Myeloid zinc finger 1 (Mzf1) differentially modulates murine cardiogenesis by interacting with an Nkx2.5 cardiac enhancer

PLoS ONE

Volumn 9, Issue 12, 2014, Pages

  Doppler, Stefanie A ^a   Werner, Astrid ^a   Barz, Melanie ^a   Lahm, Harald ^a   Deutsch, Marcus André ^a   Dreßen, Martina ^a   Schiemann, Matthias ^a,b   Voss, Bernhard ^a   Gregoire, Serge ^c   Kuppusamy, Rajarajan ^d   Wu, Sean M ^d   Lange, Rüdiger ^a,e   Krane, Markus ^a,e  

^a TECHNICAL UNIVERSITY OF MUNICH   (Germany)

^b INSTITUTE OF EPIDEMIOLOGY   (Germany)

^c MASSACHUSETTS GENERAL HOSPITAL   (United States)

^d STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

^e DZHK GERMAN CENTRE FOR CARDIOVASCULAR RESEARCH   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

BRACHYURY PROTEIN; KRUPPEL LIKE FACTOR 4; MYELOID ZINC FINGER PROTEIN 1; PROTEIN HAND1; PROTEIN MESP1; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR ELK 1; TRANSCRIPTION FACTOR GATA 4; TRANSCRIPTION FACTOR MSX1; TRANSCRIPTION FACTOR NKX2.5; TRANSCRIPTION FACTOR SOX17; UNCLASSIFIED DRUG; ZINC FINGER PROTEIN; HOMEODOMAIN PROTEIN; KRUPPEL LIKE FACTOR; MZF1 PROTEIN, MOUSE; NKX2-5 PROTEIN, MOUSE;

ANIMAL TISSUE; ARTICLE; BINDING AFFINITY; CARDIAC STEM CELL; CELL DIFFERENTIATION; CONTROLLED STUDY; EMBRYO; ENHANCER REGION; GENE EXPRESSION; HEART DEVELOPMENT; HEART MUSCLE CELL; IN VITRO STUDY; MOUSE; NKX2.5 GENE; NONHUMAN; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; ANIMAL; CELL CULTURE; CELL LINE; COMPUTER SIMULATION; CYTOLOGY; EMBRYOLOGY; EMBRYONIC STEM CELL; GENE EXPRESSION REGULATION; GENETICS; HEART; HEK293 CELL LINE; HUMAN; METABOLISM; TRANSGENIC MOUSE;

MURINAE;

ANIMALS; CELL DIFFERENTIATION; CELL LINE; CELLS, CULTURED; COMPUTER SIMULATION; EMBRYONIC STEM CELLS; ENHANCER ELEMENTS, GENETIC; GENE EXPRESSION REGULATION, DEVELOPMENTAL; HEART; HEK293 CELLS; HOMEODOMAIN PROTEINS; HUMANS; KRUPPEL-LIKE TRANSCRIPTION FACTORS; MICE; MICE, TRANSGENIC; TRANSCRIPTION FACTORS;

EID: 84914689466     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0113775     Document Type: Article

References (39)

