The yolk sac tumor: Reflections on a remarkable neoplasm and two of the many intrigued by it - Gunnar Teilum and Aleksander Talerman - And the bond it formed between them

International Journal of Surgical Pathology

Volumn 22, Issue 8, 2014, Pages 677-687

  Young, Robert H ^a,b  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

^b HARVARD MEDICAL SCHOOL   (United States)

Author keywords

germ cell tumor; ovary; testis; yolk sac tumor

Indexed keywords

ADULT; CHILD; DIFFERENTIAL DIAGNOSIS; EMBRYOID BODY; FEMALE; FRIENDSHIP; GERM CELL TUMOR; HISTOGENESIS; HISTOLOGY; HUMAN; MALE; MORPHOLOGY; NONHUMAN; OVARY TUMOR; PATHOLOGIST; PLACENTA; PUBLICATION; RAT; REVIEW; TESTIS TUMOR; TUMOR DIAGNOSIS; YOLK SAC; YOLK SAC TUMOR; ADENOCARCINOMA; PATHOLOGY;

ADENOCARCINOMA, CLEAR CELL; DIAGNOSIS, DIFFERENTIAL; ENDODERMAL SINUS TUMOR; FEMALE; HUMANS; MALE; OVARIAN NEOPLASMS; TESTICULAR NEOPLASMS;

EID: 84916228377     PISSN: 10668969     EISSN: 19402465     Source Type: Journal    
DOI: 10.1177/1066896914558265     Document Type: Review

References (54)

