DHEA and mortality: What is the nature of the association?

Journal of Steroid Biochemistry and Molecular Biology

Volumn 145, Issue , 2015, Pages 248-253

  Ohlsson, Claes ^a   Vandenput, Liesbeth ^a   Tivesten, A ^b  

^a UNIVERSITY OF GOTHENBURG   (Sweden)

^b UNIVERSITY OF GOTHENBURG   (Sweden)

Author keywords

Dehydroepiandrosterone; Dehydroepiandrosterone sulfate; Mortality

Indexed keywords

PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR ALPHA; PRASTERONE; PRASTERONE SULFATE; HORMONE;

AGE; ATHEROGENESIS; CANCER MORTALITY; CARDIOVASCULAR MORTALITY; CARDIOVASCULAR RISK; CAUSE SPECIFIC SURVIVAL; HUMAN; IMMUNE RESPONSE; MORTALITY; OXIDATIVE STRESS; POPULATION RESEARCH; REVIEW; SEX DIFFERENCE; VASCULAR BIOLOGY; ADRENAL GLAND; CARDIOVASCULAR DISEASE; FEMALE; MALE; METABOLISM; NEOPLASM; RISK FACTOR; TREATMENT OUTCOME;

ADRENAL GLANDS; CARDIOVASCULAR DISEASES; DEHYDROEPIANDROSTERONE; DEHYDROEPIANDROSTERONE SULFATE; FEMALE; HORMONES; HUMANS; MALE; NEOPLASMS; RISK FACTORS; SEX FACTORS; TREATMENT OUTCOME;

EID: 84915785227     PISSN: 09600760     EISSN: 18791220     Source Type: Journal    
DOI: 10.1016/j.jsbmb.2014.03.006     Document Type: Review

References (59)

