메뉴 건너뛰기




Volumn 11, Issue 4, 2014, Pages 196-205

Enclomiphene citrate stimulates serum testosterone in men with low testosterone within 14 days

Author keywords

Clomid; Clomiphene citrate; Enclomiphene citrate; Secondary hypogonadism; Testosterone replacement therapy

Indexed keywords

ANDROSTANOLONE; ENCLOMIFENE CITRATE; TESTOSTERONE;

EID: 84914821529     PISSN: 18756867     EISSN: 18756859     Source Type: Journal    
DOI: 10.1089/jomh.2014.0006     Document Type: Article
Times cited : (7)

References (37)
  • 1
    • 26444515048 scopus 로고    scopus 로고
    • The decline of androgen levels in elderly men and its clinical and therapeutic implications
    • Kaufman JM, Vermeulen A. The decline of androgen levels in elderly men and its clinical and therapeutic implications. Endocr Rev 2005;26:833-876.
    • (2005) Endocr Rev , vol.26 , pp. 833-876
    • Kaufman, J.M.1    Vermeulen, A.2
  • 2
    • 77954409942 scopus 로고    scopus 로고
    • Testosterone therapy in adult men with androgen deficiency syndromes: An Endocrine Society clinical practice guideline
    • Bhasin S, Cunningham GR, Hayes FJ, et al. Testosterone therapy in adult men with androgen deficiency syndromes: An Endocrine Society clinical practice guideline. J Clin Endocrinol Metab 2010;95:2536-2559.
    • (2010) J Clin Endocrinol Metab , vol.95 , pp. 2536-2559
    • Bhasin, S.1    Cunningham, G.R.2    Hayes, F.J.3
  • 3
    • 84872852291 scopus 로고    scopus 로고
    • Testosterone deficiency in men: Systematic review and standard operating procedures for diagnosis and treatment.
    • Buvat J, Maggi M, Guay A, Torres LO. Testosterone deficiency in men: Systematic review and standard operating procedures for diagnosis and treatment. J Sex Med 2013;10: 245-284.
    • (2013) J Sex Med , vol.10 , pp. 245-284
    • Buvat, J.1    Maggi, M.2    Guay, A.3    Torres, L.O.4
  • 5
    • 0035097033 scopus 로고    scopus 로고
    • Longitudinal effects of aging on serum total and free testosterone levels in healthy men Baltimore Longitudinal Study of Aging.
    • Harman SM, Metter EJ, Tobin JD, Pearson J, BlackmanMR. Longitudinal effects of aging on serum total and free testosterone levels in healthy men. Baltimore Longitudinal Study of Aging. J Clin Endocrinol Metab 2001;86:724-731.
    • (2001) J Clin Endocrinol Metab , vol.86 , pp. 724-731
    • Harman, S.M.1    Metter, E.J.2    Tobin, J.D.3    Pearson, J.4    Blackman, M.R.5
  • 6
    • 12944266970 scopus 로고    scopus 로고
    • Normal, bound and nonbound testosterone levels in normally ageing men: Results from the Massachusetts Male Ageing Study
    • Mohr BA, Guay AT, O'Donnell AB, McKinlay JB. Normal, bound and nonbound testosterone levels in normally ageing men: Results from the Massachusetts Male Ageing Study. Clin Endocrinol (Oxf) 2005;62:64-73.
    • (2005) Clin Endocrinol (Oxf) , vol.62 , pp. 64-73
    • Mohr, B.A.1    Guay, A.T.2    O'Donnell, A.B.3    McKinlay, J.B.4
  • 7
    • 66149143224 scopus 로고    scopus 로고
    • Time for international action on treating testosterone deficiency Syndrome
    • Carruthers M. Time for international action on treating testosterone deficiency Syndrome. Aging Male 2009;12:21-28.
