Potential avoidance of adverse analgesic effects using a biologically "smart" hydrogel capable of controlled bupivacaine release

Journal of Pharmaceutical Sciences

Volumn 103, Issue 11, 2014, Pages 3724-3732

  Taraballi, Francesca ^a,b   Minardi, Silvia ^a,c   Corradetti, Bruna ^a,d   Yazdi, Iman K ^a,e   Balliano, Marta A ^a   Van Eps, Jeffrey L ^a,f   Allegri, Massimo ^b,g   Tasciotti, Ennio ^a  

^a HOUSTON METHODIST RESEARCH INSTITUTE   (United States)

^b FONDAZIONE IRCCS POLICLINICO SAN MATTEO   (Italy)

^c CNR   (Italy)

^d UNIVERSITÀ POLITECNICA DELLE MARCHE   (Italy)

^e UNIVERSITY OF HOUSTON   (United States)

^f HOUSTON METHODIST HOSPITAL   (United States)

^g UNIVERSITY OF PAVIA   (Italy)

Author keywords

Biomaterials; Controlled release; Drug delivery; Inflammation; Injectables; Microparticles; Pain

Indexed keywords

BUPIVACAINE; LOCAL ANESTHETIC AGENT; POLOXAMER; POLYGLACTIN; POLYMER; POLYVINYL ALCOHOL; RHODAMINE B; AUTACOID; CHITOSAN; DELAYED RELEASE FORMULATION; DRUG CARRIER; HYDROGEL; LACTIC ACID; POLYGLYCOLIC ACID; POLYLACTIC ACID-POLYGLYCOLIC ACID COPOLYMER;

ANALGESIC ACTIVITY; ANIMAL CELL; ARTICLE; CONTROLLED DRUG RELEASE; CONTROLLED STUDY; CYTOTOXICITY; DRUG DELIVERY SYSTEM; DRUG UPTAKE; ENCAPSULATION; HYDROGEL; INFLAMMATION; MACROPHAGE; MACROPHAGE ACTIVATION; MOUSE; NONHUMAN; OPSONIZATION; PAIN; ANIMAL; CELL LINE; CHEMISTRY; DELAYED RELEASE FORMULATION; IMMUNOLOGY; KINETICS; MEDICINAL CHEMISTRY; METABOLISM; PARTICLE SIZE; PH; PHAGOCYTOSIS; PHARMACEUTICS; PROCEDURES; SOLUBILITY;

ANESTHETICS, LOCAL; ANIMALS; BUPIVACAINE; CELL LINE; CHEMISTRY, PHARMACEUTICAL; CHITOSAN; DELAYED-ACTION PREPARATIONS; DRUG CARRIERS; HYDROGELS; HYDROGEN-ION CONCENTRATION; INFLAMMATION MEDIATORS; KINETICS; LACTIC ACID; MACROPHAGES; MICE; PARTICLE SIZE; PHAGOCYTOSIS; POLOXAMER; POLYGLYCOLIC ACID; SOLUBILITY; TECHNOLOGY, PHARMACEUTICAL;

EID: 84915789611     PISSN: 00223549     EISSN: 15206017     Source Type: Journal    
DOI: 10.1002/jps.24190     Document Type: Article

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