic Acids Res 37: 5081-5092.
    • (2009) Nucleic Acids Res , vol.37 , pp. 5081-5092
    • Agmon, N.1    Pur, S.2    Liefshitz, B.3    Kupiec, M.4
  • 4
    • 36749086400 scopus 로고    scopus 로고
    • An FKBP destabilization domain modulates protein levels in Plasmodium falciparum
    • Armstrong, C.M., and Goldberg, D.E. (2007) An FKBP destabilization domain modulates protein levels in Plasmodium falciparum. Nat Methods 4: 1007-1009.
    • (2007) Nat Methods , vol.4 , pp. 1007-1009
    • Armstrong, C.M.1    Goldberg, D.E.2
  • 5
    • 0141644145 scopus 로고    scopus 로고
    • Identification and molecular characterisation of DNA damaging agent induced expression of Plasmodium falciparum recombination protein PfRad51
    • Bhattacharyya, M.K., and Kumar, N. (2003) Identification and molecular characterisation of DNA damaging agent induced expression of Plasmodium falciparum recombination protein PfRad51. Int J Parasitol 33: 1385-1392.
    • (2003) Int J Parasitol , vol.33 , pp. 1385-1392
    • Bhattacharyya, M.K.1    Kumar, N.2
  • 6
    • 11144321643 scopus 로고    scopus 로고
    • Characterization of kinetics of DNA strand-exchange and ATP hydrolysis activities of recombinant PfRad51, a Plasmodium falciparum recombinase
    • Bhattacharyya, M.K., Bhattacharyya nee Deb, S., Jayabalasingham, B., and Kumar, N. (2005) Characterization of kinetics of DNA strand-exchange and ATP hydrolysis activities of recombinant PfRad51, a Plasmodium falciparum recombinase. Mol Biochem Parasitol 139: 33-39.
    • (2005) Mol Biochem Parasitol , vol.139 , pp. 33-39
    • Bhattacharyya, M.K.1    Bhattacharyya nee Deb, S.2    Jayabalasingham, B.3    Kumar, N.4
  • 7
    • 32644466860 scopus 로고    scopus 로고
    • Roles of ATP binding and ATP hydrolysis in human Rad51 recombinase function
    • Chi, P., Van Komen, S., Sehorn, M.G., Sigurdsson, S., and Sung, P. (2006) Roles of ATP binding and ATP hydrolysis in human Rad51 recombinase function. DNA Repair (Amst) 5: 381-391.
    • (2006) DNA Repair (Amst) , vol.5 , pp. 381-391
    • Chi, P.1    Van Komen, S.2    Sehorn, M.G.3    Sigurdsson, S.4    Sung, P.5
  • 8
    • 33846624650 scopus 로고    scopus 로고
    • Cytotoxic effect of curcumin on malaria parasite Plasmodium falciparum: inhibition of histone acetylation and generation of reactive oxygen species
    • Cui, L., Miao, J., and Cui, L. (2007) Cytotoxic effect of curcumin on malaria parasite Plasmodium falciparum: inhibition of histone acetylation and generation of reactive oxygen species. Antimicrob Agents Chemother 51: 488-494.
    • (2007) Antimicrob Agents Chemother , vol.51 , pp. 488-494
    • Cui, L.1    Miao, J.2    Cui, L.3
  • 9
    • 33947396376 scopus 로고    scopus 로고
    • The human Rad51 K133A mutant is functional for DNA double-strand break repair in human cells
    • Forget, A.L., Loftus, M.S., McGrew, D.A., Bennett, B.T., and Knight, K.L. (2007) The human Rad51 K133A mutant is functional for DNA double-strand break repair in human cells. Biochemistry 46: 3566-3575.
    • (2007) Biochemistry , vol.46 , pp. 3566-3575
    • Forget, A.L.1    Loftus, M.S.2    McGrew, D.A.3    Bennett, B.T.4    Knight, K.L.5
  • 10
    • 0025034286 scopus 로고
    • DNA double-strand breaks: their repair and relationship to cell killing in yeast
    • Frankenberg-Schwager, M., and Frankenberg, D. (1990) DNA double-strand breaks: their repair and relationship to cell killing in yeast. Int J Radiat Biol 58: 569-575.
    • (1990) Int J Radiat Biol , vol.58 , pp. 569-575
    • Frankenberg-Schwager, M.1    Frankenberg, D.2
  • 11
    • 33845406168 scopus 로고    scopus 로고
    • The rad51-K191R ATPase-defective mutant is impaired for presynaptic filament formation
    • Fung, C.W., Fortin, G.S., Peterson, S.E., and Symington, L.S. (2006) The rad51-K191R ATPase-defective mutant is impaired for presynaptic filament formation. Mol Cell Biol 26: 9544-9554.