1. A.M. Traish, H.P. Kang, F. Saad, and A.T. Guay Dehydroepiandrosterone (DHEA) - A precursor steroid or an active hormone in human physiology J Sex Med 8 11 2011 2960 2982 (quiz 2983)
2. S.J. Webb, T.E. Geoghegan, R.A. Prough, and K.K. Michael Miller The biological actions of dehydroepiandrosterone involves multiple receptors Drug Metab Rev 38 1-2 2006 89 116
3. F. Labrie, V. Luu-The, A. Belanger, S.X. Lin, J. Simard, G. Pelletier, and C. Labrie Is dehydroepiandrosterone a hormone? J Endocrinol 187 2 2005 169 196
4. S. Bhagra, T.B. Nippoldt, and K.S. Nair Dehydroepiandrosterone in adrenal insufficiency and ageing Curr Opin Endocrinol Diab Obes 15 3 2008 239 243
5. E. Barrett-Connor, K.T. Khaw, and S.S. Yen A prospective study of dehydroepiandrosterone sulfate, mortality, and cardiovascular disease N Engl J Med 315 24 1986 1519 1524
6. E. Barrett-Connor, and K.T. Khaw Absence of an inverse relation of dehydroepiandrosterone sulfate with cardiovascular mortality in postmenopausal women N Engl J Med 317 11 1987 711
7. C. Berr, S. Lafont, B. Debuire, J.F. Dartigues, and E.E. Baulieu Relationships of dehydroepiandrosterone sulfate in the elderly with functional, psychological, and mental status, and short-term mortality: A French community-based study Proc Natl Acad Sci U S A 93 23 1996 13410 13415
8. R.S. Tilvis, M. Kahonen, and M. Harkonen Dehydroepiandrosterone sulfate, diseases and mortality in a general aged population Aging (Milano) 11 1 1999 30 34
9. D.P. Trivedi, and K.T. Khaw Dehydroepiandrosterone sulfate and mortality in elderly men and women J Clin Endocrinol Metab 86 9 2001 4171 4177
10. D.A. Glei, and N. Goldman Dehydroepiandrosterone sulfate (DHEAS) and risk for mortality among older Taiwanese Ann Epidemiol 16 7 2006 510 515
11. M. Maggio, F. Lauretani, G.P. Ceda, S. Bandinelli, S.M. Ling, E.J. Metter, A. Artoni, L. Carassale, A. Cazzato, G. Ceresini, J.M. Guralnik, S. Basaria, G. Valenti, and L. Ferrucci Relationship between low levels of anabolic hormones and 6-year mortality in older men: the aging in the Chianti Area (InCHIANTI) study Arch Intern Med 167 20 2007 2249 2254
12. A.R. Cappola, E.S. O'Meara, W. Guo, T.M. Bartz, L.P. Fried, and A.B. Newman Trajectories of dehydroepiandrosterone sulfate predict mortality in older adults: the cardiovascular health study J Gerontol A Biol Sci Med Sci 64 12 2009 1268 1274
13. C. Ohlsson, F. Labrie, E. Barrett-Connor, M.K. Karlsson, O. Ljunggren, L. Vandenput, D. Mellstrom, and A. Tivesten Low serum levels of dehydroepiandrosterone sulfate predict all-cause and cardiovascular mortality in elderly Swedish men J Clin Endocrinol Metab 95 9 2010 4406 4414
14. P. Forti, B. Maltoni, V. Olivelli, G.L. Pirazzoli, G. Ravaglia, and M. Zoli Serum dehydroepiandrosterone sulfate and adverse health outcomes in older men and women Rejuvenation Res 15 4 2012 349 358
15. R. Haring, Z. Teng, V. Xanthakis, A. Coviello, L. Sullivan, S. Bhasin, J.M. Murabito, H. Wallaschofski, and R.S. Vasan Association of sex steroids, gonadotrophins, and their trajectories with clinical cardiovascular disease and all-cause mortality in elderly men from the Framingham Heart Study Clin Endocrinol (Oxf) 78 4 2013 629 634
16. M. Enomoto, H. Adachi, A. Fukami, K. Furuki, A. Satoh, M. Otsuka, S. Kumagae, Y. Nanjo, Y. Shigetoh, and T. Imaizumi Serum dehydroepiandrosterone sulfate levels predict longevity in men: 27-year follow-up study in a community-based cohort (Tanushimaru study) J Am Geriatr Soc 56 6 2008 994 998