1. Young RH, Teilum D, Talerman A. History of gynecological pathology XXV. Dr. Gunnar Teilum. Int J Gynecol Pathol. 2013 ; 32: 520-527
2. Roth LM, Young RH, Aleksander Talerman M.D.. Int J Gynecol Pathol. 2013 ; 32: 246-247
3. Teilum G Special Tumors of Ovary and Testis. Comparative Pathology and Histological Identification. Copenhagen, Denmark: Munksgaard ; 1971 :
4. Schiller W. Mesonephroma ovarii. Am J Cancer. 1939 ; 35: 1-21
5. Young RH. Dusting off another shelf: further comments on classic gynecologic pathology books of yesteryear. Int J Gynecol Pathol. 2004 ; 24: 100-110
6. Pierce GB, Dixon. FJ. Testicular teratomas. I. Demonstration of teratogenesis by metamorphosis of multipotential cells. Cancer. 1959 ; 12: 573-583
7. Pierce GB, Dixon FJ. Testicular teratomas. II. Teratocarcinoma as an ascitic tumor. Cancer. 1959 ; 12: 584-589
8. Huntington RW, Morgenstern NL, Sargent JA, Giem RN, Richards A, Hanford KC. Germinal tumors exhibiting the endodermal sinus pattern of Teilum in young children. Cancer. 1963 ; 16: 24-47
9. Janovski NA, Paramanandhan TL Major Problems in Obstetrics and Gynecology. Friedman EA, ed. Philadelphia, PA: WB Saunders ; 1973: 96.
10. The Human Yolk Sac and Yolk Sac Tumors. Nogales FF, ed. New York, NY: Springer-Verlag ; 1993 :
11. Nogales FF, Preda O, Nicolae A. Yolk sac tumor revisited. a review of their many faces and names. Histopathology. 2012 ; 60: 1023-1033
12. Gonzalez-Crussi F. The human yolk sac and yolk sac (endodermal sinus) tumors. Perspect Pediatr Pathol. 1979 ; 5: 179-215
13. Talerman A. Yolk sac tumor associated with seminoma of the testis in adults. Cancer. 1974 ; 33: 1468-1473
14. Talerman A. The incidence of yolk sac tumor (endodermal sinus tumor) elements in germ cell tumors of the testis in adults. Cancer. 1975 ; 36: 211-215
15. Talerman A. Endodermal sinus (yolk sac) tumor elements in testicular germ-cell tumors in adults: comparison of prospective and retrospective studies. Cancer. 1980 ; 46: 1213-1217
16. Klemi PJ, Meurman L, Grönroos M, Talerman A. Clear cell (mesonephroid) tumors of the ovary with characteristics resembling endodermal sinus tumor. Int J Gynecol Pathol. 1982 ; 1: 95-100
17. Jacobsen GK, Talerman A Atlas of Germ Cell Tumors. Copenhagen, Denmark: Muuksgaard ; 1989 :
18. Nogales FF, Quiñonez E, López-Marín L, Dulcey I, Ovidiu P. A diagnostic immunohistochemical panel for yolk sac (primitive endodermal) tumours based on an immunohistochemical comparison with the human yolk sac. Histopathology. 2014 ; 65: 51-59
19. Al-Nafussi AI, Hughes DE, Williams ARW. Hyaline globules in ovarian tumors. Histopathology. 1993 ; 23: 563-566
20. Kao CK, Idrees MT, Young RH, Ulbright TM. Solid pattern yolk sac tumor: a morphologic and immunohistochemical study of 52 cases. Am J Surg Pathol. 2012 ; 36: 360-367
21. Kurman RJ, Norris HJ. Endodermal sinus tumor of the ovary. A clinical and pathologic analysis of 71 cases. Cancer. 1976 ; 38: 2404-2419
22. Nogales FF, Matilla A, Nogales-Ortiz F, Galera-Davidson HL. Yolk sac tumors with pure and mixed polyvesicular vitelline patterns. Hum Pathol. 1978 ; 9: 553-566
23. Young RH, Ulbright TM, Policarpio-Nicolas M. Polyvesicular vitelline tumor of the ovary. A report of three cases. Am J Surg Pathol. 2013 ; 37: 393-398
24. Prat J, Bhan AK, Dickersin GR, Robboy SJ, Scully RE. Hepatoid yolk sac tumor of the ovary (endodermal sinus tumor with hepatoid differentiation). A light microscopic, ultrastructural and immunohistochemical study of seven cases. Cancer. 1982 ; 50: 2355-2368
25. Clement PB, Young RH, Scully RE. Endometrioid-like yolk sac tumor of the ovary. A clinicopathological analysis of eight cases. Am J Surg Pathol. 1987 ; 11: 767-778
26. Cohen MB, Friend DS, Molnar JJ, Talerman A. Gonadal endodermal sinus (yolk sac) tumor with pure intestinal differentiation: a new histologic type. Pathol Res Pract. 1987 ; 182: 609-616
27. Ulbright TM, Roth LM, Brodhecker CA. Yolk sac differentiation in germ cell tumors. A morphologic study of 50 cases with emphasis on hepatic, enteric, and parietal yolk sac features. Am J Surg Pathol. 1986 ; 10: 151-164
