Reductions in cortisol associated with primary care brief mindfulness program for veterans with PTSD

Medical Care

Volumn 52, Issue , 2014, Pages S25-S31

  Bergen Cico, Dessa ^a   Possemato, Kyle ^b   Pigeon, Wilfred ^c  

^a SYRACUSE UNIVERSITY   (United States)

^b VA Center for Integrated Healthcare   (United States)

^c VETERANS AFFAIRS MEDICAL CENTER   (United States)

Author keywords

Cortisol; Mindfulness; Primary Care; PTSD; Veterans

Indexed keywords

HYDROCORTISONE;

ADULT; AREA UNDER THE CURVE; ARTICLE; BLOOD LEVEL; CLINICAL ARTICLE; CONTROLLED STUDY; CORTISOL AWAKENING RESPONSE; ETHNIC DIFFERENCE; FEMALE; FOLLOW UP; HEALTH PROGRAM; HUMAN; HYDROCORTISONE RELEASE; HYPOTHALAMUS HYPOPHYSIS SYSTEM; MALE; MIDDLE AGED; PATIENT HEALTH QUESTIONNAIRE 9; PATIENT PARTICIPATION; POSTTRAUMATIC STRESS DISORDER; PRIMARY CARE BRIEF MINDFULNESS PROGRAM; PROGRAM EFFECTIVENESS; RANDOMIZED CONTROLLED TRIAL; WAKEFULNESS; CHEMISTRY; COMBAT DISORDERS; MINDFULNESS; PRIMARY HEALTH CARE; PSYCHOLOGY; SALIVA; STRESS DISORDERS, POST-TRAUMATIC; TREATMENT OUTCOME; VETERAN;

COMBAT DISORDERS; FEMALE; HUMANS; HYDROCORTISONE; MALE; MIDDLE AGED; MINDFULNESS; PRIMARY HEALTH CARE; SALIVA; STRESS DISORDERS, POST-TRAUMATIC; TREATMENT OUTCOME; VETERANS;

EID: 84916200748     PISSN: 00257079     EISSN: 15371948     Source Type: Journal    
DOI: 10.1097/MLR.0000000000000224     Document Type: Article

References (56)

