The right ventricle in pulmonary arterial hypertension

European Respiratory Review

Volumn 23, Issue 134, 2014, Pages 476-487

  Naeije, Robert ^a   Manes, Alessandra ^b  

^a ERASME HOSPITAL   (Belgium)

^b UNIVERSITY OF BOLOGNA   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

BISOPROLOL; CARVEDILOL; CATECHOLAMINE; ENDOTHELIN RECEPTOR ANTAGONIST; ILOPROST; METOPROLOL; MONOCROTALINE; NORADRENALIN; PHOSPHODIESTERASE V INHIBITOR; PROPRANOLOL; PROSTACYCLIN; SEMAXANIB;

AEROBIC EXERCISE; CARDIOGENIC SHOCK; CHRONIC DRUG ADMINISTRATION; CLINICAL EVALUATION; DIASTOLIC BLOOD PRESSURE; DIASTOLIC DYSFUNCTION; ECHOCARDIOGRAPHY; HEART AFTERLOAD; HEART CATHETERIZATION; HEART DILATATION; HEART LEFT VENTRICLE FILLING; HEART MUSCLE CONTRACTILITY; HEART MUSCLE FIBROSIS; HEART RIGHT VENTRICLE; HEART RIGHT VENTRICLE ENDDIASTOLIC VOLUME; HEART RIGHT VENTRICLE FAILURE; HUMAN; LUNG CIRCULATION; LUNG VASOCONSTRICTION; NONHUMAN; NUCLEAR MAGNETIC RESONANCE IMAGING; PATHOPHYSIOLOGY; PROGNOSIS; PULMONARY HYPERTENSION; RESIDUAL VOLUME; REVIEW; SYMPTOM; SYSTOLIC BLOOD PRESSURE; ADAPTATION; BLOOD PRESSURE; CASE REPORT; CHILD; ETIOLOGY; EXERCISE TOLERANCE; FEMALE; HEART OUTPUT; HEART RIGHT VENTRICLE FUNCTION; HEART VENTRICLE; HYPERTENSION, PULMONARY; MALE; PHYSIOLOGY; YOUNG ADULT;

ADAPTATION, PHYSIOLOGICAL; BLOOD PRESSURE; CARDIAC OUTPUT; CHILD; EXERCISE TOLERANCE; FEMALE; HEART VENTRICLES; HUMANS; HYPERTENSION, PULMONARY; MALE; PROGNOSIS; VENTRICULAR DYSFUNCTION, RIGHT; YOUNG ADULT;

EID: 84914163059     PISSN: 09059180     EISSN: 16000617     Source Type: Journal    
DOI: 10.1183/09059180.00007414     Document Type: Review

References (64)