    • (2009) Aging Male , vol.12 , pp. 21-28
    • Carruthers, M.1
  • 8
    • 29144469309 scopus 로고    scopus 로고
    • Adverse events associated with testosterone replacement in middle-aged and older men: A meta-analysis of randomized, placebo-controlled trials
    • Calof OM, Singh AB, Lee ML, et al. Adverse events associated with testosterone replacement in middle-aged and older men: A meta-analysis of randomized, placebo-controlled trials. J Gerontol A Biol Sci Med Sci 2005;60:1451-1457.
    • (2005) J Gerontol A Biol Sci Med Sci , vol.60 , pp. 1451-1457
    • Calof, O.M.1    Singh, A.B.2    Lee, M.L.3
  • 9
    • 23844509633 scopus 로고    scopus 로고
    • Transdermal androgens: pharmacology and applicability to hypogonadal elderly men
    • Swerdloff RS, Wang C. Transdermal androgens: pharmacology and applicability to hypogonadal elderly men. J Endocrinol Invest 2005;28:112-116.
    • (2005) J Endocrinol Invest , vol.28 , pp. 112-116
    • Swerdloff, R.S.1    Wang, C.2
  • 10
    • 77954421915 scopus 로고    scopus 로고
    • Adverse events associated with testosterone administration
    • Basaria S, Coviello AD, Travison TG, et al. Adverse events associated with testosterone administration. N Engl J Med 2010;8:109-122.
    • (2010) N Engl J Med , vol.8 , pp. 109-122
    • Basaria, S.1    Coviello, A.D.2    Travison, T.G.3
  • 11
    • 0035206972 scopus 로고    scopus 로고
    • Combination of subcutaneous levonorgestrel implants and transdermal dihydrotestosterone gel for male hormonal contraception
    • Pöllänen P, Nikkanen V, Huhtaniemi I. Combination of subcutaneous levonorgestrel implants and transdermal dihydrotestosterone gel for male hormonal contraception. Int J Androl 2001;24:369-380.
    • (2001) Int J Androl , vol.24 , pp. 369-380
    • Pöllänen, P.1    Nikkanen, V.2    Huhtaniemi, I.3
  • 12
    • 84864708706 scopus 로고    scopus 로고
    • Topical testosterone supplementation for the treatment of male hypogonadism.
    • Abadilla KA, Dobs AS. Topical testosterone supplementation for the treatment of male hypogonadism. Drugs 2012; 72:1591-603.
    • (2012) Drugs , vol.72 , pp. 1591-1603
    • Abadilla, K.A.1    Dobs, A.S.2
  • 13
    • 0033323816 scopus 로고    scopus 로고
    • Clinical trial of transdermal testosterone and oral levonorgestrel for male contraception
    • Büchter D, von Eckardstein S, von Eckardstein A, et al. Clinical trial of transdermal testosterone and oral levonorgestrel for male contraception. J Clin Endocrinol Metab. 1999;84:1244-1249.
    • (1999) J Clin Endocrinol Metab. , vol.84 , pp. 1244-1249
    • Büchter, D.1    von Eckardstein, S.2    von Eckardstein, A.3
  • 14
    • 84867271392 scopus 로고    scopus 로고
    • A new combination of testosterone and nestorone transdermal gels for male hormonal contraception.
    • Ilani N, Roth MY, Amory JK, et al. A new combination of testosterone and nestorone transdermal gels for male hormonal contraception. J Clin Endocrinol Metab 2012;97 3476-3486.
    • (2012) J Clin Endocrinol Metab , vol.97 , pp. 3476-3486
    • Ilani, N.1    Roth, M.Y.2    Amory, J.K.3
  • 15
    • 67650224522 scopus 로고    scopus 로고
    • Combined Transdermal testosterone gel and the progestin nestorone suppresses serum gonadotropins in men
    • Mahabadi V, Amory JK, Swerdloff RS, et al. Combined Transdermal testosterone gel and the progestin nestorone suppresses serum gonadotropins in men. J Clin Endocrinol Metab 2009;94:2313-2320.
    • (2009) J Clin Endocrinol Metab , vol.94 , pp. 2313-2320
    • Mahabadi, V.1    Amory, J.K.2    Swerdloff, R.S.3
  • 16
    • 0019814002 scopus 로고
    • Agonistic and antagonistic effects of clomiphene citrate and its isomers.
    • Clark J, Guthrie SC. Agonistic and antagonistic effects of clomiphene citrate and its isomers. Biol Reprol 1981;25: 667-672.
    • (1981) Biol Reprol , vol.25 , pp. 667-672
    • Clark, J.1    Guthrie, S.C.2
  • 17
    • 0033305436 scopus 로고    scopus 로고
    • Effect of estrogen agonists and antagonists on induction of progesterone receptor in a rat hypothalamic cell line
    • Fitzpatrick SL, Berrodin TJ, Jenkins SF, Sindoni DM, Deecher DC, Frail DE. Effect of estrogen agonists and antagonists on induction of progesterone receptor in a rat hypothalamic cell line. Endocrinology 1999;140:3928-3937.
    • (1999) Endocrinology , vol.140 , pp. 3928-3937
    • Fitzpatrick, S.L.1    Berrodin, T.J.2    Jenkins, S.F.3    Sindoni, D.M.4    Deecher, D.C.5    Frail, D.E.6
  • 18
    • 0023220521 scopus 로고
    • Gap junction modulation in rat uterus. III. Structure-activity relationships of estrogen receptor-binding ligands on myometrial and serosal cells.
    • Burghardt RC, Gaddy-Kurten D, Burghardt RL, Kurten RC, Mitchell PA. Gap junction modulation in rat uterus. III. Structure-activity relationships of estrogen receptor-binding ligands on myometrial and serosal cells. Biol Reprod 1987; 36:741-751.
    • (1987) Biol Reprod , vol.36 , pp. 741-751
    • Burghardt, R.C.1    Gaddy-Kurten, D.2    Burghardt, R.L.3    Kurten, R.C.4    Mitchell, P.A.5
  • 19
    • 0025942781 scopus 로고
    • Qualitative differences in estrogenic/antiestrogenic effects of clomiphene and Zuclomiphene
    • Young RL, Goldzieher JW, Chakraborty PK, Panko WB, Bridges CN. Qualitative differences in estrogenic/antiestrogenic effects of clomiphene and Zuclomiphene. Int J Fertil 1991;36:291-295.
    • (1991) Int J Fertil , vol.36 , pp. 291-295
    • Young, R.L.1    Goldzieher, J.W.2    Chakraborty, P.K.3    Panko, W.B.4    Bridges, C.N.5
  • 20
    • 0028824137 scopus 로고
    • Effect of raising endogenous testosterone levels in impotent men with secondary hypogonadism: Double blind placebo-controlled trial with clomiphene citrate
    • Guay AT, Bansal S, Heatley GJ. Effect of raising endogenous testosterone levels in impotent men with secondary hypogonadism: Double blind placebo-controlled trial with clomiphene citrate. J Clin Endocrinol Meta 1995;80:3546-3552.
    • (1995) J Clin Endocrinol Meta , vol.80 , pp. 3546-3552
    • Guay, A.T.1    Bansal, S.2    Heatley, G.J.3
  • 21
    • 0041670895 scopus 로고    scopus 로고
    • Clomiphene increases free testosterone levels in men with both secondary hypogonadism and erectile dysfunction: Who does and does not benefit?
    • Guay AT, Jacobson J, Perez JB, Hodge MB, Velasquez E. Clomiphene increases free testosterone levels in men with both secondary hypogonadism and erectile dysfunction: Who does and does not benefit? Int J Impot Res 2003;15:156-165.
    • (2003) Int J Impot Res , vol.15 , pp. 156-165
    • Guay, A.T.1    Jacobson, J.2    Perez, J.B.3    Hodge, M.B.4    Velasquez, E.5
  • 22
    • 26944485833 scopus 로고    scopus 로고
    • Clomiphene administration for cases of nonobstructive azoospermia: a multicenter study
    • discussion 792-793
    • Hussein A, Ozgok Y, Ross L, Niederberger C. Clomiphene administration for cases of nonobstructive azoospermia: a multicenter study. J Androl 2005;26:787-791, discussion 792-793.
    • (2005) J Androl , vol.26 , pp. 787-791
    • Hussein, A.1    Ozgok, Y.2    Ross, L.3    Niederberger, C.4
  • 23
    • 28544441542 scopus 로고    scopus 로고
    • Clomiphene citrate effects on testosterone/estrogen ratio in male hypogonadism
    • Shabsigh A, Kang Y, Shabsigh R, Gonzalez M, et al. Clomiphene citrate effects on testosterone/estrogen ratio in male hypogonadism. J Sex Med 2005;2:716-721.
    • (2005) J Sex Med , vol.2 , pp. 716-721
    • Shabsigh, A.1    Kang, Y.2    Shabsigh, R.3    Gonzalez, M.4
  • 24
    • 0037226905 scopus 로고    scopus 로고
    • Use of clomiphene citrate to reverse premature andropause secondary to steroid abuse
    • Tan RS, Vasudevan D. Use of clomiphene citrate to reverse premature andropause secondary to steroid abuse. Fertil Steril 2003;79:203-205.
    • (2003) Fertil Steril , vol.79 , pp. 203-205
    • Tan, R.S.1    Vasudevan, D.2
  • 25
    • 84878686321 scopus 로고    scopus 로고
    • Oral enclomiphene citrate stimulates the endogenous production of testosterone and sperm counts in men with low testosterone: comparison with testosterone gel.
    • Kaminetsky J, Werner M, Fontenot G, Wiehle RD. Oral enclomiphene citrate stimulates the endogenous production of testosterone and sperm counts in men with low testosterone: comparison with testosterone gel. J Sex Med 2013;10: 1628-1635.
    • (2013) J Sex Med , vol.10 , pp. 1628-1635
    • Kaminetsky, J.1    Werner, M.2    Fontenot, G.3    Wiehle, R.D.4
  • 26
    • 84887284539 scopus 로고    scopus 로고
    • Testosterone restoration by enclomiphene citrate in men with secondary hypogonadism: Pharmacodynamics and pharmacokinetics
    • Wiehle R, Cunningham GR, Pitteloud N, Wike J, et al. Testosterone restoration by enclomiphene citrate in men with secondary hypogonadism: Pharmacodynamics and pharmacokinetics. BJU Int 2013;112:1188-1200.
    • (2013) BJU Int , vol.112 , pp. 1188-1200
    • Wiehle, R.1    Cunningham, G.R.2    Pitteloud, N.3    Wike, J.4
  • 27
    • 0033821819 scopus 로고    scopus 로고
    • Validation of a screening questionnaire for androgen deficiency in aging males
    • Morley JE, Charlton E, Patrick P, et al. Validation of a screening questionnaire for androgen deficiency in aging males. Metabolism 2000;49:1239-1242.
    • (2000) Metabolism , vol.49 , pp. 1239-1242
    • Morley, J.E.1    Charlton, E.2    Patrick, P.3
  • 28
    • 84890069835 scopus 로고    scopus 로고
    • Free testosterone by direct and calculated measurement versus equilibrium dialysis in a clinical population.
    • Kacker R, Hornstein A, Morgentaler A. Free testosterone by direct and calculated measurement versus equilibrium dialysis in a clinical population. Aging Male 2013;16: 164-168.
    • (2013) Aging Male , vol.16 , pp. 164-168
    • Kacker, R.1    Hornstein, A.2    Morgentaler, A.3
  • 29
    • 84914813734 scopus 로고    scopus 로고
    • The testis and male sexual function.
    • In: Goldman L, Schafer AI, eds. Philadelphia: Saunders Elsevier chap 242
    • Swerdloff RS, Wang C. The testis and male sexual function. In: Goldman L, Schafer AI, eds. Cecil medicine, 24th ed. Philadelphia: Saunders Elsevier; 2011:chap 242.
    • (2011) Cecil medicine, 24th ed.
