Central and peripheral blood flow during exercise with a continuous-flow left ventricular assist device constant versus increasing pump speed: A pilot study

Circulation: Heart Failure

Volumn 4, Issue 5, 2011, Pages 554-560

  Brassard, Patrice ^a   Jensen, Annette S ^a   Nordsborg, Nikolai ^a   Gustafsson, Finn ^a   Møller, Jacob E ^a   Hassager, Christian ^a   Boesgaard, Søren ^a   Hansen, Peter Bo ^a   Olsen, Peter Skov ^a   Sander, Kåre ^a   Secher, Niels H ^a   Madsen, Per Lav ^a  

^a UNIVERSITY OF COPENHAGEN   (Denmark)

Author keywords

Cardiac output; Cerebrovascular circulation; Heart failure; Left ventricular assist device

Indexed keywords

BETA ADRENERGIC RECEPTOR BLOCKING AGENT; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; SPIRONOLACTONE; WARFARIN;

ADULT; ARTICLE; BLOOD FLOW VELOCITY; BRAIN PERFUSION; CLINICAL ARTICLE; CONTROLLED STUDY; EXERCISE; EXERCISE TEST; FEMALE; HEART FAILURE; HEART OUTPUT; HUMAN; LEFT VENTRICULAR ASSIST DEVICE; LEG BLOOD FLOW; MALE; MIDDLE CEREBRAL ARTERY; ORGAN BLOOD FLOW; PERIPHERAL CIRCULATION; PILOT STUDY; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; BLOOD FLOW; BLOOD PRESSURE; BRAIN; CIRCULATION; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; HEART ASSIST DEVICE; HEART RATE; HEMODYNAMICS; LEG; MIDDLE AGED; PATHOPHYSIOLOGY; PHYSIOLOGY; TIME; VASCULARIZATION;

ADULT; BLOOD CIRCULATION; BLOOD PRESSURE; BRAIN; CARDIAC OUTPUT; EXERCISE; FEMALE; HEART FAILURE; HEART RATE; HEART-ASSIST DEVICES; HEMODYNAMICS; HUMANS; LEG; MALE; MIDDLE AGED; MIDDLE CEREBRAL ARTERY; PILOT PROJECTS; REGIONAL BLOOD FLOW; TIME FACTORS;

EID: 84856379721     PISSN: 19413289     EISSN: 19413297     Source Type: Journal    
DOI: 10.1161/CIRCHEARTFAILURE.110.958041     Document Type: Article

References (35)