1. Hoeper MM, Bogaard HJ, Condliffe R, et al. Definitions and diagnosis of pulmonary hypertension. J Am Coll Cardiol 2013; 62: Suppl. 25, D45-D50.
2. Vonk-Noordegraaf A, Haddad F, Chin KM, et al. Right heart adaptation to pulmonary arterial hypertension: physiology and pathobiology. J Am Coll Cardiol 2013; 62: Suppl. 25, D22-D33.
3. Haddad F, Hunt SA, Rosenthal DN, et al. Right ventricular function in cardiovascular disease, part I. Anatomy, physiology, aging and functional assessment of the right ventricle. Circulation 2008; 117: 1436-1448.
4. Guyton AC, Lindsey AW, Gilluly JJ. The limits of right ventricular compensation following acute increase in pulmonary circulatory resistance. Circ Res 1954; 2: 326-332.
5. Sagawa K, Maughan L, Suga H, eds, et al. Cardiac Contraction and the Pressure-Volume Relationship. Oxford, Oxford University Press, 1988.
6. Sarnoff SJ, Mitchell JH, Gilmore JP, et al. Homeometric autoregulation of the heart. Circ Res 1960; 8: 1077-1091.
7. von Anrep G. On the part played by the suprarenals in the normal vascular reactions of the body. J Physiol 1912; 45: 307-317.
8. Taquini AC, Fermoso JD, Aramendia P. Behaviour of the right ventricle following acute constriction of the pulmonary artery. Circ Res 1960: 315-318.
9. Vonk-Noordegraaf A, Westerhof N. Describing right ventricular function. Eur Respir J 2013; 41: 1419-1423.
10. Naeije R, Brimioulle S, Dewachter C. Biomechanics of the right ventricle. Pulm Circ 2014; 4: 395-406.
11. Suga H, Sagawa K, Shoukas AA. Load independence of the instantaneous pressure-volume ratio of the canine left ventricle and effects of epinephrine and heart rate on the ratio. Circ Res 1973; 32: 314-322.
12. Maughan WL, Shoukas AA, Sagawa K, et al. Instantaneous pressure-volume relationship of the canine right ventricle. Circ Res 1979; 44: 309-315.
13. Redington AN, Rigby RL, Shinebourne EA, et al. Changes in pressure-volume relation of the right ventricle when its loading conditions are modified. Br Heart J 1990; 63: 45-49.
14. Tedford RJ, Mudd JO, Girgis RE, et al. Right ventricular dysfunction in systemic sclerosis associated pulmonary arterial hypertension. Circulation Heart Fail 2013; 6: 953-963.
15. Sunagawa K, Yamada A, Senda Y, et al. Estimation of the hydromotive source pressure from ejecting beats of the left ventricle. IEEE Trans Biomed Eng 1980; 57: 299-305.
16. Brimioulle S, Wauthy P, Ewalenko P, et al. Single-beat estimation of right ventricular end-systolic pressure-volume relationship. Am J Physiol Heart Circ Physiol 2003; 284: H1625-H1630.
17. Vanderpool RR, Pinsky MR, Naeije R, et al. RV-pulmonary arterial coupling predicts outcome in patients referred for pulmonary hypertension. Heart 2014 [In press DOI: 10.1136/heartjnl-2014-306142].
18. Dell’Italia LJ, Walsh RA. Application of a time-varying elastance model to right ventricular performance in man. Cardiovasc Res 1988; 22: 864-874.
19. Kuehne T, Yilmaz S, Steendijk P, et al. Magnetic resonance imaging analysis of right ventricular pressure-volume loops: in vivo validation and clinical application in patients with pulmonary hypertension. Circulation 2004; 110: 2010-2016.
20. Wauthy P, Naeije R, Brimioulle S. Left and right ventriculo-arterial coupling in a patient with congenitally corrected transposition. Cardiol Young 2005; 15: 647-649.
21. McCabe C, White PA, Hoole SP, et al. Right ventricular dysfunction in chronic thromboembolic obstruction of the pulmonary artery. J Appl Physiol 2013; 116: 355-363.
22. Rosenblueth A, Alanis J, Lopez E, et al. The adaptation of ventricular muscle to different circulatory conditions. Arch Int Physiol Biochim 1959; 67: 358-373.
23. Bogaard HJ, Abe K, Vonk Noordegraaf A, et al. The right ventricle under pressure. Cellular and molecular mechanisms of right heart failure in pulmonary hypertension. Chest 2009; 135: 794-780.