    • (2006) Mol Cell Biol , vol.26 , pp. 9544-9554
    • Fung, C.W.1    Fortin, G.S.2    Peterson, S.E.3    Symington, L.S.4
  • 12
    • 84879589677 scopus 로고    scopus 로고
    • Opposing roles for two molecular forms of replication protein A in Rad51-Rad54-mediated DNA recombination in Plasmodium falciparum
    • e00252-e00213
    • Gopalakrishnan, A.M., and Kumar, N. (2013) Opposing roles for two molecular forms of replication protein A in Rad51-Rad54-mediated DNA recombination in Plasmodium falciparum. MBio 4: e00252-13.
    • (2013) MBio , vol.4
    • Gopalakrishnan, A.M.1    Kumar, N.2
  • 13
    • 0035945241 scopus 로고    scopus 로고
    • Bypass of heterology during strand transfer by Saccharomyces cerevisiae Rad51 protein
    • Holmes, V.F., Benjamin, K.R., Crisona, N.J., and Cozzarelli, N.R. (2001) Bypass of heterology during strand transfer by Saccharomyces cerevisiae Rad51 protein. Nucleic Acids Res 29: 5052-5057.
    • (2001) Nucleic Acids Res , vol.29 , pp. 5052-5057
    • Holmes, V.F.1    Benjamin, K.R.2    Crisona, N.J.3    Cozzarelli, N.R.4
  • 14
    • 64749102772 scopus 로고    scopus 로고
    • Tagging of endogenous genes in a Toxoplasma gondii strain lacking Ku80
    • Huynh, M.H., and Carruthers, V.B. (2009) Tagging of endogenous genes in a Toxoplasma gondii strain lacking Ku80. Eukaryot Cell 8: 530-539.
    • (2009) Eukaryot Cell , vol.8 , pp. 530-539
    • Huynh, M.H.1    Carruthers, V.B.2
  • 15
    • 0028067935 scopus 로고
    • RuvA and RuvB proteins facilitate the bypass of heterologous DNA insertions during RecA protein-mediated DNA strand exchange
    • Iype, L.E., Wood, E.A., Inman, R.B., and Cox, M.M. (1994) RuvA and RuvB proteins facilitate the bypass of heterologous DNA insertions during RecA protein-mediated DNA strand exchange. J Biol Chem 269: 24967-24978.
    • (1994) J Biol Chem , vol.269 , pp. 24967-24978
    • Iype, L.E.1    Wood, E.A.2    Inman, R.B.3    Cox, M.M.4
  • 16
    • 0019403398 scopus 로고
    • Repair of interstrand cross-links in DNA of Saccharomyces cerevisiae requires two systems for DNA repair: the RAD3 system and the RAD51 system
    • Jachymczyk, W.J., von Borstel, R.C., Mowat, M.R., and Hastings, P.J. (1981) Repair of interstrand cross-links in DNA of Saccharomyces cerevisiae requires two systems for DNA repair: the RAD3 system and the RAD51 system. Mol Gen Genet 182: 196-205.
    • (1981) Mol Gen Genet , vol.182 , pp. 196-205
    • Jachymczyk, W.J.1    von Borstel, R.C.2    Mowat, M.R.3    Hastings, P.J.4
  • 17
    • 0030455820 scopus 로고    scopus 로고
    • Genomic libraries and a host strain designed for highly efficient two-hybrid selection in yeast
    • James, P., Halladay, J., and Craig, E.A. (1996) Genomic libraries and a host strain designed for highly efficient two-hybrid selection in yeast. Genetics 144: 1425-1436.
    • (1996) Genetics , vol.144 , pp. 1425-1436
    • James, P.1    Halladay, J.2    Craig, E.A.3
  • 18
    • 34247507377 scopus 로고    scopus 로고
    • High-efficiency transfection and drug selection of genetically transformed blood stages of the rodent malaria parasite Plasmodium berghei
    • Janse, C.J., Ramesar, J., and Waters, A.P. (2006) High-efficiency transfection and drug selection of genetically transformed blood stages of the rodent malaria parasite Plasmodium berghei. Nat Protoc 1: 346-356.
    • (2006) Nat Protoc , vol.1 , pp. 346-356
    • Janse, C.J.1    Ramesar, J.2    Waters, A.P.3
  • 19
    • 84866424521 scopus 로고    scopus 로고
    • RAD51 mutants cause replication defects and chromosomal instability
    • Kim, T.M., Ko, J.H., Hu, L., Kim, S.A., Bishop, A.J., Vijg, J., etal. (2012) RAD51 mutants cause replication defects and chromosomal instability. Mol Cell Biol 32: 3663-3680.
