Endocrine disruption in human placenta: Expression of the dioxin-inducible enzyme, Cyp1a1, is correlated with that of thyroid hormone-regulated genes

Journal of Clinical Endocrinology and Metabolism

Volumn 99, Issue 12, 2014, Pages E2735-E2743

  Wadzinski, Thomas L ^a,b   Geromini, Katherine ^a   Brewer, Judy McKinley ^a   Bansal, Ruby ^a   Abdelouahab, Nadia ^c   Langlois, Marie France ^c   Takser, Larissa ^c   Zoeller, R Thomas ^a  

^a UNIVERSITY OF MASSACHUSETTS   (United States)

^b BAYSTATE MEDICAL CENTER   (United States)

^c UNIVERSITY OF SHERBROOKE   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOCHROME P450 1A1; GROWTH HORMONE; HYPOXANTHINE PHOSPHORIBOSYLTRANSFERASE; LIOTHYRONINE; MESSENGER RNA; PLACENTA LACTOGEN; THYROID HORMONE; THYROXINE; DIOXIN; ENDOCRINE DISRUPTOR; HUMAN GROWTH HORMONE;

ARTICLE; CONTROLLED STUDY; CYP1A1 GENE; ENDOCRINE DISEASE; FEMALE; FREE LIOTHYRONINE INDEX; FREE THYROXINE INDEX; GENE CONTROL; GENE EXPRESSION REGULATION; GENE TARGETING; GENETIC ASSOCIATION; GH V GENE; HUMAN; HUMAN CELL; HUMAN TISSUE; MATERNAL BLOOD; PL GENE; PROTEIN EXPRESSION; SMOKING; THYROID HORMONE BLOOD LEVEL; TISSUE LEVEL; UMBILICAL CORD BLOOD; ADULT; BIOSYNTHESIS; BLOOD; CELL LINE; CHEMISTRY; DRUG EFFECTS; ENZYMOLOGY; FETUS BLOOD; GENETICS; METABOLISM; PHYSIOLOGY; PLACENTA; PREGNANCY;

ANIMALIA;

ADULT; CELL LINE; CYTOCHROME P-450 CYP1A1; DIOXINS; ENDOCRINE DISRUPTORS; FEMALE; FETAL BLOOD; GENE EXPRESSION REGULATION, ENZYMOLOGIC; HUMAN GROWTH HORMONE; HUMANS; PLACENTA; PLACENTAL LACTOGEN; PREGNANCY; SMOKING; THYROID HORMONES;

EID: 84916613591     PISSN: 0021972X     EISSN: 19457197     Source Type: Journal    
DOI: 10.1210/jc.2014-2629     Document Type: Article

References (31)