24. Voelkel NF, Gomez-Arroyo J, Abbate A, et al. Pathobiology of pulmonary arterial hypertension and right ventricular failure. Eur Respir J 2012; 40: 1555-1565.
25. Voelkel NF, Gomez-Arroyo J, Abbate A, et al. Mechanisms of right heart failure - a work in progress and plea for further prevention. Pulm Circ 2013; 3: 137-143.
26. Gómez A, Bialostozky D, Zajarias A, et al. Right ventricular ischemia in patients with primary pulmonary hypertension. J Am Coll Cardiol 2001; 38: 1137-1141.
27. Dewachter C, Dewachter L, Rondelet B, et al. Activation of apoptotic pathways in experimental acute afterloadinduced right ventricular failure. Crit Care Med 2010; 38: 1405-1413.
28. Belhaj A, Dewachter L, Kerbaul F, et al. Heme oxygenase-1 and inflammation in experimental right ventricular failure on prolonged overcirculation-induced pulmonary hypertension. PLoS One 2013; 8: e69470.
29. Hoeper MM, Granton J. Intensive care unit management of patients with severe pulmonary hypertension and right heart failure. Am J Respir Crit Care Med 2011; 184: 1114-1124.
30. Sztrymf B, Günther S, Artaud-Macari E, et al. Left ventricular ejection time in acute heart failure complicating precapillary pulmonary hypertension. Chest 2013; 144: 1512-1520.
31. Kerbaul F, Rondelet B, Motte S, et al. Effects of norepinephrine and dobutamine on pressure load-induced right ventricular failure. Crit Care Med 2004; 32: 1035-1040.
32. de Man FS, Handoko ML, van Ballegoij JJ, et al. Bisoprolol delays progression towards right heart failure in experimental pulmonary hypertension. Circ Heart Fail 2012; 5: 97-105.
33. Bogaard HJ, Natarajan R, Mizuno S, et al. Adrenergic blockade reverses right heart remodeling and dysfunction in pulmonary hypertensivre rats. Am J Respir Crit Care Med 2010; 182: 652-656.
34. Rich S, McLaughlin VV. The effects of chronic prostacyclin therapy on cardiac output and symptoms in primary pulmonary hypertension. J Am Coll Cardiol 1999; 34: 1184-1187.
35. Nagendran J, Archer SL, Soliman D, et al. Phosphodiesterase type 5 is highly expressed in the hypertrophied human right ventricle, and acute inhibition of phosphodiesterase type 5 improves contractility. Circulation 2007; 116: 238-248.
36. Wauthy P, Kafi AS, Mooi W, et al. Effects of nitric oxide and prostacyclin in an over-circulation model of pulmonary hypertension. J Thorac Cardiovasc Surg 2003; 125: 1430-1437.
37. Kerbaul F, Brimioulle S, Rondelet B, et al. How prostacyclin improves cardiac output in right heart failure in conjunction with pulmonary hypertension. Am J Respir Crit Care Med 2007; 175: 846-850.
38. Rex S, Missant C, Segers P, et al. Epoprostenol treatment of acute pulmonary hypertension is associated with a paradoxical decrease in right ventricular contractility. Intens Care Med 2008; 34: 179-189.
39. Fesler P, Pagnamenta A, Rondelet B, et al. Effects of sildenafil on hypoxic pulmonary vascular function in dogs. J Appl Physiol 2006; 101: 1085-1090.
40. Borgdorff MA, Bartelds B, Dickinson MG, et al. Sildenafil enhances systolic adaptation, but does not prevent diastolic dysfunction, in the pressure-loaded right ventricle. Eur J Heart Fail 2012; 14: 1067-1074.
41. Rondelet B, Kerbaul F, Motte S, et al. Bosentan for the prevention of overcirculation-induced pulmonary hypertension. Circulation 2003; 107: 1329-1335.
42. Sanz J, García-Alvarez A, Fernández-Friera L, et al. Right ventriculo-arterial coupling in pulmonary hypertension: a magnetic resonance study. Heart 2012; 98: 238-243.
43. Trip P, Kind T, van de Veerdonk MC, et al. Accurate assessment of load-independent right ventricular systolic function in patients with pulmonary hypertension. J Heart Lung Transplant 2013; 32: 50-55.
44. van de Veerdonk MC, Kind T, Marcus JT, et al. Progressive right ventricular dysfunction in patients with pulmonary arterial hypertension responding to therapy. J Am Coll Cardiol 2011; 58: 2511-2519.