17. C. Wang, D.H. Catlin, L.M. Demers, B. Starcevic, and R.S. Swerdloff Measurement of total serum testosterone in adult men: comparison of current laboratory methods versus liquid chromatography-tandem mass spectrometry J Clin Endocrinol Metab 89 2 2004 534 543
18. D.J. Handelsman, and L. Wartofsky Requirement for mass spectrometry sex steroid assays in the Journal of Clinical Endocrinology and Metabolism J Clin Endocrinol Metab 98 10 2013 3971 3973
19. L. Mazat, S. Lafont, C. Berr, B. Debuire, J.F. Tessier, J.F. Dartigues, and E.E. Baulieu Prospective measurements of dehydroepiandrosterone sulfate in a cohort of elderly subjects: relationship to gender, subjective health, smoking habits, and 10-year mortality Proc Natl Acad Sci U S A 98 14 2001 8145 8150
20. A.R. Cappola, Q.L. Xue, J.D. Walston, S.X. Leng, L. Ferrucci, J. Guralnik, and L.P. Fried DHEAS levels and mortality in disabled older women: the Women's Health and Aging Study I J Gerontol A Biol Sci Med Sci 61 9 2006 957 962
21. H.A. Feldman, C.B. Johannes, A.B. Araujo, B.A. Mohr, C. Longcope, and J.B. McKinlay Low dehydroepiandrosterone and ischemic heart disease in middle-aged men: prospective results from the Massachusetts Male Aging Study Am J Epidemiol 153 1 2001 79 89
22. J. Arnlov, M.J. Pencina, S. Amin, B.H. Nam, E.J. Benjamin, J.M. Murabito, T.J. Wang, P.E. Knapp, R.B. D'Agostino Sr., S. Bhasin, and R.S. Vasan Endogenous sex hormones and cardiovascular disease incidence in men Ann Intern Med 145 3 2006 176 184
23. A.C. Phillips, D. Carroll, C.R. Gale, J.M. Lord, W. Arlt, G.D. Batty, and Cortisol DHEA sulphate, their ratio, and all-cause and cause-specific mortality in the Vietnam Experience Study Eur J Endocrinol 163 2 2010 285 292
24. R.H. Straub, M. Cutolo, F. Buttgereit, and G. Pongratz Energy regulation and neuroendocrine-immune control in chronic inflammatory diseases J Intern Med 267 6 2010 543 560
25. C. Marx, S. Petros, S.R. Bornstein, M. Weise, M. Wendt, M. Menschikowski, L. Engelmann, and G. Hoffken Adrenocortical hormones in survivors and nonsurvivors of severe sepsis: diverse time course of dehydroepiandrosterone, dehydroepiandrosterone-sulfate, and cortisol Crit Care Med 31 5 2003 1382 1388
26. A. Grossman, G. Johannsson, M. Quinkler, and P. Zelissen Therapy of endocrine disease: Perspectives on the management of adrenal insufficiency: clinical insights from across Europe Eur J Endocrinol 169 6 2013 R165 R175
27. R. Bergthorsdottir, M. Leonsson-Zachrisson, A. Oden, and G. Johannsson Premature mortality in patients with Addison's disease: a population-based study J Clin Endocrinol Metab 91 12 2006 4849 4853
28. S. Bensing, L. Brandt, F. Tabaroj, O. Sjoberg, B. Nilsson, A. Ekbom, P. Blomqvist, and O. Kampe Increased death risk and altered cancer incidence pattern in patients with isolated or combined autoimmune primary adrenocortical insufficiency Clin Endocrinol (Oxf) 69 5 2008 697 704
29. S. Bonnet, R. Paulin, G. Sutendra, P. Dromparis, M. Roy, K.O. Watson, J. Nagendran, A. Haromy, J.R. Dyck, and E.D. Michelakis Dehydroepiandrosterone reverses systemic vascular remodeling through the inhibition of the Akt/GSK3-{beta}/NFAT axis Circulation 120 13 2009 1231 1240
30. J.P. Camporez, E.H. Akamine, A.P. Davel, C.R. Franci, L.V. Rossoni, and C.R. Carvalho Dehydroepiandrosterone protects against oxidative stress-induced endothelial dysfunction in ovariectomized rats J Physiol 589 Pt 10 2011 2585 2596
31. M. Kalimi, Y. Shafagoj, R. Loria, D. Padgett, and W. Regelson Anti-glucocorticoid effects of dehydroepiandrosterone (DHEA) Mol Cell Biochem 131 2 1994 99 104
