Urinary acetoacetate or capillary β-hydroxybutyrate for the diagnosis of ketoacidosis in the Emergency Department setting

European Journal of Emergency Medicine

Volumn 11, Issue 5, 2004, Pages 251-258

  Taboulet, Pierre ^a   Haas, Laurent ^a   Porcher, Raphael ^a   Manamani, Jaffar ^a   Fontaine, Jean Paul ^a   Feugeas, Jean Paul ^a   Gautier, Jean Francois ^a  

^a SAINT LOUIS HOSPITAL   (France)

Author keywords

3 hydroxybutyrate; Acetoacetate; Diabetic ketoacidosis; Emergency; Ketone bodies

Indexed keywords

3 HYDROXYBUTYRIC ACID; ACETOACETIC ACID; ACETOACETIC ACID DERIVATIVE; BIOLOGICAL MARKER; KETONE BODY;

ARTICLE; CAPILLARY; CHEMISTRY; COMPARATIVE STUDY; CRITICAL ILLNESS; DIABETIC KETOACIDOSIS; EMERGENCY HEALTH SERVICE; EMERGENCY TREATMENT; FEMALE; HUMAN; MALE; METHODOLOGY; PREDICTION AND FORECASTING; PROGNOSIS; RETROSPECTIVE STUDY; RISK ASSESSMENT; SENSITIVITY AND SPECIFICITY; URINALYSIS; URINE;

3-HYDROXYBUTYRIC ACID; ACETOACETATES; BIOLOGICAL MARKERS; CAPILLARIES; CRITICAL ILLNESS; DIABETIC KETOACIDOSIS; EMERGENCY SERVICE, HOSPITAL; EMERGENCY TREATMENT; FEMALE; HUMANS; KETONE BODIES; MALE; PREDICTIVE VALUE OF TESTS; PROGNOSIS; RETROSPECTIVE STUDIES; RISK ASSESSMENT; SENSITIVITY AND SPECIFICITY; URINALYSIS;

EID: 16644385657     PISSN: 09699546     EISSN: 14735695     Source Type: Journal    
DOI: 10.1097/00063110-200410000-00003     Document Type: Article

References (37)