1. Srivastava D (2006) Making or breaking the heart: from lineage determination to morphogenesis. Cell 126: 1037-1048.
2. Murry CE, Keller G (2008) Differentiation of embryonic stem cells to clinically relevant populations: lessons from embryonic development. Cell 132: 661-680.
3. Wu SM, Fujiwara Y, Cibulsky SM, Clapham DE, Lien CL, et al. (2006) Developmental origin of a bipotential myocardial and smooth muscle cell precursor in the mammalian heart. Cell 127: 1137-1150.
4. Moretti A, Caron L, Nakano A, Lam JT, Bernshausen A, et al. (2006) Multipotent embryonic isl1+ progenitor cells lead to cardiac, smooth muscle, and endothelial cell diversification. Cell 127: 1151-1165.
5. Kattman SJ, Huber TL, Keller GM (2006) Multipotent flk-1+ cardiovascular progenitor cells give rise to the cardiomyocyte, endothelial, and vascular smooth muscle lineages. Dev Cell 11: 723-732.
6. Domian IJ, Chiravuri M, van der Meer P, Feinberg AW, Shi X, et al. (2009) Generation of functional ventricular heart muscle from mouse ventricular progenitor cells. Science 326: 426-429.
7. Lien CL, Wu C, Mercer B, Webb R, Richardson JA, et al. (1999) Control of early cardiac-specific transcription of Nkx2-5 by a GATA-dependent enhancer. Development 126: 75-84.
8. Morris JF, Rauscher FJ 3rd, Davis B, Klemsz M, Xu D, et al. (1995) The myeloid zinc finger gene, MZF-1, regulates the CD34 promoter in vitro. Blood 86: 3640-3647.
9. Bavisotto L, Kaushansky K, Lin N, Hromas R (1991) Antisense oligonucleotides from the stage-specific myeloid zinc finger gene MZF-1 inhibit granulopoiesis in vitro. J Exp Med 174: 1097-1101.
10. Gaboli M, Kotsi PA, Gurrieri C, Cattoretti G, Ronchetti S, et al. (2001) Mzf1 controls cell proliferation and tumorigenesis. Genes Dev 15: 1625-1630.
11. Morris JF, Hromas R, Rauscher FJ, 3rd (1994) Characterization of the DNA-binding properties of the myeloid zinc finger protein MZF1: two independent DNA-binding domains recognize two DNA consensus sequences with a common G-rich core. Mol Cell Biol 14: 1786-1795.
12. Hromas R, Collins SJ, Hickstein D, Raskind W, Deaven LL, et al. (1991) A retinoic acid-responsive human zinc finger gene, MZF-1, preferentially expressed in myeloid cells. J Biol Chem 266: 14183-14187.
13. Mudduluru G, Vajkoczy P, Allgayer H (2010) Myeloid zinc finger 1 induces migration, invasion, and in vivo metastasis through Axl gene expression in solid cancer. Mol Cancer Res 8: 159-169.
14. Hsieh YH, Wu TT, Tsai JH, Huang CY, Hsieh YS, et al. (2006) PKCalpha expression regulated by Elk-1 and MZF-1 in human HCC cells. Biochem Biophys Res Commun 339: 217-225.
15. Hsieh YH, Wu TT, Huang CY, Hsieh YS, Liu JY (2007) Suppression of tumorigenicity of human hepatocellular carcinoma cells by antisense oligonucleotide MZF-1. Chin J Physiol 50: 9-15.
16. Tsai SJ, Hwang JM, Hsieh SC, Ying TH, Hsieh YH (2012) Overexpression of myeloid zinc finger 1 suppresses matrix metalloproteinase-2 expression and reduces invasiveness of SiHa human cervical cancer cells. Biochem Biophys Res Commun 425: 462-467.
17. Claycomb WC, Lanson NA Jr, Stallworth BS, Egeland DB, Delcarpio JB, et al. (1998) HL-1 cells: a cardiac muscle cell line that contracts and retains phenotypic characteristics of the adult cardiomyocyte. Proc Natl Acad Sci U S A 95: 2979-2984.
18. Chen JX, Krane M, Deutsch MA, Wang L, Rav-Acha M, et al. (2012) Inefficient reprogramming of fibroblasts into cardiomyocytes using Gata4, Mef2c, and Tbx5. Circ Res 111: 50-55.
19. Stadtfeld M, Maherali N, Breault DT, Hochedlinger K (2008) Defining molecular cornerstones during fibroblast to iPS cell reprogramming in mouse. Cell Stem Cell 2: 230-240.
