Proteasome inhibitor lactacystin enhances cisplatin cytotoxicity by increasing endoplasmic reticulum stress.associated apoptosis in HeLa cells

Molecular Medicine Reports

Volumn 11, Issue 1, 2015, Pages 189-195

  Xu, Ye ^a   Li, Di ^b   Zeng, Linchuan ^a   Wang, Chunyan ^a   Zhang, Lili ^a   Wang, Yan ^a   Yu, Yang ^a   Liu, Shibing ^a   Li, Zhixin ^a  

^a JILIN MEDICAL COLLEGE   (China)

^b FOURTH MILITARY MEDICAL UNIVERSITY   (China)

Author keywords

Apoptosis; Cervical cancer; Cisplatin; ER stress; Lactacystin

Indexed keywords

CASPASE 3; CASPASE 4; CISPLATIN; LACTACYSTIN; PROTEASOME INHIBITOR; ACETYLCYSTEINE; ANTINEOPLASTIC AGENT;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CANCER COMBINATION CHEMOTHERAPY; CANCER THERAPY; CELL GROWTH; CONTROLLED STUDY; CYTOTOXICITY; DRUG EFFECT; ENDOPLASMIC RETICULUM STRESS; FEMALE; HELA CELL LINE; HUMAN; HUMAN CELL; UTERINE CERVIX CANCER; ANALOGS AND DERIVATIVES; CELL PROLIFERATION; DOUBLE STRANDED DNA BREAK; DRUG EFFECTS; DRUG POTENTIATION;

ACETYLCYSTEINE; ANTINEOPLASTIC AGENTS; APOPTOSIS; CELL PROLIFERATION; CISPLATIN; DNA BREAKS, DOUBLE-STRANDED; DRUG SYNERGISM; ENDOPLASMIC RETICULUM STRESS; HELA CELLS; HUMANS; PROTEASOME INHIBITORS;

EID: 84916237709     PISSN: 17912997     EISSN: 17913004     Source Type: Journal    
DOI: 10.3892/mmr.2014.2683     Document Type: Article

References (31)