1. Marshall SM, Walker M, Alberti KGMM. Diabetic ketoacidosis and hyperglycaemic non-ketotic coma. In: Alberti KGMM, DeFronzo RA, Keen H, Zimmet P, (editors): International textbook of diabetes mellitus. New York: John Wiley and Sons; 1992. pp. 1151-1166.
2. Adrogue HJ, Wilson H, Boyd AE III, Suki WN, Eknoyan G. Plasma acid-base patterns in diabetic ketoacidosis. N Engl J Med 1982; 307: 1603-1610.
3. Stephens JM, Sulway MJ, Watkins PJ. Relationship of blood acetoacetate and 3-hydroxybutyrate in diabetes. Diabetes 1971; 20: 485-489.
4. Laffel L. Ketone bodies: a review of physiology, pathophysiology and application of monitoring to diabetes. Diabetes Metab Res Rev 1999; 15: 412-426.
5. Nuwayhid NF, Johnson GF, Feld RD. Kinetic measurement of the combined concentrations of acetoacetate and β-hydroxybutyrate in serum. Clin Chem 1988; 34: 1790-1793.
6. MacGillivray MH, Li PK, Lee JT, Mills BJ, Voorhess ML, Putnam TI, Schaefer PA. Elevated plasma beta-hydroxybutyrate concentrations without ketonuria in healthy insulin-dependent diabetic patients. J Clin Endocrinol Metab 1982; 54: 665-668.
7. Oster JR, Epstein M. Acid-base aspects of ketoacidosis. Am J Nephrol 1984; 4: 137-151.
8. Hood VL, Tannen RL. Maintenance of acid-base homeostasis during ketoacidosis and lactic acidosis. Diabetes Rev 1994; 2: 177-194.
9. American Diabetes Association. Tests of glycemia in diabetes. Diabetes Care 1998; 21(Suppl. 1): S69-S71.
10. Schwab TM, Hendey GW, Soliz TC. Screening for ketonemia in patients with diabetes. Ann Emerg Med 1999; 34: 342-346.
11. Foster DW, McGarry JD. The metabolic derangements and treatment of diabetic ketocidosis. N Engl J Med 1983; 309: 159-169.
12. Sulway MJ, Malins JM. Acetone in diabetic ketoacidosis. Lancet 1970; 2: 736-740.
13. Csako G. False-positive results for ketones with the drug mesna and other free-sulfhydryl compounds. Clin Chem 1987; 33: 289-292.
14. Williamson J, Davidson DF, Zboag DE. Contamination of a specimen with N-acetyl-cysteine infusion: a cause of spurious ketonaemia and hyperglycaemia. Ann Clin Biochem 1989; 26: 207.
15. Rosenbloom AL, Malone JI. Recognition of impending ketoacidosis delayed by ketone reagent strip failure. JAMA 1978; 240: 2462-2464.
16. Foreback CC. Bhydroxybutyrate and cetoacetate levels. Am J Clin Pathol 1997; 108: 602-604.
17. Mercer DW, Losos FJ III, Mason L, Kessler GF Jr. Monitoring therapy with insulin in ketoacidotic patients by quantifying 3-hydroxybutyrate with a commercial kit. Clin Chem 1986; 32: 224-225.
18. Marliss EB, Ohman JL Jr, Aoki TT, Kozak GP. Altered redox state obscuring ketoacidosis in diabetic patients with lactic acidosis. N Engl J Med 1970; 283: 978-980.
19. McMurray CH, Blanchflower WJ, Rice DA. Automated kinetic method for D-3-hydroxybutyrate in plasma or serum. Clin Chem 1984; 30: 421-425.
20. Kuch DD, Feldbruegge DH. Optimized kinetic method for automated determination of beta-hydroxybutyrate. Clin Chem 1987; 33: 1761-1766.
21. Byrne HA, Tieszen KL, Hollis S, New JP. Evaluation of an electrochemical sensor for measuring blood ketones. Diabetes Care 2000; 23: 500-503.
22. Williamson DH. Ketone body production and metabolism in the fetus and newborn. In: Polin RA, Fox WW, (editors): Fetal and neonatal physiology. Philadelphia: W.B. Saunders Co.; 1992. pp. 330-340.
23. Fishbein HA. Diabetic ketoacidosis, hyperosmolar nonketotic coma, lactic acidosis and hypoglycemia. In: Harris MI, Hamman RF, (editors): Diabetes in America (National Diabetes Group). Washington, DC: Department of Health and Human Services; 1985. pp. 1-22.
24. Laffel L. Sick-day management in type 1 diabetes. Endocrinol Metab Clin North Am 2000; 29: 707-723.
25. Wallace TM, Meston NM, Gardner SG, Matthews DR. The hospital and home use of a 30-second hand-held blood ketone meter: guidelines for clinical practice. Diabet Med 2001; 18: 640-645.
26. American Diabetes Association. Tests of glycemia in diabetes. Diabetes Care 2002; 21 (Suppl. 1): S97-S99.
27. Chiu RW, Ho CS, Tong SF, Ng KF, Lam CW. Evaluation of a new handheld biosensor for point-of-care testing of whole blood beta-hydroxybutyrate concentration. Hong Kong Med J 2002; 8: 172-176.
28. Umpierrez GE, Watts NB, Phillips LS. Clinical utility of beta-hydroxybutyrate determined by reflectance meter in the management of diabetic ketoacidosis. Diabetes Care 1995; 18: 137-138.
29. McNemar Q. Note on the sampling error of the differences between correlated proportions of percentages. Psychometrika 1947; 12: 153-157.
30. Paulson WD. Anion gap-bicarbonate relation in diabetic ketoacidosis. Am J Med 1986; 81: 995-1000.
31. Timmons JA, Myer P, Maturen A, Webster R, Schaller E, Leikin J, Barkin R. Use of beta-hydroxybutyric acid levels in the emergency department. Am J Ther 1998; 5: 159-163.
32. Jenkins D, Close CF, Krentz AJ, Nattrass M, Wright AD. Euglycaemic diabetic ketoacidosis: does it exist? Acta Diabetol 1993; 30: 251-253.
33. Wiggam MI, O’Kane MJ, Harper R, Atkinson AB, Hadden DR, Trimble ER, Bell PM. Treatment of diabetic ketoacidosis using normalization of blood 3-hydroxybutyrate concentration as the endpoint of emergency management. A randomized controlled study. Diabetes Care 1997; 20: 1347-1352.
34. Wagner A, Risse A, Brill HL, WienhausenWilke V, Rottmann M, Sondern K, Angelkort B. Therapy of severe diabetic ketoacidosis. Zero-mortality under very-low-dose insulin application. Diabetes Care 1999; 22: 674-677.
35. Elisaf MS, Tsatsoulis AA, Katopodis KP, Siamopoulos KC. Acid-base and electrolyte disturbances in patients with diabetic ketoacidosis. Diabetes Res Clin Pract 1996; 34: 23-27.
36. Munro JF, Campbell IW, McCuish AC, Duncan LJ. Euglycaemic ketoacidosis. BMJ 1973; 2: 578-580.
37. Baldwin L, Price L, Henderson A, Hickman P, Cuneo R. Spurious euglycaemia in severe diabetic ketoacidosis. Lancet 1992; 340: 1407-1408.