Antigen affinity, costimulation, and cytokine inputs sum linearly to amplify T cell expansion

Science

Volumn 346, Issue 6213, 2014, Pages 1123-1127

  Marchingo, Julia M ^a,b   Kan, Andrey ^a,b   Sutherland, Robyn M ^a,b   Duffy, Ken R ^c   Wellard, Cameron J ^a,b   Belz, Gabrielle T ^a,b   Lew, Andrew M ^a,b   Dowling, Mark R ^a,b,d   Heinzel, Susanne ^a,b   Hodgkin, Philip D ^a,b  

^a WALTER AND ELIZA HALL INSTITUTE OF MEDICAL RESEARCH   (Australia)

^b UNIVERSITY OF MELBOURNE   (Australia)

^c NATIONAL UNIVERSITY OF IRELAND   (Ireland)

^d ROYAL MELBOURNE HOSPITAL   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIGEN; CYTOKINE; INTERLEUKIN 12; INTERLEUKIN 2; INTERLEUKIN 4; OVALBUMIN; T LYMPHOCYTE RECEPTOR; LYMPHOCYTE ANTIGEN RECEPTOR;

ANTIGEN; GROWTH REGULATOR; IMMUNE RESPONSE; SIGNALING;

ARTICLE; B LYMPHOCYTE; BINDING AFFINITY; CD8+ T LYMPHOCYTE; CELL CONTACT; CELL COUNT; CELL CYCLE PHASE; CELL DIVISION; CELL EXPANSION; CELL PROLIFERATION; CELL TRACKING; HUMAN; IMMUNE RESPONSE; IMMUNOMODULATION; IN VITRO STUDY; IN VIVO STUDY; INFLUENZA VIRUS; MEDIASTINUM LYMPH NODE; MITOSIS; NONHUMAN; STIMULATION; T LYMPHOCYTE; ANIMAL; CYTOLOGY; IMMUNOLOGICAL TOLERANCE; IMMUNOLOGY; LYMPHOCYTE ACTIVATION; MOUSE; SIGNAL TRANSDUCTION;

ANIMALS; ANTIGENS; CD8-POSITIVE T-LYMPHOCYTES; CELL DIVISION; CELL PROLIFERATION; CYTOKINES; IMMUNE TOLERANCE; LYMPHOCYTE ACTIVATION; MICE; RECEPTORS, ANTIGEN, T-CELL; SIGNAL TRANSDUCTION;

EID: 84914690072     PISSN: 00368075     EISSN: 10959203     Source Type: Journal    
DOI: 10.1126/science.1260044     Document Type: Article

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