Correlation between urine ketones (acetoacetate) and capillary blood ketones (3-beta-hydroxybutyrate) in hyperglycaemic patients

Diabetes and Metabolism

Volumn 33, Issue 2, 2007, Pages 135-139

  Taboulet, P ^a   Deconinck, N ^a   Thurel, A ^a   Haas, L ^a   Manamani, J ^a   Porcher, R ^a   Schmit, C ^a   Fontaine, J P ^a   Gautier, J F ^a  

^a SAINT LOUIS HOSPITAL   (France)

Author keywords

3 Beta hydroxybutyrate; Acetoacetate; Diabetes; Ketoacidosis; Ketones

Indexed keywords

3 HYDROXYBUTYRIC ACID; ACETOACETIC ACID; GLUCOSE; KETONE DERIVATIVE;

AGED; ARTICLE; BLOOD ANALYSIS; CAPILLARY BLOOD; DEVICE; DIAGNOSTIC ACCURACY; EMERGENCY WARD; FEMALE; GLUCOSE BLOOD LEVEL; HOSPITALIZATION; HUMAN; HYPERGLYCEMIA; KETOACIDOSIS; MAJOR CLINICAL STUDY; MALE; RETROSPECTIVE STUDY; RISK ASSESSMENT; URINE LEVEL;

3-HYDROXYBUTYRIC ACID; ACETOACETATES; ADOLESCENT; ADULT; AGED; AGED, 80 AND OVER; FEMALE; HUMANS; HYPERGLYCEMIA; KETONES; MALE; MIDDLE AGED; RETROSPECTIVE STUDIES; ROC CURVE;

EID: 34147177100     PISSN: 12623636     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.diabet.2006.11.006     Document Type: Article

References (29)