    • (2012) Mol Cell Biol , vol.32 , pp. 3663-3680
    • Kim, T.M.1    Ko, J.H.2    Hu, L.3    Kim, S.A.4    Bishop, A.J.5    Vijg, J.6
  • 20
    • 84891821143 scopus 로고    scopus 로고
    • Malaria parasites utilize both homologous recombination and alternative end joining pathways to maintain genome integrity
    • Kirkman, L.A., Lawrence, E.A., and Deitsch, K.W. (2014) Malaria parasites utilize both homologous recombination and alternative end joining pathways to maintain genome integrity. Nucleic Acids Res 42: 370-379.
    • (2014) Nucleic Acids Res , vol.42 , pp. 370-379
    • Kirkman, L.A.1    Lawrence, E.A.2    Deitsch, K.W.3
  • 21
    • 33746318909 scopus 로고    scopus 로고
    • A family affair: var genes, PfEMP1 binding, and malaria disease
    • Kraemer, S.M., and Smith, J.D. (2006) A family affair: var genes, PfEMP1 binding, and malaria disease. Curr Opin Microbiol 9: 374-380.
    • (2006) Curr Opin Microbiol , vol.9 , pp. 374-380
    • Kraemer, S.M.1    Smith, J.D.2
  • 22
    • 33847643223 scopus 로고    scopus 로고
    • Patterns of gene recombination shape var gene repertoires in Plasmodium falciparum: comparisons of geographically diverse isolates
    • Kraemer, S.M., Kyes, S.A., Aggarwal, G., Springer, A.L., Nelson, S.O., Christodoulou, Z., etal. (2007) Patterns of gene recombination shape var gene repertoires in Plasmodium falciparum: comparisons of geographically diverse isolates. BMC Genomics 8: 45.
    • (2007) BMC Genomics , vol.8 , pp. 45
    • Kraemer, S.M.1    Kyes, S.A.2    Aggarwal, G.3    Springer, A.L.4    Nelson, S.O.5    Christodoulou, Z.6
  • 24
    • 0029909565 scopus 로고    scopus 로고
    • A mutation in mouse rad51 results in an early embryonic lethal that is suppressed by a mutation in p53
    • Lim, D.S., and Hasty, P. (1996) A mutation in mouse rad51 results in an early embryonic lethal that is suppressed by a mutation in p53. Mol Cell Biol 16: 7133-7143.
    • (1996) Mol Cell Biol , vol.16 , pp. 7133-7143
    • Lim, D.S.1    Hasty, P.2
  • 25
    • 84871385531 scopus 로고    scopus 로고
    • Aberrant sporogonic development of Dmc1 (a meiotic recombinase) deficient Plasmodium berghei parasites
    • Mlambo, G., Coppens, I., and Kumar, N. (2012) Aberrant sporogonic development of Dmc1 (a meiotic recombinase) deficient Plasmodium berghei parasites. PLoS ONE 7: e52480.
    • (2012) PLoS ONE , vol.7 , pp. e52480
    • Mlambo, G.1    Coppens, I.2    Kumar, N.3
  • 26
    • 0017820581 scopus 로고
    • Responses of radiation-sensitive mutants of Saccharomyces cerevisiae to lethal effects of bleomycin
    • Moore, C.W. (1978) Responses of radiation-sensitive mutants of Saccharomyces cerevisiae to lethal effects of bleomycin. Mutat Res 51: 165-180.
    • (1978) Mutat Res , vol.51 , pp. 165-180
    • Moore, C.W.1
  • 27
    • 0027985084 scopus 로고
    • Effect of length and location of heterologous sequences on RecA-mediated strand exchange
    • Morel, P., Stasiak, A., Ehrlich, S.D., and Cassuto, E. (1994) Effect of length and location of heterologous sequences on RecA-mediated strand exchange. J Biol Chem 269: 19830-19835.
    • (1994) J Biol Chem , vol.269 , pp. 19830-19835
    • Morel, P.1    Stasiak, A.2    Ehrlich, S.D.3    Cassuto, E.4
  • 28
    • 63049136021 scopus 로고    scopus 로고
    • PfEMP1: an antigen that plays a key role in the pathogenicity and immune evasion of the malaria parasite Plasmodium falciparum
    • Pasternak, N.D., and Dzikowski, R. (2009) PfEMP1: an antigen that plays a key role in the pathogenicity and immune evasion of the malaria parasite Plasmodium falciparum. Int J Biochem Cell Biol 41: 1463-1466.
    • (2009) Int J Biochem Cell Biol , vol.41 , pp. 1463-1466
    • Pasternak, N.D.1    Dzikowski, R.2
  • 29
    • 20844461121 scopus 로고    scopus 로고
    • Human Rad51 filaments on double- and single-stranded DNA: correlating regular and irregular forms with recombination function
    • Ristic, D., Modesti, M., van der Heijden, T., van Noort, J., Dekker, C., Kanaar, R., etal. (2005) Human Rad51 filaments on double- and single-stranded DNA: correlating regular and irregular forms with recombination function. Nucleic Acids Res 33: 3292-3302.
