Utility of ketone measurement in the prevention, diagnosis and management of diabetic ketoacidosis

Diabetic Medicine

Volumn 32, Issue 1, 2015, Pages 14-23

  Misra, S ^a,b   Oliver, N S ^a  

^a IMPERIAL COLLEGE LONDON   (United Kingdom)

^b IMPERIAL COLLEGE HEALTHCARE NHS TRUST   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

3 HYDROXYBUTYRIC ACID; KETONE; ACETOACETIC ACID DERIVATIVE; BIOLOGICAL MARKER; DIAGNOSTIC KIT;

BLOOD GLUCOSE MONITORING; CAPILLARY BLOOD; COST EFFECTIVENESS ANALYSIS; DIABETES EDUCATION; DIABETIC KETOACIDOSIS; DIAGNOSTIC ACCURACY; DISEASE SEVERITY; HUMAN; KETONURIA; PRACTICE GUIDELINE; REVIEW; SELF MONITORING; BLOOD; CAPILLARY; COST BENEFIT ANALYSIS; DIAGNOSTIC KIT; EVIDENCE BASED MEDICINE; PREDICTIVE VALUE; PROCEDURES; PROGNOSIS; SENSITIVITY AND SPECIFICITY; SEVERITY OF ILLNESS INDEX; URINALYSIS; URINE;

3-HYDROXYBUTYRIC ACID; ACETOACETATES; BIOLOGICAL MARKERS; CAPILLARIES; COST-BENEFIT ANALYSIS; DIABETIC KETOACIDOSIS; EVIDENCE-BASED MEDICINE; HUMANS; KETONES; PREDICTIVE VALUE OF TESTS; PROGNOSIS; REAGENT KITS, DIAGNOSTIC; SENSITIVITY AND SPECIFICITY; SEVERITY OF ILLNESS INDEX; URINALYSIS;

EID: 84916622985     PISSN: 07423071     EISSN: 14645491     Source Type: Journal    
DOI: 10.1111/dme.12604     Document Type: Review

References (50)