1. Muggia F: Platinum compounds 30 years after the introduction of cisplatin: implications for the treatment of ovarian cancer. Gynecol Oncol 112: 275-281, 2009.
2. Florea AM and Büsselberg D: Cisplatin as an anti-tumor drug: cellular mechanisms of activity, drug resistance and induced side effects. Cancers (Basel) 3: 1351-1371, 2011.
3. Galluzzi L, Senovilla L, Vitale I, Michels J, Martins I, Kepp O, Castedo M and Kroemer G: Molecular mechanisms of cisplatin resistance. Oncogene 31: 1869-1883, 2012.
4. Eastman A: The formation, isolation and characterization of DNA adducts produced by anticancer platinum complexes. Pharmacol Ther 34: 155-166, 1987.
5. Wozniak K and Błasiak J: Recogn it ion a nd repair of DNA-cisplat in adducts. Acta Biochim Pol 49: 583-596, 2002.
6. Basu A and Krishnamurthy S: Cellular responses to Cisplatin-induced DNA damage. J Nucleic Acids 2010: pii: 201367, 2010.
7. Mandic A, Hansson J, Linder S and Shoshan MC: Cisplatin induces endoplasmic reticulum stress and nucleus-independent apoptotic signaling. J Biol Chem 278: 9100-9106, 2003.
8. Liu H and Baliga R: Endoplasmic reticulum stress-associated caspase 12 mediates cisplatin-induced LLC-PK1 cell apoptosis. J Am Soc Nephrol 16: 1985-1992, 2005.
9. Peyrou M, Hanna PE and Cribb AE: Cisplatin, gentamicin, and p-aminophenol induce markers of endoplasmic reticulum stress in the rat kidneys. Toxicol Sci 99: 346-353, 2007.
10. Yu F, Megyesi J and Price PM: Cytoplasmic initiation of cisplatin cytotoxicity. Am J Physiol Renal Physiol 295: F44-F52, 2008.
11. Berridge MJ: The endoplasmic reticulum: a multifunctional signaling organelle. Cell Calcium 32: 235-249, 2002.
12. Jørgensen MM, Bross P and Gregersen N: Protein quality control in the endoplasmic reticulum. APMIS Suppl 109: 86-91, 2003.
13. Rao RV, Ellerby HM and Bredesen DE: Coupling endoplasmic reticulum stress to the cell death program. Cell Death Differ 11: 372-380, 2004.
14. Kim R, Emi M, Tanabe K and Murakami S: Role of the unfolded protein response in cell death. Apoptosis 11: 5-13, 2006.
15. Benbrook DM and Long A: Integration of autophagy, prote-asomal degradation, unfolded protein response and apoptosis. Exp Oncol 34: 286-297, 2012.
16. Høyer-Hansen M and Jäättelä M: Connecting endoplasmic reticulum stress to autophagy by unfolded protein response and calcium. Cell Death Differ 14: 1576-1582, 2007.
17. Yu H, Su J, Xu Y, Kang J, Li H, Zhang L, Yi H, Xiang X, Liu F and Sun L p62/SQSTM1 involved in cisplatin resistance in human ovarian cancer cells by clearing ubiquitinated proteins. Eur J Cancer 47: 1585-1594, 2011.
18. Xu Y, Yu H, Qin H, Kang J, et al: Inhibition of autophagy enhances cisplatin cytotoxicity through endoplasmic reticulum stress in human cervical cancer cells. Cancer Lett 314: 232-243, 2012.
19. Zhong JT, Xu Y, Yi HW, et al: The BH3 mimetic S1 induces autophagy through ER stress and disruption of Bcl-2/Beclin 1 interaction in human glioma U251 cells. Cancer Lett 323: 180-187, 2012.
20. Liu N, Xu Y, Sun JT, et al: The BH3 mimetic S1 induces endoplasmic reticulum stress-associated apoptosis in cisplatin-resistant human ovarian cancer cells although it activates autophagy. Oncol Rep 30: 2677-2684, 2013.
21. Fenteany G, Standaert RF, Lane WS, Choi S, Corey EJ and Schreiber SL: Inhibition of proteasome activities and subunit-specifc amino-terminal threonine modifcation by lacta-cystin. Science 268: 726-731, 1995
22. Craiu A, Gaczynska M, Akopian T, et al: Lactacystin and clasto-lactacystin beta-lactone modify multiple proteasome beta-subunits and inhibit intracellular protein degradation and major histocompatibility complex class I antigen presentation. J Biol Chem 272: 13437-13445, 1997
23. Ostrowska H, Wojcik C, Omura S and Worowski K: Lactacystin, a specifc inhibitor of the proteasome, inhibits human platelet lysosomal cathepsin A-like enzyme. Biochem Biophys Res Commun 234: 729-732, 1997.
24. Geier E, Pfeifer G, Wilm M, et al: A giant protease with potential to substitute for some functions of the proteasome. Science 283: 978-981, 1999.
25. Rebillard A, Lagadic-Gossmann D and Dimanche-Boitrel MT: Cisplatin cytotoxicity: DNA and plasma membrane targets. Curr Med Chem 15: 2656-2663, 2008.
26. Ogata M, Hino S, Saito A, Morikawa K, et al: Autophagy is activated for cell survival after endoplasmic reticulum stress. Mol Cell Biol 26: 9220-9231, 2006.
27. Lin X, Li S, Zhao Y, Ma X, Zhang K, He X and Wang Z: Interaction domains of p62: a bridge between p62 and selective autophagy. DNA Cell Biol 32: 220-227, 2013.
28. Tanida I: Autophagosome formation and molecular mechanism of autophagy. Antioxid Redox Signal 14: 2201-2214, 2011.
29. Szegezdi E, Logue SE, Gorman AM and Samali A: Mediators of endoplasmic reticulum stress-induced apoptosis. EMBO Rep 7: 880-885, 2006.
30. Tabas I and Ron D: Integrating the mechanisms of apoptosis induced by endoplasmic reticulum stress. Nat Cell Biol 13: 184-190, 2011.
31. Olive PL and Banáth JP: Kinetics of H2AX phosphorylation after exposure to cisplatin. Cytometry B Clin Cytom 76: 79-90, 2009.