Endoplasmic reticulum stress preconditioning antagonizes low-density lipoprotein-induced inflammation in human mesangial cells through upregulation of XBP1 and suppression of the IRE1α/IKK/NF-B pathway

Molecular Medicine Reports

Volumn 11, Issue 3, 2015, Pages 2048-2054

  Yu, Yuan ^a   Zhang, Ling ^a   Liu, Qi ^a   Tang, Lin ^a   Sun, Hang ^a   Guo, Hui ^a  

^a CHONGQING MEDICAL UNIVERSITY   (China)

Author keywords

Chronic kidney disease; Endoplasmic reticulum stress; Feedback regulation; Inflammation; Protective effects

Indexed keywords

BINDING PROTEIN; I KAPPA B KINASE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INOSITOL REQUIRING ENZYME 1 ALPHA; LOW DENSITY LIPOPROTEIN; SMALL INTERFERING RNA; TUNICAMYCIN; UNCLASSIFIED DRUG; X BOX BINDING PROTEIN 1; AUTACOID; CD40 ANTIGEN; CYTOKINE; DNA BINDING PROTEIN; ERN1 PROTEIN, HUMAN; PROTEIN SERINE THREONINE KINASE; REGULATORY FACTOR X TRANSCRIPTION FACTORS; RIBONUCLEASE; TRANSCRIPTION FACTOR;

ARTICLE; CONTROLLED STUDY; ENDOPLASMIC RETICULUM STRESS; GENE EXPRESSION; HUMAN; HUMAN CELL; IMMUNOHISTOCHEMISTRY; MESANGIUM CELL; NEPHRITIS; PROTEIN BINDING; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; UPREGULATION; CELL CULTURE; DRUG EFFECTS; GENE SILENCING; GENETICS; INFLAMMATION; METABOLISM; PATHOLOGY; SIGNAL TRANSDUCTION;

ANTIGENS, CD40; CELLS, CULTURED; CYTOKINES; DNA-BINDING PROTEINS; ENDOPLASMIC RETICULUM STRESS; ENDORIBONUCLEASES; GENE EXPRESSION; GENE SILENCING; HUMANS; I-KAPPA B KINASE; INFLAMMATION; INFLAMMATION MEDIATORS; LIPOPROTEINS, LDL; MESANGIAL CELLS; NF-KAPPA B; PROTEIN-SERINE-THREONINE KINASES; SIGNAL TRANSDUCTION; TRANSCRIPTION FACTORS; TUNICAMYCIN;

EID: 84916607982     PISSN: 17912997     EISSN: 17913004     Source Type: Journal    
DOI: 10.3892/mmr.2014.2960     Document Type: Article

References (30)

1. Wakasugi M, Kazama JJ and Narita I: Differences in the local and national prevalences of chronic kidney disease based on annual health check program data. Clin Exp Nephrol 16: 749-754, 2012.
2. Nitta K: Clinical assessment and management of dyslipidemia in patients with chronic kidney disease. Clin Exp Nephrol 16: 522-529, 2012.
3. Vaziri ND and Norris K: Lipid disorders and their relevance to outcomes in chronic kidney disease. Blood Purif 31: 189-196, 2011.
4. Podrez EA: Anti-oxidant properties of high-density lipoprotein and atherosclerosis. Clin Exp Pharmacol Physiol 37: 719-725, 2010.
5. Pirillo A, Norata GD and Catapano AL: LOX-1, OxLDL, and atherosclerosis. Mediators Inflamm 2013: 152786, 2013.
6. Xu C, Bailly-Maitre B and Reed JC: Endoplasmic reticulum stress: cell life and death decisions. J Clin Invest 115: 2656-2664, 2005.
7. Inagi R: Endoplasmic reticulum stress as a progression factor for kidney injury. Curr Opin Pharmacol 10: 156-165, 2010.
8. Dickhout JG and Krepinsky JC: Endoplasmic reticulum stress and renal disease. Antioxid Redox Signal 11: 2341-2352, 2009.
9. Chiang CK, Hsu SP, Wu CT, et al: Endoplasmic reticulum stress implicated in the development of renal fibrosis. Mol Med 17: 1295-1305, 2011.
10. Li J, Wang JJ and Zhang SX: Preconditioning with endoplasmic reticulum stress mitigates retinal endothelial inflammation via activation of X-box binding protein 1. J Biol Chem 286: 4912-4921, 2011.
11. Aminzadeh MA, Sato T and Vaziri ND: Participation of endoplasmic reticulum stress in the pathogenesis of spontaneous glomerulosclerosis ? role of intra-renal angiotensin system. Transl Res 160: 309-318, 2012.
12. Inagi R, Kumagai T, Nishi H, et al: Preconditioning with endoplasmic reticulum stress ameliorates mesangioproliferative glomerulonephritis. J Am Soc Nephrol 19: 915-922, 2008.
13. Cottone S, Lorito MC, Riccobene R, et al: Oxidative stress, inflammation and cardiovascular disease in chronic renal failure. J Nephrol 21: 175-179, 2008.
14. Santini E, Lupi R, Baldi S, et al: Effects of different LDL particles on inflammatory molecules in human mesangial cells. Diabetologia 51: 2117-2125, 2008.
15. Livak MJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods 25: 402-408, 2001.
16. Meng Z, Yan C, Deng Q, et al: Oxidized low-density lipoprotein induces inflammatory responses in cultured human mast cells via Toll-like receptor 4. Cell Physiol Biochem 31: 842-853, 2013.
17. van Tits LJ, Stienstra R, van Lent PL, et al: Oxidized LDL enhances pro-inflammatory responses of alternatively activated M2 macrophages: a crucial role for Krüppel-like factor 2. Atherosclerosis 214: 345-349, 2011.
18. Massy ZA, Kim Y, Guijarro C, et al: Low-density lipoprotein-induced expression of interleukin-6, a marker of human mesangial cell inflammation: effects of oxidation and modulation by lovastatin. Biochem Biophys Res Commun 267: 536-540, 2000.
19. Antoniades C, Bakogiannis C, Tousoulis D, Antonopoulos AS and Stefanadis C: The CD40/CD40 ligand system: linking inflammation with atherothrombosis. J Am Coll Cardiol 54: 669-677, 2009.
20. Yellin MJ, D'Agati V, Parkinson G, et al: Immunohistologic analysis of renal CD40 and CD40L expression in lupus nephritis and other glomerulonephritides. Arthritis Rheum 40: 124-134, 1997.
21. Kuroiwa T, Schlimgen R, Illei GG, McInnes IB and Boumpas DT: Distinct T cell/renal tubular epithelial cell interactions define differential chemokine production: implications for tubulointerstitial injury in chronic glomerulonephritides. J Immunol 164: 3323-3329, 2000.
22. Tanaka T, Kuroiwa T, Ikeuchi H, et al: Human platelets stimulate mesangial cells to produce monocyte chemoattractant protein-1 via the CD40/CD40 ligand pathway and may amplify glomerular injury. J Am Soc Nephrol 13: 2488-2496, 2002.
23. Deambrosis I, Scalabrino E, Deregibus MC, Camussi G and Bussolati B: CD40-dependent activation of phosphatidylinositol 3-kinase/AKT pathway inhibits apoptosis of human cultured mesangial cells induced by oxidized LDL. Int J Immunopathol Pharmacol 18: 327-337, 2005.
24. Su J, Zhou L, Kong X, et al: Endoplasmic reticulum is at the crossroads of autophagy, inflammation, and apoptosis signaling pathways and participates in the pathogenesis of diabetes mellitus. J Diabetes Res 2013: 193461, 2013.
25. Li J, Wang JJ, Yu Q, Wang M and Zhang SX: Endoplasmic reticulum stress is implicated in retinal inflammation and diabetic retinopathy. FEBS Lett 583: 1521-1527, 2009.
26. Hayakawa K, Hiramatsu N, Okamura M, et al: Acquisition of anergy to proinflammatory cytokines in nonimmune cells through endoplasmic reticulum stress response: a mechanism for subsidence of inflammation. J Immunol 182: 1182-1191, 2009.
27. Gora S, Maouche S, Atout R, et al: Phospholipolyzed LDL induces an inflammatory response in endothelial cells through endoplasmic reticulum stress signaling. FASEB J 24: 3284-3297, 2010.
28. Hung CC, Ichimura T, Stevens JL and Bonventre JV: Protection of renal epithelial cells against oxidative injury by endoplasmic reticulum stress preconditioning is mediated by ERK1/2 activation. J Biol Chem 278: 29317-29326, 2003.
29. So JS, Hur KY, Tarrio M, et al: Silencing of lipid metabolism genes through IRE1α-mediated mRNA decay lowers plasma lipids in mice. Cell Metab 16: 487-499, 2012.
30. Lee AH, Heidtman K, Hotamisligil GS and Glimcher LH: Dual and opposing roles of the unfolded protein response regulated by IRE1alpha and XBP1 in proinsulin processing and insulin secretion. Proc Natl Acad Sci USA 108: 8885-8890, 2011.