1. Magruder KM, Frueh BC, Knapp RG, et al. PTSD symptoms, demographic characteristics, and functional status among veterans treated in VA primary care clinics. J Traum Stress. 2004;17:293-301.
2. Hoge C, Terhakopian A, Castro C, et al. Association of posttraumatic stress disorder with somatic symptoms, health care visits, and absenteeism among Iraq war veterans. Am J Psychiatry. 2007;164:150-153.
3. Boscarino JA. Posttraumatic stress disorder and mortality among US Army veterans 30 years after military service. Ann Epidemiol. 2006;16:248-256.
4. Boscarino JA. Psychobiologic predictors of disease mortality after psychological trauma: implications for research and clinical surveillance. J Nerv Ment Dis. 2008;196:100-107.
5. Dedert EA, Calhoun PS, Watkins LL, et al. Posttraumatic stress disorder, cardiovascular and metabolic disease: a review of the evidence. Ann Behav Med. 2010;39:61-78.
6. Chrousos GP, Gold PW. Editorial: a healthy body in a healthy mind- and vice versa-the damaging power of 'uncontrollable stress'. J Clin Endocrinol. 1998;56:1842-1845.
7. Kim SH, Schneider SM, Bevans M, et al. PTSD symptom reduction with mindfulness-based stretching and deep breathing exercise: randomized controlled clinical trial of efficacy. J Clin Endocrinol Metab. 2013;98:2984-2992.
8. Reagan LP, Grillo CA, Piroli GG. The A's and D's of stress: metabolic, morphological and behavioral consequences. Eur J Pharmacol. 2008;585:64-75.
9. Yehuda R. Clinical relevance of biological findings in PTSD. Psychiatr Q. 2002;73:123-133.
10. Morris MC, Compas BE, Garber J. Relations among posttraumatic stress disorder, comorbid major depression, and HPA function: a systematic review and meta analysis. Clin Psychol Rev. 2012;32:301-315.
11. Sapolsky RM, Romero LM, Munck AU. How do glucocorticoids influence stress responses? Integrating permissive, suppressive, stimulatory, and preparative actions. Endocr Rev. 2000;21:55-89.
12. Miller GE, Chen E, Zhou ES. If it goes up, must it come down? Chronic stress and the hypothalamic-pituitary-adrenocortical axis in humans. Psychol Bull. 2007;133:25-45.
13. Hucklebridge F, Hussain T, Evans P, et al. The diurnal patterns of the adrenal steroids cortisol and dehydroepiandrosterone (DHEA) in relation to awakening. Psychoneuroendocrinology. 2005;30:51-57.
14. Lindley SE, Carlson EB, Benoit M. Basal and dexamethasone suppressed salivary cortisol concentrations in a community sample of patients with posttraumatic stress disorder. Biol Psychiatry. 2004;55:940-945.
15. Rohleder N, Joksimovic L, Wolf JM, et al. Hypocortisolism and increased glucocorticoid sensitivity of proinflammatory cytokine production in Bosnian war refugees with posttraumatic stress disorder. Biol Psychiatry. 2004;55:745-751.
16. Edwards S, Evans P, Hucklebridge F, et al. Association between time of awakening and diurnal cortisol secretory activity. Psychoneuroendocrinology. 2001;26:613-622.
17. Federenko I, Wüst S, Hellhammer DH, et al. Free cortisol awakening responses are influenced by awakening time. Psychoneuroendocrinology. 2004;29:174-184.
18. Pruessner JC, Wolf OT, Hellhammer DH, et al. Free cortisol levels after awakening: a reliable biological marker for the assessment of adrenocortical activity. Life Sci. 1997;61:2539-2549.
19. Wilhelm I, Born J, Kudielka BM, et al. Is the cortisol awakening rise a response to awakening? Psychoneuroendocrinology. 2007;32:358-366.
20. Pruessner JC, Hellhammer DH, Kirschbaum C. Burnout, perceived stress, and cortisol responses to awakening. Psychosom Med. 1999;61:197-204.
21. Chida Y, Steptoe A. Cortisol awakening response and psychosocial factors: a systematic review and meta-analysis. Biol Psychol. 2009;80:265-278.
22. Fries E, Dettenborn L, Kirschbaum C. The cortisol awakening response (CAR): facts and future directions. Int J Psychophysiol. 2009;72:67-73.
23. Adam EK, Hawkley LC, Kudielka BM, et al. Day-to-day dynamics of experience-cortisol associations in a population-based sample of older adults. Proc Natl Acad Sci USA. 2006;103:17058-17063.
24. Wahbeh H, Oken BS. Salivary cortisol lower in posttraumatic stress disorder. J Trauma Stress. 2013;26:241-248.
25. Klaassens ER, Giltay EJ, Cuijpers P, et al. Adulthood trauma and HPAaxis functioning in healthy subjects and PTSD patients: a meta-analysis. Psychoneuroendocrinology. 2012;37:317-331.
26. Greaves-Lord K, Ferdinand RF, Oldehinkel AJ, et al. Higher cortisol awakening response in young adolescents with persistent anxiety problems. Acta Psychiat Scand. 2007;116:137-144.
27. Kabat-Zinn J. Full Catastrophe Living: Using the Wisdom of Your Body and Mind to Face Stress, Pain, and Illness. New York: Delta; 2009.
28. Hofmann SG, Sawyer AT, Witt AA, et al. The effect of mindfulnessbased therapy on anxiety and depression: a meta-analytic review. J Cons Clin Psych. 2010;78:169-183.