45. Sniderman AD, Fitchett DH. Vasodilators and pulmonary arterial hypertension: the paradox of therapeutic success and clinical failure. Int J Cardiol 1988; 20: 173-181.
46. Zhang QB, Sun JP, Gao RF, et al. Feasibility of single-beat full volume capture real-time three-dimensional echocardiography for quantification of right ventricular volume: validation by cardiac magnetic resonance imaging. Int J Cardiol 2013; 168: 3991-3995.
47. Elzinga G, Westerhof N. The effect of an increase in inotropic state and end-diastolic volume on the pumping ability of the feline left heart. Circ Res 1978; 42: 620-628.
48. Overbeek MJ, Lankhaar JW, Westerhof N, et al. Right ventricular contractility in systemic sclerosis-associated and idiopathic pulmonary arterial hypertension. Eur Respir J 2008; 31: 1160-1166.
49. Haddad F, Vrtovec B, Ashley EA, et al. The concept of ventricular reserve in heart failure and pulmonary hypertension: an old metric that brings us one step closer in our quest for prediction. Curr Opin Cardiol 2011; 26: 123-131.
50. Faber MJ, Dalinghaus M, Lankhuizen IM, et al. Right and left ventricular function after chronic pulmonary artery banding in rats assessed with biventricular pressure-volume loops. Am J Physiol Heart Circ Physiol 2006; 291: H1580-H1586.
51. Grünig E, Tiede H, Enyimayew EO, et al. Assessment and prognostic relevance of right ventricular contractile reserve in patients with pulmonary arterial hypertension. Circulation 2013; 128: 2005-2015.
52. Saouti N, Westerhof N, Helderman F, et al. Right ventricular oscillatory power is a constant fraction of total power irrespective of pulmonary artery pressure. Am J Respir Crit Care Med 2010; 182: 1315-1320.
53. Bossone E, D’Andrea A, D’Alto M, et al. Echocardiography in pulmonary arterial hypertension: from diagnosis to prognosis. J Am Soc Echocardiogr 2013; 26: 1-14.
54. Roberts JD, Forfia PR. Diagnosis and assessment of pulmonary vascular disease by Doppler echocardiography. Pulm Circ 2011; 1: 160-181.
55. Ernande L, Cottin V, Leroux PY, et al. Right isovolumic contraction velocity predicts survival in pulmonary hypertension. J Am Soc Echocardiogr 2013; 26: 297-306.
56. Vogel M, Schmidt MR, Christiansen SB, et al. Validation of myocardial acceleration during isovolumic contraction as a novel non-invasive index of right ventricular contractility. Circulation 2002; 105: 1693-1699.
57. Rain S, Handoko ML, Trip P, et al. Right ventricular diastolic impairment in patients with pulmonary arterial hypertension. Circulation 2013; 128: 2016-2025.
58. Santamore WP, Dell’Italia LJ. Ventricular interdependence: significant left ventricular contributions to right ventricular systolic function. Progr Cardiovasc Dis 1998; 40: 289-308.
59. Lazar JM, Flores AR, Grandis DJ, et al. Effects of chronic right ventricular pressure overload on left ventricular diastolic function. Am J Cardiol 1993; 72: 1179-1182.
60. Belenkie I, Horne SG, Dani R, et al. Effects of aortic constriction during experimental acute right ventricular pressure loading. Further insights into diastolic and systolic ventricular interaction. Circulation 1995; 92: 546-554.
61. Damiano RJ Jr, La Follette P Jr, Cox JL, et al. Significant left ventricular contribution to right ventricular systolic function. Am J Physiol 1991; 261: H1514-H1524.
62. Marcus JT, Gan CT, Zwanenburg JJ, et al. Interventricular mechanical asynchrony in pulmonary arterial hypertension: left-to-right delay in peak shortening is related to right ventricular overload and left ventricular underfilling. J Am Coll Cardiol 2008; 51: 750-757.
63. Huez S, Faoro V, Vachiery JL, et al. Images in cardiovascular medicine. High-altitude-induced right-heart failure. Circulation 2007; 115: e308-e309.
64. Smith BC, Dobson G, Dawson D, et al. Three-dimensional speckle tracking of the right ventricle: toward optimal quantification of right ventricular dysfunction in pulmonary hypertension. J Am Coll Cardiol 2014; 64: 41-51.