1. Rose EA, Gelijns AC, Moskowitz AJ, Heitjan DF, Stevenson LW, Dembitsky W, Long JW, Ascheim DD, Tierney AR, Levitan RG, Watson JT, Meier P, Ronan NS, Shapiro PA, Lazar RM, Miller LW, Gupta L, Frazier OH, Desvigne-Nickens P, Oz MC, Poirier VL. Long-term use of a left ventricular assist device for end-stage heart failure. N Engl J Med. 2001;345:1435-1443.
2. Pagani FD, Miller LW, Russell SD, Aaronson KD, John R, Boyle AJ, Conte JV, Bogaev RC, MacGillivray TE, Naka Y, Mancini D, Massey HT, Chen L, Klodell CT, Aranda JM, Moazami N, Ewald GA, Farrar DJ, Frazier OH. Extended mechanical circulatory support with a continuous-flow rotary left ventricular assist device. J Am Coll Cardiol. 2009;54:312-321.
3. Jaski BE, Kim J, Maly RS, Branch KR, Adamson R, Favrot LK, Smith SC Jr, Dembitsky WP. Effects of exercise during long-term support with a left ventricular assist device: results of the Experience With Left Ventricular Assist Device With Exercise (EVADE) pilot trial. Circulation. 1997;95:2401-2406. (Pubitemid 27224735)
4. Haft J, Armstrong W, Dyke DB, Aaronson KD, Koelling TM, Farrar DJ, Pagani FD. Hemodynamic and exercise performance with pulsatile and continuous-flow left ventricular assist devices. Circulation. 2007;116:I8-I15. (Pubitemid 47480764)
5. Slaughter MS, Rogers JG, Milano CA, Russell SD, Conte JV, Feldman D, Sun B, Tatooles AJ, Delgado RM III, Long JW, Wozniak TC, Ghumman W, Farrar DJ, Frazier OH. Advanced heart failure treated with continuous-flow left ventricular assist device. N Engl J Med. 2009;361:2241-2251.
6. Mancini D, Goldsmith R, Levin H, Beniaminovitz A, Rose E, Catanese K, Flannery M, Oz M. Comparison of exercise performance in patients with chronic severe heart failure versus left ventricular assist devices. Circulation. 1998;98:1178-1183. (Pubitemid 28436167)
7. Travis AR, Giridharan GA, Pantalos GM, Dowling RD, Prabhu SD, Slaughter MS, Sobieski M, Undar A, Farrar DJ, Koenig SC. Vascular pulsatility in patients with a pulsatile-or continuous-flow ventricular assist device. J Thorac Cardiovasc Surg. 2007;133:517-524. (Pubitemid 46136291)
8. Slaughter MS, Pagani FD, Rogers JG, Miller LW, Sun B, Russell SD, Starling RC, Chen L, Boyle AJ, Chillcott S, Adamson RM, Blood MS, Camacho MT, Idrissi KA, Petty M, Sobieski M, Wright S, Myers TJ, Farrar DJ. Clinical management of continuous-flow left ventricular assist devices in advanced heart failure. J Heart Lung Transplant. 2010;29:S1-S39.
9. Sakamoto T. Evaluation of native left ventricular function during mechanical circulatory support: theoretical basis and clinical limitations. Ann Thorac Cardiovasc Surg. 2002;8:1-6.
10. Chen SH. Baroreflex-based physiological control of a left ventricular assist device. Doctoral dissertation. Pittsburg, PA: University of Pittsburg; 2006.
11. Foray A, Williams D, Reemtsma K, Oz M, Mancini D. Assessment of submaximal exercise capacity in patients with left ventricular assist devices. Circulation. 1996;94:II222-II226. (Pubitemid 26363396)
12. Bassett DR Jr, Howley ET. Limiting factors for maximum oxygen uptake and determinants of endurance performance. Med Sci Sports Exerc. 2000;32:70-84. (Pubitemid 30056961)
13. Seifert T, Rasmussen P, Secher NH, Nielsen HB. Cerebral oxygenation decreases during exercise in humans with beta-adrenergic blockade. Acta Physiol (Oxf). 2009;196:295-302.
14. Subudhi AW, Dimmen AC, Roach RC. Effects of acute hypoxia on cerebral and muscle oxygenation during incremental exercise. J Appl Physiol. 2007;103:177-183. (Pubitemid 47092290)
15. de Jonge N, Kirkels H, Lahpor JR, Klopping C, Hulzebos EJ, de la Riviere AB, Robles de Medina EO. Exercise performance in patients with end-stage heart failure after implantation of a left ventricular assist device and after heart transplantation: an outlook for permanent assisting? J Am Coll Cardiol. 2001;37:1794-1799. (Pubitemid 32499961)