32. A.H. Payne, and D.B. Hales Overview of steroidogenic enzymes in the pathway from cholesterol to active steroid hormones Endocr Rev 25 6 2004 947 970
33. A. Tivesten, L. Vandenput, F. Labrie, M.K. Karlsson, O. Ljunggren, D. Mellstrom, and C. Ohlsson Low serum testosterone and estradiol predict mortality in elderly men J Clin Endocrinol Metab 94 7 2009 2482 2488
34. C. Ohlsson, E. Barrett-Connor, S. Bhasin, E. Orwoll, F. Labrie, M.K. Karlsson, O. Ljunggren, L. Vandenput, D. Mellstrom, and A. Tivesten High serum testosterone is associated with reduced risk of cardiovascular events in elderly men. The MrOS (Osteoporotic Fractures in Men) study in Sweden J Am Coll Cardiol 58 16 2011 1674 1681
35. J.S. Finkelstein, H. Lee, S.A. Burnett-Bowie, J.C. Pallais, E.W. Yu, L.F. Borges, B.F. Jones, C.V. Barry, K.E. Wulczyn, B.J. Thomas, and B.Z. Leder Gonadal steroids and body composition, strength, and sexual function in men N Engl J Med 369 11 2013 1011 1022
36. A. Tchernof, and F. Labrie Dehydroepiandrosterone, obesity and cardiovascular disease risk: a review of human studies Eur J Endocrinol 151 1 2004 1 14
37. D.T. Villareal, and J.O. Holloszy Effect of DHEA on abdominal fat and insulin action in elderly women and men: a randomized controlled trial JAMA 292 18 2004 2243 2248
38. K.S. Nair, R.A. Rizza, P. O'Brien, K. Dhatariya, K.R. Short, A. Nehra, J.L. Vittone, G.G. Klee, A. Basu, R. Basu, C. Cobelli, G. Toffolo, C. Dalla Man, D.J. Tindall, L.J. Melton III, G.E. Smith, S. Khosla, and M.D. Jensen DHEA in elderly women and DHEA or testosterone in elderly men N Engl J Med 355 16 2006 1647 1659
39. C.M. Jankowski, W.S. Gozansky, R.S. Schwartz, D.J. Dahl, J.M. Kittelson, S.M. Scott, R.E. Van Pelt, and W.M. Kohrt Effects of dehydroepiandrosterone replacement therapy on bone mineral density in older adults: a randomized, controlled trial J Clin Endocrinol Metab 91 8 2006 2986 2993
40. D. von Muhlen, G.A. Laughlin, D. Kritz-Silverstein, J. Bergstrom, and R. Bettencourt Effect of dehydroepiandrosterone supplementation on bone mineral density, bone markers, and body composition in older adults: the DAWN trial Osteoporos Int 19 5 2008 699 707
41. V. Sherk, C. Jankowski, S. Khosla, D. Kritz-Silverstein, G. Laughlin, S. Nair, K. Shah, D. Villareal, D. Von Muhlen, D. Weiss, P. Wolfe, and W. Kohrt Sex-specific effects of DHEA supplementation on bone mineral density and body composition: A pooled analysis of four randomized controlled trials. Abstract ASBMR annual meeting J Bone Miner Res 27 Suppl 1 2012
42. D. Liu, and J.S. Dillon Dehydroepiandrosterone activates endothelial cell nitric-oxide synthase by a specific plasma membrane receptor coupled to Galpha(i2, 3) J Biol Chem 277 24 2002 21379 21388
43. D. Liu, M. Iruthayanathan, L.L. Homan, Y. Wang, L. Yang, and J.S. Dillon Dehydroepiandrosterone stimulates endothelial proliferation and angiogenesis through extracellular signal-regulated kinase 1/2-mediated mechanisms Endocrinology 149 3 2008 889 898
44. M.R. Williams, T. Dawood, S. Ling, A. Dai, R. Lew, K. Myles, J.W. Funder, K. Sudhir, and P.A. Komesaroff Dehydroepiandrosterone increases endothelial cell proliferation in vitro and improves endothelial function in vivo by mechanisms independent of androgen and estrogen receptors J Clin Endocrinol Metab 89 9 2004 4708 4715
45. M.R. Williams, S. Ling, T. Dawood, K. Hashimura, A. Dai, H. Li, J.P. Liu, J.W. Funder, K. Sudhir, and P.A. Komesaroff Dehydroepiandrosterone inhibits human vascular smooth muscle cell proliferation independent of ARs and ERs J Clin Endocrinol Metab 87 1 2002 176 181
46. M. Ii, M. Hoshiga, N. Negoro, R. Fukui, T. Nakakoji, E. Kohbayashi, N. Shibata, D. Furutama, T. Ishihara, T. Hanafusa, D.W. Losordo, and N. Ohsawa Adrenal androgen dehydroepiandrosterone sulfate inhibits vascular remodeling following arterial injury Atherosclerosis 206 1 2009 77 85
47. R. Altman, D.D. Motton, R.S. Kota, and J.C. Rutledge Inhibition of vascular inflammation by dehydroepiandrosterone sulfate in human aortic endothelial cells: roles of PPARalpha and NF-kappaB Vasc Pharmacol 48 2-3 2008 76 84
48. J.S. Dillon Dehydroepiandrosterone, dehydroepiandrosterone sulfate and related steroids: their role in inflammatory, allergic and immunological disorders Curr Drug Targets Inflamm Allergy 4 3 2005 377 385
49. C.C. Chen, and C.R. Parker Jr. Adrenal androgens and the immune system Semin Reprod Med 22 4 2004 369 377
50. P. Alexandersen, J. Haarbo, I. Byrjalsen, H. Lawaetz, and C. Christiansen Natural androgens inhibit male atherosclerosis: A study in castrated, cholesterol-fed rabbits Circ Res 84 7 1999 813 819
51. H. Kawano, H. Yasue, A. Kitagawa, N. Hirai, T. Yoshida, H. Soejima, S. Miyamoto, M. Nakano, and H. Ogawa Dehydroepiandrosterone supplementation improves endothelial function and insulin sensitivity in men J Clin Endocrinol Metab 88 7 2003 3190 3195
52. J.J. Christiansen, N.H. Andersen, K.E. Sorensen, E.M. Pedersen, P. Bennett, M. Andersen, J.S. Christiansen, J.O. Jorgensen, and C.H. Gravholt Dehydroepiandrosterone substitution in female adrenal failure: no impact on endothelial function and cardiovascular parameters despite normalization of androgen status Clin Endocrinol (Oxf) 66 3 2007 426 433
53. S.P. Rice, N. Agarwal, H. Bolusani, R. Newcombe, M.F. Scanlon, M. Ludgate, and D.A. Rees Effects of dehydroepiandrosterone replacement on vascular function in primary and secondary adrenal insufficiency: a randomized crossover trial J Clin Endocrinol Metab 94 6 2009 1966 1972
54. W. Arlt, and M. Hewison Hormones and immune function: implications of aging Aging Cell 3 4 2004 209 216
55. J. Hazeldine, W. Arlt, and J.M. Lord Dehydroepiandrosterone as a regulator of immune cell function J Steroid Biochem Mol Biol 120 2-3 2010 127 136
56. G. Zhai, A. Teumer, L. Stolk, J.R. Perry, L. Vandenput, A.D. Coviello, A. Koster, J.T. Bell, S. Bhasin, J. Eriksson, A. Eriksson, F. Ernst, L. Ferrucci, T.M. Frayling, D. Glass, E. Grundberg, R. Haring, A.K. Hedman, A. Hofman, D.P. Kiel, H.K. Kroemer, Y. Liu, K.L. Lunetta, M. Maggio, M. Lorentzon, M. Mangino, D. Melzer, I. Miljkovic, A. Nica, B.W. Penninx, R.S. Vasan, F. Rivadeneira, K.S. Small, N. Soranzo, A.G. Uitterlinden, H. Volzke, S.G. Wilson, L. Xi, W.V. Zhuang, T.B. Harris, J.M. Murabito, C. Ohlsson, A. Murray, F.H. de Jong, T.D. Spector, and H. Wallaschofski Eight common genetic variants associated with serum DHEAS levels suggest a key role in ageing mechanisms PLoS Genet 7 4 2011 e1002025
57. M.E. Poynter, and R.A. Daynes Peroxisome proliferator-activated receptor alpha activation modulates cellular redox status, represses nuclear factor-kappaB signaling, and reduces inflammatory cytokine production in aging J Biol Chem 273 49 1998 32833 32841
58. E. Barrett-Connor, and D. Goodman-Gruen The epidemiology of DHEAS and cardiovascular disease Ann N Y Acad Sci 774 1995 259 270
59. E. Barrett-Connor, and D. Goodman-Gruen Dehydroepiandrosterone sulfate does not predict cardiovascular death in postmenopausal women. The Rancho Bernardo Study Circulation 91 6 1995 1757 1760