Antibiotic exposure in a low-income country: Screening urine samples for presence of antibiotics and antibiotic resistance in coagulase negative staphylococcal contaminants

PLoS ONE

Volumn 9, Issue 12, 2014, Pages

  Lerbech, Anne Mette ^a   Opintan, Japheth A ^b   Bekoe, Samuel Oppong ^a   Ahiabu, Mary Anne ^a   Tersbøl, Britt Pinkowski ^a   Hansen, Martin ^a   Brightson, Kennedy T C ^c   Ametepeh, Samuel ^c   Frimodt Møller, Niels ^d   Styrishave, Bjarne ^a  

^a UNIVERSITY OF COPENHAGEN   (Denmark)

^b UNIVERSITY OF GHANA   (Ghana)

^c Microbiology Laboratory Shai Osudoku District Hospital   (Ghana)

^d HVIDOVRE HOSPITAL   (Denmark)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBIOTIC AGENT; CEFOXITIN; CHLORAMPHENICOL; CIPROFLOXACIN; CLINDAMYCIN; COAGULASE; ERYTHROMYCIN; FUSIDIC ACID; GENTAMICIN; METICILLIN; METRONIDAZOLE; PENICILLIN V; RIFAMPICIN; SULFAMETHOXAZOLE; SULFONAMIDE; TETRACYCLINE; TRIMETHOPRIM; VANCOMYCIN; TETRACYCLINE DERIVATIVE;

ADULT; AGED; ANTIBIOTIC RESISTANCE; ANTIBIOTIC SENSITIVITY; ARTICLE; COAGULASE NEGATIVE STAPHYLOCOCCUS; CONTROLLED STUDY; DISK DIFFUSION; DRUG DETERMINATION; DRUG EXPOSURE; ELECTROSPRAY; ENZYME ASSAY; FEMALE; GHANA; GRAM STAINING; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; LOWEST INCOME GROUP; MALE; MATRIX ASSISTED LASER DESORPTION IONIZATION TIME OF FLIGHT MASS SPECTROMETRY; MULTIDRUG RESISTANCE; NONHUMAN; PREVALENCE; SOLID PHASE EXTRACTION; STAPHYLOCOCCUS EPIDERMIDIS; STAPHYLOCOCCUS HAEMOLYTICUS; STAPHYLOCOCCUS HOMINIS; TANDEM MASS SPECTROMETRY; URINALYSIS; ADOLESCENT; DRUG EFFECTS; ENZYMOLOGY; GENETICS; MICROBIOLOGY; MIDDLE AGED; PENICILLIN RESISTANCE; STAPHYLOCOCCAL INFECTIONS; URINE; VERY ELDERLY;

ADOLESCENT; ADULT; AGED; AGED, 80 AND OVER; COAGULASE; FEMALE; GHANA; HUMANS; METHICILLIN RESISTANCE; MIDDLE AGED; STAPHYLOCOCCAL INFECTIONS; STAPHYLOCOCCUS EPIDERMIDIS; STAPHYLOCOCCUS HAEMOLYTICUS; TETRACYCLINES;

EID: 84914696635     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0113055     Document Type: Article

References (58)