16. Borg G. Perceived exertion as an indicator of somatic stress. Scand J Rehabil Med. 1970;2:92-98.
17. Krustrup P, Secher NH, Relu MU, Hellsten Y, Soderlund K, Bangsbo J. Neuromuscular blockade of slow twitch muscle fibres elevates muscle oxygen uptake and energy turnover during submaximal exercise in humans. J Physiol. 2008;586:6037-6048.
18. Andersen P, Saltin B. Maximal perfusion of skeletal muscle in man. J Physiol. 1985;366:233-249. (Pubitemid 16245480)
19. Aaslid R, Markwalder TM, Nornes H. Noninvasive transcranial Doppler ultrasound recording of flow velocity in basal cerebral arteries. J Neurosurg. 1982;57:769-774. (Pubitemid 13208286)
20. Jorgensen LG, Perko G, Secher NH. Regional cerebral artery mean flow velocity and blood flow during dynamic exercise in humans. J Appl Physiol. 1992;73:1825-1830.
21. Madsen PL, Lych F, Pedersen M, Olesen HL, Nielsen H, Secher NH. Brain and muscle oxygen saturation during head-up-tilt-induced central hypovolaemia in humans. Clin Physiol. 1999;15:11.
22. Madsen PL, Secher NH. Near-infrared oximetry of the brain. Prog Neurobiol. 1999;58:541-560. (Pubitemid 29268400)
23. Madsen PL, Nielsen HB, Christiansen P. Well-being and cerebral oxygen saturation during acute heart failure in humans. Clin Physiol. 1999;20:7.
24. Butler KC, Dow JJ, Litwak P, Kormos RL, Borovetz HS. Development of the Nimbus/University of Pittsburgh innovative ventricular assist system. Ann Thorac Surg. 1999;68:790-794. (Pubitemid 29521169)
25. Choi S. Modeling and control of left ventricular assist system. Doctoral dissertation. Pittsburg, PA: University of Pittsburg; 1998.
26. Pawelczyk JA, Hanel B, Pawelczyk RA, Warberg J, Secher NH. Leg vasoconstriction during dynamic exercise with reduced cardiac output. J Appl Physiol. 1992;73:1838-1846.
27. Schmidt TA, Bundgaard H, Olesen HL, Secher NH, Kjeldsen K. Digoxin affects potassium homeostasis during exercise in patients with heart failure. Cardiovasc Res. 1995;29:506-511.
28. Franciosa JA, Park M, Levine TB. Lack of correlation between exercise capacity and indexes of resting left ventricular performance in heart failure. Am J Cardiol. 1981;47:33-39. (Pubitemid 11217567)
29. Higginbotham MB, Morris KG, Conn EH, Coleman RE, Cobb FR. Determinants of variable exercise performance among patients with severe left ventricular dysfunction. Am J Cardiol. 1983;51:52-60. (Pubitemid 13220678)
30. Linkis P, Jorgensen LG, Olesen HL, Madsen PL, Lassen NA, Secher NH. Dynamic exercise enhances regional cerebral artery mean flow velocity. J Appl Physiol. 1995;78:12-16.
31. Secher NH, Seifert T, Van Lieshout JJ. Cerebral blood flow and metabolism during exercise: Implications for fatigue. J Appl Physiol. 2008;104:306-314.
32. Ogoh S, Brothers RM, Barnes Q, Eubank WL, Hawkins MN, Purkayastha S, A OY, Raven PB. The effect of changes in cardiac output on middle cerebral artery mean blood velocity at rest and during exercise. J Physiol. 2005;569:697-704. (Pubitemid 41830133)
33. Ide K, Gullov AL, Pott F, Van Lieshout JJ, Koefoed BG, Petersen P, Secher NH. Middle cerebral artery blood velocity during exercise in patients with atrial fibrillation. Clin Physiol. 1999;19:284-289. (Pubitemid 29373813)
34. Ide K, Pott F, Van Lieshout JJ, Secher NH. Middle cerebral artery blood velocity depends on cardiac output during exercise with a large muscle mass. Acta Physiol Scand. 1998;162:13-20. (Pubitemid 28037111)
35. Larsen TS, Rasmussen P, Overgaard M, Secher NH, Nielsen HB. Nonselective beta-adrenergic blockade prevents reduction of the cerebral metabolic ratio during exhaustive exercise in humans. J Physiol. 2008;586:2807-2815. (Pubitemid 351761793)