    • (2005) Nucleic Acids Res , vol.33 , pp. 3292-3302
    • Ristic, D.1    Modesti, M.2    van der Heijden, T.3    van Noort, J.4    Dekker, C.5    Kanaar, R.6
  • 32
    • 84891607293 scopus 로고    scopus 로고
    • A plausible mechanism for the antimalarial activity of artemisinin: a computational approach
    • Shandilya, A., Chacko, S., Jayaram, B., and Ghosh, I. (2013) A plausible mechanism for the antimalarial activity of artemisinin: a computational approach. Sci Rep 3: 2513.
    • (2013) Sci Rep , vol.3 , pp. 2513
    • Shandilya, A.1    Chacko, S.2    Jayaram, B.3    Ghosh, I.4
  • 33
    • 77956308656 scopus 로고    scopus 로고
    • Functional evaluation of Plasmodium export signals in Plasmodium berghei suggests multiple modes of protein export
    • Sijwali, P.S., and Rosenthal, P.J. (2010) Functional evaluation of Plasmodium export signals in Plasmodium berghei suggests multiple modes of protein export. PLoS ONE 5: e10227.
    • (2010) PLoS ONE , vol.5 , pp. e10227
    • Sijwali, P.S.1    Rosenthal, P.J.2
  • 34
    • 0037036354 scopus 로고    scopus 로고
    • ATP hydrolysis by mammalian RAD51 has a key role during homology-directed DNA repair
    • Stark, J.M., Hu, P., Pierce, A.J., Moynahan, M.E., Ellis, N., and Jasin, M. (2002) ATP hydrolysis by mammalian RAD51 has a key role during homology-directed DNA repair. J Biol Chem 277: 20185-20194.
    • (2002) J Biol Chem , vol.277 , pp. 20185-20194
    • Stark, J.M.1    Hu, P.2    Pierce, A.J.3    Moynahan, M.E.4    Ellis, N.5    Jasin, M.6
  • 35
    • 0036900120 scopus 로고    scopus 로고
    • Role of RAD52 epistasis group genes in homologous recombination and double-strand break repair
    • Symington, L. (2002) Role of RAD52 epistasis group genes in homologous recombination and double-strand break repair. Microbiol Mol Biol Rev 66: 630-670.
    • (2002) Microbiol Mol Biol Rev , vol.66 , pp. 630-670
    • Symington, L.1
  • 36
    • 0033737488 scopus 로고    scopus 로고
    • Var gene diversity in Plasmodium falciparum is generated by frequent recombination events
    • Taylor, H.M., Kyes, S.A., and Newbold, C.I. (2000) Var gene diversity in Plasmodium falciparum is generated by frequent recombination events. Mol Biochem Parasitol 110: 391-397.
    • (2000) Mol Biochem Parasitol , vol.110 , pp. 391-397
    • Taylor, H.M.1    Kyes, S.A.2    Newbold, C.I.3
  • 38
    • 0020668522 scopus 로고
    • Disorder of the repair of DNA double-stranded breaks in radiosensitive mutants of Saccharomyces cerevisiae yeasts
    • Vishnevetskaia, O., Luchnik, A.N., Arutiunova, L.S., and Shestakov, S.V. (1983) Disorder of the repair of DNA double-stranded breaks in radiosensitive mutants of Saccharomyces cerevisiae yeasts. Genetika 19: 26-32.
    • (1983) Genetika , vol.19 , pp. 26-32
    • Vishnevetskaia, O.1    Luchnik, A.N.2    Arutiunova, L.S.3    Shestakov, S.V.4
  • 39
    • 0037124114 scopus 로고    scopus 로고
    • Plasmodium falciparum possesses a cell cycle-regulated short type replication protein A large subunit encoded by an unusual transcript
    • Voss, T.S., Mini, T., Jenoe, P., and Beck, H.P. (2002) Plasmodium falciparum possesses a cell cycle-regulated short type replication protein A large subunit encoded by an unusual transcript. J Biol Chem 277: 17493-17501.
    • (2002) J Biol Chem , vol.277 , pp. 17493-17501
    • Voss, T.S.1    Mini, T.2    Jenoe, P.3    Beck, H.P.4
  • 40
    • 84884719955 scopus 로고    scopus 로고
    • Fighting drug-resistant Plasmodium falciparum: the challenge of artemisinin resistance
    • Wongsrichanalai, C., and Sibley, C.H. (2013) Fighting drug-resistant Plasmodium falciparum: the challenge of artemisinin resistance. Clin Microbiol Infect 19: 908-916.
    • (2013) Clin Microbiol Infect , vol.19 , pp. 908-916
    • Wongsrichanalai, C.1    Sibley, C.H.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.