    • Swerdloff, R.S.1    Wang, C.2
  • 30
    • 33645517241 scopus 로고    scopus 로고
    • Somatotropic and gonadotropic axes linkages in infancy, childhood, and the puberty-adult transition
    • Veldhuis JD, Roemmich JN, Richmond EJ, Bowers CY. Somatotropic and gonadotropic axes linkages in infancy, childhood, and the puberty-adult transition. Endocr Rev 2006;27:101-140.
    • (2006) Endocr Rev , vol.27 , pp. 101-140
    • Veldhuis, J.D.1    Roemmich, J.N.2    Richmond, E.J.3    Bowers, C.Y.4
  • 31
    • 0030657462 scopus 로고    scopus 로고
    • Effects of age on the irregularity of LH and FSH serum concentrations in women and men.
    • Pincus SM, Veldhuis JD, Mulligan T, Iranmanesh A, Evans WS. Effects of age on the irregularity of LH and FSH serum concentrations in women and men. Am J Physio 1997:273: E989-995.
    • (1997) Am J Physio , vol.273 , pp. E989-E995
    • Pincus, S.M.1    Veldhuis, J.D.2    Mulligan, T.3    Iranmanesh, A.4    Evans, W.S.5
  • 32
    • 0018939760 scopus 로고
    • Effect of clomiphene citrate on testicular steroid metabolism in man.
    • Carlstrom K, Fredricsson B. Effect of clomiphene citrate on testicular steroid metabolism in man. Int J Androl 1980;3: 417-428.
    • (1980) Int J Androl , vol.3 , pp. 417-428
    • Carlstrom, K.1    Fredricsson, B.2
  • 33
    • 17744374771 scopus 로고    scopus 로고
    • Long-term pharmacokinetics of transdermal testosterone gel in hypogonadal men
    • Swerdloff RS, Wang C, Cunningham G. Long-term pharmacokinetics of transdermal testosterone gel in hypogonadal men. J Clin Endocrinol Metab 2005;85:4500-4510.
    • (2005) J Clin Endocrinol Metab , vol.85 , pp. 4500-4510
    • Swerdloff, R.S.1    Wang, C.2    Cunningham, G.3
  • 34
    • 0023277707 scopus 로고
    • Serum bioactive and immunoreactive folliclestimulating hormone levels and the response to clomiphene in healthy young and elderly men
    • Tenover JS, Dahl KD, Hsueh AJ, Lim P, Matsumoto AM, Bremner WJ. Serum bioactive and immunoreactive folliclestimulating hormone levels and the response to clomiphene in healthy young and elderly men. J Clin Endocrinol Metab 1987;64:1103-1108.
    • (1987) J Clin Endocrinol Metab , vol.64 , pp. 1103-1108
    • Tenover, J.S.1    Dahl, K.D.2    Hsueh, A.J.3    Lim, P.4    Matsumoto, A.M.5    Bremner, W.J.6
  • 35
    • 0034940921 scopus 로고    scopus 로고
    • Enzymology of the hair follicle
    • Hoffmann R. Enzymology of the hair follicle. Eur J Dermatol 2001;11:296-300.
    • (2001) Eur J Dermatol , vol.11 , pp. 296-300
    • Hoffmann, R.1
  • 36
    • 0028173882 scopus 로고
    • Steroid 5 alpha-reductase: Two genes/two enzymes
    • Russell DW, Wilson JD. Steroid 5 alpha-reductase: Two genes/two enzymes. Annu Rev Biochem 1994;63:25-61.
    • (1994) Annu Rev Biochem , vol.63 , pp. 25-61
    • Russell, D.W.1    Wilson, J.D.2
  • 37
    • 0013912652 scopus 로고
    • Diurnal testosterone levels in peripheral plasma of human male subjects
    • Resko JA, Eik-Nes KB. Diurnal testosterone levels in peripheral plasma of human male subjects. J Clin Endocrinol Metab 1966;26:573-576.
    • (1966) J Clin Endocrinol Metab , vol.26 , pp. 573-576
    • Resko, J.A.1    Eik-Nes, K.B.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.