20. Gregoire S, Karra R, Passer D, Deutsch MA, Krane M, et al. (2013) Essential and unexpected role of yin yang 1 to promote mesodermal cardiac differentiation. Circ Res 112: 900-910.
21. Wasserman WW, Sandelin A (2004) Applied bioinformatics for the identification of regulatory elements. Nat Rev Genet 5: 276-287.
22. Chekmenev DS, Haid C, Kel AE (2005) P-Match: transcription factor binding site search by combining patterns and weight matrices. Nucleic Acids Res 33: W432-437.
23. Firulli AB, McFadden DG, Lin Q, Srivastava D, Olson EN (1998) Heart and extra-embryonic mesodermal defects in mouse embryos lacking the bHLH transcription factor Hand1. Nat Genet 18: 266-270.
24. Liu Y, Asakura M, Inoue H, Nakamura T, Sano M, et al. (2007) Sox17 is essential for the specification of cardiac mesoderm in embryonic stem cells. Proc Natl Acad Sci U S A 104: 3859-3864.
25. Liao X, Haldar SM, Lu Y, Jeyaraj D, Paruchuri K, et al. (2010) Kruppel-like factor 4 regulates pressure-induced cardiac hypertrophy. J Mol Cell Cardiol 49: 334-338.
26. Babu GJ, Lalli MJ, Sussman MA, Sadoshima J, Periasamy M (2000) Phosphorylation of elk-1 by MEK/ERK pathway is necessary for c-fos gene activation during cardiac myocyte hypertrophy. J Mol Cell Cardiol 32: 1447-1457.
27. Chen YH, Ishii M, Sun J, Sucov HM, Maxson RE Jr (2007) Msx1 and Msx2 regulate survival of secondary heart field precursors and post-migratory proliferation of cardiac neural crest in the outflow tract. Dev Biol 308: 421-437.
28. Herrmann BG, Labeit S, Poustka A, King TR, Lehrach H (1990) Cloning of the T gene required in mesoderm formation in the mouse. Nature 343: 617-622.
29. Bondue A, Lapouge G, Paulissen C, Semeraro C, Iacovino M, et al. (2008) Mesp1 acts as a master regulator of multipotent cardiovascular progenitor specification. Cell Stem Cell 3: 69-84.
30. Huang X, Wu SM (2010) Isolation and functional characterization of pluripotent stem cell-derived cardiac progenitor cells. Curr Protoc Stem Cell Biol Chapter 1: Unit 1F 10.
31. Van Handel B, Montel-Hagen A, Sasidharan R, Nakano H, Ferrari R, et al. (2012) Scl represses cardiomyogenesis in prospective hemogenic endothelium and endocardium. Cell 150: 590-605.
32. Kitajima S, Takagi A, Inoue T, Saga Y (2000) MesP1 and MesP2 are essential for the development of cardiac mesoderm. Development 127: 3215-3226.
33. Ema M, Takahashi S, Rossant J (2006) Deletion of the selection cassette, but not cis-acting elements, in targeted Flk1-lacZ allele reveals Flk1 expression in multipotent mesodermal progenitors. Blood 107: 111-117.
34. Ismailoglu I, Yeamans G, Daley GQ, Perlingeiro RC, Kyba M (2008) Mesodermal patterning activity of SCL. Exp Hematol 36: 1593-1603.
35. Caprioli A, Koyano-Nakagawa N, Iacovino M, Shi X, Ferdous A, et al. (2011) Nkx2-5 represses Gata1 gene expression and modulates the cellular fate of cardiac progenitors during embryogenesis. Circulation 123: 1633-1641.
36. Perrotti D, Melotti P, Skorski T, Casella I, Peschle C, et al. (1995) Overexpression of the zinc finger protein MZF1 inhibits hematopoietic development from embryonic stem cells: correlation with negative regulation of CD34 and c-myb promoter activity. Mol Cell Biol 15: 6075-6087.
37. Bober E, Lyons GE, Braun T, Cossu G, Buckingham M, et al. (1991) The muscle regulatory gene, Myf-6, has a biphasic pattern of expression during early mouse development. J Cell Biol 113: 1255-1265.
38. Nguyen HT, Bodmer R, Abmayr SM, McDermott JC, Spoerel NA (1994) D-mef2: a Drosophila mesoderm-specific MADS box-containing gene with a biphasic expression profile during embryogenesis. Proc Natl Acad Sci U S A 91: 7520-7524.
39. Bondue A, Blanpain C (2010) Mesp1: a key regulator of cardiovascular lineage commitment. Circ Res 107: 1414-1427.