Early development of calcific aortic valve disease and left ventricular hypertrophy in a mouse model of combined dyslipidemia and type 2 diabetes mellitus

Arteriosclerosis, Thrombosis, and Vascular Biology

Volumn 34, Issue 10, 2014, Pages 2283-2291

  Quang, Khai Le ^a   Bouchareb, Rihab ^a   Lachance, Dominic ^a   Laplante, Marc André ^a   El Husseini, Diala ^a   Boulanger, Marie Chloé ^a   Fournier, Dominique ^a   Fang, Xiang Ping ^a,b   Avramoglu, Rita Kohen ^a   Pibarot, Philippe ^a   Deshaies, Yves ^a   Sweeney, Gary ^b   Mathieu, Patrick ^a   Marette, André ^a  

^a UNIVERSITÉ LAVAL   (Canada)

^b YORK UNIVERSITY   (Canada)

Author keywords

Aortic valve stenosis; Diabetes mellitus, type 2; Inflammation; Obesity

Indexed keywords

ATRIAL NATRIURETIC FACTOR; BRAIN NATRIURETIC PEPTIDE; CADHERIN; COLLAGEN TYPE 1; MESSENGER RNA; MYOSIN HEAVY CHAIN BETA; T CADHERIN; UNCLASSIFIED DRUG; APOB PROTEIN, MOUSE; APOLIPOPROTEIN B; CHOLESTEROL INTAKE; IGF2 PROTEIN, MOUSE; LOW DENSITY LIPOPROTEIN RECEPTOR; SOMATOMEDIN B; SUGAR INTAKE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; AORTA ROOT FIBROSIS; AORTA STENOSIS; AORTA VALVE; AORTA VALVE DISEASE; AORTIC VALVE CALCIFICATION; ARTICLE; BLOOD VESSEL CALCIFICATION; BLOOD VESSEL PARAMETERS; CALCIFIC AORTIC VALVE DISEASE; CHOLESTEROL DIET; CONTROLLED STUDY; DYSLIPIDEMIA; ELECTRON MICROSCOPY; HEART LEFT VENTRICLE FUNCTION; HEART LEFT VENTRICLE HYPERTROPHY; INFLAMMATORY INFILTRATE; LEFT VENTRICULAR DIASTOLIC FUNCTION; LEFT VENTRICULAR SYSTOLIC FRACTIONAL SHORTENING; LIPID DIET; MICRO-COMPUTED TOMOGRAPHY; MOUSE; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; OBESITY; PEAK AORTIC JET VELOCITY; PROTEIN EXPRESSION; ROENTGEN SPECTROSCOPY; TRANSTHORACIC ECHOCARDIOGRAPHY; UPREGULATION; ANIMAL; AORTIC VALVE STENOSIS; C57BL MOUSE; CALCINOSIS; CHOLESTEROL INTAKE; COMPLICATION; DEFICIENCY; DISEASE MODEL; ETIOLOGY; GENE EXPRESSION REGULATION; GENETICS; GENOTYPE; HYPERTROPHY, LEFT VENTRICULAR; KNOCKOUT MOUSE; MALE; METABOLISM; PATHOLOGY; PATHOPHYSIOLOGY; PHENOTYPE; SUGAR INTAKE; TIME;

ANIMALS; AORTIC VALVE; AORTIC VALVE STENOSIS; APOLIPOPROTEINS B; CALCINOSIS; CHOLESTEROL, DIETARY; DIABETES MELLITUS, TYPE 2; DIET, HIGH-FAT; DIETARY SUCROSE; DISEASE MODELS, ANIMAL; DYSLIPIDEMIAS; GENE EXPRESSION REGULATION; GENOTYPE; HYPERTROPHY, LEFT VENTRICULAR; INSULIN-LIKE GROWTH FACTOR II; MALE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; PHENOTYPE; RECEPTORS, LDL; TIME FACTORS; VENTRICULAR DYSFUNCTION, LEFT; VENTRICULAR FUNCTION, LEFT;

EID: 84914181658     PISSN: 10795642     EISSN: 15244636     Source Type: Journal    
DOI: 10.1161/ATVBAHA.114.304205     Document Type: Article

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