1. Taboulet P., Haas L., Porcher R., Manamani J., Fontaine J.P., Feugeas J.P., et al. Urinary acetoacetate or capillary 3-hydroxybutyrate for the diagnosis of ketoacidosis in the Emergency Department setting. Eur. J. Emerg. Med. 11 (2004) 251-258
2. Sacks D.B., Bruns D.E., Goldstein D.E., Maclaren N.K., McDonald J.M., and Parrot M. Guidelines and recommendations for laboratory analysis in the diagnosis and management of diabetes mellitus. Clin. Chem. 48 (2002) 436-472
3. Laffel L. Ketone bodies: a review of physiology, pathophysiology and application of monitoring to diabetes. Diabetes Metab. Res. Rev. 15 (1999) 412-426
4. Foreback C.C. Hydroxybutyrate and acetoacetate levels. Am. J. Clin. Pathol. 108 (1997) 602-604
5. Byrne H.A., Tieszen K.L., Hollis S., Dornan T.L., and New J.P. Evaluation of an electrochemical sensor for measuring capillary blood ketones. Diabetes Care 23 (2000) 500-503
6. Guerci B., Tubiana-Rufi N., Bauduceau B., Bresson R., Cuperlier A., Delcroix C., et al. Advantages to using capillary blood 3-hydroxybutyrate determination for the detection and treatment of diabetic ketosis. Diabetes Metab. 31 (2005) 401-406
7. Guerci B., Benichou M., Floriot M., Bohme P., Fougnot S., Franck P., et al. Accuracy of an electrochemical sensor for measuring capillary blood ketones by fingerstick samples during metabolic deterioration after continuous subcutaneous insulin infusion interruption in type 1 diabetic patients. Diabetes Care 26 (2003) 1137-1141
8. American Diabetes Association. Tests of glycemia in diabetes. Diabetes Care 27 (2004) 91-93
9. Meas T., Taboulet P., Sobngwi E., and Gautier J.F. Is capillary ketone determination useful in clinical practice? In which circumstances?. Diabetes Metab. 31 (2005) 299-303
10. American Diabetes Association. Tests of glycemia in diabetes. Diabetes Care 21 (1998) S69-S71
11. Zhang J., and Yu K.F. What's the relative risk? A method of correcting the odds ratio in cohort studies of common outcomes. JAMA 280 (1998) 1690-1691
12. DeLong E.R., DeLong D.M., and Clarke-Pearson D.L. Comparing the areas under two or more correlated receiver operating characteristic curves: a nonparametric approach. Biometrics 44 (1988) 837-845
13. Harris S., Ng R., Syed H., and Hillson R. Near patient blood ketone measurements and their utility in predicting diabetic ketoacidosis. Diabet. Med. 22 (2005) 221-224
14. Tantiwong P., Puavilai G., Ongphiphadhanakul B., Bunnag P., and Ngarmukos C. Capillary blood 3-hydroxybutyrate measurement by reagent strip in diagnosing diabetic ketoacidosis. Clin. Lab. Sci. 18 (2005) 139-144
15. Bektas F., Eray O., Sari R., and Akbas H. Point of care blood ketone testing of diabetic patients in the Emergency Department. Endocr. Res. 30 (2004) 395-402
16. Vanelli M., Chiari G., Capuano C., Iovane B., Bernardini A., and Giacalone T. The direct measurement of 3-hydroxybutyrate enhances the management of diabetic ketoacidosis in children and reduces time and costs of treatment. Diabetes Nutr. Metab. 16 (2003) 312-316
17. Naunheim R., Jang T.J., Banet G., Richmond A., and McGill J. Point-of-care test identifies diabetic ketoacidosis at triage. Acad. Emerg. Med. 13 (2006) 683-685
18. MacGillivray M.H., Li P.K., Lee J.T., Mills B.J., Voorhess M.L., Putman T.I., et al. Elevated plasma 3-hydroxybutyrate concentrations without urine ketones in healthy insulin-dependent diabetic patients. J. Clin. Endocrinol. Metab. 54 (1982) 665-668
19. Foster D.W., and McGarry J.D. The metabolic derangements and treatment of diabetic ketoacidosis. N. Engl. J. Med. 309 (1983) 159-169
20. Sulway M.J., and Malins J.M. Acetone in diabetic ketoacidosis. Lancet 2 (1970) 736-740
21. Samuelsson U., and Ludvigsson J. When should determination of ketonemia be recommended?. Diabetes Technol. Ther. 4 (2002) 645-650
22. Wallace T.M., and Matthews D.R. Recent advances in the monitoring and management of diabetic ketoacidosis. Q. J. Med. 97 (2004) 773-780
23. Wijaya I.P., Soewondo P., Widodo D., and Sudoyo A.W. Beta-hydroxybutirate levels as a determinant for the success of diabetic ketoacidosis management. Acta Med. Indones. 36 (2004) 70-77
24. Ham M.R., Okada P., and White P.C. Bedside ketone determination in diabetic children with hyperglycemia and ketosis in the acute care setting. Pediatr. Diabetes 5 (2004) 39-43
25. Umpierrez G.E., Watts N.B., and Phillips L.S. Clinical utility of 3-hydroxybutyrate determined by reflectance meter in the management of diabetic ketoacidosis. Diabetes Care 18 (1995) 137-138
26. Wiggam M.I., O'Kane M.J., Harper R., Atkinson A.B., Hadden D.R., Trimble E.R., et al. Treatment of diabetic ketoacidosis using normalization of blood 3-hydroxybutyrate concentration as the endpoint of emergency management. A randomized controlled study. Diabetes Care 20 (1997) 1347-1352
27. Wallace T.M., Meston N.M., Gardner S.G., and Matthews D.R. The hospital and home use of a 30-second hand-held blood ketone meter: guidelines for clinical practice. Diabet. Med. 18 (2001) 640-645
28. Schwab T.M., Hendey G.W., and Soliz T.C. Screening for ketonemia in patients with diabetes. Ann. Emerg. Med. 34 (1999) 342-346
29. Ma O.J., Rush M.D., Godfrey M.M., and Gaddis G. Arterial blood gas results rarely influence emergency physician management of patients with suspected diabetic ketoacidosis. Acad. Emerg. Med. 10 (2003) 836-841