1. Basu A, Close CF, Jenkins D, Krentz AJ, Nattrass M, Wright AD. Persisting mortality in diabetic ketoacidosis. Diabet Med 1993; 10: 782.
2. Laffel L. Ketone bodies: a review of physiology, pathophysiology and application of monitoring to diabetes. Diabetes Metab Res Rev 1999; 15: 412-426.
3. English P, Williams G. Hyperglycaemic crises and lactic acidosis in diabetes mellitus. Postgrad Med J 2004; 80: 253-261.
4. Sacks DB, Arnold M, Bakris GL, Bruns DE, Horvath AR, Kirkman MS et al. Guidelines and recommendations for laboratory analysis in the diagnosis and management of diabetes mellitus. Diabetes Care 2011; 34: e61-99.
5. Taboulet P, Haas L, Porcher R, Manamani J, Fontaine J-P, Feugeas J-P et al. Urinary acetoacetate or capillary beta-hydroxybutyrate for the diagnosis of ketoacidosis in the Emergency Department setting. Eur J Emerg Med 2004; 11: 251-258.
6. Voulgari C, Tentolouris N. The Performance of a Glucose-Ketone Meter in the Diagnosis of Diabetic Ketoacidosis in Patients with Type 2 Diabetes in the Emergency Room. Diabetes Technol Ther 2010; 12: 529-535.
7. Charles RA, Bee YM, Eng PHK, Goh SY. Point-of-care blood ketone testing: screening for diabetic ketoacidosis at the emergency department. Singapore Med J 2007; 48: 986-989.
8. Noyes KJ, Crofton P, Bath LE, Holmes A, Stark L, Oxley CD et al. Hydroxybutyrate near-patient testing to evaluate a new end-point for intravenous insulin therapy in the treatment of diabetic ketoacidosis in children. Pediatr Diabetes 2007; 8: 150-156.
9. Sheikh-Ali M, Karon BS, Basu A, Kudva YC, Muller LA, Xu J et al. Can serum beta-hydroxybutyrate be used to diagnose diabetic ketoacidosis? Diabetes Care 2008; 31: 643-647.
10. Savage MW, Dhatariya KK, Kilvert A, Rayman G, Rees JA, Courtney CH et al. Joint British Diabetes Societies guideline for the management of diabetic ketoacidosis. Diabet Med 2011; 28: 508-515.
11. Umpierrez GE, Watts N, Phillips L. Clinical Utility of β3-Hydroxybutyrate Determined by Reflectance Meter in the Management of Diabetic Ketoacidosis. Diabetes Care 1995; 18: 137-138.
12. Guerci B, Benichou M, Floriot M, Bohme P, Fougnot S, Franck P et al. Accuracy of an electrochemical sensor for measuring capillary blood ketones by fingerstick samples during metabolic deterioration after continuous subcutaneous insulin infusion interruption in type 1 diabetic patients. Diabetes Care 2003; 26: 1137-1141.
13. Chiu RWK, Ho CS, Tong SF, Ng KF, Lam CW. Evaluation of a new handheld biosensor for point-of-care testing of whole blood beta-hydroxybutyrate concentration. Hong Kong Med J 2002; 8: 172-176.
14. Byrne HA, Tieszen KL, Hollis S, Dornan TL, New JP. Evaluation of an electrochemical sensor for measuring blood ketones. Diabetes Care 2000; 23: 500-503.
15. Wallace TM, Meston NM, Gardner SG, Matthews DR. The hospital and home use of a 30-second hand-held blood ketone meter: guidelines for clinical practice. Diabet Med 2001; 18: 640-645.
16. Yu H-YE, Agus M, Kellogg MD. Clinical utility of Abbott Precision Xceed Pro® ketone meter in diabetic patients. Pediatr Diabetes 2011; 12: 649-655.
17. Ham MR, Okada P, White PC. Bedside ketone determination in diabetic children with hyperglycemia and ketosis in the acute care setting. Pediatr Diabetes 2004; 5: 39-43.
18. Khan ASA, Talbot JA, Tieszen KL, Gardener EA, Gibson JM, New JP. Evaluation of a bedside blood ketone sensor: the effects of acidosis, hyperglycaemia and acetoacetate on sensor performance. Diabet Med 2004; 21: 782-785.
19. Yu H-YE, Agus M, Kellogg MD. Clinical utility of Abbott Precision Xceed Pro® ketone meter in diabetic patients. Pediatr Diabetes 2011; 12: 649-655.
20. Janssen MJW, Hendrickx BHE. Habets-van Der Poel CD, Van Den Bergh JPW, Haagen AAM, Bakker JA. Accuracy of the Precision® point-of-care ketone test examined by liquid chromatography tandem-mass spectrometry (LC-MS/MS) in the same fingerstick sample. Clin Chem Lab Med 2010; 48: 1781-1784.
21. Klocke A, Phelan H, Twigg S, Craig M. Systematic Review: Blood beta-hydroxybutyrate vs. urine acetoacetate testing for the prevention and management of ketoacidosis in Type 1 diabetes. Diabet Med 2013; 30: 818-824.
22. National External Quality Assurance Scheme, Clinical Chemistry. Available at: http://www.ukneqas.org.uk/content/PageServer.asp?S=606515537&C=1252&Type=N&AID=16&SID=99 website. Last accessed 10 July 2014.
23. Welsh External Quality Assurance Scheme for point-of-care testing. Available at: http://www.weqas.com/poct/index.html. Last accessed 10 July 2014.
24. Kitabchi AE, Umpierrez GE, Miles JM, Fisher JN. Hyperglycemic crises in adult patients with diabetes. Diabetes Care 2009; 32: 1335-1343.
25. Wolfsdorf J, Craig ME, Daneman D, Dunger D, Edge J, Lee W et al. Diabetic ketoacidosis in children and adolescents with diabetes. Pediatr Diabetes 2009; 10(Suppl. 1): 118-133.