1. Kunin CM (1993) Resistance to Antimicrobial Drugs - a Worldwide Calamity. Annals of Internal Medicine 118: 557-561.
2. Levy SB (1997) Antibiotic resistance: an ecological imbalance. Ciba Found Symp 207: 1-9; discussion 9-14.
3. Newman MJ, Frimpong E, Donkor ES, Opintan JA, Asamoah-Adu A (2011) Resistance to antimicrobial drugs in Ghana. Infect Drug Resist 4: 215-220.
4. Denno DM, Frimpong E, Gregory M, Steele RW (2002) Nasopharyngeal carriage and susceptibility patterns of Streptococcus pneumoniae in Kumasi, Ghana. West Afr J Med 21: 233-236.
5. Mills-Robertson F, Addy ME, Mensah P, Crupper SS (2002) Molecular characterization of antibiotic resistance in clinical Salmonella typhi isolated in Ghana. FEMS Microbiol Lett 215: 249-253.
6. Nys S, Okeke IN, Kariuki S, Dinant GJ, Driessen C, et al. (2004) Antibiotic resistance of faecal Escherichia coli from healthy volunteers from eight developing countries. J Antimicrob Chemother 54: 952-955.
7. Senah KA (1997) Money be man: the popularity of medicines in a rural Ghanaian community. Amsterdam: Het Spinhuis. xvi, 256 p. p.
8. Wolf-Gould CS, Taylor N, Horwitz SM, Barry M (1991) Misinformation about medications in rural Ghana. Soc Sci Med 33: 83-89.
9. Okeke IN, Aboderin OA, Byarugaba DK, Ojo KK, Opintan JA (2007) Growing problem of multidrugresistant enteric pathogens in Africa. Emerg Infect Dis 13: 1640-1646.
10. Radyowijati A, Haak H (2003) Improving antibiotic use in low-income countries: an overview of evidence on determinants. Soc Sci Med 57: 733-744.
11. World Bank (2009) The pharmaceutical sector in Ghana: policy note. Washington DC: World Bank. Available: http://documents.worldbank.org/curated/en/2009/11/18241232/pharmaceutical-sector-ghana-policy-note. Accessed 2014 May 17.
12. Adu-Sarkodie YA (1997) Antimicrobial self medication in patients attending a sexually transmitted diseases clinic. Int J STD AIDS 8: 456-458.
13. Polage CR, Bedu-Addo G, Owusu-Ofori A, Frimpong E, Lloyd W, et al. (2006) Laboratory use in Ghana: physician perception and practice. Am J Trop Med Hyg 75: 526-531.
14. Ma XX, Sun DD, Hu J, Wang EH, Luo EJ (2011) Epidemiological and molecular characterization of Staphylococcus haemolyticus strains, from a hematology ward, with decreased susceptibility to glycopeptides. Can J Microbiol 57: 476-484.
15. Cove JH, Eady EA, Cunliffe WJ (1990) Skin carriage of antibiotic-resistant coagulase-negative staphylococci in untreated subjects. J Antimicrob Chemother 25: 459-469.
16. Hoiby N, Jarlov JO, Kemp M, Tvede M, Bangsborg JM, et al. (1997) Excretion of ciprofloxacin in sweat and multiresistant Staphylococcus epidermidis. Lancet 349: 167-169.
17. Hoiby N, Johansen HK (1995) Ciprofloxacin in sweat and antibiotic resistance. The Copenhagen Study Group on Antibiotics in Sweat. Lancet 346: 1235.
18. Tollefson L, Karp BE (2004) Human health impact from antimicrobial use in food animals. Med Mal Infect 34: 514-521.
19. van den Bogaard AE, Stobberingh EE (1999) Antibiotic usage in animals: impact on bacterial resistance and public health. Drugs 58: 589-607.
20. Marshall BM, Levy SB (2011) Food animals and antimicrobials: impacts on human health. Clin Microbiol Rev 24: 718-733.
21. Khachatourians GG (1998) Agricultural use of antibiotics and the evolution and transfer of antibioticresistant bacteria. CMAJ 159: 1129-1136.
22. Addo VN (2007) Herbal medicines: socio-demographic characteristics and pattern of use by patients in a tertiary obstetrics and gynaecology unit. Journal of Science & Technology (Ghana) 27: 149-155.
23. Bosu WK, Mabey D (1998) The availability and cost of antibiotics for treating PID in the Central Region of Ghana and implications for compliance with national treatment guidelines. Int J STD AIDS 9: 551-553.\
24. Donkor ES, Tetteh-Quarcoo PB, Nartey P, Agyeman IO (2012) Self-medication practices with antibiotics among tertiary level students in Accra, Ghana: a cross-sectional study. Int J Environ Res Public Health 9: 3519-3529.
25. Ministry of Health (2010) Standard Treatment Guidelines.6th ed. Ghana: Ministry of Health.
26. The European Committee on Antimicrobial Susceptibility Testing (2013) Breakpoint tables for interpretation of MICs and zone diameters. Version 3.1. Available: http://www.eucast.org.
27. Wilcox MH (2009) The tide of antimicrobial resistance and selection. Int J Antimicrob Agents 34 Suppl 3: S6-10.
28. Gould IM (2009) Antibiotic resistance: the perfect storm. Int J Antimicrob Agents 34 Suppl 3: S2-5.
29. Marshall SA, Wilke WW, Pfaller MA, Jones RN (1998) Staphylococcus aureus and coagulasenegative staphylococci from blood stream infections: frequency of occurrence, antimicrobial susceptibility, and molecular (mecA) characterization of oxacillin resistance in the SCOPE program. Diagn Microbiol Infect Dis 30: 205-214.
30. Isturiz RE, Carbon C (2000) Antibiotic use in developing countries. Infect Control Hosp Epidemiol 21: 394-397.
31. Akinkunmi EO, Lamikanra A (2010) Species Distribution and Antibiotic Resistance in Coagulasenegative Staphylococci Colonizing the Gastrointestinal Tract of Children in Ile-Ife, Nigeria. Trop J Pharm Res 9: 35-43.