1. Zoeller RT, Brown TR, Doan LL, et al. Endocrine-disrupting chemicals and public health protection: a statement of principles from the endocrine society. Endocrinology. 2012;153:4097-4110.
2. Gilbert ME, Rovet J, Chen Z, Koibuchi N. Developmental thyroid hormone disruption: prevalence, environmental contaminants and neurodevelopmental consequences. Neurotoxicology. 2012;33:842-852.
3. Arrojo EDR, Fonseca TL, Werneck-de-Castro JP, Bianco AC. Role of the type 2 iodothyronine deiodinase (D2) in the control of thyroid hormone signaling. Biochim Biophys Acta. 2013;1830:3956-3964.
4. Centers for Disease Control and Prevention. Fourth National Report on Human Exposure to Environmental Chemicals. Atlanta: Centers for Disease Control and Prevention; 2009.
5. Brucker-Davis F. Effects of environmental synthetic chemicals on thyroid function. Thyroid. 1998;8:827-856.
6. Boas M, Feldt-Rasmussen U, Main KM. Thyroid effects of endocrine disrupting chemicals. Mol. Cell. Endocrinol. 2012;355:240-248.
7. Huuskonen P, Storvik M, Reinisalo M, et al. Microarray analysis of the global alterations in the gene expression in the placentas from cigarette-smoking mothers. Clin Pharmacol Ther. 2008;83:542-550.
8. Stejskalova L, Pavek P. The function of cytochrome P450 1A1 enzyme (CYP1A1) and aryl hydrocarbon receptor (AhR) in the placenta. Curr Pharm Biotechnol. 2011;12:715-730.
9. Whyatt RM, Garte SJ, Cosma G, et al. CYP1A1 messenger RNA levels in placental tissue as a biomarker of environmental exposure. Cancer Epidemiol Biomarkers Prev. 1995;4:147-153.
10. Gauger KJ, Giera S, Sharlin DS, Bansal R, Iannacone E, Zoeller RT. Polychlorinated biphenyls 105 and 118 form thyroid hormone receptor agonists after cytochrome P4501A1 activation in rat pituitary GH3 cells. Environ Health Perspect. 2007;115:1623-1630.
11. Freitas J, Cano P, Craig-Veit C, Goodson ML, Furlow JD, Murk AJ. Detection of thyroid hormone receptor disruptors by a novel stable in vitro reporter gene assay. Toxicol In Vitro. 2011;25:257-266.
12. Amano I, Miyazaki W, Iwasaki T, Shimokawa N, Koibuchi N. The effect of hydroxylated polychlorinated biphenyl (OH-PCB) on thyroid hormone receptor (TR)-mediated transcription through nativethyroid hormone response element (TRE). Ind Health. 2010;48:115-118.
13. You SH, Gauger KJ, Bansal R, Zoeller RT. 4-Hydroxy-PCB106 acts as a direct thyroid hormone receptor agonist in rat GH3 cells. Mol Cell Endocrinol. 2006;257-258:26-34.
14. Giera S, Bansal R, Ortiz-Toro TM, Taub DG, Zoeller RT. Individual polychlorinated biphenyl (PCB) congeners produce tissue- and gene-specific effects on thyroid hormone signaling during development. Endocrinology. 2011;152:2909-2919.
15. Abdelouahab N, Langlois MF, Lavoie L, Corbin F, Pasquier JC, Takser L. Maternal and cord-blood thyroid hormone levels and exposure to polybrominated diphenyl ethers and polychlorinated biphenyls during early pregnancy. Am J Epidemiol. 2013;178:701-713.
16. Nickel BE, Cattini PA. Tissue-specific expression and thyroid hormone regulation of the endogenous placental growth hormone variant and chorionic somatomammotropin genes in a human choriocarcinoma cell line. Endocrinology. 1991;128:2353-2359.
17. Samuels HH, Stanley F, Casanova J. Depletion of L-3,5,3′-triiodothyronine and L-thyroxine in euthyroid calf serum for use in cell culture studies of the action of thyroid hormone. Endocrinology. 1979;105:80-85.
18. Pfaffl MW. Anew mathematical model for relative quantification in real-time RT-PCR. Nucleic Acids Res. 2001;29:e45.
19. Meller M, Vadachkoria S, Luthy DA, Williams MA. Evaluation of housekeeping genes in placental comparative expression studies. Placenta. 2005;26:601-607.
20. Statistics Canada. Canadian Health Measures Survey: Cycle 2 Data Tables, 2009 to 2011. Industry Division, ed. 1st ed. Ottawa: Statistics Canada; 2013.
21. Abbassi-Ghanavati M, Greer LG, Cunningham FG. Pregnancy and laboratory studies: a reference table for clinicians. Obstet Gynecol. 2009;114:1326-1331.
22. Santini F, Chiovato L, Ghirri P, et al. Serum iodothyronines in the human fetus and the newborn: evidence for an important role of placenta in fetal thyroid hormone homeostasis. J Clin Endocrinol Metab. 1999;84:493-498.
23. Pasanen M, Pelkonen O. The expression and environmental regulation of P450 enzymes in human placenta. Crit Rev Toxicol. 1994;24:211-229.
24. Bansal R, You SH, Herzig CT, Zoeller RT. Maternal thyroid hormone increases HES expression in the fetal rat brain: an effect mimicked by exposure to a mixture of polychlorinated biphenyls (PCBs). Brain Res Dev Brain Res. 2005;156:13-22.
25. Zoeller RT, Dowling AL, Vas AA. Developmental exposure to polychlorinated biphenyls exerts thyroid hormone-like effects on the expression of RC3/neurogranin and myelin basic protein messenger ribonucleic acids in the developing rat brain. Endocrinology. 2000;141:181-189.
26. Bansal R, Zoeller RT. Polychlorinated biphenyls (Aroclor 1254) do not uniformly produce agonist actions on thyroid hormone responses in the developing rat brain. Endocrinology. 2008;149:4001-4008.
27. Schantz SL, Widholm JJ, Rice DC. Effects of PCB exposure on neuropsychological function in children. Environ Health Perspect. 2003;111:357-576.
28. Tsai PC, Huang W, Lee YC, Chan SH, Guo YL. Genetic polymorphisms in CYP1A1 and GSTM1 predispose humans to PCBs/PCDFs-induced skin lesions. Chemosphere. 2006;63(8):1410-1418.
29. Goth-Goldstein R, Stampfer MR, Erdmann CA, Russell M. Inter-individual variation in CYP1A1 expression in breast tissue and the role of genetic polymorphism. Carcinogenesis. 2000;21:2119-2122.
30. Patel J, Landers K, Li H, Mortimer RH, Richard K. Delivery of maternal thyroid hormones to the fetus. Trends Endocrinol Metab. 2011;22:164-170.
31. Barber KJ, Franklyn JA, McCabe CJ, et al. The in vitro effects of triiodothyronine on epidermal growth factor-induced trophoblast function. J Clin Endocrinol Metab. 2005;90:1655-1661.