28. Santesson L, Marrubini G. Clinical and pathological survey of ovarian embryonal carcinomas, including so-called "mesonephromas" (Schiller) or "mesoblastomas" (Teilum) treated at the Radiumhemmet. Acta Obstet Gynecol Scand. 1957 ; 36: 399-419
29. Huntington RW, Bullock WK. Yolk sac tumors of the ovary. Cancer. 1970 ; 25: 1357-1367
30. Langley FA, Goven ADT, Anderson MC, Gowing NF, Woodcock AS, Harilal KR. Yolk sac and allied tumours of the ovary. Histopathology. 1981 ; 5: 389-401
31. Morris HHB, LaVecchia C, Draper GJ. Endodermal sinus tumor and embryonal carcinoma of the ovary in children. Gynecol Oncol. 1985 ; 21: 7-17
32. Stadlmann S, Gueth U, Baumhoer D, Moch H, Terracciano L, Singer G. Glypican-3 expression in primary and recurrent ovarian carcinomas. Int J Gynecol Pathol. 2007 ; 26: 341-344
33. Zirker TA, Silva EG, Morris M, Ordóñez N. Immunohistochemical differentiation of clear-cell carcinoma of the female genital tract and endodermal sinus tumor with the use of alpha-fetoprotein and Leu-MI. Am J Clin Pathol. 1989 ; 91: 511-514
34. Young RH, Dudley G, Scully RE. Granulosa cell, Sertoli-Leydig cell and unclassified sex cord-stromal tumors associated with pregnancy: a clinicopathological analysis of thirty-six cases. Gynecol Oncol. 1984 ; 18: 181-205
35. White CP. A case of carcinoma myxomatodes of the testis occurring in infancy. J Pathol Bacteriol. 1910 ; 14: 522-544
36. Magner D, Bryant AJS. Adenocarcinoma of the testis occurring in infants. Arch Pathol. 1951 ; 51: 82-89
37. Magner D, Campbell JS, Wiglesworth FW. Testicular adenocarcinoma with clear cells, occurring in infancy. Cancer. 1956 ; 9: 165-175
38. Teoh TB, Steward JK, Willis RA. The distinctive adenocarcinoma of the infant's testis: an account of 15 cases. J Pathol Bacteriol. 1960 ; 80: 147-156
39. Pierce GB, Bullock WK, Huntington RW. Yolk sac tumors of the testis. Cancer. 1970 ; 25: 644-658
40. Wold LE, Kramer SA, Farrow GM. Testicular yolk sac and embryonal carcinomas in pediatric patients: comparative immunohisotchemical and clinicopathologic study. Am J Clin Pathol. 1984 ; 81: 427-435
41. Woodtli W, Hedinger C. Endodermal sinus tumor or orchioblastoma in children and adults. Virchows Arch A Pathol Anat Histol. 1974 ; 364: 93-110
42. Ulbright TM, Young RH. Testicular and paratesticular tumors and tumor-like lesions in the first 2 decades. Semin Diagn Pathol. In press ;:
43. Kurman RJ, Norris HJ. Malignant mixed germ cell tumors of the ovary. A clinical and pathologic analysis of 30 cases. Obstet Gynecol. 1976 ; 48: 579-89
44. Peyron A. Faits nouveaux relatifs a I'origine et a I'histogenese des embryomas. Bull Assoc Franc l'etude Cancer. 1939 ; 28: 658-681
45. Marin-Padilla M. Origin, nature and significance of the "embryoids" of human teratomas. Virchows Arch A Pathol Anat Histol. 1965 ; 340: 105-121
46. Gaillard JA. Yolk sac tumor patterns and entoblastic structures in polyembryomas. Acta Pathol Microbiol Scand Suppl. 1972 ; 233: 18-25
47. Evans RW. Developmental stages of embyro-like bodies in teratoma testis. J Clin Pathol. 1957 ; 10: 31-39
48. Simard LC. Polyembryonic embryoma of the ovary of parthenogenetic origin. Cancer. 1957 ; 10: 215-223
49. Takeda A, Ishizuka T, Goto T, et al. Polyembryoma of ovary producing alpha-fetoprotein and HCG: immunoperoxidase and electron microscopic study. Cancer. 1982 ; 14: 1878-1889
50. Prat J, Matias-Guiu X, Scully RE. Hepatic yolk sac differentiation in an ovarian polyembryoma. Surg Pathol. 1989 ; 2: 147-150
51. Young RH, Scully RE. Endodermal sinus tumor of the vagina: a report of nine cases and review of the literature. Gynecol Oncol. 1984 ; 18: 380-392
52. Nogales F, Bergeron C, Carvia RE, Alvaro T, Fulwood HR. Ovarian endometrioid tumors with yolk sac tumor component, an unusual form of ovarian neoplasm. Analysis of six cases. Am J Surg Pathol. 1996 ; 20: 1056-1066
53. Magers MJ, Kao CS, Cole CD, et al. Somatic-type malignancies arising from testicular germ cell tumors. A clinicopathologic study of 124 cases with emphasis on glandular tumors supporting frequent yolk sac tumor origin. Am J Surg Pathol. 2014 ; 38: 1396-1409
54. Howitt BE, Magers MJ, Rice KR, Cole CD, Ulbright TM. Many postchemotherapy sarcomatous tumors in patients with testicular germ cell tumors are sarcomatoid yolk sac tumors. Am J Surg Pathol. 2014 ;: