O-phospho-L-serine mediates hyporesponsiveness toward FVIII in Hemophilia A-murine model by inducing tolerogenic properties in dendritic cells

Journal of Pharmaceutical Sciences

Volumn 103, Issue 11, 2014, Pages 3457-3463

  Fathallah, Anas M ^a   Ramakrishnan, Radha ^a   Balu Iyer, Sathy V ^a  

^a UNIVERSITY AT BUFFALO   (United States)

Author keywords

Biotechnology; Immunology; Lipids; Proteins; Vaccine adjuvant

Indexed keywords

CD40 ANTIGEN; CYTOKINE; DEXAMETHASONE; INTERLEUKIN 12P70; PHOSPHOSERINE; RECOMBINANT BLOOD CLOTTING FACTOR 8; TRANSFORMING GROWTH FACTOR BETA; TUMOR NECROSIS FACTOR ALPHA; ANTIBODY; BLOOD CLOTTING FACTOR 8; COAGULATING AGENT; F8 PROTEIN, HUMAN; IMMUNOLOGICAL ADJUVANT; INTERLEUKIN 12;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIBODY RESPONSE; ARTICLE; BONE MARROW DERIVED DENDRITIC CELL; CELL CULTURE; CONTROLLED STUDY; CYTOKINE PRODUCTION; DENDRITIC CELL; DRUG RESPONSE; FLOW CYTOMETRY; HEMOPHILIA A; IMMUNE RESPONSE; IMMUNOGENICITY; IN VIVO STUDY; INFLAMMATION; MOUSE; NONHUMAN; UPREGULATION; ANIMAL; BLOOD; DISEASE MODEL; DRUG EFFECTS; GENETICS; IMMUNOLOGICAL TOLERANCE; IMMUNOLOGY; METABOLISM; TIME; TRANSGENIC MOUSE;

ADJUVANTS, IMMUNOLOGIC; ANIMALS; ANTIBODIES; ANTIGENS, CD40; CELLS, CULTURED; COAGULANTS; DENDRITIC CELLS; DISEASE MODELS, ANIMAL; FACTOR VIII; HEMOPHILIA A; IMMUNE TOLERANCE; INTERLEUKIN-12; MICE, TRANSGENIC; PHOSPHOSERINE; TIME FACTORS; TRANSFORMING GROWTH FACTOR BETA; TUMOR NECROSIS FACTOR-ALPHA;

EID: 84915760439     PISSN: 00223549     EISSN: 15206017     Source Type: Journal    
DOI: 10.1002/jps.24173     Document Type: Article

References (30)

1. Fathallah AM, Bankert RB, Balu-Iyer SV. 2013. Immunogenicity of subcutaneously administered therapeutic proteins-a mechanistic perspective. AAPS J 15:897-900.
2. Purohit VS, Ramani K, Sarkar R, Kazazian HH, , Jr., Balasubramanian SV. 2005. Lower inhibitor development in hemophilia A mice following administration of recombinant factor VIII-O-phospho-L-serine complex. J Biol Chem 280(18):17593-17600.
3. Gaitonde P, Peng A, Straubinger RM, Bankert RB, Balu-Iyer SV. 2011. Phosphatidylserine reduces immune response against human recombinant Factor VIII in Hemophilia A mice by regulation of dendritic cell function. Clin Immunol 138(2):135-145.
4. Gaitonde P, Ramakrishnan R, Chin J, Kelleher RJ Jr., Bankert RB, Balu-Iyer SV. 2013. Exposure to factor VIII protein in the presence of phosphatidylserine induces hypo-responsiveness toward factor VIII challenge in hemophilia A mice. J Biol Chem 288(24):17051-17056.
5. Miclea RD, Purohit VS, Balu-Iyer SV. 2007. O-phospho-L-serine, multi-functional excipient for B domain deleted recombinant factor VIII. AAPS J 9(2):E251-259.
6. Chaurio RA, Janko C, Munoz LE, Frey B, Herrmann M, Gaipl US. 2009. Phospholipids: Key players in apoptosis and immune regulation. Molecules 14(12):4892-4914.
7. Henson PM, Bratton DL, Fadok VA. 2001. The phosphatidylserine receptor: A crucial molecular switch? Nat Rev Mol Cell Biol 2(8):627-633.
8. Pittoni V, Valesini G. 2002. The clearance of apoptotic cells: Implications for autoimmunity. Autoimmun Rev 1(3):154-161.
9. Hoffmann PR, Kench JA, Vondracek A, Kruk E, Daleke DL, Jordan M, Marrack P, Henson PM, Fadok VA. 2005. Interaction between phosphatidylserine and the phosphatidylserine receptor inhibits immune responses in vivo. J Immunol 174(3):1393-1404.
10. Kinchen JM, Ravichandran KS. 2007. Journey to the grave: Signaling events regulating removal of apoptotic cells. J Cell Sci 120(Pt 13):2143-2149.
11. Chen X, Doffek K, Sugg SL, Shilyansky J. 2004. Phosphatidylserine regulates the maturation of human dendritic cells. J Immunol 173(5):2985-2994.
12. Park SY, Jung MY, Kim HJ, Lee SJ, Kim SY, Lee BH, Kwon TH, Park RW, Kim IS. 2007. Rapid cell corpse clearance by stabilin-2, a membrane phosphatidylserine receptor. Cell Death Differ 15(1):192-201.
13. Park D, Tosello-Trampont AC, Elliott MR, Lu M, Haney LB, Ma Z, Klibanov AL, Mandell JW, Ravichandran KS. 2007. BAI1 is an engulfment receptor for apoptotic cells upstream of the ELMO/Dock180/Rac module. Nature 450(7168):430-434.
14. Miyanishi M, Tada K, Koike M, Uchiyama Y, Kitamura T, Nagata S. 2007. Identification of Tim4 as a phosphatidylserine receptor.Nature 450(7168):435-439.
15. Freeman GJ, Casasnovas JM, Umetsu DT, DeKruyff RH. 2010. TIM genes: A family of cell surface phosphatidylserine receptors that regulate innate and adaptive immunity. Immunolog Rev 235(1):172-189.
16. Lucas M, Stuart LM, Zhang A, Hodivala-Dilke K, Febbraio M, Silverstein R, Savill J, Lacy-Hulbert A. 2006. Requirements for apoptotic cell contact in regulation of macrophage responses. J Immunol 177(6):4047-4054.
17. Hanayama R, Tanaka M, Miwa K, Shinohara A, Iwamatsu A, Nagata S. 2002. Identification of a factor that links apoptotic cells to phagocytes. Nature 417(6885):182-187.
18. Fadok VA, Bratton DL, Guthrie L, Henson PM. 2001. Differential effects of apoptotic versus lysed cells on macrophage production of cytokines: Role of proteases. J Immunol 166(11):6847-6854.
19. Albacker LA, Karisola P, Chang YJ, Umetsu SE, Zhou M, Akbari O, Kobayashi N, Baumgarth N, Freeman GJ, Umetsu DT, DeKruyff RH. 2010. TIM-4, a receptor for phosphatidylserine, controls adaptive immunity by regulating the removal of antigen-specific T cells. J Immunol 185(11):6839-6849.
20. Crowther JR. 2000. The ELISA guidebook. Methods in Molecular Biology (Clifton, NJ) 149:Iii-iv, 1-413.
21. Lutz MB, Kukutsch N, Ogilvie AL, Rossner S, Koch F, Romani N, Schuler G. 1999. An advanced culture method for generating large quantities of highly pure dendritic cells from mouse bone marrow. J Immunol Methods 223(1):77-92.
22. Verbovetski I, Bychkov H, Trahtemberg U, Shapira I, Hareuveni M, Ben-Tal O, Kutikov I, Gill O, Mevorach D. 2002. Opsonization of apoptotic cells by autologous iC3b facilitates clearance by immature dendritic cells, down-regulates DR and CD86, and up-regulates CC chemokine receptor 7. J Exp Med 196(12):1553-1561.
23. Mahnke K, Schmitt E, Bonifaz L, Enk AH, Jonuleit H. 2002. Immature, but not inactive: The tolerogenic function of immature dendritic cells. Immunol Cell Biol 80(5):477-483.
24. Lutz MB, Schuler G. 2002. Immature, semi-mature and fully mature dendritic cells: Which signals induce tolerance or immunity? Trends Immunol 23(9):445-449.
25. Steinman RM, Turley S, Mellman I, Inaba K. 2000. The induction of tolerance by dendritic cells that have captured apoptotic cells. J Exp Med 191(3):411-416.
26. Frey A, Di Canzio J, Zurakowski D. 1998. A statistically defined endpoint titer determination method for immunoassays. J Immunol Methods 221(1-2):35-41.
27. Qadura M, Othman M, Waters B, Chegeni R, Walker K, Labelle A, Ozelo M, Hough C, Lillicrap D. 2008. Reduction of the immune response to factor VIII mediated through tolerogenic factor VIII presentation by immature dendritic cells. J Thromb Haemostasis 6(12):2095-2104.
28. Pfistershammer K, Stockl J, Siekmann J, Turecek PL, Schwarz HP, Reipert BM. 2006. Recombinant factor VIII and factor VIII-von Willebrand factor complex do not present danger signals for human dendritic cells. Thromb Haemost 96(3):309-316.
29. Morelli AE, Thomson AW. 2007. Tolerogenic dendritic cells and the quest for transplant tolerance. Nat Rev Immunol 7(8):610-621.
30. Randolph GJ. 2001. Dendritic cell migration to lymph nodes: Cytokines, chemokines, and lipid mediators. Semin Immunol 13(5):267-274.