29. Loizzo J. Meditation research, past, present, and future: perspectives from the Nalanda contemplative science tradition. Advances in meditation research: neuroscience and clinical applications. J Ann NY Acad Sci. 2014;1307:43-54.
30. Kearney DJ, McDermott K, Malte C, et al. Association of participation in a mindfulness program with measures of PTSD, depression and quality of life in a veteran sample. J Cons Clin Psych. 2012;68:101-116.
31. Davidson RJ, Pizagalli D, Nitschke KB, et al. Depression: perspectives from affective neuroscience. Ann Rev Psychol. 2002;53:545-574.
32. Van den Hurk P, Janssen B, Giommi F, et al. Mindfulness meditation associated with alterations in bottom-up processing: psychophysiological evidence for reduced reactivity. Int J Psychophysiol. 2010;78:151-157.
33. MacLean CR, Walton KG, Wenneberg SR, et al. Altered responses of cortisol, GH, TSH and testosterone to acute stress after four months' practice of transcendental meditation (TM). Ann N Y Acad Sci. 1994;746:381-384.
34. Sudsuang R, Chentanez V, Veluvan K. Effect of Buddhist meditation on serum cortisol and total protein levels, blood pressure, pulse rate, lung volume and reaction time. Physiol Behav. 1991;50:543-548.
35. Marcus MT, Fine P, Moeller F, et al. Change in stress levels following mindfulness-based stress reduction in a therapeutic community. Addict Disord Their Treat. 2003;2:63-68.
36. Olff M, Güzelcan Y, de Vries GJ, et al. HPA- and HPT-axis alterations in chronic posttraumatic stress disorder. Psychoneuroendocrinology. 2006;31:1220-1230.
37. Niles BL, Klunk-Gillis J, Ryngala DJ, et al. Comparing mindfulness and psychoeducation treatments for combat-related PTSD using a telehealth approach. Psychol Trauma. 2012;4:538-547.
38. Bormann JE, Thorp SR, Wetherell JL, et al. A spiritually based group intervention for combat Veterans with posttraumatic stress disorder: feasibility study. J Holist Nurs. 2008;26:109-116.
39. Wahbeh H, Oken BS. Mindful awareness and non-judging in relation to posttrraumatic stress disorder symptoms. Mindfulness. 2011;2:219-227.
40. Chiesa A, Serretti A. A systematic review of neurobiological and clinical features of mindfulness meditations. Psych Med. 2010;40:1239-1252.
41. Carlson LE, Speca M, Patel KD, et al. Mindfulness-based stress reduction in relation to quality of life, mood, symptoms of stress and levels of cortisol, dehydroepiandrosterone sulfate (DHEAS) and melatonin in breast and prostate cancer outpatients. Psychoneuroendocrinology. 2004;29:448-474.
42. Schmidt-Reinwald A, Pruessner JC, Hellhammer DH, et al. The cortisol response to awakening in relation to different challenge tests and a 12-hour cortisol rhythm. Life Sci. 1999;64:1653-1660.
43. Blake DD, Weathers FW, Nagy LM, et al. The development of a Clinician-Administered PTSD Scale. J Trauma Stress. 1995;8:75-90.
44. Katzman R, Brown T, Fuld P, et al. Validation of a short orientationmemoryconcentration test of cognitive impairment. Am J Psychiatry. 1983;140:734-739.
45. Kroenke K, Spitzer RL, Williams J B W. The PHQ-9: validity of a brief depression severity measure. J Gen Intern Med. 2001;16:606-613.
46. Weathers F, Huska J, Keane T. The PTSD Checklist Military Version (PCL-M). Boston, MA: National Center for PTSD; 1991.
47. Vining RF, McGinley RA, Maksvytis JJ, et al. Salivary cortisol: a better measure of adrenal cortical function than serum cortisol. Ann Clin Biochem. 1983;20:329-335.
48. Clow A, Thorn L, Evans P, et al. The awakening cortisol response: methodological issues and significance. Stress. 2004;7:29-37.
49. Salimetrics. Understanding cortisol data reports. Salimetrics, State College, PA. 2008. Available at: http://www.salimetrics.com. Accessed May 2014.
50. Fekedulegn DB, Andrew ME, Burchfiel CM, et al. Area under the curve and other summary indicators of repeated waking cortisol measurements. Psychosom Med. 2007;69:651-659.
51. Pruessner JC, Kirschbaum C, Meinlschmid G, et al. Two formulas for computation of the area under the curve represent measures of total hormone concentration versus time-dependent change. Psychoneuroendocrinology. 2003;28:916-931.
52. Graham JW. Missing data analysis: making it work in the real world. Annu Rev Psychol. 2009;60:549-576.
53. Keselman HJ, Othman AR, Wilcox RR, et al. The new and improved two-sample t test. Psychol Sci. 2004;15:47-51.
54. Urry HL, Van Reekum CM, Johnstone T, et al. Amygdala and ventromedial prefrontal cortex are inversely coupled during regulation of negative affect and predict the diurnal pattern of cortisol secretion among older adults. Am J Neurosci. 2006;26:4415-4425.
55. Hölzel BK, Carmody J, Vangel M, et al. Mindfulness practice leads to increases in regional brain gray matter density. Psychiatry Res Neuroimaging. 2011;191:36-43.
56. Libby DJ, Pilver CE, Desai R. Complementary and alternative medicine use among individuals with posttraumatic stress disorder. Psychol Trauma. 2013;5:277-285.