N-terminal cleavage and release of the ectodomain of Flt1 is mediated via ADAM10 and ADAM 17 and regulated by VEGFR2 and the Flt1 intracellular domain

PLoS ONE

Volumn 9, Issue 11, 2014, Pages

  Raikwar, Nandita S ^a   Liu, Kang Z ^a   Thomas, Christie P ^a,b  

^a UNIVERSITY OF IOWA   (United States)

^b VETERANS AFFAIRS MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADAM10 ENDOPEPTIDASE; HETERODIMER; MEMBRANE PROTEIN; METALLOPROTEINASE; PROTEIN KINASE C; RING FINGER PROTEIN; TUMOR NECROSIS FACTOR ALPHA CONVERTING ENZYME; TYROSINE; UBIQUITIN PROTEIN LIGASE; VASCULOTROPIN INHIBITOR; VASCULOTROPIN RECEPTOR 1; VASCULOTROPIN RECEPTOR 2; ACETYLLEUCYL-LEUCYL-NORLEUCINAL; ADAM PROTEIN; ADAM10 PROTEIN, HUMAN; ADAM17 PROTEIN, HUMAN; DIPEPTIDE; FLT1 PROTEIN, HUMAN; HYDROXAMIC ACID; KDR PROTEIN, HUMAN; LEUPEPTIN; MATRIX METALLOPROTEINASE INHIBITOR; N-((2-(HYDROXYAMINOCARBONYL)METHYL)-4-METHYLPENTANOYL)-3-(2'-NAPHTHYL)ALANYLALANINE, 2-AMINOETHYLAMIDE; N-(2(R)-2-(HYDROXAMIDOCARBONYLMETHYL)-4-METHYLPENTANOYL)-L-TRYPTOPHAN METHYLAMIDE; SECRETASE; VASCULOTROPIN A; VEGFA PROTEIN, HUMAN;

AMINO TERMINAL SEQUENCE; ARTICLE; CARBOXY TERMINAL SEQUENCE; CONTROLLED STUDY; CYTOSOLIC FRACTION; ENZYME LINKED IMMUNOSORBENT ASSAY; HEK293 CELL LINE; HUMAN; HUMAN CELL; IMMUNOPRECIPITATION; PROTEIN CLEAVAGE; PROTEIN DEGRADATION; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN SECRETION; WESTERN BLOTTING; GENETICS; METABOLISM; MUTATION; PROTEIN TERTIARY STRUCTURE; UMBILICAL VEIN ENDOTHELIAL CELL;

ADAM PROTEINS; ADAM10 PROTEIN; ADAM17 PROTEIN; AMYLOID PRECURSOR PROTEIN SECRETASES; DIPEPTIDES; HEK293 CELLS; HUMAN UMBILICAL VEIN ENDOTHELIAL CELLS; HUMANS; HYDROXAMIC ACIDS; LEUPEPTINS; MATRIX METALLOPROTEINASE INHIBITORS; MEMBRANE PROTEINS; MUTATION; PROTEIN STRUCTURE, TERTIARY; VASCULAR ENDOTHELIAL GROWTH FACTOR A; VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR-1; VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR-2;

EID: 84914690727     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0112794     Document Type: Article

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