Effect of increasing pump speed during exercise on peak oxygen uptake in heart failure patients supported with a continuous-flow left ventricular assist device. A double-blind randomized study

European Journal of Heart Failure

Volumn 16, Issue 4, 2014, Pages 403-408

  Jung, Mette Holme ^a   Hansen, Peter Bo ^a   Sander, Kaare ^a   Olsen, Peter Skov ^a   Rossing, Kasper ^a   Boesgaard, Soeren ^a   Russell, Stuart D ^b   Gustafsson, Finn ^a  

^a Rigshospitalet   (Denmark)

^b JOHNS HOPKINS HOSPITAL   (United States)

Author keywords

Heart failure; LVAD; Peak oxygen uptake; Ventricular assistance

Indexed keywords

LACTATE DEHYDROGENASE; OXYGEN;

ADULT; AGED; ARTICLE; CARBON DIOXIDE EXCRETION; CARDIOVASCULAR PARAMETERS; CLINICAL ARTICLE; CONTINUOUS FLOW LEFT VENTRICULAR ASSIST DEVICE; CONTROLLED STUDY; DOUBLE BLIND PROCEDURE; EQUIPMENT DESIGN; ERGOMETRY; EXERCISE TEST; FEMALE; FUNCTIONAL STATUS; HEART FAILURE; HEART LEFT VENTRICLE EJECTION FRACTION; HUMAN; LACTATE DEHYDROGENASE BLOOD LEVEL; LUNG MINUTE VOLUME; MALE; OXYGEN CONSUMPTION; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; TRANSTHORACIC ECHOCARDIOGRAPHY; BLOOD; BLOOD PRESSURE; DEVICES; ECHOCARDIOGRAPHY; ECHOGRAPHY; EXERCISE; HEART ASSIST DEVICE; HEART VENTRICLE; MIDDLE AGED; PATHOPHYSIOLOGY; PHYSIOLOGY; PROCEDURES; YOUNG ADULT;

ADULT; AGED; BLOOD PRESSURE; DOUBLE-BLIND METHOD; ECHOCARDIOGRAPHY; EXERCISE; EXERCISE TEST; FEMALE; HEART FAILURE; HEART VENTRICLES; HEART-ASSIST DEVICES; HUMANS; MALE; MIDDLE AGED; OXYGEN; OXYGEN CONSUMPTION; YOUNG ADULT;

EID: 84916605607     PISSN: 13889842     EISSN: 18790844     Source Type: Journal    
DOI: 10.1002/ejhf.52     Document Type: Article

References (26)

1. Kirklin JK, Naftel DC, Kormos RL, Stevenson LW, Pagani FD, Miller MA, Timothy Baldwin J, Young JB,. Fifth INTERMACS annual report: risk factor analysis from more than 6,000 mechanical circulatory support patients. J Heart Lung Transplant 2013; 32: 141-56.
2. Slaughter MS, Pagani FD, Rogers JG, Miller LW, Sun B, Russell SD, Starling RC, Chen L, Boyle AJ, Chillcott S, Adamson RM, Blood MS, Camacho MT, Idrissi KA, Petty M, Sobieski M, Wright S, Myers TJ, Farrar DJ,. Clinical management of continuous-flow left ventricular assist devices in advanced heart failure. J Heart Lung Transplant 2010; 29: 1-39.
3. Rose EA, Gelijns AC, Moskowitz AJ, Heitjan DF, Stevenson LW, Dembitsky W, Long JW, Ascheim DD, Tierney AR, Levitan RG, Watson JT, Meier P, Ronan NS, Shapiro PA, Lazar RM, Miller LW, Gupta L, Frazier OH, Desvigne-Nickens P, Oz MC, Poirier VL,. Long-term use of a left ventricular assist device for end-stage heart failure. N Engl J Med 2001; 345: 1435-1443.
4. Rogers JG, Aaronson KD, Boyle AJ, Russell SD, Milano CA, Pagani FD, Edwards BS, Park S, John R, Conte JV, Farrar DJ, Slaughter MS,. Continuous flow left ventricular assist device improves functional capacity and quality of life of advanced heart failure patients. J Am Coll Cardiol 2010; 55: 1826-1834.
5. Brassard P, Jensen AS, Nordsborg N, Gustafsson F, Moller JE, Hassager C, Boesgaard S, Hansen PB, Olsen PS, Sander K, Secher NH, Madsen PL,. Central and peripheral blood flow during exercise with a continuous-flow left ventricular assist device: constant versus increasing pump speed: a pilot study. Circ Heart Fail 2011; 4: 554-560.
6. Beaver WL, Wasserman K, Whipp BJ,. A new method for detecting anaerobic threshold by gas exchange. J Appl Physiol 1986; 60: 2020-2027.
7. TM during exercise. Int J Sports Med 2009; 30: 747-753.
8. Sheth SS, Maxey DM, Drain AE, Feinstein JA,. Validation of the Innocor device for noninvasive measurement of oxygen consumption in children and adults. Pediatr Cardiol 2013; 34: 847-852.
9. Scheeren TW, Schober P, Schwarte LA,. Monitoring tissue oxygenation by near infrared spectroscopy (NIRS): background and current applications. J Clin Monit Comput 2012; 26: 279-287.
10. Noor MR, Bowles C, Banner NR,. Relationship between pump speed and exercise capacity during HeartMate II left ventricular assist device support: influence of residual left ventricular function. Eur J Heart Fail 2012; 14: 613-620.
11. Jakovljevic DG, George RS, Nunan D, Donovan G, Bougard RS, Yacoub MH, Birks EJ, Brodie DA,. The impact of acute reduction of continuous-flow left ventricular assist device support on cardiac and exercise performance. Heart 2010; 96: 1390-1395.
12. Myers TJ, Bolmers M, Gregoric ID, Kar B, Frazier OH,. Assessment of arterial blood pressure during support with an axial flow left ventricular assist device. J Heart Lung Transplant 2009; 28: 423-427.
13. Andersen M, Gustafsson F, Madsen PL, Brassard P, Jensen AS, Secher N, Hassager C, Nordsborg N, Møller JE,. Hemodynamic stress echocardiography in patients supported with a continuous flow left ventricular assist device. JACC Cardiovasc Imaging 2010; 3: 854-859.
14. Balady GJ, Arena R, Sietsema K, Myers J, Coke L, Fletcher GF, Forman D, Franklin B, Guazzi M, Gulati M, Keteyian SJ, Lavie CJ, Macko R, Mancini D, Milani RV,. Clinician's Guide to cardiopulmonary exercise testing in adults: a scientific statement from the American Heart Association. Circulation 2010; 122: 191-225.
15. Lang CC, Agostoni P, Mancini DM,. Prognostic significance and measurement of exercisederived hemodynamic variables in patients with heart failure. J Card Fail 2007; 13: 672-679.
16. Leibner ES, Cysyk J, Eleuteri K, El-Banayosy A, Boehmer JP, Pae WE,. Changes in the functional status measures of heart failure patients with mechanical assist devices. ASAIO J 2013; 59: 117-122.
17. Haft J, Armstrong W, Dyke DB, Aaronson KD, Koelling TM, Farrar DJ, Pagani FD,. Hemodynamic and exercise performance with pulsatile and continuous-flow left ventricular assist devices. Circulation 2007; 116: 8-15.
18. Mezzani A, Agostoni P, Cohen-Solal A, Corra U, Jegier A, Kouidi E, Mazic S, Meurin P, Piepoli M, Simon A, Laethem CV, Vanhees L,. Standards for the use of cardiopulmonary exercise testing for the functional evaluation of cardiac patients: a report from the Exercise Physiology Section of the European Association for Cardiovascular Prevention and Rehabilitation. Eur J Cardiovasc Prev Rehabil 2009; 16: 249-267.
19. Cohn JN, Johnson G, Ziesche S, Cobb F, Francis G, Tristani F, Smith R, Dunkman WB, Loeb H, Wong M,. A comparison of enalapril with hydralazine-isosorbide dinitrate in the treatment of chronic congestive heart failure. N Engl J Med 1991; 325: 303-310.
20. Young JB, Abraham WT, Smith AL, Leon AR, Lieberman R, Wilkoff B, Canby RC, Schroeder JS, Liem LB, Hall S, Wheelan K,. Combined cardiac resynchronization and implantable cardioversion defibrillation in advanced chronic heart failure: the MIRACLE ICD Trial. JAMA 2003; 289: 2685-2694.
21. Fletcher GF, Ades PA, Kligfield P, Arena R, Balady GJ, Bittner VA, Coke LA, Fleg JL, Forman DE, Gerber TC, Gulati M, Madan K, Rhodes J, Thompson PD, Williams MS,. Exercise standards for Testing and Training: A Scientific Statement from the American Heart Association. Circulation 2013; 128: 873-934.
22. Tumminello G, Guazzi M, Lancellotti P, Piérard,. Exercise ventilation inefficiency in heart failure: pathophysiological and clinical significance. Eur Heart J 2007; 28: 673-678.
23. Spruit MA, Wouters EF, Eterman RM, Meijer K, Wagers SS, Stakenborg KH, Uszko-Lencer NH,. Task-related oxygen uptake and symptoms during activities of daily life in CHF patients and healthy subjects. J Appl Physiol 2011; 111: 1679-1686.
24. Rudski LG, Lai WW, Afilalo J, Hua L, Handschumacher MD, Chandrasekaran K, Solomon SD, Louie EK, Schiller NB,. Guidelines for the echocardiographic assessment of the right heart in adults: a report from the American Society of Echocardiography endorsed by the European Association of Echocardiography, a registered branch of the European Society of Cardiology, and the Canadian Society of Echocardiography. JAM Soc Echocardiogr 2010; 23: 685-713.
25. Maddahi J, Berman DS, Matsuoka DT, Waxman AD, Forrester JS, Swan HJ,. Right ventricular ejection fraction during exercise in normal subjects and in coronary artery disease patients: assessment by multiple-gated equilibrium scintigraphy. Circulation 1980; 62: 133-140.
26. Uriel N, Morrison KA, Garan AR, Kato TS, Yuzefpolskaya M, Latif F, Restaino SW, Mancini DM, Flannery M, Takayama H, John R, Colombo PC, Naka Y, Jorde UP,. Development of a novel echocardiography ramp test for speed optimization and diagnosis of device thrombosis in continuous-flow left ventricular assist devices: the Columbia ramp study. J Am Coll Cardiol 2012; 60: 1764-75.