26. Turan S, Omar A, Bereket A. Comparison of capillary blood ketone measurement by electrochemical method and urinary ketone in treatment of diabetic ketosis and ketoacidosis in children. Acta Diabetol 2008; 45: 83-85.
27. Arora S, Henderson SO, Long T, Menchine M. Diagnostic accuracy of point-of-care testing for diabetic ketoacidosis at emergency-department triage: beta-hydroxybutyrate versus the urine dipstick. Diabetes Care 2011; 34: 852-854.
28. Naunheim R, Jang TJ, Banet G, Richmond A, McGill J. Point-of-care Test Identifies Diabetic Ketoacidosis at Triage. Acad Emerg Med 2006; 13: 683-685.
29. Bektas F, Eray O, Sari R, Akbas H. Point of care blood ketone testing of diabetic patients in the emergency department. Endocr Res 2004; 30: 395-402.
30. Arora S, Henderson SO, Long T, Menchine M. Diagnostic accuracy of point-of-care testing for diabetic ketoacidosis at emergency-department triage: {beta}-hydroxybutyrate versus the urine dipstick. Diabetes Care 2011; 34: 852-854.
31. Samuelsson U, Ludvigsson J. When should determination of ketonemia be recommended? Diabetes Technol Ther 2002; 4: 645-650.
32. Harris S, Ng R, Syed H, Hillson R. Near patient blood ketone measurements and their utility in predicting diabetic ketoacidosis. Diabet Med 2005; 22: 221-224.
33. Taboulet P, Deconinck N, Thurel A, Haas L, Manamani J, Porcher R et al. Correlation between urine ketones (acetoacetate) and capillary blood ketones (3-beta-hydroxybutyrate) in hyperglycaemic patients. Diabetes Metab 2007; 33: 135-139.
34. Mackay L, Lyall M, Delaney S, McKnight J, Strachan M. Are blood ketones a better predictor than urine ketones of acid base balance in diabetic ketoacidosis? Pract Diabetes Int 2010; 27: 396-399.
35. Mesa J, Salcedo D, Calle Hde L, Delgado E, Nóvoa J, Hawkins F et al. Detection of ketonemia and its relationship with hyperglycemia in type 1 diabetic patients. Diabetes Res Clin Pract 2006; 72: 292-297.
36. Fulop M, Murthy V, Michilli A, Nalamati J, Qian Q, Saitowitz A. Serum beta-hydroxybutyrate measurement in patients with uncontrolled diabetes mellitus. Arch Intern Med 1999; 159: 381-384.
37. Prisco F, Picardi A, Iafusco D, Lorini R, Minicucci L, Martinucci ME et al. Blood ketone bodies in patients with recent-onset type 1 diabetes (a multicenter study). Pediatr Diabetes 2006; 7: 223-228.
38. Arora S, Probst MA, Agy C, Menchine M. Point-of-care beta-hydroxybutyrate testing for assessing diabetic ketoacidosis severity prior to treatment in the emergency department. Diabetes Res Clin Pract 2011; 94: e86-88.
39. Wiggam M, O'Kane M, Harper R, Atkinson A, Hadden D, Trimble E et al. Treatment of diabetic ketoacidosis using endpoint of emergency management. A randomized controlled study. Diabetes Care 1997; 20: 1347-1352.
40. Rewers A, McFann K, Chase HP. Bedside monitoring of blood beta-hydroxybutyrate levels in the management of diabetic ketoacidosis in children. Diabetes Technol Ther 2006; 8: 671-676.
41. Loh TP, Saw S, Sethi SK. Bedside monitoring of blood ketone for management of diabetic ketoacidosis: proceed with care. Diabet Med 2012; 29: 827-828.
42. Wallace TM, Matthews DR. Recent advances in the monitoring and management of diabetic ketoacidosis. QJM 2004; 97: 773-780.
43. Laffel LMB, Wentzell K, Loughlin C, Tovar A, Moltz K, Brink S. Sick day management using blood 3-hydroxybutyrate (3-OHB) compared with urine ketone monitoring reduces hospital visits in young people with T1DM: a randomized clinical trial. Diabet Med 2006; 23: 278-284.
44. Orsini-Federici M, Akwi JA, Canonico V, Celleno R, Ferolla P, Pippi R et al. Early detection of insulin deprivation in continuous subcutaneous insulin infusion-treated patients with type 1 diabetes. Diabetes Technol Ther 2006; 8: 67-75.
45. Evans NR, Richardson LS, Dhatariya KK, Sampson MJ. Diabetes specialist nurse telemedicine: admissions avoidance, costs and casemix. Pract Diabetes 2012; 29: 25-29.
46. Bismuth E, Svoren B, Volkening L, Butler D, Laffel L. Impact of insulin pump therapy and blood BOHB ketone monitoring on glycemic outcomes in youth with type 1 diabetes. Diabetes 2007; 56: pA485.
47. Vanelli M, Chiari G, Ghizzoni L, Costi G, Giacalone T, Chiarelli F. Effectiveness of a prevention program for diabetic ketoacidosis in children. An 8-year study in schools and private practices. Diabetes Care 1999; 22: 7-9.
48. Misra S, Barth JH. Clinica Chimica Acta How good is the evidence base for test selection in clinical guidelines ? Clin Chim Acta 2014; 432: 27-32.
49. Lijmer JG, Leeflang M, Bossuyt PMM. Proposals for a phased evaluation of medical tests. Med Decis Making 2009; 29: E13?E21.
50. Sampson M. Adoption and outcomes of Joint British Diabetes guidelines for inpatient care. Present Diabetes UK 2013. Available at: http://www.diabetes.org.uk/upload/DPC_Speakers2013/Thur/11.10_Thu_Sampson_Hall.pdf. Last accessed 10 July 2014.