32. Germer J, Sinar E (2010) Pharmaceutical consumption and residuals potentially relevant to nutrient cycling in Greater Accra, Ghana. J Agr Rural Develop Trop Subtrop 111: 41-53.
33. Valentin T, Leitner E, Rohn A, Zollner-Schwetz I, Hoenigl M, et al. (2011) Rifaximin intake leads to emergence of rifampin-resistant staphylococci. J Infect 62: 34-38.
34. Kloos WE, Bannerman TL (1994) Update on clinical significance of coagulase-negative staphylococci. Clin Microbiol Rev 7: 117-140.
35. John JF Jr, Gramling PK, O'Dell NM (1978) Species identification of coagulase-negative staphylococci from urinary tract isolates. J Clin Microbiol 8: 435-437.
36. Froggatt JW, Johnston JL, Galetto DW, Archer GL (1989) Antimicrobial resistance in nosocomial isolates of Staphylococcus haemolyticus. Antimicrob Agents Chemother 33: 460-466.
37. Lebeaux D, Barbier F, Angebault C, Benmahdi L, Ruppe E, et al. (2012) Evolution of nasal carriage of methicillin-resistant coagulase-negative staphylococci in a remote population. Antimicrob Agents Chemother 56: 315-323.
38. Barros EM, Ceotto H, Bastos MC, Dos Santos KR, Giambiagi-Demarval M (2012) Staphylococcus haemolyticus as an important hospital pathogen and carrier of methicillin resistance genes. J Clin Microbiol 50: 166-168.
39. Levy SB (1998) The challenge of antibiotic resistance. Sci Am 278: 46-53.
40. Gold HS, Moellering RC Jr (1996) Antimicrobial-drug resistance. N Engl J Med 335: 1445-1453.
41. John JF, Harvin AM (2007) History and evolution of antibiotic resistance in coagulase-negative staphylococci: Susceptibility profiles of new anti-staphylococcal agents. Ther Clin Risk Manag 3: 1143-1152.
42. Huebner J, Goldmann DA (1999) Coagulase-negative staphylococci: Role as pathogens. Annual Review of Medicine 50: 223-236.
43. Agvald-Ohman C, Lund B, Edlund C (2004) Multiresistant coagulase-negative staphylococci disseminate frequently between intubated patients in a multidisciplinary intensive care unit. Crit Care 8: R42-47.
44. Akinkunmi E, Lamikanra A (2012) A study of the intestinal carriage of antibiotic resistant Staphylococcus aureus by Nigerian children. Afr Health Sci 12: 381-387.
45. Leclercq R (2009) Epidemiological and resistance issues in multidrug-resistant staphylococci and enterococci. Clin Microbiol Infect 15: 224-231.
46. Ma XX, Wang EH, Liu Y, Luo EJ (2011) Antibiotic susceptibility of coagulase-negative staphylococci (CoNS): emergence of teicoplanin-non-susceptible CoNS strains with inducible resistance to vancomycin. J Med Microbiol 60: 1661-1668.
47. Barbier F, Ruppe E, Hernandez D, Lebeaux D, Francois P, et al. (2010) Methicillin-resistant coagulase-negative staphylococci in the community: high homology of SCCmec IVa between Staphylococcus epidermidis and major clones of methicillin-resistant Staphylococcus aureus. J Infect Dis 202: 270-281.
48. Akinkunmi EO, Lamikanra A (2006) A study of the microbial quality and organoleptic properties of ophthalmic preparations obtained from traditional medical practitioners in South Western Nigeria. Afr J Med Med Sci 35: 15-20.
49. Hanssen AM, Ericson Sollid JU (2006) SCCmec in staphylococci: genes on the move. FEMS Immunol Med Microbiol 46: 8-20.
50. Berglund C, Soderquist B (2008) The origin of a methicillin-resistant Staphylococcus aureus isolate at a neonatal ward in Sweden-possible horizontal transfer of a staphylococcal cassette chromosome mec between methicillin-resistant Staphylococcus haemolyticus and Staphylococcus aureus. Clin Microbiol Infect 14: 1048-1056.
51. de Lencastre H, Oliveira D, Tomasz A (2007) Antibiotic resistant Staphylococcus aureus: a paradigm of adaptive power. Curr Opin Microbiol 10: 428-435.
52. Ghana Statistical Service (2008) Ghana living standards survey report of the fifth round (GLSS 5). Available: http://www.statsghana.gov.gh/docfiles/glss5-report.pdf. Accessed 2014 May 21.
53. Grady KE, Wallston BS (1988) Research in health care settings. Newbury Park, Calif.: Sage Publications. 176pp.
54. K'Oreje KO, Demeestere K, De Wispelaere P, Vergeynst L, Dewulf J, et al. (2012) From multi-residue screening to target analysis of pharmaceuticals in water: development of a new approach based on magnetic sector mass spectrometry and application in the Nairobi River basin, Kenya. Sci Total Environ 437: 153-164.
55. Annan-Prah A, Agbemafle E, Asare PT, Akorli SY (2012) Antibiotic use, Abuse and their Public Health Implication: The Contributory role of management Flaws in the Poultry Industry in two Agro-Ecological Zones in Ghana. Jurnal of Veterinary Advances 2: 199-208.
56. Donkor ES, Newman MJ, Yeboah-Manu D (2012) Epidemiological aspects of non-human antibiotic usage and resistance: implications for the control of antibiotic resistance in Ghana. Trop Med Int Health 17: 462-468.
57. Turkson PK (2008) Use of drugs and antibiotics in poultry production in Ghana. Ghana Journal of Agricultural Science. 41
58. Gustafsson I, Sjolund M, Torell E, Johannesson M, Engstrand L, et al. (2003) Bacteria with increased mutation frequency and antibiotic resistance are enriched in the commensal flora of patients with high antibiotic usage. J Antimicrob Chemother 52: 645-650.